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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Publications

Is Tumor Budding a New Predictor for Early Cystectomy in pT1 High-Grade Bladder Cancer?

PMID: 34352790
Journal: UROLOGIA INTERNATIONALIS
Year: 2022
Reference: Urol Int. 2022;106(2):154-162. doi: 10.1159/000517543. Epub 2021 Aug 5.
Impact factor: 2.089
Publication type: Paper in international publication
Authors: Raventos Busquets, Carles X; Semidey, M Eugenia; Lozano Palacio, Fernando; Carrion Puig, Albert; Aula Olivar, Ana; De Torres Ramirez, Ines M; Trilla Herrera, Enrique et al.
DOI: 10.1159/000517543

Variant t(11;22)(q13;q11.2) with IGL involvement in mantle cell lymphoma.

PMID: 35129412
Journal: LEUKEMIA & LYMPHOMA
Year: 2022
Reference: Leuk Lymphoma. 2022 Jul;63(7):1746-1749. doi: 10.1080/10428194.2022.2034158. Epub 2022 Feb 7.
Impact factor: 3.28
Publication type: Letter or abstract
Authors: Cabirta, Alba; Hidalgo-Gomez, Gloria; Marin-Niebla, Ana; Gallur, Laura; Saumell, Silvia; Castellvi, Josep; Blanco, Adoracion; Lopez-Andreoni, Laura; Montoro, Maria Julia; Navarrete, Mayda et al.
DOI: 10.1080/10428194.2022.2034158

Placental Tissue Destruction and Insufficiency from COVID-19 Causes Stillbirth and Neonatal Death from Hypoxic-Ischemic Injury: A Study of 68 Cases with SARS-CoV-2 Placentitis from 12 Countries.

PMID: 35142798
Journal: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Year: 2022
Reference: Arch Pathol Lab Med. 2022 Jun 1;146(6):660-676. doi: 10.5858/arpa.2022-0029-SA.
Impact factor: 5.534
Publication type: Paper in international publication
Authors: Schwartz, David A; Avvad-Portari, Elyzabeth; Babal, Pavel; Baldewijns, Marcella; Blomberg, Marie; Bouachba, Amine; Saad, Ali G; Sand, Anna; Schoenmakers, Sam; Sehn, Jennifer K et al.
DOI: 10.5858/arpa.2022-0029-SA

Mesenchymal Stem Cells Delivery in Individuals with Different Pathologies: Multimodal Tracking, Safety and Future Applications.

PMID: 35163605
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Jan 31;23(3). pii: ijms23031682. doi: 10.3390/ijms23031682.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Vassaux, Georges; Medel-Martinez, Ana; Burnet, Jerome; Quintanilla, Miguel; Ramon Y Cajal, Santiago; Hernandez-Losa, Javier; De la Vieja, Antonio; Martin-Duque, Pilar; Belmar-Lopez, Carolina et al.
DOI: 10.3390/ijms23031682

Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer.

PMID: 33397968
Journal: npj Breast Cancer
Year: 2021
Reference: NPJ Breast Cancer. 2021 Jan 4;7(1):1. doi: 10.1038/s41523-020-00208-2.
Impact factor:
Publication type: Paper in international publication
Authors: Adamo, Barbara; Barnadas, Esther; Barrios, Carlos H; Braso-Maristany, Fara; Cejalvo, Juan Miguel; Chic, Nuria; Conte, Benedetta; De Placido, Sabino; Fasani, Roberta; Fernandez-Martinez, Aranzazu et al.
DOI: 10.1038/s41523-020-00208-2

Clinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study.

PMID: 32426847
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2021
Reference: Br J Haematol. 2021 Jan;192(1):82-99. doi: 10.1111/bjh.16741. Epub 2020 May 19.
Impact factor:
Publication type: Paper in international publication
Authors: Aliste, Carlos; Bellas, Carmen; Bendana, Angeles; Blanco Munez, Oscar Javier; Borrero, Juan Jose; Caballero, Dolores; Carpio, Cecilia; Castellvi, Josep; Climent, Fina; Cordoba, Raul et al.
DOI: 10.1111/bjh.16741

Nodal metastatic load in papillary thyroid carcinoma. Morphological and molecular analysis with one-step nucleic acid amplification on more than 550 lymph nodes.

PMID: 34556265
Journal: Endocrinologia Diabetes y Nutricion
Year: 2021
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2021 May;68(5):346-353. doi: 10.1016/j.endien.2021.08.003.
Impact factor:
Publication type: Paper in international publication
Authors: Caubet, Enric; Garcia-Burillo, Amparo; Gonzalez, Oscar; Iglesias, Carmela; Ramon Y Cajal, Santiago; Temprana-Salvador, Jordi; Zafon, Carles et al.
DOI: 10.1016/j.endien.2021.08.003

When Is Sentinel Node Biopsy Indicated in High-Risk Ductal Carcinoma in situ? Four Hundred Sixty-Eight Cases from Three Institutions.

PMID: 35087365
Journal: Breast Care
Year: 2021
Reference: Breast Care (Basel). 2021 Dec;16(6):630-636. doi: 10.1159/000514849. Epub 2021 Mar 30.
Impact factor: 2.86
Publication type: Paper in international publication
Authors: Acosta, Juan, Jurado, Judith, Peiró, Ricardo, Gomez, Margarita, Gonzalez-Farré, Xavier, Martinez, Milagros, Luna, Miguel, Peg, Vicente, Gil-Moreno, Antonio, Xiberta, Manel et al.
DOI: 10.1159/000514849

Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma.

PMID: 33110059
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Oct 27;11(1):5376. doi: 10.1038/s41467-020-19175-0.
Impact factor: 12.121
Publication type: Paper in international publication
Authors: Gros, Luis, Ramon Y Cajal, Santiago, Poca, Maria A, Puente, Xose S, Sahuquillo, Juan, Gallego, Soledad, Seoane, Joan, Hladun, Raquel, Lesende-Rodriguez, Ivan, Vazquez-Mendez, Elida et al.
DOI: 10.1038/s41467-020-19175-0

External validation of putative biomarkers in eutopic endometrium of women with endometriosis using NanoString technology.

PMID: 33033989
Journal: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Year: 2020
Reference: J Assist Reprod Genet. 2020 Dec;37(12):2981-2987. doi: 10.1007/s10815-020-01965-6. Epub 2020 Oct 9.
Impact factor: 2.829
Publication type: Paper in international publication
Authors: Vallve-Juanico, Julia, Lopez-Gil, Carlos, Ponomarenko, Julia, Melnychuk, Taisiia, Castellvi, Josep, Ballesteros, Agustin, Colas, Eva, Santamaria Costa, Xavier, Gil-Moreno, Antonio et al.
DOI: 10.1007/s10815-020-01965-6

Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells.

PMID: 33003486
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Sep 29;12(10). pii: cancers12102798. doi: 10.3390/cancers12102798.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Aasen, Trond, Ramon Y Cajal, Santiago, Girao, Henrique, Pearce, Christopher, Tishchenko, Alexander, Azorin, Daniel D, Vidal-Brime, Laia, Munoz, Maria Jose, Arenas, Pol Jimenez et al.
DOI: 10.3390/cancers12102798

Publisher Correction: ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells.

PMID: 32934237
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Sep 15;11(1):4730. doi: 10.1038/s41467-020-18674-4.
Impact factor: 12.121
Publication type: Letter or abstract
Authors: Fuentes, Pedro, Sese, Marta, Guijarro, Pedro J, Emperador, Marta, Sanchez-Redondo, Sara, Peinado, Hector, Hummer, Stefan, Cajal, Santiago Ramon Y et al.
DOI: 10.1038/s41467-020-18674-4

Autophagy inhibition as a promising therapeutic target for laryngeal cancer.

PMID: 31050705
Journal: CARCINOGENESIS
Year: 2019
Reference: Carcinogenesis. 2019 Dec 31;40(12):1525-1534. doi: 10.1093/carcin/bgz080.
Impact factor: 4.004
Publication type: Paper in international publication
Authors: Lorente, Juan, Paciucci, Rosanna, LLeonart, Matilde E, Maggio, Valentina, Temprana, Jordi, Benavente, Sergi, Garcia-Mayea, Yoelsis, Mir, Cristina, Munoz, Lisandra, Castellvi, Josep et al.
DOI: 10.1093/carcin/bgz080

Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages.

PMID: 31028084
Journal: EMBO JOURNAL
Year: 2019
Reference: EMBO J. 2019 Jun 3;38(11). pii: embj.2018100299. doi: 10.15252/embj.2018100299. Epub 2019 Apr 26.
Impact factor: 11.227
Publication type: Paper in international publication
Authors: Guo, Manman, Hartlova, Anetta, Gierlinski, Marek, Prescott, Alan, Castellvi, Josep, Losa, Javier Hernandez, Petersen, Sine K, Wenzel, Ulf A, Dill, Brian D, Emmerich, Christoph H et al.
DOI: 10.15252/embj.2018100299

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways.

PMID: 31001323
Journal: Frontiers in Genetics
Year: 2019
Reference: Front Genet. 2019 Apr 2;10:281. doi: 10.3389/fgene.2019.00281. eCollection 2019.
Impact factor: 3.517
Publication type: Paper in international publication
Authors: Ramon Y Cajal, Santiago, Segura, Miguel F, Hummer, Stefan et al.
DOI: 10.3389/fgene.2019.00281

Lymphoepithelial carcinoma of the accessory parotid gland.

PMID: 30928150
Journal: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Year: 2019
Reference: Br J Oral Maxillofac Surg. 2019 May;57(4):365-367. doi: 10.1016/j.bjoms.2018.09.017. Epub 2019 Mar 28.
Impact factor: 1.164
Publication type: Paper in international publication
Authors: Prieto Gundin, A, Salcedo-Gil, C A, Rubio-Palau, J, Alberola Ferranti, M et al.
DOI: 10.1016/j.bjoms.2018.09.017

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients.

PMID: 30250996
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2018
Reference: Mol Biol Rep. 2018 Dec;45(6):2345-2358. doi: 10.1007/s11033-018-4399-x. Epub 2018 Sep 24.
Impact factor: 1.889
Publication type: Paper in international publication
Authors: Said, Rahma, Garcia-Mayea, Yoelsis, Trabelsi, Nesrine, Setti Boubaker, Nouha, Mir, Cristina, Blel, Ahlem, Ati, Nidhal, Paciucci, Rosanna, Hernandez-Losa, Javier, Rammeh, Soumaya et al.
DOI: 10.1007/s11033-018-4399-x

Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - Clinical associations in NSCLC patients of the ETOP Lungscape cohort.

PMID: 30240851
Journal: Journal of Thoracic Oncology
Year: 2018
Reference: J Thorac Oncol. 2018 Dec;13(12):1851-1863. doi: 10.1016/j.jtho.2018.08.2034. Epub 2018 Sep 18.
Impact factor: 10.336
Publication type: Paper in international publication
Authors: Geiger, Thomas, Tsourti, Zoi, Casanova, Ruben, Deml, Karl-Friedrich, Verbeken, Eric, Thunnissen, Erik, Warth, Arne, Cheney, Richard, Sejda, Aleksandra, Speel, Ernst Jan et al.
DOI: 10.1016/j.jtho.2018.08.2034

Extracellular HMGA1 promotes tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

PMID: 30135148
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Dec 15;24(24):6367-6382. doi: 10.1158/1078-0432.CCR-18-0517. Epub 2018 Aug 22.
Impact factor: 10.199
Publication type: Paper in international publication
Authors: Salvans, Candida, Pujals, Mireia, Fernandez, Yolanda, Abasolo, Ibane, Perez, Jose, Matres, Ana, Valeri, Marta, Gregori, Josep, Villarreal, Laura, Schwartz, Simo et al.
DOI: 10.1158/1078-0432.CCR-18-0517

High Resolution Computed Tomography and Fiberoptic Bronchoscopy in the Study of Severe Asthma.

PMID: 30054117
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2018
Reference: Arch Bronconeumol. 2018 Dec;54(12):627. doi: 10.1016/j.arbres.2018.05.018. Epub 2018 Jul 24.
Impact factor: 2.633
Publication type: Paper in national publication
Authors: Clofent, David, Sansano, Irene, Ojanguren, Inigo et al.
DOI: 10.1016/j.arbres.2018.05.018

Analysis of expression of programmed cell death 1 ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM).

PMID: 25774992
Journal: PLoS One
Year: 2015
Reference: PLoS One. 2015 Mar 16;10(3):e0121071. doi: 10.1371/journal.pone.0121071. eCollection 2015.
Impact factor: 3.234
Publication type: Paper in international publication
Authors: Cedres, Susana, Ponce-Aix, Santiago, Zugazagoitia, Jon, Sansano, Irene, Enguita, Ana, Navarro-Mendivil, Alejandro, Martinez-Marti, Alex, Martinez, Pablo, Felip, Enriqueta et al.
DOI: 10.1371/journal.pone.0121071

Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion.

PMID: 25924802
Journal: CLINICAL & EXPERIMENTAL METASTASIS
Year: 2015
Reference: Clin Exp Metastasis. 2015 Jun;32(5):467-78. doi: 10.1007/s10585-015-9720-7. Epub 2015 Apr 30.
Impact factor: 3.491
Publication type: Paper in international publication
Authors: Alameda, Francesc, Pedrola, Nuria, Devis, Laura, Llaurado, Marta, Campoy, Irene, Martinez-Garcia, Elena, Garcia, Marta, Muinelo-Romay, Laura, Alonso-Alconada, Lorena, Abal, Miguel et al.
DOI: 10.1007/s10585-015-9720-7

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.

PMID: 25923732
Journal: PLoS One
Year: 2015
Reference: PLoS One. 2015 Apr 29;10(4):e0123352. doi: 10.1371/journal.pone.0123352. eCollection 2015.
Impact factor: 3.234
Publication type: Paper in international publication
Authors: Martinez, Alba, Sese, Marta, Losa, Javier Hernandez, Robichaud, Nathaniel, Sonenberg, Nahum, Aasen, Trond, Ramon Y Cajal, Santiago et al.
DOI: 10.1371/journal.pone.0123352

Post-transcriptional regulation of connexins.

PMID: 26009192
Journal: BIOCHEMICAL SOCIETY TRANSACTIONS
Year: 2015
Reference: Biochem Soc Trans. 2015 Jun 1;43(3):465-70. doi: 10.1042/BST20150033.
Impact factor: 3.194
Publication type: Paper in international publication
Authors: Salat-Canela, Claudia, Munoz, Maria Jose, Sese, Marta, Ramon Y Cajal, Santiago, Aasen, Trond et al.
DOI: 10.1042/BST20150033

Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice.

PMID: 24127882
Journal: BJU INT
Year: 2014
Reference: BJU Int. 2014 May;113(5b):E164-77. doi: 10.1111/bju.12503. Epub 2014 Feb 14.
Impact factor: 3.13
Publication type: Paper in international publication
Authors: Garcia, Marta, Velez, Roberto, Romagosa, Cleofe, Majem, Blanca, Pedrola, Nuria, Rigau, Marina, Guiu, Marc, Gomis, Roger R, Morote, Juan, Reventos, Jaume et al.
DOI: 10.1111/bju.12503

The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors.

PMID: 24284518
Journal: KIDNEY INT
Year: 2014
Reference: Kidney Int. 2014 May;85(5):1161-8. doi: 10.1038/ki.2013.461. Epub 2013 Nov 27.
Impact factor: 8.52
Publication type: Paper in international publication
Authors: Trilla, Enric, Sellares, Joana, Morote, Joan, Seron, Daniel, Montero, Angeles, Torres, Irina B, Perello, Manel, Cantarell, Carme, Antonieta Azancot, M, Moreso, Francesc et al.
DOI: 10.1038/ki.2013.461

Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1.

PMID: 23455324
Journal: ONCOGENE
Year: 2014
Reference: Oncogene. 2014 Feb 27;33(9):1124-34. doi: 10.1038/onc.2013.51. Epub 2013 Mar 4.
Impact factor: 8.559
Publication type: Paper in international publication
Authors: Marques, N, Sese, M, Canovas, V, Valente, F, Bermudo, R, de Torres, I, Fernandez, Y, Abasolo, I, Fernandez, P L, Contreras, H et al.
DOI: 10.1038/onc.2013.51

Early predictors of antiviral treatment response in liver transplant recipients with recurrent hepatitis C genotype 1.

PMID: 24620835
Journal: J VIRAL HEPATITIS
Year: 2014
Reference: J Viral Hepat. 2014 Oct;21(10):e118-28. doi: 10.1111/jvh.12246. Epub 2014 Mar 12.
Impact factor: 3.307
Publication type: Paper in international publication
Authors: Campos-Varela, I, Esteban, J I, Bes, M, Caralt, M, Allende, H, Rodriguez-Frias, F, Salcedo, M T, Sauleda, S, Charco, R, Guardia, J et al.
DOI: 10.1111/jvh.12246

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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