Jaume Alijotas Reig Instituciones de las que forman parte Jefe de grupo Enfermedades Sistémicas Vall Hebron Institut de Recerca Email Jaume Alijotas Reig Email Instituciones de las que forman parte Jefe de grupo Enfermedades Sistémicas Vall Hebron Institut de Recerca
Líneas de investigación Immunobiology and immunopathology of recurrent pregnancy loses and spontaneous loses. Around 2-3% of reproductive-age couples suffer recurrent pregnancy loses. Almost 18% of couples that wish to have children suffer infertility problems. Simultaneously, 2-3% of all pregnant women are diagnosed with spontaneous loses. The expression of HLA molecules, specially type G, the degree of trophoblastic apoptosis, the outsourcing of new neoantigens such as phospholipids, the balance between Th1/Th2/Th3 cytokines, the type and quantity of CD4+CD25+Foxp3+ lymphocytes, the kind and the activity of uterine NK cells (uNK) cells, the presence or absence of blocking antibodies, and other mechanisms play different roles in the achievement of the so-called "tolerant microenvironment" needed to develop a normal pregnancy. Therefore, both autoimmune and alloimmune mechanisms are important. We aim at studying which isolated, and specially associated, anomalies can be identified as risk markers to be able to evaluate possible treatments. IP: Jaume Alijotas Reig Cellular microparticles study in women with and without antiphospholipid antibodies with recurrent pregnancy loses and preeclampsia. Cellular microparticles (CMP) are released depending on the activation and/or the presence of cell apoptosis. They are capable of activating both inflammatory and coagulation pathways. It seems that levels of CMP are higher in healthy pregnant women. A working hypothesis establishes that an increase of CMP levels may be found in recurrent pregnancy loses and preeclampsia. It is thought that their thrombophilic capacity may be higher in those patients with anti-phospholipid antibodies, especially among those with lupus anticoagulant. We want to determine MPC levels in non-pregnant healthy women, pregnant women without previous abnormal obstetric events, women with recurrent pregnancy loses, and women with severe preeclampsia. We are also evaluating whether there are differences related to the presence or absence of antiphospholipid antibodies. Finally, we will also characterize the exact type of CMP (endothelial, platelet-like, leuco-monocyte, and throphoblastic). IP: Jaume Alijotas Reig Pathogenic role of cellular microparticles and anti-phospholipid/anti-cofactor antibodies in recurrent implantation failures related to In Vitro Fertilization (IVF). The prevalence of failed IVF is high or very high. Besides problems intrinsic to the technique, we know almost nothing about the possible underlying causes. Anti-phospholipid/anti-cofactor (aPL/aCF) antibodies have been associated to several obstetric complications. Nevertheless, the role that these aPL/aCF antibodies may have in failed IVF is not well defined. With this randomized study we want to understand better the use that these antibodies may have on a clinical daily basis. Along with the microparticles analysis, we could end up by finding several elements that might act as risk markers; in turn, it might even help us to fine-tune the currently used therapeutic approaches. IP: Jaume Alijotas Reig Development of the European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS/EUROMAP). The so-called obstetric antiphospholipid syndrome seems to have pathogenic, biologic, therapeutic, and evolution features somehow different from the ones observed in those patients who suffer from "classic" antiphospholipid syndrome. Although experience and scientific evidence seem to support this idea, there is a lack of information that allows us to suggest changes in the classification and/or therapeutic criteria. The European Forum on Antiphospholipid Antibody Syndrome has decided to carry on this project and it has chosen the Vall d'Hebron Hospital as the European Coordinating Centre. Many important Spanish and European hospitals will participate in this multicentric study. IP: Jaume Alijotas Reig Paginación Primera página « Página anterior ‹ Página 1 Página actual 2 Página 3 Siguiente página › Última página » Proyectos Incorporación del ratio sFlt1/PlGF en el diagnóstico y clasificación de preeclampsia: Ensayo clínico randomizado (EuroPE estudio) IP: Elisa Llurba Olivé Colaboradores: Jaume Alijotas Reig, Manel Mendoza Cobaleda Entidad financiadora: Instituto de Salud Carlos III Financiación: 111925 Referencia: PI16/00375 Duración: 01/01/2017 - 13/06/2017 Sulfato de magnesio en pauta continua versus discontinua en la conducta expectante de la preeclampsia grave: ensayo clínico aleatorizado IP: Anna Suy Franch Colaboradores: Jaume Alijotas Reig Entidad financiadora: Ministerio Sanidad Financiación: 57120 Referencia: EC11-474 Duración: 01/01/2012 - 31/12/2018 Sulfato de magnesio en pauta continua versus discontinua en la conducta expectante de la preeclampsia grave: ensayo clínico randomizado IP: Anna Suy Franch Colaboradores: Jaume Alijotas Reig, Maria del Mar Goya Canino Entidad financiadora: Instituto de Salud Carlos III Financiación: 62012.5 Referencia: PI11/00388 Duración: 01/01/2012 - 30/06/2016 GLOBE: Gestación Ligada a Obesidad y al Entorno. Estudio longitudinal multicéntrico de factores de riesgo asociados a la obesidad en el embarazo IP: - Colaboradores: Jaume Alijotas Reig, Inés Zulema Calero Fernández, Maite Avilés García Entidad financiadora: Instituto de Salud Carlos III Financiación: 135883 Referencia: PI10/01367 Duración: 01/01/2011 - 31/12/2014 Paginación Primera página « Página anterior ‹ Página 1 Página actual 2 Página 3 Siguiente página › Última página »
