The prevalence of failed IVF is high or very high. Besides problems intrinsic to the technique, we know almost nothing about the possible underlying causes. Anti-phospholipid/anti-cofactor (aPL/aCF) antibodies have been associated to several obstetric complications. Nevertheless, the role that these aPL/aCF antibodies may have in failed IVF is not well defined. With this randomized study we want to understand better the use that these antibodies may have on a clinical daily basis. Along with the microparticles analysis, we could end up by finding several elements that might act as risk markers; in turn, it might even help us to fine-tune the currently used therapeutic approaches.

Entre el 3 y el 5% de los embarazos se complican debido a la preeclampsia (PE). La PE es un desorden multisistémico mediado por una disfunción endotelial caracterizado por hipertensión, proteinuria y daño renal. A pesar de una considerable investigación, su etiología y su patología todavía no están claras. Diferentes teorías que implican diferentes vías incluyendo la trombofilia, los cambios inmunológicos, los factores angiogénicos/antiangiogénicos circulantes y un incremento en el estrés oxidativo, se han relacionado con su patogénesis. El papel de los anticuerpos anti-fosfolípido (aFL) es motivo de discusión en la PE. La evidencia de la disfunción endotelial relacionada con la PE/FGR se ha mostrado mediante marcadores plasmáticos modificados, incluyendo la fibronectina, el factor von Willebrand y la ICAM-1 de una manera similar a lo que ocurre en las complicaciones obstétricas mediadas por aFL. Actualmente estamos tratando de encontrar el papel que pueden jugar diferentes aFL y anticuerpos dirigidos contra ciertos cofactores, así como su relación con factores angiogénicos/antiangiogénicos y el número de micropartículas en la PE severa.

The late clinical manifestations that arise when bioimplants are applied seem to have an immunologic basis. We are studying both the histological characteristics and the lesional mechanisms of the most frequently used implants. We try to analyze the role that bacteria may have in the induction and/or maintenance of these reactions and the possible correlation between particular HLA haplotypes and the adverse effects.

Around 2-3% of reproductive-age couples suffer recurrent pregnancy loses. Almost 18% of couples that wish to have children suffer infertility problems. Simultaneously, 2-3% of all pregnant women are diagnosed with spontaneous loses. The expression of HLA molecules, specially type G, the degree of trophoblastic apoptosis, the outsourcing of new neoantigens such as phospholipids, the balance between Th1/Th2/Th3 cytokines, the type and quantity of CD4+CD25+Foxp3+ lymphocytes, the kind and the activity of uterine NK cells (uNK) cells, the presence or absence of blocking antibodies, and other mechanisms play different roles in the achievement of the so-called "tolerant microenvironment" needed to develop a normal pregnancy. Therefore, both autoimmune and alloimmune mechanisms are important. We aim at studying which isolated, and specially associated, anomalies can be identified as risk markers to be able to evaluate possible treatments.