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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability: Insights from McArdle disease.

PMID: 38030066
Journal:
Year: 2023
Reference: J Sport Health Sci. 2023 Nov 27:S2095-2546(23)00115-1. doi: 10.1016/j.jshs.2023.11.006.
Impact factor:
Publication type: Paper in international publication
Authors: Alejo, Lidia B; Barranco-Gil, David; Bestard, Oriol; Bustos, Asuncion; Castellote-Belles, Laura; Couzi, Lionel; Fernandez-Ruiz, Mario; Ferrer-Costa, Roser; Kaminski, Hannah; Lucia, Alejandro et al.
DOI: 10.1016/j.jshs.2023.11.006

Prognostic Biomarkers in Kidney Transplantation: a Systematic Review and Critical Appraisal.

PMID: 38053242
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2023
Reference: J Am Soc Nephrol. 2023 Dec 6. doi: 10.1681/ASN.0000000000000260.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Awadhi, Solaf; Aubert, Olivier; Bailly, Elodie; Bestard, Oriol; Bouquegneau, Antoine; Collins, Gary; Del Bello, Arnaud; Demir, Zeynep; Divard, Gillian; Friedewald, John J et al.
DOI: 10.1681/ASN.0000000000000260

A Randomized Phase III Study of Arfolitixorin Versus Leucovorin with 5-Fluorouracil, Oxaliplatin and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial.

PMID: 38059497
Journal: Cancer research communications
Year: 2023
Reference: Cancer Res Commun. 2023 Dec 7. doi: 10.1158/2767-9764.CRC-23-0361.
Impact factor:
Publication type: Paper in international publication
Authors: de Gramont, Aimery; Gibbs, Peter; Jankowska, Magdalena; Jonker, Derek; Lenz, Heinz-Josef; Nygren, Peter; Papadimitriou, Christos A; Prager, Gerald W; Soler, Maria Jose; Stevens, Kate I et al.
DOI: 10.1158/2767-9764.CRC-23-0361

Initial Experience with the Solitaire X 3 mm Stent Retriever for the Treatment of Distal Medium Vessel Occlusions.

PMID: 38068341
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Nov 24;12(23):7289. doi: 10.3390/jcm12237289.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Awadhi, Solaf; Aubert, Olivier; Bailly, Elodie; Bestard, Oriol; Blackham, Kristine Ann; Bouquegneau, Antoine; Brehm, Alex; Caragliano, Antonio Armando; Collins, Gary; Del Bello, Arnaud et al.
DOI: 10.3390/jcm12237289

Welcome editorial by the new CKJ Editor-in-Chief: Facing the future of CKJ with enthusiasm!

PMID: 35664277
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2022 May 30;15(6):1029-1033. doi: 10.1093/ckj/sfac121. eCollection 2022 Jun.
Impact factor:
Publication type: Editorail in international publication
Authors: Soler, Maria Jose et al.
DOI: 10.1093/ckj/sfac121

Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study.

PMID: 35629041
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 May 21;11(10). pii: jcm11102915. doi: 10.3390/jcm11102915.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Fabiola; Batalha, Paula; Blasco, Miquel; Bolufer, Monica; Buxeda, Anna; Draibe, Juliana; Garcia-Carro, Clara; Melero, Maria Rosa; Merino, Ana; Quintana, Luis F et al.
DOI: 10.3390/jcm11102915

Anti-myeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in anti-neutrophil cytoplasmic antibody-associated vasculitis.

PMID: 33533909
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Mar 25;37(4):697-704. doi: 10.1093/ndt/gfab020.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Barrios, Clara; Buxeda, Anna; de la Prada, Francisco Jose; Draibe, Juliana; Duran, Xavier; Garcia-Carro, Clara; Latzke, Belen; Lozano, Ines; Pascual, Julio et al.
DOI: 10.1093/ndt/gfab020

Usefulness of urinary biomarkers to estimate the interstitial fibrosis surface in diabetic nephropathy with normal kidney function.

PMID: 35583251
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Oct 19;37(11):2102-2110. doi: 10.1093/ndt/gfac185.
Impact factor:
Publication type: Paper in international publication
Authors: Abo, Anabel; Garcia, Alicia; Gonzalez, Jorge; Jatem, Elias; Ostos, Elena; Roig, Jordi; Santacana, Maria; Segarra, Alfons; Valtierra, Naiara et al.
DOI: 10.1093/ndt/gfac185

Biomarkers in Fabry Disease. Implications for Clinical Diagnosis and Follow-up.

PMID: 33924567
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Apr 13;10(8). pii: jcm10081664. doi: 10.3390/jcm10081664.
Impact factor:
Publication type: Review in international publication
Authors: Agraz-Pamplona, Irene; Armengol-Bellapart, Mar; Arranz-Amo, Jose Antonio; Camprodon-Gomez, Maria; Carnicer-Caceres, Clara; Cea-Arestin, Cristina; Del-Toro-Riera, Mireia; Hernandez-Vara, Jorge; Lucas-Del-Pozo, Sara; Molto-Abad, Marc et al.
DOI: 10.3390/jcm10081664

A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management.

PMID: 33928108
Journal: Frontiers in Medicine
Year: 2021
Reference: Front Med (Lausanne). 2021 Apr 13;8:655871. doi: 10.3389/fmed.2021.655871. eCollection 2021.
Impact factor:
Publication type: Review in international publication
Authors: Azancot, Maria A; Azancot, Maria A; Bermejo, Sheila; Garcia-Carro, Clara; Sellares, Joana; Soler, Maria Jose; Vergara, Ander et al.
DOI: 10.3389/fmed.2021.655871

Validation of a Histologic Scoring Index for C3 Glomerulopathy.

PMID: 33359150
Journal: AMERICAN JOURNAL OF KIDNEY DISEASES
Year: 2021
Reference: Am J Kidney Dis. 2021 May;77(5):684-695.e1. doi: 10.1053/j.ajkd.2020.11.011. Epub 2020 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Natalia; Alonso, Marina; Ariceta, Gema; Avila, Ana; Barros, Xoana; Bravo, Luis; Cabello, Virginia; Calvo, Consuelo; Caravaca, Francisco; Caravaca-Fontan, Fernando et al.
DOI: 10.1053/j.ajkd.2020.11.011

Secondary antibody deficiency is associated with development of infection in kidney transplantation: results of a multicenter study.

PMID: 33064917
Journal: Transplant Infectious Disease
Year: 2021
Reference: Transpl Infect Dis. 2021 Apr;23(2):e13494. doi: 10.1111/tid.13494. Epub 2020 Oct 27.
Impact factor:
Publication type: Paper in international publication
Authors: Alarcon, Alba; Anaya, Fernando; Arias, Manuel; Calahorra, Leticia; Carbone, Javier; Ezzahouri, Ikram; Jaramillo, Maria; Jimenez, Maricela; Karanovic, Boris; Lopez-Hoyos, Marcos et al.
DOI: 10.1111/tid.13494

Efficacy and safety of bortezomib in refractory lupus nephritis: a single-center experience.

PMID: 31865857
Journal: LUPUS
Year: 2020
Reference: Lupus. 2020 Feb;29(2):118-125. doi: 10.1177/0961203319896018. Epub 2019 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, I; Arredondo, K V; Carnicer, C; Jaramillo, J; Jatem, E; Ostos, E; Ramos, N; Salcedo, M T; Segarra, A; Valtierra, N et al.
DOI: 10.1177/0961203319896018

A misprocessed form of Apolipoprotein A-I is specifically associated with recurrent Focal Segmental Glomerulosclerosis.

PMID: 31980684
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Jan 24;10(1):1159. doi: 10.1038/s41598-020-58197-y.
Impact factor:
Publication type: Paper in international publication
Authors: Helm, Dominic; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Meseguer, Anna; Moreso, Francesc J; Puig-Gay, Natalia; Rettel, Mandy; Savitski, Mikhail M; Sellares, Joana; Seron, Daniel et al.
DOI: 10.1038/s41598-020-58197-y

Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: the 2019 Expert Consensus From the Transplant Society Working Group.

PMID: 31895348
Journal: TRANSPLANTATION
Year: 2020
Reference: Transplantation. 2020 May;104(5):911-922. doi: 10.1097/TP.0000000000003095.
Impact factor:
Publication type: Paper in international publication
Authors: Ahn, Curie; Askar, Medhat; Budde, Klemens; Chadban, Steven J; Chong, Anita S; Crespo, Marta; Feng, Sandy; Haas, Mark; Jordan, Stanley C; Knechtle, Stuart et al.
DOI: 10.1097/TP.0000000000003095

MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade.

PMID: 31913319
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Jan 8;10(1):26. doi: 10.1038/s41598-019-56856-3.
Impact factor:
Publication type: Paper in international publication
Authors: Escalada, Francisco Javier; Fernandez-Seara, Maria A; Garcia-Fernandez, Nuria; Mora-Gutierrez, Jose Maria; Orbe, Josune; Paramo, Jose Antonio; Riera, Marta; Rodriguez, Jose Antonio; Slon Roblero, Maria Fernanda; Soler, Maria Jose et al.
DOI: 10.1038/s41598-019-56856-3

Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population.

PMID: 30701578
Journal: CLINICAL AND EXPERIMENTAL DERMATOLOGY
Year: 2019
Reference: Clin Exp Dermatol. 2019 Jun;44(4):e103-e109. doi: 10.1111/ced.13915. Epub 2019 Jan 30.
Impact factor: 1.771
Publication type: Paper in international publication
Authors: Ferrandiz-Pulido, C, Torres, I B, Juarez-Dobjanschi, C, Zarzoso-Munoz, I, Berastegui, C, Castells, L, Garcia-Patos, V, Moreso, F et al.
DOI: 10.1111/ced.13915

Cutaneous infections by dematiaceous opportunistic fungi: diagnosis and management in 11 solid organ transplant recipients.

PMID: 30230044
Journal: MYCOSES
Year: 2019
Reference: Mycoses. 2019 Feb;62(2):121-127. doi: 10.1111/myc.12853. Epub 2018 Oct 17.
Impact factor: 3.065
Publication type: Paper in international publication
Authors: Ferrandiz-Pulido, C, Martin-Gomez, M T, Repiso, T, Juarez, C, Ferrer, B, Lopez-Lerma, I, Gonzalez-Cruz, C, Moreso, F, Roman, A, Garcia-Patos, V et al.
DOI: 10.1111/myc.12853

Will the new molecules be effective in renal and cardiovascular protection in diabetes mellitus and diabetic kidney disease?

PMID: 30290959
Journal: NEFROLOGIA
Year: 2019
Reference: Nefrologia. 2019 Jan - Feb;39(1):3-10. doi: 10.1016/j.nefro.2018.05.011. Epub 2018 Oct 2.
Impact factor: 1.439
Publication type: Paper in national publication
Authors: Navarro-Gonzalez, Juan F, Gorriz, Jose Luis, Soler, M Jose, Martinez Martinez-Castelao, Alberto et al.
DOI: 10.1016/j.nefro.2018.05.011

Lancet Countdown paper: what does it mean for nephrology?

PMID: 30496519
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2019
Reference: Nephrol Dial Transplant. 2019 Jan 1;34(1):4-6. doi: 10.1093/ndt/gfy369.
Impact factor: 4.198
Publication type: Paper in international publication
Authors: Fouque, Denis, Blankestijn, Peter J, Bruchfeld, Annette, Capasso, Giovambattista, Fliser, Danilo, Rychlik, Ivan, Soler, Maria Jose, Spasovski, Goce, Stevens, Kate, Wanner, Christoph et al.
DOI: 10.1093/ndt/gfy369

The Interplay between inflammation and fibrosis in kidney transplantation.

PMID: 24991565
Journal: BIOMED RES INT
Year: 2014
Reference: Biomed Res Int. 2014;2014:750602. doi: 10.1155/2014/750602. Epub 2014 Jun 4.
Impact factor: 2.134
Publication type: Paper in international publication
Authors: Torres, Irina B, Moreso, Francesc, Sarro, Eduard, Meseguer, Anna, Seron, Daniel et al.
DOI: 10.1155/2014/750602

Antibody-mediated rejection: analyzing the risk, proposing solutions.

PMID: 25093441
Journal: TRANSPLANTATION
Year: 2014
Reference: Transplantation. 2014 Aug 15;98 Suppl 3:S3-21. doi: 10.1097/TP.0000000000000218.
Impact factor: 3.535
Publication type: Paper in international publication
Authors: Schwaiger, Elisabeth, Arias, Manuel, Rush, David N, Wiebe, Chris, Gibson, Ian W, Blydt-Hansen, Tom D, Nickerson, Peter W, Sellares, Joana, Lopez-Hoyos, Marcos, San Segundo, David et al.
DOI: 10.1097/TP.0000000000000218

A randomized controlled study of CPAP effect on plasma aldosterone concentration in patients with resistant hypertension and obstructive sleep apnea.

PMID: 24879492
Journal: J HYPERTENS
Year: 2014
Reference: J Hypertens. 2014 Aug;32(8):1650-7. doi: 10.1097/HJH.0000000000000238.
Impact factor: 4.222
Publication type: Paper in international publication
Authors: Martinez-Garcia, Miguel-Angel, Tovar, Jose-Luis, Ferrer, Roser, Romero, Odile, Segarra, Alfons, Lloberes, Patricia, Sampol, Gabriel, Espinel, Eugenia, Ramon, Maria-Antonia et al.
DOI: 10.1097/HJH.0000000000000238

The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors.

PMID: 24284518
Journal: KIDNEY INT
Year: 2014
Reference: Kidney Int. 2014 May;85(5):1161-8. doi: 10.1038/ki.2013.461. Epub 2013 Nov 27.
Impact factor: 8.52
Publication type: Paper in international publication
Authors: Trilla, Enric, Sellares, Joana, Morote, Joan, Seron, Daniel, Montero, Angeles, Torres, Irina B, Perello, Manel, Cantarell, Carme, Antonieta Azancot, M, Moreso, Francesc et al.
DOI: 10.1038/ki.2013.461

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Hypertension, a key risk factor for heart disease that contributes significantly to cardiovascular mortality and morbidity and damage to vital organs, was the focus of this multi-centre study.

The new findings were presented at the American Society of Nephrology's Kidney Week 2024 meeting in San Diego and simultaneously published in the prestigious journal Nature Medicine.