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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

A multicenter blinded preclinical randomized controlled trial on Jak1/2 inhibition in MRL/MpJ-Fas(lpr) mice with proliferative lupus nephritis predicts low effect size.

PMID: 33607177
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Jun;99(6):1331-1341. doi: 10.1016/j.kint.2021.01.024. Epub 2021 Feb 16.
Impact factor: 10.612
Publication type: Paper in international publication
Authors: Lei, Yutian, Sehnert, Bettina, Voll, Reinhard E, Jacobs-Cacha, Conxita, Soler, Maria Jose, Sanchez-Nino, Maria D, Ortiz, Alberto, Bulow, Roman D, Boor, Peter, Anders, Hans-Joachim et al.
DOI: 10.1016/j.kint.2021.01.024

Progression of Interstitial Fibrosis and Tubular Atrophy in Low Immunological Risk Renal Transplants Monitored by Sequential Surveillance Biopsies: The Influence of TAC Exposure and Metabolism.

PMID: 33406589
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jan 4;10(1). pii: jcm10010141. doi: 10.3390/jcm10010141.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Chamoun, Betty, Torres, Irina B, Gabaldon, Alejandra, Sellares, Joana, Perello, Manel, Castella, Eva, Guri, Xavier, Salcedo, Maite, Toapanta, Nestor G, Cidraque, Ignacio et al.
DOI: 10.3390/jcm10010141

Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring.

PMID: 33181156
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Jan;99(1):227-237. doi: 10.1016/j.kint.2020.10.032. Epub 2020 Nov 9.
Impact factor: 10.612
Publication type: Paper in international publication
Authors: Agraz, Irene, Sinaii, Ninet, Cravedi, Paolo, Manrique, Joaquin, Slon, Maria F, Bini, Claudia, Waldman, Meryl, Soler, Maria J, Garcia-Carro, Clara, Lightstone, Liz et al.
DOI: 10.1016/j.kint.2020.10.032

Blog

News

A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.

An international study involving the Hospital del Mar Research Institute and VHIR shows that there are substantial differences between men and women in the energy metabolism of of renal tubular cells.

Dr. Conxita Jacobs' research has been awarded in the clinical project category, while Dr. Anna Meseguer's research has been recognised in the basic research category.