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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

Finerenone: towards a holistic therapeutic approach to patients with diabetic kidney disease.

PMID: 37813743
Journal: Nefrologia
Year: 2023
Reference: Nefrologia (Engl Ed). 2023 Oct 7:S2013-2514(23)00146-3. doi: 10.1016/j.nefroe.2023.09.002.
Impact factor:
Publication type: Review in international publication
Authors: Facila, Lorenzo; Gonzalez-Juanatey, Jose Ramon; Gorriz, Jose Luis; Ortiz, Alberto; Soler, Maria Jose; Valle, Alfonso et al.
DOI: 10.1016/j.nefroe.2023.09.002

Molecular determinants of clinical outcomes of pembrolizumab in recurrent ovarian cancer: Exploratory analysis of KEYNOTE-100.

PMID: 37862791
Journal: Gynecologic Oncology
Year: 2023
Reference: Gynecol Oncol. 2023 Oct 18;178:119-129. doi: 10.1016/j.ygyno.2023.09.012.
Impact factor:
Publication type: Paper in international publication
Authors: Birrer, Michael; Boixadera, A; Castany-Aregall, M; Colombo, Nicoletta; Cristescu, Razvan; Distefano, L; Edmondson, Mackenzie; Garcia-Arumi, J; Garrell-Salat, X; Gonzalez-Martin, Antonio et al.
DOI: 10.1016/j.ygyno.2023.09.012

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: Primary results from the phase 3 MARIPOSA-2 study.

PMID: 37879444
Journal: ANNALS OF ONCOLOGY
Year: 2023
Reference: Ann Oncol. 2023 Oct 17:S0923-7534(23)04281-3. doi: 10.1016/j.annonc.2023.10.117.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Azuma, K; Baneras, Jordi; Barala, P; Bauml, J M; Bearz, A; Boixadera, Anna; Bourla, A B; Califano, R; Campelo, R G et al.
DOI: 10.1016/j.annonc.2023.10.117

Response to "Do we actively and early mobilize patients admitted to an intensive care unit during mechanical ventilation?".

PMID: 37949757
Journal: Enfermeria intensiva
Year: 2023
Reference: Enferm Intensiva (Engl Ed). 2023 Nov 8:S2529-9840(23)00057-5. doi: 10.1016/j.enfie.2023.06.002.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Al-Maghrabi, Reem; Alain, Sophie; Ballesteros-Reviriego, G; Beauvais, David; Bestard, Oriol; Bestard, Oriol; Blumberg, Emily; Boeken, Udo; Chemaly, Roy; Daniel Marti, J et al.
DOI: 10.1016/j.enfie.2023.06.002

Ageing meets kidney disease.

PMID: 35768070
Journal: AGE AND AGEING
Year: 2022
Reference: Age Ageing. 2022 Aug 2;51(8). pii: 6609704. doi: 10.1093/ageing/afac157.
Impact factor:
Publication type: Editorail in international publication
Authors: Fouque, Denis; Mattace-Raso, Francesco; Ortiz, Alberto; Soler, Maria Jose et al.
DOI: 10.1093/ageing/afac157

COVID-19 pandemic waves and mortality among patients on kidney replacement therapy.

PMID: 35757188
Journal: Kidney International Reports
Year: 2022
Reference: Kidney Int Rep. 2022 Sep;7(9):2091-2096. doi: 10.1016/j.ekir.2022.06.007. Epub 2022 Jun 20.
Impact factor:
Publication type: Paper in international publication
Authors: Arnol, Miha; Duivenvoorden, Raphael; Facundo, Carme; Franssen, Casper F M; Gansevoort, Ron T; Groeneveld, Marc; Hemmelder, Marc H; Hilbrands, Luuk B; Jager, Kitty J; Lepeytre, Fanny et al.
DOI: 10.1016/j.ekir.2022.06.007

Longitudinal change in proteinuria and kidney outcomes in C3 glomerulopathy.

PMID: 33779754
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Jun 23;37(7):1270-1280. doi: 10.1093/ndt/gfab075.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Natalia; Ariceta, Gema; Avila, Ana; Barros, Xoana; Bravo, Luis; Cabello, Virginia; Cano-Megias, Marta; Caravaca-Fontan, Fernando; Cruz, Sonia; Da Silva, Iara et al.
DOI: 10.1093/ndt/gfab075

Long-lasting adaptive Immune memory specific to SARS-CoV-2 in convalescent COVID-19 Stable People living with HIV.

PMID: 35730384
Journal: AIDS
Year: 2022
Reference: AIDS. 2022 Aug 1;36(10):1373-1382. doi: 10.1097/QAD.0000000000003276. Epub 2022 Jun 22.
Impact factor:
Publication type: Paper in international publication
Authors: Ardanuy, Carmen; Bestard, Oriol; Calatayud, Laura; Cidraque, Ignacio; Crespo, Elena; Donadeu, Laura; Fava, Alexandre; Jouve, Thomas; Lozano, Juan J; Meneghini, Maria et al.
DOI: 10.1097/QAD.0000000000003276

Renin-Angiotensin System Blockers and the Risk of COVID-19-Related Mortality in Patients with Kidney Failure.

PMID: 34088718
Journal: Clinical Journal of the American Society of Nephrology
Year: 2021
Reference: Clin J Am Soc Nephrol. 2021 Jul;16(7):1061-1072. doi: 10.2215/CJN.18961220. Epub 2021 Jun 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abramowicz, Daniel; Basile, Carlo; Covic, Adrian; Crespo, Marta; de Arriba, Gabriel; Duivenvoorden, Raphael; Gansevoort, Ronald; Massy, Ziad; Noordzij, Marlies; Ortiz, Alberto et al.
DOI: 10.2215/CJN.18961220

COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease.

PMID: 34098555
Journal: KIDNEY & BLOOD PRESSURE RESEARCH
Year: 2021
Reference: Kidney Blood Press Res. 2021;46(4):452-459. doi: 10.1159/000515714. Epub 2021 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Baldallo, Cinthia; Bury, Roxana; Gabaldon, Alejandra; Garcia-Carro, Clara; Roman, Juan Leon; Seron, Daniel; Soler, Maria Jose; Toapanta, Nestor; Torres, Irina et al.
DOI: 10.1159/000515714

A Specific Tubular ApoA-I Distribution Is Associated to FSGS Recurrence after Kidney Transplantation.

PMID: 34069888
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 May 18;10(10). pii: jcm10102174. doi: 10.3390/jcm10102174.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Gabaldon, Maria-Alejandra; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Moreso, Francesc; Puig-Gay, Natalia; Sellares, Joana; Seron, Daniel; Soler, Maria Jose; Vergara, Ander et al.
DOI: 10.3390/jcm10102174

Diabetes, Albuminuria and the Kidney-Brain Axis.

PMID: 34072230
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 May 27;10(11). pii: jcm10112364. doi: 10.3390/jcm10112364.
Impact factor:
Publication type: Review in international publication
Authors: Ariton, Diana Maria; Delgado, Pilar; Jimenez-Balado, Joan; Maisterra, Olga; Pujadas, Francesc; Soler, Maria Jose et al.
DOI: 10.3390/jcm10112364

Anti-HBc impacts on the risk of hepatitis B reactivation but not on survival of solid-organ transplant recipients.

PMID: 32118794
Journal: MEDICINE
Year: 2020
Reference: Medicine (Baltimore). 2020 Feb;99(9):e19407. doi: 10.1097/MD.0000000000019407.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Berastegui, Cristina; Buti, Maria; Castells, Lluis; Esteban, Rafael; Flores-Cortes, Claudia; Oleas-Vega, Diana; Perello, Manel; Riveiro-Barciela, Mar; Roman, Antonio et al.
DOI: 10.1097/MD.0000000000019407

A new clinical and immuno-virological score for predicting the risk of late severe infection in solid organ transplant recipients: the CLIV Score.

PMID: 32112085
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2020
Reference: J Infect Dis. 2020 Jul 6;222(3):479-487. doi: 10.1093/infdis/jiaa090.
Impact factor:
Publication type: Paper in international publication
Authors: Aguado, Jose Maria; Albert, Eliseo; Andres, Amado; Azancot, Maria Antonieta; Azancot, Maria Antonieta; Escudero-Sanchez, Rosa; Fernandez-Ruiz, Mario; Fortun, Jesus; Gimenez, Estela; Len, Oscar et al.
DOI: 10.1093/infdis/jiaa090

The Urinary Exosomal miRNA Expression Profile is Predictive of Clinical Response in Lupus Nephritis.

PMID: 32085620
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 Feb 18;21(4). pii: ijms21041372. doi: 10.3390/ijms21041372.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Cortes-Hernandez, Josefina; Garcia-Vives, Eloi; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina; Vidal, Marta et al.
DOI: 10.3390/ijms21041372

Cellular Immunity to Predict the Risk of Cytomegalovirus Infection in Kidney Transplantation: A Prospective, Interventional, Multicenter Clinical Trial.

PMID: 32076718
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2020
Reference: Clin Infect Dis. 2020 Dec 3;71(9):2375-2385. doi: 10.1093/cid/ciz1209.
Impact factor:
Publication type: Paper in international publication
Authors: Bestard, Oriol; Crespo, Elena; Cruzado, Josep M; Facundo, Carme; Gil Vernet, Salvador; Grinyo, Josep M; Guirado, Lluis; Gutierrez, Alex; Jarque, Marta; Manonelles, Anna et al.
DOI: 10.1093/cid/ciz1209

Nephrology and Public Policy Committee propositions to stimulate research collaboration in adults and children in Europe.

PMID: 31197325
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2019
Reference: Nephrol Dial Transplant. 2019 Sep 1;34(9):1469-1480. doi: 10.1093/ndt/gfz089.
Impact factor: 4.198
Publication type: Paper in international publication
Authors: Sever, Mehmet Sukru, Massy, Ziad A, Caskey, Fergus J, Finne, Patrik, Harambat, Jerome, Jager, Kitty J, Nagler, Evi, Stengel, Benedicte, Bruchfeld, Annette, Capasso, Giovambattista et al.
DOI: 10.1093/ndt/gfz089

Sodium-glucose cotransporter inhibitors: beyond glycaemic control.

PMID: 31198226
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2019 Mar 6;12(3):322-325. doi: 10.1093/ckj/sfz019. eCollection 2019 Jun.
Impact factor: 2.975
Publication type: Paper in international publication
Authors: Vergara, Ander, Jacobs-Cacha, Conxita, Soler, Maria Jose et al.
DOI: 10.1093/ckj/sfz019

Kidney transplant from controlled donors following circulatory death: Results from the GEODAS-3 multicentre study.

PMID: 30497696
Journal: NEFROLOGIA
Year: 2019
Reference: Nefrologia. 2019 Mar - Apr;39(2):151-159. doi: 10.1016/j.nefro.2018.07.013. Epub 2018 Nov 27.
Impact factor: 1.439
Publication type: Paper in national publication
Authors: Ramos, Ana, Pascual, Julio, Gavela, Eva, Jimenez, Carlos, Fernandez-Garcia, Anton, Perez Flores, Isabel, Portoles, Jose M, Perez-Saez, Maria Jose, Lopez-Sanchez, Paula, Lafuente-Covarrubias, Omar et al.
DOI: 10.1016/j.nefro.2018.07.013

Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials.

PMID: 30815678
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2019
Reference: Nephrol Dial Transplant. 2019 Jul 1;34(7):1112-1114. doi: 10.1093/ndt/gfz023.
Impact factor: 4.198
Publication type: Paper in international publication
Authors: Goumenos, Dimitrios, Ketteler, Markus, Massy, Ziad, Rychlik, Ivan, Soler, Maria, Stevens, Kate, Spasovski, Goce, Wanner, Christoph, Fouque, Denis, Fliser, Danilo et al.
DOI: 10.1093/ndt/gfz023

Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients: A Guidance Report and Clinical Checklist by the Consensus on Managing Modifiable Risk in Transplantation (COMMIT) Group.

PMID: 28328734
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 Apr;101(4S Suppl 2):S1-S56. doi: 10.1097/TP.0000000000001651.
Impact factor: 3.678
Publication type: Paper in international publication
Authors: Rodriguez-Peralvarez, Manuel L, Samuel, Didier, Schneeberger, Stefan, Seron, Daniel, Trunecka, Pavel, Tisone, Giuseppe, van Gelder, Teun, Pirenne, Jacques, Nevens, Frederik, Kramer, Bernhard K et al.
DOI: 10.1097/TP.0000000000001651

Clinical Trials for Immunosuppression in Transplantation; The Case for Reform and Change in Direction.

PMID: 28207630
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 Jul;101(7):1527-1534. doi: 10.1097/TP.0000000000001648.
Impact factor: 3.678
Publication type: Review in international publication
Authors: Woodle, E Steve, Kuypers, Dirk, Mannon, Roslyn R, Abecassis, Michael, Chadban, Stephen, Gill, John S, Murphy, Barbara, Nickerson, Peter W, Schold, Jesse D, Stock, Peter et al.
DOI: 10.1097/TP.0000000000001648

[Adherence to treatment after kidney transplantation as quality indicator of the information received: Longitudinal study of 2 years follow-up].

PMID: 27425627
Journal: Revista de calidad asistencial : organo de la Soci
Year: 2017
Reference: Rev Calid Asist. 2017 Jan - Feb;32(1):33-39. doi: 10.1016/j.cali.2016.05.004. Epub 2016 Jul 15.
Impact factor: 0
Publication type: Paper in national publication
Authors: Costa-Requena, G, Cantarell, M C, Moreso, F, Parramon, G, Seron, D et al.
DOI: 10.1016/j.cali.2016.05.004

The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology.

PMID: 27862883
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2017
Reference: Am J Transplant. 2017 Jan;17(1):28-41. doi: 10.1111/ajt.14107.
Impact factor: 6.165
Publication type: Editorail in international publication
Authors: Alachkar, N, Bagnasco, S, Becker, J U, Cornell, L, Drachenberg, C, Dragun, D, de Kort, H, Gibson, I W, Kraus, E S, Lefaucheur, C et al.
DOI: 10.1111/ajt.14107

Comparing transplant glomerulopathy in the absence of C4d deposition and donor-specific antibodies to chronic antibody-mediated rejection.

PMID: 25103874
Journal: CLIN TRANSPLANT
Year: 2014
Reference: Clin Transplant. 2014 Oct;28(10):1148-54. doi: 10.1111/ctr.12433. Epub 2014 Sep 11.
Impact factor: 1.486
Publication type: Paper in international publication
Authors: Torres, Irina B, Salcedo, Maite, Moreso, Francesc, Sellares, Joana, Castella, Eva, Azancot, M Antonieta, Perello, Manel, Cantarell, Carme, Seron, Daniel et al.
DOI: 10.1111/ctr.12433

Low serum mannose-binding lectin levels are associated with inflammation and apoptosis in early surveillance allograft biopsies.

PMID: 25073029
Journal: TRANSPL IMMUNOL
Year: 2014
Reference: Transpl Immunol. 2014 Sep;31(3):152-6. doi: 10.1016/j.trim.2014.07.001. Epub 2014 Jul 26.
Impact factor: 1.832
Publication type: Paper in international publication
Authors: Ibernon, M, Moreso, F, O'Valle, F, Grinyo, J M, Moral, R G, Seron, D et al.
DOI: 10.1016/j.trim.2014.07.001

[Early detection, prevention and management of renal failure in liver transplantation].

PMID: 25060591
Journal: GASTROENT HEPAT-BARC
Year: 2014
Reference: Gastroenterol Hepatol. 2014 Oct;37(8):480-91. doi: 10.1016/j.gastrohep.2013.11.006. Epub 2014 Jul 22.
Impact factor: 0.832
Publication type: Paper in national publication
Authors: Castells, Lluis, Baliellas, Carme, Bilbao, Itxarone, Cantarell, Carme, Cruzado, Josep Maria, Esforzado, Nuria, Garcia-Valdecasas, Juan Carlos, Llado, Laura, Seron, Daniel, Oppenheimer, Federico et al.
DOI: 10.1016/j.gastrohep.2013.11.006

Banff fibrosis study: multicenter visual assessment and computerized analysis of interstitial fibrosis in kidney biopsies.

PMID: 24712330
Journal: AM J TRANSPLANT
Year: 2014
Reference: Am J Transplant. 2014 Apr;14(4):897-907. doi: 10.1111/ajt.12641. Epub 2014 Feb 20.
Impact factor: 6.19
Publication type: Paper in international publication
Authors: Mengel, M, Farris, A B, Chan, S, Climenhaga, J, Adam, B, Bellamy, C O C, Seron, D, Colvin, R B, Reeve, J et al.
DOI: 10.1111/ajt.12641

Diagnosis and treatment of lupus nephritis. Consensus document from the systemic auto-immune disease group (GEAS) of the Spanish Society of Internal Medicine (SEMI) and Spanish Society of Nephrology (S.E.N.).

PMID: 22293933
Journal: NEFROLOGIA
Year: 2012
Reference: Nefrologia. 2012;32 Suppl 1:1-35. doi: 10.3265/Nefrologia.pre2011.Dec.11298.
Impact factor: 1
Publication type: Paper in national publication
Authors: Espinosa, Gerard, Ruiz Irastorza, Guillermo, Praga, Manuel, Pallares, Lucio, Rivera, Francisco, Robles Marhuenda, Angel, Segarra, Alfons, Quereda, Carlos, Jimenez Alonso, Juan, Frutos, Miguel A et al.
DOI: 10.3265/Nefrologia.pre2011.Dec.11298

Sleep-Related Painful Erections Associated with Obstructive Sleep Apnea Syndrome.

PMID: 22350120
Journal: Archives of sexual behavior
Year: 2012
Reference: Arch Sex Behav. 2012 Aug;41(4):1059-63. doi: 10.1007/s10508-011-9894-2. Epub 2012 Feb 14.
Impact factor:
Publication type: Letter or abstract
Authors: , , , , , , et al.
DOI: 10.1007/s10508-011-9894-2

Early Subclinical Rejection as a Risk Factor for Late Chronic Humoral Rejection.

PMID: 22094957
Journal: TRANSPLANTATION
Year: 2012
Reference: Transplantation. 2012 Jan 15;93(1):41-6.
Impact factor: 4.003
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1097/TP.0b013e31823bb647

Histology and proteinuria after renal transplantation.

PMID: 22137728
Journal: Transplantation reviews (Orlando, Fla.)
Year: 2012
Reference: Transplant Rev (Orlando). 2012 Jan;26(1):20-6.
Impact factor:
Publication type: Letter or abstract
Authors: Seron, Daniel, Burgos, Dolores, Alonso, Angel et al.
DOI: 10.1016/j.trre.2011.07.009

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Hypertension, a key risk factor for heart disease that contributes significantly to cardiovascular mortality and morbidity and damage to vital organs, was the focus of this multi-centre study.

The new findings were presented at the American Society of Nephrology's Kidney Week 2024 meeting in San Diego and simultaneously published in the prestigious journal Nature Medicine.