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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

Mutual modulation of gut microbiota and the immune system in type 1 diabetes models.

PMID: 38012160
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Nov 27;14(1):7770. doi: 10.1038/s41467-023-43652-x.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Fabiola; Arpa, Berta; Aunon, Pilar; Corral-Pujol, Marta; Cosovanu, Catalina; Egia-Mendikute, Leire; Garcia, Patricia; Garcia-Carro, Clara; Gutierrez, Eduardo; Manichanh, Chaysavanh et al.
DOI: 10.1038/s41467-023-43652-x

Cytomegalovirus Cell-Mediated Immunity: Ready for Routine Use?

PMID: 38020746
Journal: TRANSPLANT INTERNATIONAL
Year: 2023
Reference: Transpl Int. 2023 Nov 7;36:11963. doi: 10.3389/ti.2023.11963. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bestard, Oriol; Couzi, Lionel; Del Carmen, Amin; Fernandez-Ruiz, Mario; Garnacho-Castano, Manuel V; Kaminski, Hannah; Manuel, Oriol; Miravitlles, Marc; Moreno, Eva; Pleguezuelos, Eulogio et al.
DOI: 10.3389/ti.2023.11963

Obesity Weight Loss Phenotypes in CKD: Measured GFR and Albumin-to-Creatinine Excretion Ratio Place for Stratification.

PMID: 38025231
Journal: Kidney International Reports
Year: 2023
Reference: Kidney Int Rep. 2023 Sep 20;8(11):2492. doi: 10.1016/j.ekir.2023.08.011. eCollection 2023 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Aguasca, Gerard Marti; Alujas, Teresa Gonzalez; Barcelo, Maria Calvo; Barrabes, Jose A; Belahnech, Yassin; Bellera, Neus; Calabuig, Alvaro; Fernandez-Galera, Ruben; Galian-Gay, Laura; Garcia Del Blanco, Bruno et al.
DOI: 10.1016/j.ekir.2023.08.011

Impact of graft reperfusion on cardiac function assessed by transesophageal echocardiography during liver transplantation: an observational retrospective study.

PMID: 38032448
Journal: JOURNAL OF CLINICAL MONITORING AND COMPUTING
Year: 2023
Reference: J Clin Monit Comput. 2023 Nov 30. doi: 10.1007/s10877-023-01110-5.
Impact factor:
Publication type: Paper in international publication
Authors: Corbett, Matthew; Gonzalez-Suarez, Susana; Hernandez-Martinez, Alberto; Lopez-Martinez, Marina; Machado, Miriam; Rico-Fontalvo, Jorge; Soler, Maria Jose et al.
DOI: 10.1007/s10877-023-01110-5

Alloimmune Risk Stratification for Kidney Transplant Rejection.

PMID: 35669972
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10138. doi: 10.3389/ti.2022.10138. eCollection 2022.
Impact factor:
Publication type: Editorail in international publication
Authors: Bellini, Maria Irene; Bestard, Oriol; Bohmig, Georg A; Budde, Klemens; Claas, Frans; Couzi, Lionel; Furian, Lucrezia; Heemann, Uwe; Mamode, Nizam; Naesens, Maarten et al.
DOI: 10.3389/ti.2022.10138

Evolution of the Definition of Rejection in Kidney Transplantation and Its Use as an Endpoint in Clinical Trials.

PMID: 35669978
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10141. doi: 10.3389/ti.2022.10141. eCollection 2022.
Impact factor:
Publication type: Editorail in international publication
Authors: Becker, Jan Ulrich; Naesens, Maarten; Rabant, Marion; Roufosse, Candice; Seron, Daniel et al.
DOI: 10.3389/ti.2022.10141

Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation.

PMID: 35669975
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10135. doi: 10.3389/ti.2022.10135. eCollection 2022.
Impact factor:
Publication type: Review in international publication
Authors: Becker, Jan Ulrich; Bellini, Maria Irene; Bohmig, Georg A; Budde, Klemens; Diekmann, Fritz; Glotz, Denis; Hilbrands, Luuk; Loupy, Alexandre; Naesens, Maarten; Oberbauer, Rainer et al.
DOI: 10.3389/ti.2022.10135

Proposed Definitions of Antibody-Mediated Rejection for Use as a Clinical Trial Endpoint in Kidney Transplantation.

PMID: 35669973
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10140. doi: 10.3389/ti.2022.10140. eCollection 2022.
Impact factor:
Publication type: Editorail in international publication
Authors: Becker, Jan Ulrich; Bellini, Maria Irene; Bohmig, Georg A; Budde, Klemens; Diekmann, Fritz; Glotz, Denis; Hilbrands, Luuk; Loupy, Alexandre; Naesens, Maarten; Oberbauer, Rainer et al.
DOI: 10.3389/ti.2022.10140

Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA.

PMID: 33340043
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2021
Reference: Nephrol Dial Transplant. 2021 Jan 1;36(1):87-94. doi: 10.1093/ndt/gfaa314.
Impact factor:
Publication type: Paper in international publication
Authors: Cozzolino, Mario; Duivenvoorden, Raphael; Fliser, Danilo; Fouque, Denis; Franssen, Casper F M; Gansevoort, Ron T; Gansevoort, Ron T; Goumenos, Dimitrios; Hemmelder, Marc H; Hilbrands, Luuk B et al.
DOI: 10.1093/ndt/gfaa314

Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience.

PMID: 33986388
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 May 13;11(1):10171. doi: 10.1038/s41598-021-89562-0.
Impact factor:
Publication type: Paper in international publication
Authors: Bello, Irene; Berastegui, Cristina; Bravo, Carlos; Burgos, Rosa; Escobar, Roser; Ferrandiz-Pulido, Carla; Gomez, Alba; Gomez-Olles, Susana; Lopez-Meseguer, Manuel; Mendez, Alejandra et al.
DOI: 10.1038/s41598-021-89562-0

COVID-19 in transplant recipients: The Spanish experience.

PMID: 33098200
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2021
Reference: Am J Transplant. 2021 May;21(5):1825-1837. doi: 10.1111/ajt.16369. Epub 2020 Nov 10.
Impact factor:
Publication type: Paper in international publication
Authors: Aguado, Beatriz; Bada-Bosch, Teresa; Bravo, Carlos; Burgos, Elena; Cabello, Mercedes; Coll, Elisabeth; Crespo, Marta; de Pablo, Alicia; Dominguez-Gil, Beatriz; Facundo, Carme et al.
DOI: 10.1111/ajt.16369

HIV-Positive Deceased Donor to HIV-Positive Recipient Kidney Transplantation: The HOPE Must Go On.

PMID: 32810390
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2021
Reference: Am J Transplant. 2021 May;21(5):1683-1684. doi: 10.1111/ajt.16272. Epub 2020 Sep 9.
Impact factor:
Publication type: Editorail in international publication
Authors: Cruzado, Josep M; Montero, Nuria; Moreso, Francesc et al.
DOI: 10.1111/ajt.16272

Molecular analysis of the novel L243R mutation in STXBP2 reveals impairment of degranulation activity.

PMID: 31865540
Journal: INTERNATIONAL JOURNAL OF HEMATOLOGY
Year: 2020
Reference: Int J Hematol. 2020 Mar;111(3):440-450. doi: 10.1007/s12185-019-02796-7. Epub 2019 Dec 21.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, Laia; Catala, Albert; Colobran, Roger; de la Campa, Elena Alvarez; de la Cruz, Xavier; Donadeu, Laura; Esteve-Sole, Ana; Martinez-Gallo, Monica; Rincon, Rafael; Sayos, Joan et al.
DOI: 10.1007/s12185-019-02796-7

Matrix Metalloproteinases in Diabetic Kidney Disease.

PMID: 32046355
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Feb 8;9(2). pii: jcm9020472. doi: 10.3390/jcm9020472.
Impact factor:
Publication type: Review in international publication
Authors: Garcia-Fernandez, Nuria; Jacobs-Cacha, Conxita; Mora-Gutierrez, Jose Maria; Orbe, Josune; Soler, Maria Jose; Vergara, Ander et al.
DOI: 10.3390/jcm9020472

Kidney function changes and their relation with the progression of cerebral small vessel disease and cognitive decline.

PMID: 31869590
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2020
Reference: J Neurol Sci. 2020 Feb 15;409:116635. doi: 10.1016/j.jns.2019.116635. Epub 2019 Dec 14.
Impact factor:
Publication type: Paper in international publication
Authors: Delgado, Pilar; Espinel, Eugenia; Jimenez-Balado, Joan; Maisterra, Olga; Palasi, Antoni; Penalba, Anna; Pizarro, Jesus; Pujadas, Francesc; Ramirez, Clara; Ramos, Natalia et al.
DOI: 10.1016/j.jns.2019.116635

Sodium-glucose cotransporter 2 inhibition: towards an indication to treat diabetic kidney disease.

PMID: 32003834
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2020
Reference: Nephrol Dial Transplant. 2020 Jan 1;35(Supplement_1):i13-i23. doi: 10.1093/ndt/gfz237.
Impact factor:
Publication type: Paper in international publication
Authors: Gorriz, Jose Luis; Jacobs-Cacha, Conxita; Martinez-Castelao, Alberto; Navarro-Gonzalez, Juan F; Nunez, Julio; Ortiz, Alberto; Soler, Maria Jose; Vergara, Ander et al.
DOI: 10.1093/ndt/gfz237

Renal transplantation from seropositive hepatitis C virus donors to seronegative recipients in Spain: A prospective study.

PMID: 30773693
Journal: TRANSPLANT INTERNATIONAL
Year: 2019
Reference: Transpl Int. 2019 Jul;32(7):710-716. doi: 10.1111/tri.13410. Epub 2019 Mar 10.
Impact factor: 3.526
Publication type: Paper in international publication
Authors: Franco, A, Moreso, F, Merino, E, Sancho, A, Kanter, J, Gimeno, A, Balibrea, N, Perez Contreras, J, Rodriguez, M et al.
DOI: 10.1111/tri.13410

Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis.

PMID: 30760090
Journal: LUPUS
Year: 2019
Reference: Lupus. 2019 Mar;28(3):396-405. doi: 10.1177/0961203319828521. Epub 2019 Feb 13.
Impact factor: 2.924
Publication type: Paper in international publication
Authors: Garcia-Vives, E, Sole, C, Moline, T, Alvarez-Rios, A M, Vidal, M, Agraz, I, Ordi-Ros, J, Cortes-Hernandez, J et al.
DOI: 10.1177/0961203319828521

Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy.

PMID: 30747149
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2019 Feb;12(1):33-35. doi: 10.1093/ckj/sfy079. Epub 2018 Oct 3.
Impact factor: 2.975
Publication type: Paper in international publication
Authors: Diaz, Montserrat, Agraz, Irene, Soler, Maria Jose et al.
DOI: 10.1093/ckj/sfy079

Apolipoprotein A-Ib as a biomarker of FSGS recurrence after kidney transplantation: Diagnostic performance and assessment of its prognostic value - a multi-centre cohort study.

PMID: 30411406
Journal: TRANSPLANT INTERNATIONAL
Year: 2019
Reference: Transpl Int. 2019 Mar;32(3):313-322. doi: 10.1111/tri.13372. Epub 2018 Nov 28.
Impact factor: 3.526
Publication type: Paper in international publication
Authors: Puig-Gay, Natalia, Jacobs-Cacha, Conxita, Sellares, Joana, Guirado, Lluis, Gonzalez Roncero, Francisco, Jimenez, Carlos, Zarraga, Sofia, Paul, Javier, Lauzurica, Ricardo, Angel, Alonso et al.
DOI: 10.1111/tri.13372

Advancing Transplantation: New Questions, New Possibilities in Kidney and Liver Transplantation.

PMID: 28125449
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 Feb;101 Suppl 2S:S1-S41. doi: 10.1097/TP.0000000000001563.
Impact factor: 3.678
Publication type: Editorail in international publication
Authors: Grinyo, Josep, Loupy, Alexandre, Kuypers, Dirk, Mariat, Christophe, Clancy, Marc, Jardine, Alan G, Guirado, Lluis, Fellstrom, Bengt, O'Grady, John, Pirenne, Jacques et al.
DOI: 10.1097/TP.0000000000001563

Gene expression signature of tolerance and lymphocyte subsets in stable renal transplants: results of a cross-sectional study.

PMID: 24810779
Journal: TRANSPL IMMUNOL
Year: 2014
Reference: Transpl Immunol. 2014 Jun;31(1):11-6. doi: 10.1016/j.trim.2014.04.008. Epub 2014 May 5.
Impact factor: 1.832
Publication type: Paper in international publication
Authors: Moreso, Francesc, Martinez-Gallo, Monica, Benlloch, Susana, Cantarell, Carme, Perello, Manel, Jimeno, Jose, Pujol-Borrell, Ricardo, Seron, Daniel, Torres, Irina B et al.
DOI: 10.1016/j.trim.2014.04.008

Hypertension in chronic kidney disease: the influence of renal transplantation.

PMID: 24770618
Journal: TRANSPLANTATION
Year: 2014
Reference: Transplantation. 2014 Sep 15;98(5):537-42. doi: 10.1097/TP.0000000000000103.
Impact factor: 3.535
Publication type: Paper in international publication
Authors: Azancot, Maria A, Ramos, Natalia, Moreso, Francesc J, Ibernon, Meritxell, Espinel, Eugenia, Torres, Irina B, Fort, Joan, Seron, Daniel et al.
DOI: 10.1097/TP.0000000000000103

Dispositional optimism and coping strategies in patients with a kidney transplant.

PMID: 25259815
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014 Sep 26;34(5):605-10. doi: 10.3265/Nefrologia.pre2014.Jun.11881.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Costa-Requena, Gemma, Cantarell-Aixendri, M Carmen, Parramon-Puig, Gemma, Seron-Micas, Daniel et al.
DOI: 10.3265/Nefrologia.pre2014.Jun.11881

Cirrhosis, liver transplantation and HIV infection are risk factors associated with hepatitis E virus infection.

PMID: 25068388
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jul 28;9(7):e103028. doi: 10.1371/journal.pone.0103028. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Buti, Maria, Homs, Maria, Campos-Varela, Isabel, Cantarell, Carmen, Crespo, Manuel, Castells, Lluis, Tabernero, David, Quer, Josep, Esteban, Rafael et al.
DOI: 10.1371/journal.pone.0103028

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Hypertension, a key risk factor for heart disease that contributes significantly to cardiovascular mortality and morbidity and damage to vital organs, was the focus of this multi-centre study.

The new findings were presented at the American Society of Nephrology's Kidney Week 2024 meeting in San Diego and simultaneously published in the prestigious journal Nature Medicine.