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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Publications

Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression.

PMID: 38177531
Journal: EMBO Molecular Medicine
Year: 2023
Reference: EMBO Mol Med. 2023 Dec 15. doi: 10.1038/s44321-023-00006-w.
Impact factor:
Publication type: Paper in international publication
Authors: Alberici, Federico; Ansari, Mohammed Javeed; Augustine, Joshua; Ballerini, Paola; Benken, Scott; Bestard, Oriol; Bhati, Chandra; Boer, Judith M; Bueno, Clara; Calvo, Gabriel F et al.
DOI: 10.1038/s44321-023-00006-w

COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.

PMID: 35373130
Journal: Kidney360
Year: 2022
Reference: Kidney360. 2021 Dec 3;3(2):293-306. doi: 10.34067/KID.0006612021. eCollection 2022 Feb 24.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz Pamplona, Irene; Avello, Alejandro; Bestard, Oriol; Bini, Claudia; Bruchfeld, Annette; Budge, Kelly L; Cantarelli, Chiara; Chrysochou, Constantina; Comai, Giorgia; Cravedi, Paolo et al.
DOI: 10.34067/KID.0006612021

Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Mo After a Diagnosis of COVID-19.

PMID: 35320154
Journal: TRANSPLANTATION
Year: 2022
Reference: Transplantation. 2022 May 1;106(5):1012-1023. doi: 10.1097/TP.0000000000004075. Epub 2022 Apr 26.
Impact factor:
Publication type: Paper in international publication
Authors: Abd ElHafeez, Samar; Abrahams, Alferso C; Abramowicz, Daniel; Adema, Aaltje Y; Adilovic, Harun; Alferes, Daniela G; Alvila, Goncalo; Ambuehl, Patrice Max; Arias-Cabrales, Carlos; Arnol, Miha et al.
DOI: 10.1097/TP.0000000000004075

Management of post-transplant diabetes mellitus: an opportunity for novel therapeutics.

PMID: 35265335
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2021 Jul 10;15(1):5-13. doi: 10.1093/ckj/sfab131. eCollection 2022 Jan.
Impact factor:
Publication type: Review in international publication
Authors: Cruzado, Josep Maria; Montero, Nuria; Oliveras, Laia; Soler, Maria Jose et al.
DOI: 10.1093/ckj/sfab131

Safety of Obtaining an Extra Biobank Kidney Biopsy Core.

PMID: 35268550
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Mar 7;11(5). pii: jcm11051459. doi: 10.3390/jcm11051459.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Bermejo, Sheila; Bestard, Oriol; Bolufer, Monica; Gabaldon, Maria-Alejandra; Garcia-Carro, Clara; Leon, Juan Carlos; Mast, Richard; Seron, Daniel; Soler, Maria Jose et al.
DOI: 10.3390/jcm11051459

The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy.

PMID: 33166580
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Apr;99(4):986-998. doi: 10.1016/j.kint.2020.10.014. Epub 2020 Nov 7.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Avila, Ana; Bonet, Jose; Cabello, Virginia; Cao, Mercedes; Caravaca-Fontan, Fernando; Diez, Montserrat; Diezhandino, Marian Goicoechea; Egido, Jesus; Espinosa, Mario et al.
DOI: 10.1016/j.kint.2020.10.014

Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers.

PMID: 33623672
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Aug 11;14(2):482-491. doi: 10.1093/ckj/sfaa110. eCollection 2021 Feb.
Impact factor:
Publication type: Review in international publication
Authors: Agraz, Irene; Ariceta, Gema; Garcia-Carro, Clara; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Moreso, Francesc; Seron, Daniel; Soler, Maria Jose; Toapanta-Gaibor, Nestor; Vergara, Ander et al.
DOI: 10.1093/ckj/sfaa110

Direct-acting antiviral therapy improves kidney survival in hepatitis C virus-associated cryoglobulinaemia: the RENALCRYOGLOBULINEMIC study.

PMID: 33623683
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Jan 25;14(2):586-592. doi: 10.1093/ckj/sfz178. eCollection 2021 Feb.
Impact factor:
Publication type: Paper in international publication
Authors: Bada-Bosch, Teresa; Carbayo, Javier; Cases Corona, Clara Maria; Fernandez Lorente, Loreto; Goicoechea, Marian; Huerta, Ana; Malek-Marin, Tamara Gelen; Martinez Valenzuela, Laura; Perez de Jose, Ana; Pocurull, Anna et al.
DOI: 10.1093/ckj/sfz178

Change in Estimated GFR and Risk of Allograft Failure in Patients Diagnosed With Late Active Antibody-mediated Rejection Following Kidney Transplantation.

PMID: 33617203
Journal: TRANSPLANTATION
Year: 2021
Reference: Transplantation. 2021 Mar 1;105(3):648-659. doi: 10.1097/TP.0000000000003274.
Impact factor:
Publication type: Paper in international publication
Authors: Astor, Brad C; Chong, Edward; Crespo, Marta; Djamali, Arjang; Gache, Larry; Irish, William; Moreso, Francesc; Nickerson, Peter; Seron, Daniel; Wiebe, Chris et al.
DOI: 10.1097/TP.0000000000003274

Coronavirus disease 2019 in chronic kidney disease.

PMID: 32699615
Journal: Clinical Kidney Journal
Year: 2020
Reference: Clin Kidney J. 2020 Jul 16;13(3):297-306. doi: 10.1093/ckj/sfaa104. eCollection 2020 Jun.
Impact factor: 3.388
Publication type: Review in international publication
Authors: D'Marco, Luis, Puchades, Maria Jesus, Romero-Parra, Maria, Gimenez-Civera, Elena, Soler, Maria Jose, Ortiz, Alberto, Gorriz, Jose Luis et al.
DOI: 10.1093/ckj/sfaa104

Risk factors for non-diabetic renal disease in diabetic patients.

PMID: 32699618
Journal: Clinical Kidney Journal
Year: 2020
Reference: Clin Kidney J. 2020 Jan 3;13(3):380-388. doi: 10.1093/ckj/sfz177. eCollection 2020 Jun.
Impact factor: 3.388
Publication type: Paper in international publication
Authors: Lopez, Diana, Martin-Gomez, Adoracion, Garcia-Osuna, Rosa, Linares, Tania, Diaz, Montserrat, Martin, Nadia, Barros, Xoana, Marco, Helena, Navarro, Maruja Isabel, Esparza, Noemi et al.
DOI: 10.1093/ckj/sfz177

Kidney and Lung ACE2 Expression after an ACE Inhibitor or an Ang II Receptor Blocker: Implications for COVID-19.

PMID: 32669323
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2020
Reference: J Am Soc Nephrol. 2020 Sep;31(9):1941-1943. doi: 10.1681/ASN.2020050667. Epub 2020 Jul 15.
Impact factor: 9.274
Publication type: Letter whit IF
Authors: Wysocki, Jan, Lores, Enrique, Ye, Minghao, Soler, Maria Jose, Batlle, Daniel et al.
DOI: 10.1681/ASN.2020050667

Utility of transjugular renal biopsy as an alternative to percutaneous biopsy.

PMID: 32660793
Journal: NEFROLOGIA
Year: 2020
Reference: Nefrologia. 2020 Nov - Dec;40(6):634-639. doi: 10.1016/j.nefro.2020.04.018. Epub 2020 Jul 11.
Impact factor: 1.544
Publication type: Paper in national publication
Authors: Soler, Maria Jose, Seron, Daniel, Segarra, Alfons, Perez Lafuente, Mercedes, Bolufer, Monica, Garcia-Carro, Clara, Agraz, Irene, Diez Miranda, Iratxe, Jaramillo, Juliana, Arredondo, Karla et al.
DOI: 10.1016/j.nefro.2020.04.018

Blog

News

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Hypertension, a key risk factor for heart disease that contributes significantly to cardiovascular mortality and morbidity and damage to vital organs, was the focus of this multi-centre study.

The new findings were presented at the American Society of Nephrology's Kidney Week 2024 meeting in San Diego and simultaneously published in the prestigious journal Nature Medicine.