Pasar al contenido principal

Farmacología Clínica

El objetivo de nuestro grupo es investigar el uso de medicamentos y evaluar su relación beneficio-riesgo en la práctica clínica habitual. Es el centro catalán del Sistema Español de Farmacovigilancia. Las actividades de investigación en farmacología y farmacoepidemiología se compaginan con la docencia de grado en la Facultad de Medicina de la Universidad Autónoma de Barcelona, la formación de especialistas en farmacología clínica y la formación continuada en terapéutica de los profesionales sanitarios.

El grupo es un Grupo Especial de Investigación reconocido por AGAUR GenCat. Es socio del “European Consortium EU PE&PV Network ” y forma parte de la Red Europea de Centros de Farmacoepidemiología y Farmacovigilancia (ENCePP). Da apoyo institucional al Comité de Ética de Investigación con medicamentos del Hospital Universitario Vall d'Hebron (HUVH), a la Comisión Farmacoterapéutica del HUVH, y también a la Comisión Farmacoterapéutica del Institut Català de la Salut.

Líneas de investigación

Risk of blood dyscrasias associated with the use of medicines

IP: -

Study of drug-induced liver disease

IP: -

Inhibition of nanoparticle phagocytic clearance by activation of innate inhibitory receptors

Professional phagocytes are innate immune system cells that remove harmful circulating foreign particles as bacteria, as well as self particles as apoptotic cells. However, phagocytes such as macrophages may also engulf and remove from circulation nanoparticles and liposomes that have been injected as therapeutic and/or diagnostic tools. Macrophages in the spleen and liver are known to clear these particles within hours after injection into the circulation, limiting their therapeutic and/or diagnostic efficiency.  In order to increase the circulation time of specific nanoparticles, we propose to attach to those particles diverse known ligands for innate inhibitory receptors, including LAIR-1 ligand (collagen peptide), Siglec-7 ligand (sialic acids) and diverse small-neuropeptide receptors ligands. Moreover, we will analyze the effect on the circulation time of nanobeads conjugated to specific peptides, sialic acids and neuropeptides alone or in combination in order to get the best possible blocking effect without side-effects.

IP: -

Inhibition of nanoparticle phagocytic clearance by activation of innate inhibitory receptors

Professional phagocytes are innate immune system cells that remove harmful circulating foreign particles as bacteria, as well as self particles as apoptotic cells. However, phagocytes such as macrophages may also engulf and remove from circulation nanoparticles and liposomes that have been injected as therapeutic and/or diagnostic tools. Macrophages in the spleen and liver are known to clear these particles within hours after injection into the circulation, limiting their therapeutic and/or diagnostic efficiency.  In order to increase the circulation time of specific nanoparticles, we propose to attach to those particles diverse known ligands for innate inhibitory receptors, including LAIR-1 ligand (collagen peptide), Siglec-7 ligand (sialic acids) and diverse small-neuropeptide receptors ligands. Moreover, we will analyze the effect on the circulation time of nanobeads conjugated to specific peptides, sialic acids and neuropeptides alone or in combination in order to get the best possible blocking effect without side-effects.

IP: -

Actualidad

Noticias

Se ha logrado financiación para 43 proyectos en las convocatorias de Proyectos de I+D+I en Salud, Desarrollo Tecnológico en Salud e Investigación Clínica Independiente

Los resultados muestran la importancia de hacer un seguimiento continuado de los pacientes para detectar y gestionar posibles efectos adversos que aparezcan meses y años después del tratamiento.

La creació d’espais d’interacció híbrida entre avatars digitals i humans ofereix noves oportunitats en la medicina personalitzada