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Farmacologia Clínica

L'objectiu del nostre grup és investigar l'ús de medicaments i avaluar la seva relació benefici-risc a la pràctica clínica habitual. És el centre català del Sistema Espanyol de Farmacovigilància. Les activitats de recerca en farmacologia i farmacoepidemiologia s’acompanyen de la docència de grau a la Facultat de Medicina de la Universitat Autònoma de Barcelona, la formació d'especialistes en Farmacologia Clínica i la formació continuada en Terapèutica dels professionals sanitaris.

El grup està reconegut per l’Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) com a Grup Especial de Recerca. És soci del European Consortium EU PE & PV Network (Xarxa Europea de Farmacoepidemiologia i Farmacovigilància) i forma part de la Xarxa Europea de Centres de Farmacoepidemiologia i Farmacovigilància (ENCePP). 

Donem suport institucional a:

  • La Comissió Farmacoterapèutica de l'Institut Català de la Salut.
  • El Comitè d’Ètica de la Investigació amb Medicaments de l'Hospital Universitari Vall d'Hebron (HUVH).
  • La Comissió Farmacoterapèutica de l’Hospital Universitari Vall d’Hebron.

Línies de recerca

Risk of blood dyscrasias associated with the use of medicines

IP: -

Study of drug-induced liver disease

IP: -

Inhibition of nanoparticle phagocytic clearance by activation of innate inhibitory receptors

Professional phagocytes are innate immune system cells that remove harmful circulating foreign particles as bacteria, as well as self particles as apoptotic cells. However, phagocytes such as macrophages may also engulf and remove from circulation nanoparticles and liposomes that have been injected as therapeutic and/or diagnostic tools. Macrophages in the spleen and liver are known to clear these particles within hours after injection into the circulation, limiting their therapeutic and/or diagnostic efficiency.  In order to increase the circulation time of specific nanoparticles, we propose to attach to those particles diverse known ligands for innate inhibitory receptors, including LAIR-1 ligand (collagen peptide), Siglec-7 ligand (sialic acids) and diverse small-neuropeptide receptors ligands. Moreover, we will analyze the effect on the circulation time of nanobeads conjugated to specific peptides, sialic acids and neuropeptides alone or in combination in order to get the best possible blocking effect without side-effects.

IP: -

Inhibition of nanoparticle phagocytic clearance by activation of innate inhibitory receptors

Professional phagocytes are innate immune system cells that remove harmful circulating foreign particles as bacteria, as well as self particles as apoptotic cells. However, phagocytes such as macrophages may also engulf and remove from circulation nanoparticles and liposomes that have been injected as therapeutic and/or diagnostic tools. Macrophages in the spleen and liver are known to clear these particles within hours after injection into the circulation, limiting their therapeutic and/or diagnostic efficiency.  In order to increase the circulation time of specific nanoparticles, we propose to attach to those particles diverse known ligands for innate inhibitory receptors, including LAIR-1 ligand (collagen peptide), Siglec-7 ligand (sialic acids) and diverse small-neuropeptide receptors ligands. Moreover, we will analyze the effect on the circulation time of nanobeads conjugated to specific peptides, sialic acids and neuropeptides alone or in combination in order to get the best possible blocking effect without side-effects.

IP: -

Actualitat

Notícies

S’ha aconseguit finançament per a 43 projectes en les convocatòries de Projectes d’I+D+I en Salut, Desenvolupament Tecnològic en Salut i Recerca Clínica Independent

Els resultats mostren la importància de fer un seguiment continuat dels pacients per detectar i gestionar possibles efectes adversos que apareguin mesos i anys després del tractament.

La creació d’espais d’interacció híbrida entre avatars digitals i humans ofereix noves oportunitats en la medicina personalitzada