About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35249717 Journal: Actas dermo-sifiliograficas Year: 2022 Reference: Actas Dermosifiliogr. 2022 Jan;113(1):T4-T14. doi: 10.1016/j.ad.2021.06.007. Epub 2021 Jul 20. Impact factor: 0 Publication type: Paper in national publication Authors: Terradas-Montana, P, Vidal-Jorge, M, Jauregui Presa, I, Valero Santiago, A, Sastre Dominguez, J, Ortiz de Frutos, F J, Miquel-Miquel, J, Ferrer Puga, M, Silvestre Salvador, J F, Bartra Tomas, J et al. DOI: 10.1016/j.ad.2021.06.007
PMID: 35244542 Journal: Actas dermo-sifiliograficas Year: 2022 Reference: Actas Dermosifiliogr. 2022 Jan;113(1):4-14. doi: 10.1016/j.ad.2021.06.014. Epub 2022 Feb 3. Impact factor: 0 Publication type: Paper in national publication Authors: Vidal-Jorge, M, Jauregui Presa, I, Terradas-Montana, P, Valero Santiago, A, Sastre Dominguez, J, Ortiz de Frutos, F J, Ferrer Puga, M, Silvestre Salvador, J F, Bartra Tomas, J, Gimenez-Arnau, A et al. DOI: 10.1016/j.ad.2021.06.014
PMID: 35238758 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2022 Reference: Clin Exp Rheumatol. 2022 May;40 Suppl 134(5):71-80. doi: 10.55563/clinexprheumatol/qq9qup. Epub 2022 Mar 1. Impact factor: 4.473 Publication type: Review in international publication Authors: Monti, Sara, Nalli, Cecilia, Schleinitz, Nicolas, Tincani, Angela, Della Torre, Emanuel, Alexander, Tobias, Montecucco, Carlomaurizio, Martinez-Valle, Fernando, van Laar, Jan A M, Iaccarino, Luca et al. DOI:
PMID: 34115832 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Mar 2;61(3):1053-1061. doi: 10.1093/rheumatology/keab475. Impact factor: 7.58 Publication type: Paper in international publication Authors: Pardos-Gea, Jose, Marques-Soares, Joana R, Bujan, Segundo, Ordi-Ros, Jose, Alijotas-Reig, Jaume et al. DOI: 10.1093/rheumatology/keab475
PMID: 34774452 Journal: Reumatologia clinica Year: 2021 Reference: Reumatol Clin (Engl Ed). 2021 Nov 10. pii: S2173-5743(21)00189-1. doi: 10.1016/j.reumae.2021.05.001. Impact factor: 0 Publication type: Letter or abstract Authors: Macias Reyes, Maria Jose, Pluma Sanjurjo, Andrea, Marsal Barril, Sara, Grados Canovas, Maria Dolors et al. DOI: 10.1016/j.reumae.2021.05.001
PMID: 34768461 Journal: Journal of Clinical Medicine Year: 2021 Reference: J Clin Med. 2021 Oct 26;10(21). pii: jcm10214941. doi: 10.3390/jcm10214941. Impact factor: 4.242 Publication type: Paper in international publication Authors: Sans-Pola, Carla, Agusti, Antonia, Bosch, Josep Angel, Agraz, Irene, Alerany, Carmen, Danes, Immaculada et al. DOI: 10.3390/jcm10214941
PMID: 34759087 Journal: Japanese Journal of Allergology Year: 2021 Reference: Arerugi. 2021;70(9):1211-1234. doi: 10.15036/arerugi.70.1211. Impact factor: 0 Publication type: Paper in international publication Authors: Worm, Margitta, Thong, Bernard Y, Cardona, Victoria, Ansotegui, Ignacio J, Ebisawa, Motohiro, El-Gamal, Yehia, Rivas, Montserrat Fernandez, Fineman, Stanley, Geller, Mario, Gonzalez-Estrada, Alexei et al. DOI: 10.15036/arerugi.70.1211
PMID: 34732228 Journal: Orphanet Journal of Rare Diseases Year: 2021 Reference: Orphanet J Rare Dis. 2021 Nov 3;16(1):464. doi: 10.1186/s13023-021-02074-y. Impact factor: 4.123 Publication type: Paper in international publication Authors: Quijada-Fraile, Pilar, Arranz Canales, Elena, Martin-Hernandez, Elena, Ballesta-Martinez, Maria Juliana, Guillen-Navarro, Encarna, Pintos-Morell, Guillem, Molto-Abad, Marc, Moreno-Martinez, David, Garcia Morillo, Salvador, Blasco-Alonso, Javier et al. DOI: 10.1186/s13023-021-02074-y
PMID: 32291908 Journal: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Year: 2020 Reference: J Cell Mol Med. 2020 May;24(10):5865-5877. doi: 10.1111/jcmm.15260. Epub 2020 Apr 14. Impact factor: 4.486 Publication type: Paper in international publication Authors: Cheema, Amanpreet K, Sarria, Leonor, Bekheit, Mina, Collado, Fanny, Almenar-Perez, Eloy, Martin-Martinez, Eva, Alegre, Jose, Klimas, Nancy G, Oltra, Elisa, Nathanson, Lubov et al. DOI: 10.1111/jcmm.15260
PMID: 32194200 Journal: AUTOIMMUNITY REVIEWS Year: 2020 Reference: Autoimmun Rev. 2020 May;19(5):102507. doi: 10.1016/j.autrev.2020.102507. Epub 2020 Mar 17. Impact factor: 7.767 Publication type: Review in international publication Authors: Rubio-Rivas, Manuel, Corbella, Xavier, Guillen-Del-Castillo, Alfredo, Vilella, Carles Tolosa, Arguelles, Dolores Colunga, Argibay, Ana, Aznar, Carmen Pilar Simeon, Pla, Vicent Fonollosa, Trigo, Sabela Sanchez, Hitos, Jose Antonio Vargas et al. DOI: 10.1016/j.autrev.2020.102507
PMID: 32128023 Journal: World Allergy Organization Journal Year: 2020 Reference: World Allergy Organ J. 2020 Feb 25;13(2):100080. doi: 10.1016/j.waojou.2019.100080. eCollection 2020 Feb. Impact factor: 3.506 Publication type: Paper in international publication Authors: Antila, Martti, Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier et al. DOI: 10.1016/j.waojou.2019.100080
PMID: 31627910 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Allergy Clin Immunol. 2020 Jan;145(1):70-80.e3. doi: 10.1016/j.jaci.2019.06.049. Epub 2019 Oct 15. Impact factor: 10.228 Publication type: Review in international publication Authors: Menditto, Enrica, Bousquet, Jean, Schunemann, Holger J, Togias, Akdis, Bachert, Claus, Erhola, Martina, Hellings, Peter W, Klimek, Ludger, Pfaar, Oliver, Wallace, Dana et al. DOI: 10.1016/j.jaci.2019.06.049
PMID: 31320135 Journal: MEDICINA CLINICA Year: 2019 Reference: Med Clin (Barc). 2019 Dec 27;153(12):446-453. doi: 10.1016/j.medcli.2019.02.026. Epub 2019 Jul 16. Impact factor: 1.277 Publication type: Paper in national publication Authors: Mestre-Torres, Jaume, Garrido-Clua, Miriam, Lalueza-Broto, Pilar, Sanclemente-Boli, Teresa, Ponce-Ruiz, Sandra, Alvarez-Lorenzo, Consuelo, Zuriguel-Perez, Esperanza, Tapia-Melenchon, Raquel, Ramentol-Sintas, Marc, Villar-Casares, Maria Del Mar et al. DOI: 10.1016/j.medcli.2019.02.026
PMID: 31312201 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Jul 2;10:1459. doi: 10.3389/fimmu.2019.01459. eCollection 2019. Impact factor: 4.716 Publication type: Paper in international publication Authors: Aterido, Adria, Canete, Juan D, Tornero, Jesus, Blanco, Francisco, Fernandez-Gutierrez, Benjamin, Perez, Carolina, Alperi-Lopez, Mercedes, Olive, Alex, Corominas, Hector, Martinez-Taboada, Victor et al. DOI: 10.3389/fimmu.2019.01459
PMID: 31308545 Journal: NATURE GENETICS Year: 2019 Reference: Nat Genet. 2019 Aug;51(8):1207-1214. doi: 10.1038/s41588-019-0439-2. Epub 2019 Jul 15. Impact factor: 25.455 Publication type: Paper in international publication Authors: Huckins, Laura M, Gaspar, Helena A, Bryois, Julien, Hinney, Anke, Leppa, Virpi M, Mattheisen, Manuel, Medland, Sarah E, Ripke, Stephan, Yao, Shuyang, Giusti-Rodriguez, Paola et al. DOI: 10.1038/s41588-019-0439-2
PMID: 31278138 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2019 Reference: Ann Rheum Dis. 2019 Oct;78(10):1405-1411. doi: 10.1136/annrheumdis-2018-214472. Epub 2019 Jul 5. Impact factor: 14.299 Publication type: Paper in international publication Authors: Ter Haar, Nienke M, Frenkel, Joost, Papa, Riccardo, Brogan, Paul A, Kone-Paut, Isabelle, Modesto, Consuelo, Hofer, Michael, Iagaru, Nicolae, Fingerhutova, Sarka, Insalaco, Antonella et al. DOI: 10.1136/annrheumdis-2018-214472
PMID: 29452298 Journal: JOINT BONE SPINE Year: 2018 Reference: Joint Bone Spine. 2018 Dec;85(6):721-726. doi: 10.1016/j.jbspin.2018.01.014. Epub 2018 Feb 13. Impact factor: 3.304 Publication type: Paper in international publication Authors: Fernandez-Codina, Andreu, Pinilla, Blanca, Pinal-Fernandez, Iago, Lopez, Cristina, Fraile-Rodriguez, Guadalupe, Fonseca-Aizpuru, Eva, Carballo, Iago, Brito-Zeron, Pilar, Feijoo-Masso, Carlos, Lopez-Dupla, Miguel et al. DOI: 10.1016/j.jbspin.2018.01.014
PMID: 29446469 Journal: ALLERGY Year: 2018 Reference: Allergy. 2018 Sep;73(9):1775-1783. doi: 10.1111/all.13429. Epub 2018 Apr 16. Impact factor: 6.048 Publication type: Review in national publication Authors: Pfaar, O, Alvaro, M, Cardona, V, Hamelmann, E, Mosges, R, Kleine-Tebbe, J et al. DOI: 10.1111/all.13429
PMID: 29149307 Journal: RHEUMATOLOGY Year: 2018 Reference: Rheumatology (Oxford). 2018 Feb 1;57(2):388-396. doi: 10.1093/rheumatology/kex413. Impact factor: 5.245 Publication type: Paper in international publication Authors: Pinal-Fernandez, Iago, Ferrer-Fabregas, Berta, Trallero-Araguas, Ernesto, Balada, Eva, Martinez, Maria Angeles, Milisenda, Jose Cesar, Aparicio-Espanol, Gloria, Labrador-Horrillo, Moises, Garcia-Patos, Vicente, Grau-Junyent, Josep M et al. DOI: 10.1093/rheumatology/kex413
PMID: 29336994 Journal: MOLECULAR GENETICS AND METABOLISM Year: 2018 Reference: Mol Genet Metab. 2018 Feb;123(2):69-75. doi: 10.1016/j.ymgme.2018.01.002. Epub 2018 Jan 5. Impact factor: 3.774 Publication type: Review in national publication Authors: Sampayo-Cordero, Miguel, Miguel-Huguet, Bernat, Pardo-Mateos, Almudena, Molto-Abad, Marc, Munoz-Delgado, Cecilia, Perez-Lopez, Jordi et al. DOI: 10.1016/j.ymgme.2018.01.002
PMID: 28596045 Journal: PSYCHOSOMATICS Year: 2017 Reference: Psychosomatics. 2017 Sep - Oct;58(5):533-543. doi: 10.1016/j.psym.2017.04.010. Epub 2017 Apr 21. Impact factor: 1.436 Publication type: Paper in international publication Authors: Castro-Marrero, Jesus, Faro, Monica, Aliste, Luisa, Saez-Francas, Naia, Calvo, Natalia, Martinez-Martinez, Alba, de Sevilla, Tomas Fernandez, Alegre, Jose et al. DOI: 10.1016/j.psym.2017.04.010
PMID: 28570224 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2017 Reference: J Investig Allergol Clin Immunol. 2017 Jun;27(3):185-187. doi: 10.18176/jiaci.0150. Impact factor: 3.094 Publication type: Paper in international publication Authors: Basagana, M, Luengo, O, Labrador, M, Garriga, T, Mattsson, L, Lidholm, J, Cardona, V et al. DOI: 10.18176/jiaci.0150
PMID: 28496564 Journal: World Allergy Organization Journal Year: 2017 Reference: World Allergy Organ J. 2017 May 4;10(1):15. doi: 10.1186/s40413-017-0148-1. eCollection 2017. Impact factor: 0 Publication type: Review in national publication Authors: Sanchez-Borges, Mario, Cardona, Victoria, Worm, Margitta, Lockey, Richard F, Sheikh, Aziz, Greenberger, Paul A, Ansotegui, Ignacio J, Ebisawa, Motohiro, El-Gamal, Yehia, Fineman, Stanley et al. DOI: 10.1186/s40413-017-0148-1
PMID: 28475762 Journal: HUMAN MOLECULAR GENETICS Year: 2017 Reference: Hum Mol Genet. 2017 Jul 15;26(14):2803-2811. doi: 10.1093/hmg/ddx177. Impact factor: 5.34 Publication type: Paper in international publication Authors: Julia, Antonio, Absher, Devin, Lopez-Lasanta, Maria, Palau, Nuria, Pluma, Andrea, Jones, Lindsay Waite, Glossop, John R, Farrell, William E, Myers, Richard M, Marsal, Sara et al. DOI: 10.1093/hmg/ddx177
PMID: 24894104 Journal: CLIN RHEUMATOL Year: 2014 Reference: Clin Rheumatol. 2014 Aug;33(8):1119-25. doi: 10.1007/s10067-014-2685-0. Epub 2014 Jun 4. Impact factor: 1.774 Publication type: Paper in international publication Authors: Armadans-Tremolosa, Imma, Visauta-Vinacua, Bienvenido, Guilera, Georgina, Pinal-Fernandez, Iago, Vilardell-Tarres, Miquel, Selva-O'Callaghan, Albert et al. DOI: 10.1007/s10067-014-2685-0
PMID: 24776173 Journal: CLIN EXP RHEUMATOL Year: 2014 Reference: Clin Exp Rheumatol. 2014 Nov-Dec;32 Suppl 86(6):33-40. Epub 2014 Apr 28. Impact factor: 2.973 Publication type: Paper in international publication Authors: Vilardell-Tarres, Miguel, Simeon-Aznar, Carmen Pilar, Tolosa-Vilella, Carles, Gabarro-Julia, Lourdes, Campillo-Grau, Mercedes, Guillen Del Castillo, Alfredo, Fonollosa-Pla, Vincent et al. DOI:
PMID: 24773767 Journal: CLIN EXP RHEUMATOL Year: 2014 Reference: Clin Exp Rheumatol. 2014 May-Jun;32(3):404-7. Epub 2014 Apr 28. Impact factor: 2.973 Publication type: Clinical Trials Authors: Castella-Fierro, E, Martinez-Gomez, X, Vilardell-Tarres, Miquel, Selva-O'Callaghan, A, Pallisa Nunez, E, Pinal Fernandez, I et al. DOI:
PMID: 25110305 Journal: SEMIN ARTHRITIS RHEU Year: 2014 Reference: Semin Arthritis Rheum. 2014 Dec;44(3):331-7. doi: 10.1016/j.semarthrit.2014.07.002. Epub 2014 Jul 15. Impact factor: 3.629 Publication type: Paper in international publication Authors: Guillen-Del Castillo, Alfredo, Pilar Simeon-Aznar, Carmen, Fonollosa-Pla, Vicent, Alonso-Vila, Serafin, Reverte-Vinaixa, Maria M, Munoz, Xavier, Pallisa, Esther, Selva-OCallaghan, Albert, Fernandez-Codina, Andreu, Vilardell-Tarres, Miquel et al. DOI: 10.1016/j.semarthrit.2014.07.002
PMID: 21349559 Journal: MEDICINA CLINICA Year: 2012 Reference: Med Clin (Barc). 2012 May 12;138(13):596. Epub 2011 Feb 23. Impact factor: 1.385 Publication type: Paper in national publication Authors: , , , et al. DOI: 10.1016/j.medcli.2010.09.047
PMID: 21621228 Journal: MEDICINA CLINICA Year: 2012 Reference: Med Clin (Barc). 2012 May 12;138(13):557-61. Epub 2011 May 28. Impact factor: 1.385 Publication type: Paper in national publication Authors: , , , , , et al. DOI: 10.1016/j.medcli.2011.03.028
PMID: 21797962 Journal: Pain Practice Year: 2012 Reference: Pain Pract. 2012 Apr;12(4):290-306. doi: 10.1111/j.1533-2500.2011.00487.x. Epub 2011 Jul 29. Impact factor: 2.207 Publication type: Review in international publication Authors: , , , , , , , , , et al. DOI: 10.1111/j.1533-2500.2011.00487.x
PMID: 22332684 Journal: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Year: 2012 Reference: J Am Geriatr Soc. 2012 Feb;60(2):375-6. doi: 10.1111/j.1532-5415.2011.03809.x. Impact factor: 3.737 Publication type: Letter whit IF Authors: Gual-Tarrada, Neus, Selva-O'Callaghan, Albert, Ruiz-Marcellan, Carmen et al. DOI: 10.1111/j.1532-5415.2011.03809.x
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
