About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35051890 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2022 Reference: Semin Arthritis Rheum. 2022 Apr;53:151940. doi: 10.1016/j.semarthrit.2021.12.008. Epub 2021 Dec 31. Impact factor: 5.532 Publication type: Paper in international publication Authors: Trallero-Araguas, Ernesto, Gil-Vila, Albert, Martinez-Gomez, X, Pinal-Fernandez, Iago, Alvarado-Cardenas, M, Simo-Perdigo, M, Selva-O'Callaghan, Albert et al. DOI: 10.1016/j.semarthrit.2021.12.008
PMID: 34099189 Journal: BIOLOGICAL PSYCHIATRY Year: 2022 Reference: Biol Psychiatry. 2022 Jan 1;91(1):102-117. doi: 10.1016/j.biopsych.2021.02.972. Epub 2021 Mar 23. Impact factor: 13.382 Publication type: Paper in international publication Authors: Ophoff, Roel A, Jonsson, Erik G, Palotie, Aarno, Ehrenreich, Hannelore, Begemann, Martin, Steixner-Kumar, Agnes, Sham, Pak C, Iwata, Nakao, Weinberger, Daniel R, Gejman, Pablo V et al. DOI: 10.1016/j.biopsych.2021.02.972
PMID: 34649820 Journal: Reumatologia clinica Year: 2022 Reference: Reumatol Clin. 2022 Mar;18(3):131-140. doi: 10.1016/j.reumae.2021.02.002. Epub 2021 Oct 11. Impact factor: 0 Publication type: Paper in international publication Authors: Rivera Redondo, Javier, Diaz Del Campo Fontecha, Petra, Alegre de Miquel, Cayetano, Almirall Bernabe, Miriam, Casanueva Fernandez, Benigno, Castillo Ojeda, Cristina, Collado Cruz, Antonio, Monteso-Curto, Pilar, Palao Tarrero, Angela, Trillo Calvo, Eva et al. DOI: 10.1016/j.reuma.2021.02.004
PMID: 35258105 Journal: ALLERGY Year: 2022 Reference: Allergy. 2022 Mar 8. doi: 10.1111/all.15275. Impact factor: 13.146 Publication type: Paper in international publication Authors: Vieira, Rafael Jose, Sousa-Pinto, Bernardo, Sa-Sousa, Ana, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Desiree E et al. DOI: 10.1111/all.15275
PMID: 34919044 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):166-174. Epub 2021 Dec 16. Impact factor: 4.473 Publication type: Paper in international publication Authors: Sandhya, Pulukool, Retamozo, Soledad, Acar-Denizli, Nihan, Horvath, Ildiko Fanny, Ng, Wan-Fai, Rasmussen, Astrid, Dong, Xu, Li, Xiaomei, Baldini, Chiara, Olsson, Peter et al. DOI:
PMID: 34849616 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Nov 25. pii: 6440080. doi: 10.1093/rheumatology/keab876. Impact factor: 7.58 Publication type: Paper in international publication Authors: Ohrndorf, Sarah, Perko, Nejc, Schmidt, Wolfgang A, Tamborrini, Giorgio, Tomsic, Matija, Chary-Valckenaere, Isabelle, Zabotti, Alen, Keen, Helen I, Pineda, Carlos, D'Agostino, Maria-Antonietta et al. DOI: 10.1093/rheumatology/keab876
PMID: 34799647 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Nov 19;11(1):22574. doi: 10.1038/s41598-021-01992-y. Impact factor: 4.38 Publication type: Paper in international publication Authors: Remuzgo-Martinez, Sara, Atienza-Mateo, Belen, Ocejo-Vinyals, J Gonzalo, Genre, Fernanda, Pulito-Cueto, Veronica, Mora-Cuesta, Victor M, Iturbe-Fernandez, David, Lera-Gomez, Leticia, Perez-Fernandez, Raquel, Prieto-Pena, Diana et al. DOI: 10.1038/s41598-021-01992-y
PMID: 34796836 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 Nov 18. pii: 17661. Impact factor: 4.473 Publication type: Paper in international publication Authors: Castro-Marrero, Jesus, Alegre-Martin, Jose, Calvo, Natalia, Maurel, Sara, Saez-Francas, Naia et al. DOI:
PMID: 31584692 Journal: ALLERGY Year: 2020 Reference: Allergy. 2020 Apr;75(4):901-910. doi: 10.1111/all.14069. Epub 2019 Oct 21. Impact factor: 8.706 Publication type: Paper in international publication Authors: Kraft, M, Knop, M, Renaudin, J M, Scherer Hofmeier, K, Pfohler, C, Bilo, M B, Lang, R, Treudler, R, Wagner, N, Spindler, T et al. DOI: 10.1111/all.14069
PMID: 32351168 Journal: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY Year: 2020 Reference: Scand J Rheumatol. 2020 Jul;49(4):259-266. doi: 10.1080/03009742.2020.1726449. Epub 2020 Apr 30. Impact factor: 3.025 Publication type: Paper in international publication Authors: Rodriguez-Muguruza, S, Combe, B, Guillemin, F, Fautrel, B, Olive, A, Marsal, S, Valero, O, Rincheval, N, Lukas, C et al. DOI: 10.1080/03009742.2020.1726449
PMID: 32329119 Journal: LIVER INTERNATIONAL Year: 2020 Reference: Liver Int. 2020 Aug;40(8):1906-1916. doi: 10.1111/liv.14489. Epub 2020 Jun 3. Impact factor: 5.175 Publication type: Paper in international publication Authors: Riveiro-Barciela, Mar, Barreira-Diaz, Ana, Vidal-Gonzalez, Judit, Munoz-Couselo, Eva, Martinez-Valle, Fernando, Viladomiu, Lluis, Minguez, Beatriz, Ortiz-Velez, Carolina, Castells, Lluis, Esteban, Rafael et al. DOI: 10.1111/liv.14489
PMID: 32295620 Journal: ARTHRITIS RESEARCH & THERAPY Year: 2020 Reference: Arthritis Res Ther. 2020 Apr 15;22(1):82. doi: 10.1186/s13075-020-02168-1. Impact factor: 4.103 Publication type: Paper in international publication Authors: Calvo-Alen, Jaime, Sellas, Agustin, Rodriguez, Fernando Jose, Bermudez, Alberto, Romero, Manuel, Riesco, Manuel, Cobeta, Juan Carlos, Medina, Fermin, Garcia, M Luz, Urruticoechea, Ana et al. DOI: 10.1186/s13075-020-02168-1
PMID: 31396685 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2019 Reference: Rheumatol Int. 2019 Dec;39(12):2015-2024. doi: 10.1007/s00296-019-04378-6. Epub 2019 Aug 8. Impact factor: 2.2 Publication type: Paper in international publication Authors: Gomez-Centeno, Antonio, Rubio-Romero, Esteban, Ovalles, Juan Gabriel, Manrique-Arija, Sara, Marsal-Barril, Sara, Amarelo-Ramos, Juan, Del Pino-Montes, Javier, Munoz-Fernandez, Santiago, Bustabad, Sagrario, Barbazan-Alvarez, Ceferino et al. DOI: 10.1007/s00296-019-04378-6
PMID: 31396686 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2019 Reference: Rheumatol Int. 2019 Dec;39(12):2137-2145. doi: 10.1007/s00296-019-04383-9. Epub 2019 Aug 8. Impact factor: 2.2 Publication type: Paper in international publication Authors: de Agustin, Juan Jose, Erra, Alba, Ponce, Andres, Moragues, Carmen, Diaz-Torne, Cesar, Reina, Delia, Moreno, Estefania, Ramirez, Julio, Mateo, Lourdes, Pujol Busquets, Manel et al. DOI: 10.1007/s00296-019-04383-9
PMID: 31362844 Journal: Revista espanola de geriatria y gerontologia Year: 2019 Reference: Rev Esp Geriatr Gerontol. 2019 Nov - Dec;54(6):334-338. doi: 10.1016/j.regg.2019.06.004. Epub 2019 Jul 28. Impact factor: 0 Publication type: Paper in national publication Authors: Vivanco, Maria Victoria, Formiga, Francesc, Mundet Riera, Imma, San Jose Laporte, Antonio, Curto Prieto, David et al. DOI: 10.1016/j.regg.2019.06.004
PMID: 31349698 Journal: Cells Year: 2019 Reference: Cells. 2019 Jul 25;8(8). pii: cells8080773. doi: 10.3390/cells8080773. Impact factor: 5.656 Publication type: Paper in international publication Authors: Sole, Cristina, Moline, Teresa, Vidal, Marta, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al. DOI: 10.3390/cells8080773
PMID: 28887115 Journal: AMERICAN JOURNAL OF OPHTHALMOLOGY Year: 2018 Reference: Am J Ophthalmol. 2018 Mar;187:158-166. doi: 10.1016/j.ajo.2017.08.017. Epub 2017 Sep 6. Impact factor: 4.795 Publication type: Paper in international publication Authors: Russo, Ricardo, Susic, Gordana, Thatayatikom, Akaluck, Thomee, Caroline, Vastert, Sebastiaan, Bertin, John, Arostegui, Juan I, Rose, Carlos D, Wouters, Carine H, Ramanan, Athimalaipet V et al. DOI: 10.1016/j.ajo.2017.08.017
PMID: 29473763 Journal: Expert Review of Clinical Immunology Year: 2018 Reference: Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23. Impact factor: 3.436 Publication type: Paper in international publication Authors: Grau-Junyent, Josep Maria, Selva-O'Callaghan, Albert, Alvarado-Cardenas, Marcelo, Pinal-Fernandez, Iago, Trallero-Araguas, Ernesto, Milisenda, Jose Cesar, Martinez, Maria Angeles, Marin, Ana, Labrador-Horrillo, Moises, Juarez, Candido et al. DOI: 10.1080/1744666X.2018.1440206
PMID: 29461211 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2018 Reference: J Investig Allergol Clin Immunol. 2018;28(1):51-53. doi: 10.18176/jiaci.0206. Impact factor: 3.457 Publication type: Paper in international publication Authors: Peixoto, S, Monteiro, T, Carvalho, M, Santos, M, Matos, C, Bartolome, B, Labrador-Horrillo, M, Quaresma, M et al. DOI: 10.18176/jiaci.0206
PMID: 29461213 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2018 Reference: J Investig Allergol Clin Immunol. 2018;28(1):56-58. doi: 10.18176/jiaci.0208. Impact factor: 3.457 Publication type: Paper in international publication Authors: Miquel, S, Micozzi, S, Bartolome, B, Labrador-Horrillo, M, Roger, A, Prieto-Garcia, A, Basagana, M et al. DOI: 10.18176/jiaci.0208
PMID: 28658725 Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexi Year: 2017 Reference: Rev Alerg Mex. 2017 Apr-Jun;64(2):171-177. Impact factor: 0 Publication type: Paper in national publication Authors: Cardona, Victoria, Alvarez-Perea, Alberto, Ansotegui, Ignacio J, Arias-Cruz, Alfredo, Gonzalez-Diaz, Sandra Nora, Latour-Staffeld, Patricia, Ivancevich, Juan Carlos, Sanchez-Borges, Mario, Serrano, Carlos, Sole, Dirceu et al. DOI:
PMID: 28619073 Journal: ARTHRITIS RESEARCH & THERAPY Year: 2017 Reference: Arthritis Res Ther. 2017 Jun 15;19(1):138. doi: 10.1186/s13075-017-1345-6. Impact factor: 4.121 Publication type: Paper in international publication Authors: Marsal, Sara, Blanco, Ricardo, Lopez-Longo, Jose Javier, Venegas, Jose Javier Perez, Olive, Alex, Andreu, Jose Luis, Aguirre-Zamorano, Maria Angeles, Vela, Paloma, Nolla, Joan M, Marenco-de la Fuente, Jose Luis et al. DOI: 10.1186/s13075-017-1345-6
PMID: 28615037 Journal: ARTHRITIS RESEARCH & THERAPY Year: 2017 Reference: Arthritis Res Ther. 2017 Jun 14;19(1):135. doi: 10.1186/s13075-017-1327-8. Impact factor: 4.121 Publication type: Paper in international publication Authors: Guillen-Del Castillo, Alfredo, Callejas-Moraga, Eduardo L, Garcia, Gabriela, Rodriguez-Palomares, Jose F, Roman, Antonio, Berastegui, Cristina, Lopez-Meseguer, Manuel, Domingo, Enric, Fonollosa-Pla, Vicente, Simeon-Aznar, Carmen Pilar et al. DOI: 10.1186/s13075-017-1327-8
PMID: 28038794 Journal: ARCHIVOS DE BRONCONEUMOLOGIA Year: 2017 Reference: Arch Bronconeumol. 2017 Mar;53(3):120-127. doi: 10.1016/j.arbres.2016.09.014. Epub 2016 Dec 27. Impact factor: 2.979 Publication type: Paper in national publication Authors: Guillen-Del Castillo, Alfredo, Sanchez-Vidaurre, Sara, Simeon-Aznar, Carmen P, Cruz, Maria J, Fonollosa-Pla, Vicente, Munoz, Xavier et al. DOI: 10.1016/j.arbres.2016.09.014
PMID: 26972571 Journal: BRITISH JOURNAL OF DERMATOLOGY Year: 2016 Reference: Br J Dermatol. 2016 Aug;175(2):302-13. doi: 10.1111/bjd.14539. Epub 2016 May 29. Impact factor: 4.317 Publication type: Paper in international publication Authors: Sole, C, Gimenez-Barcons, M, Ferrer, B, Ordi-Ros, J, Cortes-Hernandez, J et al. DOI: 10.1111/bjd.14539
PMID: 26743605 Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY Year: 2016 Reference: J Invest Dermatol. 2016 Mar;136(3):593-602. doi: 10.1016/j.jid.2015.11.026. Epub 2015 Dec 29. Impact factor: 6.915 Publication type: Paper in international publication Authors: Aterido, Adria, Julia, Antonio, Ferrandiz, Carlos, Puig, Lluis, Fonseca, Eduardo, Fernandez-Lopez, Emilia, Dauden, Esteban, Sanchez-Carazo, Jose Luis, Lopez-Estebaranz, Jose Luis, Moreno-Ramirez, David et al. DOI: 10.1016/j.jid.2015.11.026
PMID: 26871199 Journal: PHARMACOGENOMICS Year: 2016 Reference: Pharmacogenomics. 2016 Mar;17(4):323-6. doi: 10.2217/pgs.15.168. Epub 2016 Feb 12. Impact factor: 2.71 Publication type: Review in international publication Authors: Julia, Antonio, Marsal, Sara et al. DOI:
PMID: 26815016 Journal: Ophthalmic Surgery Lasers & Imaging Retina Year: 2016 Reference: Arthritis Rheumatol. 2016 Jun;68(6):1384-91. doi: 10.1002/art.39591. Impact factor: 1.212 Publication type: Paper in international publication Authors: Bertranpetit, Jaume, Absher, Devin, Myers, Richard M, Tornero, Jesus, Marsal, Sara, Garcia-Montero, Andres C, Lluis Gelpi, Josep, Tortosa, Raul, Julia, Antonio, Blanco, Francisco et al. DOI: 10.1002/art.39591
PMID: 25433783 Journal: MEDICINA CLINICA Year: 2015 Reference: Med Clin (Barc). 2015 Mar 9;144(5):216-22. doi: 10.1016/j.medcli.2014.08.009. Epub 2014 Nov 26. Impact factor: 1.417 Publication type: Paper in national publication Authors: Cardona, Victoria, Garriga, Teresa et al. DOI: 10.1016/j.medcli.2014.08.009
PMID: 25386668 Journal: ANTIOXIDANTS & REDOX SIGNALING Year: 2015 Reference: Antioxid Redox Signal. 2015 Mar 10;22(8):679-85. doi: 10.1089/ars.2014.6181. Epub 2014 Dec 18. Impact factor: 7.407 Publication type: Paper in international publication Authors: Cordero, Mario D, Castro-Marrero, Jesus, Roman-Malo, Lourdes, Aliste, Luisa, Fernandez de Sevilla, Tomas, Alegre-Martin, Jose, Segundo, MJ, Calvo, Natalia, Saez-Francas, Naia et al. DOI: 10.1089/ars.2014.6181
PMID: 24741583 Journal: Journal of immunology research Year: 2014 Reference: J Immunol Res. 2014;2014:290797. doi: 10.1155/2014/290797. Epub 2014 Feb 4. Impact factor: 3.53 Publication type: Paper in international publication Authors: Labrador-Horrillo, Moises, Martinez, Maria Angeles, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Balada, Eva, Vilardell-Tarres, Miquel, Juarez, Candido et al. DOI: 10.1155/2014/290797
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PMID: 25182205 Journal: AUTOIMMUN REV Year: 2014 Reference: Autoimmun Rev. 2014 Oct;13(10):1008-12. doi: 10.1016/j.autrev.2014.08.038. Epub 2014 Aug 27. Impact factor: 7.095 Publication type: Paper in international publication Authors: Labrador-Horrillo, Moises, Martinez, Maria Angeles, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Grau-Junyent, Josep M, Vilardell-Tarres, Miquel, Juarez, Candido et al. DOI: 10.1016/j.autrev.2014.08.038
PMID: 25118052 Journal: LUPUS Year: 2014 Reference: Lupus. 2014 Sep;23(10):1073-8. doi: 10.1177/0961203314534303. Epub 2014 May 15. Impact factor: 2.481 Publication type: Paper in international publication Authors: Guillen-Del Castillo, A, Alonso, J, Martinez-Valle, F, Alonso-Vila, S, Garrido-Castro, A C, Vilardell-Tarres, M, Rovira, A, Ordi-Ros, J et al. DOI: 10.1177/0961203314534303
PMID: 22648008 Journal: PSYCHIATRY RESEARCH Year: 2012 Reference: Psychiatry Res. 2012 Dec 30;200(2-3):748-53. doi: 10.1016/j.psychres.2012.04.041. Epub 2012 May 28. Impact factor: 2.524 Publication type: Paper in international publication Authors: , , , , , , et al. DOI: 10.1016/j.psychres.2012.04.041
PMID: 22625665 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2012 Reference: Neurogastroenterol Motil. 2012 Aug;24(8):740-6, e348-9. doi: 10.1111/j.1365-2982.2012.01928.x. Epub 2012 May 24. Impact factor: 3.414 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1111/j.1365-2982.2012.01928.x
PMID: 22576746 Journal: Attention deficit and hyperactivity disorders Year: 2012 Reference: Atten Defic Hyperact Disord. 2012 Jun;4(2):63-75. doi: 10.1007/s12402-012-0075-5. Epub 2012 May 12. Impact factor: Publication type: Letter or abstract Authors: , , , , , , et al. DOI: 10.1007/s12402-012-0075-5
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The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
