Joaquin Seras Franzoso I am researcher and PI at the Drug Delivery & Targeting Group belonging to the "Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation - AVANT " eCORE at Vall d'Hebron Institute of Research (VHIR). I combine this main activity with acting as associate lecturer at the Autonomous University of Barcelona (UAB). Institucions de les que formen part Investigador/a principal Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia Vall Hebron Institut de Recerca LinkedIn Twitter Orcid Joaquin Seras Franzoso LinkedIn Twitter Orcid Institucions de les que formen part Investigador/a principal Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia Vall Hebron Institut de Recerca I am researcher and PI at the Drug Delivery & Targeting Group belonging to the "Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation - AVANT " eCORE at Vall d'Hebron Institute of Research (VHIR). I combine this main activity with acting as associate lecturer at the Autonomous University of Barcelona (UAB).
I performed my PhD at the Autonomous University of Barcelona (UAB, 2012). There, I focused on the development of first-in-class biomedical uses for bacterial Inclusion Bodies (IBs). IBs are recombinant protein deposits, between the nano- and micro scale, historically discarded as waste by products of protein production. My research studied the IB-exerted stimuli on mammalian cell interfaces when producing complex nanotopographies for tissue engineering. After my PhD I devoted myself to expand the catalogue of biomedical uses for IBs, as high added value biomaterials. I engineered IBs to be used as depots for the slow release of therapeutic proteins, polyvalent coatings and immunomodulatory particles. I moved to Vall d'Hebron Research Institute (VHIR) in 2015 awarded with an AECC post-doctoral fellowship. Here, I have continued my work in the nano-sphere. Particularly, I have participated in the development of Polymeric Micelles (PM) for the PM-mediated intracellular delivery of therapeutic antibodies, targeting cancer stem cell intrinsic drug resistance. In parallel, I started to explore the potential of extracellular vesicles (EVs). First, as central mediators of intercellular communication with roles in cancer cell plasticity regulation and premetastatic niche conditioning. Secondly, exploiting EVs capacity as protein delivery systems. In this regard, I focused on the generation of protein therapeutics loaded in vivo into EVs. This approach combines protein production and NP functionalization in a single step with intended applications in rare diseases and cancer therapy. I have participated in >20 competitive projects with an accumulated funding of > 3 Milion euros (PI of two). This activity rendered >50 articles (hi=25) in international journals and >60 contributions to congresses. Complementing this activity I engaged teaching undergraduates (2010-2012 & 2021 - , AQU Lecturer accreditation) at UAB and mentoring master and PhD students.
Línies de recerca Estudi de les bases moleculars i cel·lulars del càncer IP: Joaquin Seras Franzoso Projectes EXPAND-EV: EXPANDing the value of Extracellular Vesicles as carriers of biomarker and therapy in precision healhcare IP: Joaquin Seras Franzoso Col·laboradors: - Entitat finançadora: EUROPEAN COMMISSION Finançament: 82800 Referència: EXPAND-EV/EC/MSCA-SE/2024/SERAS Durada: 01/01/2025 - 31/12/2028 Impact of stem-related tumor extracellular vesicles subsets in TNBC progression. IP: Joaquin Seras Franzoso Col·laboradors: Maria Fidel Lledò, Miriam Izquierdo Sans Entitat finançadora: Instituto de Salud Carlos III Finançament: 119567 Referència: FI23/00223 Durada: 15/01/2024 - 14/01/2028 MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small Cell Lung Cancer IP: MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C Col·laboradors: Joaquin Seras Franzoso, Fernanda Raquel Da Silva Andrade, Fernanda Raquel Da Silva Andrade, Fernanda Raquel Da Silva Andrade, Fernanda Raquel Da Silva Andrade Entitat finançadora: Ministerio de Ciencia e Innovación-MICINN Finançament: 333099 Referència: CPP2022-009780 Durada: 01/07/2023 - 30/06/2026 Nanoclustered Affimers for Targeted KRAS Ablation in Pancreatic Ductal Adenocarcinoma IP: Joaquin Seras Franzoso Col·laboradors: Diana Fernandes de Rafael Entitat finançadora: Asociación Cáncer de Páncreas Finançament: 50000 Referència: ACANPAN/PROJECTES/2023/SERAS Durada: 05/12/2023 - 04/12/2025 Paginació Pàgina actual 1 Page 2 Page 3 Page 4 Pàgina següent › Última pàgina »
