Speaker: Dr. José Luis García Giménez. Dept. Physiology. Medicine and Dentistry School, University of Valencia. Biomedical Research Institute INCLIVA
CIBERER-ISCIII

Epigenetic mechanisms control the activation or inactivation of gene expression, without changes in the DNA sequence, which consequently provides a finely tuned response capacity for cells and organisms when undergoing external and internal changes. However, in the context of human physiology or disease, any cellular imbalance that modulates homeostasis has the potential to trigger molecular changes that result either in physiological adaptation to a new situation or pathological conditions. Sepsis can directly impact epigenetic mechanisms at different levels, including DNA methylation, post-translational modifications and even produce the release of histones from cells to the blood-stream. In this lecture I will focus on the changes occurring in the DNA methylation profile of septic patients and how the release of extracellular histones produces severe deleterious effects on cells and tissues activating inflammation, oxidative stress, and cell death, so contributing to endothelial damage and endothelial dysfunction. 
In addition, I will provide evidence of the potential use of circulating histones determination can help in sepsis and septic shock patient management as well as, to provide new therapeutic strategies based on the removal of extracellular histones.

Host; Dr. Juan Carlos Ruiz, Head Clinic,  Intensive Medicine Service. Vall d'Hebron University Hospital.
Shock, Organ Dysfunction and Resuscitation Research Group (SODIR). Vall d'Hebron Research Institute (VHIR)

Register here to attend by Zoom: https://gencat.zoom.us/j/92863787346