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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Gerard Cantero Recasens

Gerard Cantero Recasens

Main researcher
Kidney Physiopathology
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Ramón Vilalta Casas

Ramón Vilalta Casas

Kidney Physiopathology
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Semidey Raven, Maria Eugenia

Semidey Raven, Maria Eugenia

Research technician
Kidney Physiopathology
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Carla Soto Santoyo

Carla Soto Santoyo

Research technician
Kidney Physiopathology
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Julieta Torchia

Julieta Torchia

Predoctoral researcher
Kidney Physiopathology
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Alejandro Cruz Gual

Alejandro Cruz Gual

Research technician
Kidney Physiopathology
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Gerard Cantero Recasens

Gerard Cantero Recasens

Main researcher
Kidney Physiopathology
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Ramón Vilalta Casas

Ramón Vilalta Casas

Kidney Physiopathology
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Semidey Raven, Maria Eugenia

Semidey Raven, Maria Eugenia

Research technician
Kidney Physiopathology
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Carla Soto Santoyo

Carla Soto Santoyo

Research technician
Kidney Physiopathology
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Julieta Torchia

Julieta Torchia

Predoctoral researcher
Kidney Physiopathology
Read more
Alejandro Cruz Gual

Alejandro Cruz Gual

Research technician
Kidney Physiopathology
Read more

Research lines

Androgen activity in renal pathophysiology: Identification of androgen-regulated kidney-specific genes and functional characterization of them, in processes of inflammation, oxidative stress and fibrosis underlying chronic kidney disease, hypertension and metabolic syndrome.

Among the genes identified in our laboratory that are kidney-specific and regulated by androgens at the transcriptional level we are particularly focused on the one that codes for the kidney androgen-regulated protein (KAP). Besides characterization of  the functional promoter elements that enable KAP expression in proximal tubule epithelial cells, we have generated a transgenic (Tg) mouse model that overexpresses KAP in proximal tubule cells under the presence of androgens, in order to mimick the endogenous KAP expression pattern. KAP Tg mice show altered lipid metabolism, glycosuria, proteinuria and hypertension, as well as focal segmental glomerulosclerosis mediated by increased oxidative stress. We are currently working in this Tg model and also preparing conditional knock-out mice to further caharacterize the role of KAP in renal pathophysiology. Moreover, we are also studying the role of KAP in the metabolic syndrome. Besides KAP, we are studying the role of KAP-interacting immunophilins  in inflammation and kidney fibrosis.

IP: Anna Meseguer Navarro

Focal segmental glomerulosclerosis

Idiopathic nonfamilial focal segmental glomerulosclerosis (FSG) is a disease with no treatment, whose usual outcome is end-stage renal disease frequently recidivating after transplantation. In close cooperation with the Nephrology and Paediatric Nephrology services of  Vall d'Hebron hospital together with hospitals throughout the country that provide a significant number of patients, we intend to identify the hypothetical blood factor that causes the proteinuria observed in this disease. Identification of such plasma factor, by means of differential proteomic analysis, would allow the definition of therapeutic targets for the disease, which currently lacks an effective treatment. Our second objective is to find biomarkers that enable us to foresee a potential recidivation and the consequent loss of the graft following renal transplantation to FSG patients.

IP: Joan López Hellin

Mechanisms of chronic renal disease progression and cardiovascular risk in pediatric patients with chronic renal disease

Pediatric patients with chronic kidney disease (CKD) constitude a high risk group for cardiovascular disease (CVD) related to traditional and non-traditional risk factors. We are interested in studying the relationship between traditional CVD risk factors (obesity, overweight, anemia, dyslipemia, malnutrition, hypertension, and non-traditional CVD risk factors (homocysteine, asymmetric dymethylarginine (ADMA), FGF23, ultraselective protein C (PCR) and carotid intima-media thickness (cIMT) in children and adolescents with CKD, based on its severity and duration.  Further, we are also interested in finding a biomarker to identify early in the disease, those patients with increased CVD risk and poor outcome.

IP: Gema Ariceta Iraola

Pathologic mechanisms leading to chronic allograft disease and detection of early markers.

Chronic allograft nephropathy (CAN) is one of the major causes of graft loss in kidney-transplanted patients. The pathogenetic mechanisms of CAN are probably multifactorial, including early noxious agents as a consequence of  ischemia/ reperfusion of the graft or high loading doses of anticalcineurinics (aCN), and also chronic damage following aCN therapy, rejection or other reasons. We want to determine the proteomic and genomic changes occurring in tubular cells after different noxious agents (cyclosporin, tacrolimus, other renal toxicants, hypoxia), and also the effects caused by immunophilin silencing (anticalcineurin receptors) in the renal proximal tubule cells. Our objective is to identify specific markers of kidney injury that would be useful to anticipate toxicity or injury in early starges. Those putative markers will be clinically validated in collaboration with the Nephrology and the Pathology services of Vall d’Hebron Hospital.

IP: -

Projects

Caracterización de la respuesta inmune celular específica frente al virus Epstein-Barr en receptores de trasplante renal pediátrico (CRICE-VEB)).

IP: -
Collaborators: Gema Ariceta Iraola, Laura Donadeu Casassas, Delphine Kervella
Funding agency: Sociedad Española de Trasplantes
Funding: 20000
Reference: SET/AYUDAS.PROYECTOS/2023/LOPEZ
Duration: 01/01/2024 - 31/12/2025

RED NACIONAL DE LABORATORIOS DE FUNCION RENAL

IP: Francesc Moreso Mateos
Collaborators: Gema Ariceta Iraola, Joan López Hellin
Funding agency: Instituto de Salud Carlos III
Funding: 42900
Reference: PMP22/00119
Duration: 01/01/2023 - 31/12/2025

La variabilidad fenotípica en pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC) como oportunidad para entender las bases fisiopatológicas de la enfermedad y para la búsqueda de soluciones terapéuticas

IP: Anna Meseguer Navarro
Collaborators: Gema Ariceta Iraola, Gerard Cantero Recasens
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/MESEGUER
Duration: 27/11/2023 - 26/11/2025

Fucosylation in Clear Cell Renal Cell Carcinoma. STATing novel biomarkers and therapeutic strategies

IP: Anna Meseguer Navarro
Collaborators: Gerard Cantero Recasens, Miriam Izquierdo Sans
Funding agency: Asociación Española Contra el Cáncer
Funding: 150000
Reference: INVES234762CANT
Duration: 15/11/2023 - 14/11/2026

Publications

p27Kip1 V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor-positive breast cancer.

PMID: 36806942
Journal: JNCI cancer spectrum
Year: 2023
Reference: JNCI Cancer Spectr. 2023 Mar 1;7(2):pkad014. doi: 10.1093/jncics/pkad014.
Impact factor:
Publication type: Paper in international publication
Authors: Apala, Juan V; Bueno, Maria J; Guerra, Juan; Malon, Diego; Malumbres, Marcos; Manso, Luis; Mouron, Silvana; Munoz, Manuel; Quintela-Fandino, Miguel; Rodriguez, Sandra et al.
DOI: 10.1093/jncics/pkad014

Sodium intake and urinary losses in children on dialysis: a European multicenter prospective study.

PMID: 36988689
Journal: PEDIATRIC NEPHROLOGY
Year: 2023
Reference: Pediatr Nephrol. 2023 Oct;38(10):3389-3399. doi: 10.1007/s00467-023-05932-y. Epub 2023 Mar 29.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Aufricht, Christoph; Bakkaloglu, Sevcan A; Consolo, Silvia; Edefonti, Alberto; Grassi, Maria Rosa; Gual, Alejandro Cruz; Holtta, Tuula; Jankauskiene, Augustina; Klaus, Guenter et al.
DOI: 10.1007/s00467-023-05932-y

Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy.

PMID: 36996481
Journal: Kidney360
Year: 2023
Reference: Kidney360. 2023 Mar 30. doi: 10.34067/KID.0000000000000115.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Natalia; Ariceta, Gema; Avila, Ana; Barros, Xoana; Bravo, Luis; Cabello, Virginia; Caravaca-Fontan, Fernando; Cavero, Teresa; Cruz, Sonia; Da Silva, Iara et al.
DOI: 10.34067/KID.0000000000000115

Rituximab-associated hypogammaglobulinemia in children with idiopathic nephrotic syndrome: results of an ESPN survey.

PMID: 37014530
Journal: PEDIATRIC NEPHROLOGY
Year: 2023
Reference: Pediatr Nephrol. 2023 Sep;38(9):3035-3042. doi: 10.1007/s00467-023-05913-1. Epub 2023 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: Adams, B; Aksenova, M; Alpay, H; Andersen, R; Ariceta, G; Ariceta, G; Aris, A M; Atmis, B; Baudouin, V; Bayrakci, U S et al.
DOI: 10.1007/s00467-023-05913-1

Behavior of SelectMDx and Prostate-specific Antigen Density in the Challenging Scenario of Prostate Imaging-Reporting and Data System Category 3 Lesions.

PMID: 34602313
Journal: EUROPEAN UROLOGY
Year: 2022
Reference: Eur Urol. 2022 Jan;81(1):124-125. doi: 10.1016/j.eururo.2021.09.019. Epub 2021 Sep 30.
Impact factor: 20.096
Publication type: Letter whit IF
Authors: Morote, Juan; Diaz, Fernando; Celma, Anna; Planas, Jacques; Trilla, Enrique et al.
DOI: 10.1016/j.eururo.2021.09.019

Evaluating the impact of the learning curve on the perioperative outcomes of robot-assisted radical cystectomy with intracorporeal urinary diversion.

PMID: 34840098
Journal: Actas Urologicas Espanolas
Year: 2022
Reference: Actas Urol Esp (Engl Ed). 2022 Jan-Feb;46(1):57-62. doi: 10.1016/j.acuroe.2021.05.004. Epub 2021 Nov 25.
Impact factor: 0.994
Publication type: Paper in national publication
Authors: Trilla, E; Raventos, C X; Salvador, C; Lopez-Molina, C; Carrion, A; Campistol, M; Pinero, A; Lozano, F et al.
DOI: 10.1016/j.acuroe.2021.05.004

Reconciling short-term clinical and Immunological outcomes of SARS-CoV-2 vaccination in Solid Organ Transplant recipients.

PMID: 34554648
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2022
Reference: Am J Transplant. 2022 Feb;22(2):673-675. doi: 10.1111/ajt.16855. Epub 2021 Oct 5.
Impact factor: 8.086
Publication type: Letter or abstract
Authors: Toapanta, Nestor; Esperalba, Juliana; Campos-Varela, Isabel; Pont, Teresa; Len, Oscar; Campins, Magda; Moreso, Francesc; Crespo, Elena; Munoz, Marina; Lopez, Manuel et al.
DOI: 10.1111/ajt.16855

Is Tumor Budding a New Predictor for Early Cystectomy in pT1 High-Grade Bladder Cancer?

PMID: 34352790
Journal: UROLOGIA INTERNATIONALIS
Year: 2022
Reference: Urol Int. 2022;106(2):154-162. doi: 10.1159/000517543. Epub 2021 Aug 5.
Impact factor: 2.089
Publication type: Paper in international publication
Authors: Raventos Busquets, Carles X; Semidey, M Eugenia; Lozano Palacio, Fernando; Carrion Puig, Albert; Aula Olivar, Ana; De Torres Ramirez, Ines M; Trilla Herrera, Enrique et al.
DOI: 10.1159/000517543

Clinical and genetic characterization of a cohort of proteinuric patients with biallelic CUBN variants.

PMID: 34610128
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2021
Reference: Nephrol Dial Transplant. 2021 Oct 5. pii: 6381717. doi: 10.1093/ndt/gfab285.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Domingo-Gallego, Andrea, Pybus, Marc, Madariaga, Leire, Pinero-Fernandez, Juan Alberto, Gonzalez-Pastor, Sara, Lopez-Gonzalez, Mercedes, Simarro-Rueda, Esther, Quintanilla-Mata, Maria Luisa, Matoses-Ruiperez, Maria Luisa, Ejarque-Vila, Laia et al.
DOI: 10.1093/ndt/gfab285

Multidimensional inflammatory and immunological endotypes of idiopathic focal segmental glomerulosclerosis and their association with treatment outcomes.

PMID: 34221390
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Dec 14;14(7):1826-1834. doi: 10.1093/ckj/sfaa265. eCollection 2021 Jul.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Roca, Neus, Madrid, Alvaro, Lopez, Mercedes, Fraga, Gloria, Jatem, Elias, Gonzalez, Jorge, Martinez, Cristina, Segarra, Alfons et al.
DOI: 10.1093/ckj/sfaa265

Nutritional status and volume control in adolescents on chronic hemodialysis.

PMID: 33988730
Journal: PEDIATRIC NEPHROLOGY
Year: 2021
Reference: Pediatr Nephrol. 2021 Nov;36(11):3733-3740. doi: 10.1007/s00467-021-05089-6. Epub 2021 May 14.
Impact factor: 3.714
Publication type: Paper in international publication
Authors: Paglialonga, Fabio, Consolo, Silvia, Brambilla, Marta, Caporale, Olga, Gual, Alejandro Cruz, Grassi, Maria Rosa, Montini, Giovanni et al.
DOI: 10.1007/s00467-021-05089-6

Novel Dent Disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function.

PMID: 33987651
Journal: HUMAN MOLECULAR GENETICS
Year: 2021
Reference: Hum Mol Genet. 2021 Jul 9;30(15):1413-1428. doi: 10.1093/hmg/ddab131.
Impact factor: 6.15
Publication type: Paper in international publication
Authors: Duran, Monica, Burballa, Carla, Cantero-Recasens, Gerard, Butnaru, Cristian M, Malhotra, Vivek, Ariceta, Gema, Sarro, Eduard, Meseguer, Anna et al.
DOI: 10.1093/hmg/ddab131

Luminex screening first vs. direct single antigen bead assays: Different strategies for HLA antibody monitoring after kidney transplantation.

PMID: 32279925
Journal: HUMAN IMMUNOLOGY
Year: 2020
Reference: Hum Immunol. 2020 Jun;81(6):293-299. doi: 10.1016/j.humimm.2020.03.003. Epub 2020 Apr 9.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Cabrales, Carlos; Burballa, Carla; Crespo, Marta; Garcia, Carme; Mir, Marisa; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores; Reed, Elaine F; Valenzuela, Nicole M et al.
DOI: 10.1016/j.humimm.2020.03.003

Emergence Delirium: Can Corticosteroids Contribute to It?

PMID: 33133750
Journal: Journal of pediatric intensive care
Year: 2020
Reference: J Pediatr Intensive Care. 2020 Dec;9(4):304-306. doi: 10.1055/s-0040-1709655. Epub 2020 Apr 17.
Impact factor: 0
Publication type: Letter or abstract
Authors: Esmel-Vilomara, Roger, Cruz, Alejandro, Inoriza, Cristina, Andreu, Eva, Munar, Francisca et al.
DOI: 10.1055/s-0040-1709655

Long-term outcome in a case series of Denys-Drash syndrome.

PMID: 31807296
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2019 Mar 16;12(6):836-839. doi: 10.1093/ckj/sfz022. eCollection 2019 Dec.
Impact factor: 2.975
Publication type: Paper in international publication
Authors: Roca, Neus, Munoz, Marina, Cruz, Alejandro, Vilalta, Ramon, Lara, Enrique, Ariceta, Gema et al.
DOI: 10.1093/ckj/sfz022

Prediabetes is a risk factor for cardiovascular disease following renal transplantation.

PMID: 31611066
Journal: KIDNEY INTERNATIONAL
Year: 2019
Reference: Kidney Int. 2019 Dec;96(6):1374-1380. doi: 10.1016/j.kint.2019.06.026. Epub 2019 Aug 14.
Impact factor: 8.306
Publication type: Paper in international publication
Authors: Porrini, Esteban, Diaz, Juan Manuel, Moreso, Francesc, Lauzurrica, Ricardo, Ibernon, Meritxel, Torres, Irene Silva, Ruiz, Rocio Benitez, Rodriguez Rodriguez, Ana Elena, Mallen, Patricia Delgado, Bayes-Genis, Beatriz et al.
DOI: 10.1016/j.kint.2019.06.026

MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors.

PMID: 28411971
Journal:
Year: 2018
Reference: Nefrologia (Engl Ed). 2018 Mar-Apr;38(2):207-212. doi: 10.1016/j.nefro.2017.02.007. Epub 2017 Apr 12.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Cabrales, Carlos; Burballa, Carla; Cecchini, Lluis; Crespo, Marta; Frances, Albert; Fumado, Lluis; Mir, Marisa; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores et al.
DOI: 10.1016/j.nefro.2017.02.007

Factors associated with renal function compensation after donor nephrectomy.

PMID: 29773235
Journal:
Year: 2018
Reference: Nefrologia (Engl Ed). 2018 Sep-Oct;38(5):528-534. doi: 10.1016/j.nefro.2018.02.008.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Cabrales, Carlos; Burballa, Carla; Cecchini, Lluis; Crespo, Marta; Frances, Albert; Fumado, Lluis; Mir, Marisa; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores et al.
DOI: 10.1016/j.nefro.2018.02.008

Usefulness of the KDPI in Spain: A comparison with donor age and definition of standard/expanded criteria donor.

PMID: 29884503
Journal:
Year: 2018
Reference: Nefrologia (Engl Ed). 2018 Sep-Oct;38(5):503-513. doi: 10.1016/j.nefro.2018.03.003. Epub 2018 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Cabrales, Carlos; Bermejo, Sheila; Burballa, Carla; Buron, Andrea; Buxeda, Anna; Crespo, Marta; Mir, Marisa; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores et al.
DOI: 10.1016/j.nefro.2018.03.003

Child and Adolescent Sexual Abuse in Women Seeking Help for Sexual and Reproductive Mental Health Problems: Prevalence, Characteristics, and Disclosure.

PMID: 28471339
Journal: Journal of Child Sexual Abuse
Year: 2017
Reference: J Child Sex Abus. 2017 Apr;26(3):246-269. doi: 10.1080/10538712.2017.1288186.
Impact factor:
Publication type: Paper in international publication
Authors: Avecilla-Palau, Angels; Cobo, Jesus; Faro, Concepcio; Fernandez, Maria-Isabel; Lopetegui, Lourdes; Lopez, Silvia; Martinez, Cristina; Monteagudo, Monica; Pujol-Ribera, Enriqueta et al.
DOI: 10.1080/10538712.2017.1288186

Erratum to "Renal graft survival according to Banff 2013 classification in indication biopsies".

PMID: 28648215
Journal: NEFROLOGIA
Year: 2017
Reference: Nefrologia. 2017 May-Jun;37(3):355. doi: 10.1016/j.nefro.2017.05.003.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Cabrales, Carlos; Bermejo, Sheila; Burballa, Carla; Crespo, Marta; Gimeno, Javier; Mir, Marisa; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores; Sanchez-Guerri, Ignacio et al.
DOI: 10.1016/j.nefro.2017.05.003

[Smoking prevalence in hospital workers: meta-analysis in 45 Catalan hospitals].

PMID: 26422688
Journal: Gaceta Sanitaria
Year: 2016
Reference: Gac Sanit. 2016 Jan-Feb;30(1):55-8. doi: 10.1016/j.gaceta.2015.08.006. Epub 2015 Oct 1.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Laura; Fernandez, Esteve; Fu, Marcela; Martinez, Cristina; Martinez-Sanchez, Jose M; Quiros, Nuria; Riccobene, Anna; Salto, Esteve et al.
DOI: 10.1016/j.gaceta.2015.08.006

Renal graft survival according to Banff 2013 classification in indication biopsies.

PMID: 27595515
Journal: NEFROLOGIA
Year: 2016
Reference: Nefrologia. 2016 Nov-Dec;36(6):660-666. doi: 10.1016/j.nefro.2016.05.018. Epub 2016 Aug 30.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Cabrales, Carlos; Bermejo, Sheila; Burballa, Carla; Crespo, Marta; Gimeno, Javier; Mir, Marisa; Pascual, Julio; Perez-Saez, Maria Jose; Redondo-Pachon, Dolores; Sanchez-Guerri, Ignacio et al.
DOI: 10.1016/j.nefro.2016.05.018

The role of middle managers in tobacco control after a national smoke-free hospital campus ban.

PMID: 27663779
Journal: BMC HEALTH SERVICES RESEARCH
Year: 2016
Reference: BMC Health Serv Res. 2016 Sep 23;16(1):517. doi: 10.1186/s12913-016-1764-0.
Impact factor:
Publication type: Paper in international publication
Authors: Ballbe, Montse; Fernandez, Esteve; Fu, Marcela; Martinez, Cristina; Vilardell, Miquel et al.
DOI: 10.1186/s12913-016-1764-0

A patient with suspected non-ST elevation acute myocardial infarction and remarkably high brain natriuretic peptide levels.

PMID: 26440456
Journal: INTERNATIONAL JOURNAL OF CARDIOLOGY
Year: 2016
Reference: Int J Cardiol. 2016 Jan 1;202:485-7. doi: 10.1016/j.ijcard.2015.09.048. Epub 2015 Sep 25.
Impact factor: 4.036
Publication type: Paper in international publication
Authors: Baneras, Jordi, Buera, Irene, Oristrell, Gerard, Sansano, Irene, Fort, Joan, Ibernon, Meritxell, Marti, Gerard, Barrabes, Jose A, Dorado, David Garcia et al.
DOI: 10.1016/j.ijcard.2015.09.048

Renal Biopsy in Type 2 Diabetic Patients.

PMID: 26239461
Journal: Journal of Clinical Medicine
Year: 2015
Reference: J Clin Med. 2015 May 18;4(5):998-1009. doi: 10.3390/jcm4050998.
Impact factor: 0
Publication type: Review in international publication
Authors: Seron, Daniel, Ramos, Natalia, Espinel, Eugenia, Agraz, Irene, Ibernon, Meritxell, Fort, Joan et al.
DOI: 10.3390/jcm4050998

Low serum mannose-binding lectin levels are associated with inflammation and apoptosis in early surveillance allograft biopsies.

PMID: 25073029
Journal: TRANSPL IMMUNOL
Year: 2014
Reference: Transpl Immunol. 2014 Sep;31(3):152-6. doi: 10.1016/j.trim.2014.07.001. Epub 2014 Jul 26.
Impact factor: 1.832
Publication type: Paper in international publication
Authors: Ibernon, M, Moreso, F, O'Valle, F, Grinyo, J M, Moral, R G, Seron, D et al.
DOI: 10.1016/j.trim.2014.07.001

Hypertension in chronic kidney disease: the influence of renal transplantation.

PMID: 24770618
Journal: TRANSPLANTATION
Year: 2014
Reference: Transplantation. 2014 Sep 15;98(5):537-42. doi: 10.1097/TP.0000000000000103.
Impact factor: 3.535
Publication type: Paper in international publication
Authors: Azancot, Maria A, Ramos, Natalia, Moreso, Francesc J, Ibernon, Meritxell, Espinel, Eugenia, Torres, Irina B, Fort, Joan, Seron, Daniel et al.
DOI: 10.1097/TP.0000000000000103

Innate immunity in renal transplantation: The role of mannose-binding lectin.

PMID: 24321303
Journal: TRANSPLANT REV-ORLAN
Year: 2014
Reference: Transplant Rev (Orlando). 2014 Jan;28(1):21-5. doi: 10.1016/j.trre.2013.10.006. Epub 2013 Oct 26.
Impact factor: 2.66
Publication type: Paper in international publication
Authors: Ibernon, Meritxell, Moreso, Francesc, Seron, Daniel et al.
DOI: 10.1016/j.trre.2013.10.006

Subclinical rejection in renal transplants is associated with low serum mannose-binding lectin levels.

PMID: 25018901
Journal: Kidney international supplements
Year: 2011
Reference: Kidney Int Suppl (2011). 2011 Aug;1(2):36-39. doi: 10.1038/kisup.2011.10.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ibernon, Meritxell, Moreso, Francesc, Seron, Daniel et al.
DOI: 10.1038/kisup.2011.10

Thesis

Estudi dels mecanismes genètics i moleculars associats a les diferències fenotípiques observades en pacients amb hipomagnesèmia familiar amb hiporcalciúria i nefrocalcinosi (HFHNC)

PhD student: Mónica Vall Palomar
Director/s: Gema Ariceta Iraola, Anna Meseguer Navarro
University: Universidad Autònoma de Barcelona
Year: 2020

Identification of time- and sex-dependent pathways involved in renal ischemia-reperfusion injury in a porcine model. Link to renal cancer.

PhD student: Stephane Nemours , Stephane Nemours
Director/s: Anna Meseguer Navarro
University: Universidad Autònoma de Barcelona
Year: 2020

Desarrollo de modelos celulares de la enfermedad de Dent para la identificación de los mecanismos fisiopatológicos que subyacen a la progresión de la enfermedad

PhD student: Mónica Durán Fernández
Director/s: Anna Meseguer Navarro, Gema Ariceta Iraola
University: Universidad Autònoma de Barcelona
Year: 2020

The role of STAT3 phosphorylation state in clear cell renal cell carcinoma (ccRCC)

PhD student: Jazmine Paola Arevalo Bautista
Director/s: Anna Meseguer Navarro
University: Universidad Autònoma de Barcelona
Year: 2019

Exosomes in uterine aspirates: characterization and identification of diagnostic and prognostic biomarkers in endometrial cancer

PhD student: Irene Campoy Moncayo
Director/s: Antonio Gil Moreno, Jaume Reventós Puigjaner, Eva Colas Ortega
University: Universidad Autònoma de Barcelona
Year: 2017

Evaluación de factores moleculares asociados a la respuesta a CETUXIMAB: Integración con tratamientos de radioterapia y quimiterapia en carcinoma escamoso de cabeza y cuello

PhD student: Maria Eugenia Semidey Raven, Maria Eugenia Semidey Raven
Director/s: Jordi Giralt López de Sagred, Santiago Ramon y Cajal Agüeras, Margarita Alberola Ferranti, Margarita Alberola Ferranti
University: Universidad Autònoma de Barcelona
Year: 2016

Mecanismes moleculars implicats en la nefrotoxicitt per ciclosporina A (CsA): Estudi dels efectes de la CsA en les vies ERK i PI3K

PhD student: Eduard Sarro Tauler
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2008

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"Patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis present miRNA profiles in urinary extracellular vesicles associated with disease progression" was the awarded work.

Researchers at the VHIR have carried out a study showing that the ClC-5 protein regulates collagen levels through the β-catenin pathway and lysosomal degradation.

The research will perform a functional analysis of phenotype-modifying genetic variants in patients affected by familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (HFHNC).