Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

to study the pathophysiology of inherited rare renal tubulopathies
to understand the mechanisms of kidney injury and regeneration
to study the development of clear cell renal cell carcinoma (ccRCC)
the study the impact of androgens on those processes.

We are experts on the following areas:

the generation of cellular disease models carrying specific gene alterations,
genetically modified animal models and gene therapies,
life-imaging high-resolution microscopy
working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Enric Trilla Herrera

Kidney Physiopathology
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Ramón Vilalta Casas

Kidney Physiopathology
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Alejandro Cruz Gual

Research technician
Kidney Physiopathology
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Alvaro Domingo Madrid Aris

Kidney Physiopathology
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Anna Meseguer Navarro

Head of group
Kidney Physiopathology
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Carla Burballa Tàrrega

Predoctoral researcher
Kidney Physiopathology
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Enric Trilla Herrera

Kidney Physiopathology
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Ramón Vilalta Casas

Kidney Physiopathology
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Alejandro Cruz Gual

Research technician
Kidney Physiopathology
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Alvaro Domingo Madrid Aris

Kidney Physiopathology
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Anna Meseguer Navarro

Head of group
Kidney Physiopathology
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Carla Burballa Tàrrega

Predoctoral researcher
Kidney Physiopathology
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Research lines

Androgen activity in renal pathophysiology: Identification of androgen-regulated kidney-specific genes and functional characterization of them, in processes of inflammation, oxidative stress and fibrosis underlying chronic kidney disease, hypertension and metabolic syndrome.

Among the genes identified in our laboratory that are kidney-specific and regulated by androgens at the transcriptional level we are particularly focused on the one that codes for the kidney androgen-regulated protein (KAP). Besides characterization of the functional promoter elements that enable KAP expression in proximal tubule epithelial cells, we have generated a transgenic (Tg) mouse model that overexpresses KAP in proximal tubule cells under the presence of androgens, in order to mimick the endogenous KAP expression pattern. KAP Tg mice show altered lipid metabolism, glycosuria, proteinuria and hypertension, as well as focal segmental glomerulosclerosis mediated by increased oxidative stress. We are currently working in this Tg model and also preparing conditional knock-out mice to further caharacterize the role of KAP in renal pathophysiology. Moreover, we are also studying the role of KAP in the metabolic syndrome. Besides KAP, we are studying the role of KAP-interacting immunophilins in inflammation and kidney fibrosis.

IP: Anna Meseguer Navarro

Focal segmental glomerulosclerosis

Idiopathic nonfamilial focal segmental glomerulosclerosis (FSG) is a disease with no treatment, whose usual outcome is end-stage renal disease frequently recidivating after transplantation. In close cooperation with the Nephrology and Paediatric Nephrology services of Vall d'Hebron hospital together with hospitals throughout the country that provide a significant number of patients, we intend to identify the hypothetical blood factor that causes the proteinuria observed in this disease. Identification of such plasma factor, by means of differential proteomic analysis, would allow the definition of therapeutic targets for the disease, which currently lacks an effective treatment. Our second objective is to find biomarkers that enable us to foresee a potential recidivation and the consequent loss of the graft following renal transplantation to FSG patients.

IP: Joan López Hellin

Mechanisms of chronic renal disease progression and cardiovascular risk in pediatric patients with chronic renal disease

Pediatric patients with chronic kidney disease (CKD) constitude a high risk group for cardiovascular disease (CVD) related to traditional and non-traditional risk factors. We are interested in studying the relationship between traditional CVD risk factors (obesity, overweight, anemia, dyslipemia, malnutrition, hypertension, and non-traditional CVD risk factors (homocysteine, asymmetric dymethylarginine (ADMA), FGF23, ultraselective protein C (PCR) and carotid intima-media thickness (cIMT) in children and adolescents with CKD, based on its severity and duration. Further, we are also interested in finding a biomarker to identify early in the disease, those patients with increased CVD risk and poor outcome.

IP: Gema Ariceta Iraola

Pathologic mechanisms leading to chronic allograft disease and detection of early markers.

Chronic allograft nephropathy (CAN) is one of the major causes of graft loss in kidney-transplanted patients. The pathogenetic mechanisms of CAN are probably multifactorial, including early noxious agents as a consequence of ischemia/ reperfusion of the graft or high loading doses of anticalcineurinics (aCN), and also chronic damage following aCN therapy, rejection or other reasons. We want to determine the proteomic and genomic changes occurring in tubular cells after different noxious agents (cyclosporin, tacrolimus, other renal toxicants, hypoxia), and also the effects caused by immunophilin silencing (anticalcineurin receptors) in the renal proximal tubule cells. Our objective is to identify specific markers of kidney injury that would be useful to anticipate toxicity or injury in early starges. Those putative markers will be clinically validated in collaboration with the Nephrology and the Pathology services of Vall d’Hebron Hospital.

IP: -

Projects

Biología de sistemas para el descubrimiento de mecanismos fisiopatológicos y dianas rerapéuticas en la hipomagnesimia familiarr primaria con hipercalciuria y nefrocalcinosis.

IP: Gema Ariceta Iraola
Collaborators: Alejandro Cruz Gual, Marina Muñoz López, Mercedes López González
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI18/01107
Duration: 01/01/2019 - 30/06/2023

Biología de sistemas para el descubrimiento de mecanismos fisiopatológicos y dianas rerapéuticas en la hipomagnesimia familiarr primaria con hipercalciuria y nefrocalcinosis.

Identificación de biomarcadores y procesos moleculares que subyacen a la progresión de la enfermedad de Dent para el descubrimiento de nuevas dianes terapéuticas y desarrollo de fármacos in silico.

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 23810
Reference: SENEFRO/2019/MESEGUER
Duration: 21/04/2020 - 20/04/2022

Biología de sistemas para el descubrimiento de mecanismos fisiopatológicos y dianas rerapéuticas en la hipomagnesimia familiarr primaria con hipercalciuria y nefrocalcinosis.

Identificación de biomarcadores y procesos moleculares que subyacen a la progresión de la enfermedad de Dent para el descubrimiento de nuevas dianes terapéuticas y desarrollo de fármacos in silico.

ERK-REG: ERKNet Registry for Rare Kidney Diseases

IP: Gema Ariceta Iraola
Collaborators: Carlos Ramon Moguel Suarez
Funding agency: Ex. Agency for Health Consumers (EAHC)-CHAFEA
Funding: 38871
Reference: ERK-REG_3HP2017
Duration: 01/01/2018 - 31/12/2020

IMREGEN: Diferencias de género en la recuperación tras el daño renal agudo: Búsqueda de dianas compartidas entre la regeneración renal endógena y el desarrollo de ccRCC.

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 91960
Reference: SAF2017-89989-R
Duration: 01/01/2018 - 31/12/2020

Biología de sistemas para el descubrimiento de mecanismos fisiopatológicos y dianas rerapéuticas en la hipomagnesimia familiarr primaria con hipercalciuria y nefrocalcinosis.

Identificación de biomarcadores y procesos moleculares que subyacen a la progresión de la enfermedad de Dent para el descubrimiento de nuevas dianes terapéuticas y desarrollo de fármacos in silico.

ERK-REG: ERKNet Registry for Rare Kidney Diseases

IMREGEN: Diferencias de género en la recuperación tras el daño renal agudo: Búsqueda de dianas compartidas entre la regeneración renal endógena y el desarrollo de ccRCC.

Biología de sistemas para el descubrimiento de mecanismos fisiopatológicos y dianas rerapéuticas en la hipomagnesimia familiarr primaria con hipercalciuria y nefrocalcinosis.

Ultrasecuenciación de RNAm y microRNAs en exosomas de pacientes con Hipomagnesia Hipercalciuria y Nefrocalcinosis Familiar HFHNC con mutaciones

IP: Gema Ariceta Iraola
Collaborators: Ramón Vilalta Casas, Alvaro Domingo Madrid Aris, Luis Enrique Lara Moctezuma, Marina Muñoz López
Funding agency: Instituto de Salud Carlos III
Funding: 148830
Reference: PI14/01107
Duration: 01/01/2015 - 31/12/2018

Could TIM-1 constitute a new target for renal carcinoma immunotherapy?

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: American Association for Cancer Research
Funding: 224498.8
Reference: KURE-IT_AACR2016
Duration: 01/07/2016 - 31/12/2018

ERK-REG: ERKNet Registry for Rare Kidney Diseases

IMREGEN: Diferencias de género en la recuperación tras el daño renal agudo: Búsqueda de dianas compartidas entre la regeneración renal endógena y el desarrollo de ccRCC.

Kidney Integration sofware: Developing a new tool for diagnostic and decision making treatments for Kidney Tumours (KINESICS)

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 23000
Reference: EUIN2013-51201
Duration: 01/12/2014 - 30/11/2017

Ultrasecuenciación de RNAm y microRNAs en exosomas de pacientes con Hipomagnesia Hipercalciuria y Nefrocalcinosis Familiar HFHNC con mutaciones

Dianas dependientes de andrógenos involucradas en procesos de daño y regeneración renal capaces de promover la progresión hacia la enfermedad renal crónica y el desarrollo de enfermedad cronica de riñon y cáncer.

IP: Anna Meseguer Navarro
Collaborators: Enric Trilla Herrera, David Lorente García
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 229900
Reference: SAF2014-59945-R
Duration: 01/01/2015 - 31/12/2017

Could TIM-1 constitute a new target for renal carcinoma immunotherapy?

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: American Association for Cancer Research
Funding: 224498.8
Reference: KURE-IT_AACR2016
Duration: 01/07/2016 - 31/12/2018

Kidney Integration sofware: Developing a new tool for diagnostic and decision making treatments for Kidney Tumours (KINESICS)

Kidney and sex hormones: novel insights into development and progression of the metabolic syndrome

IP: Anna Meseguer Navarro
Collaborators: Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 45135
Reference: PRED-VHIR-2012-09
Duration: 15/01/2013 - 14/01/2016

Ultrasecuenciación de RNAm y microRNAs en exosomas de pacientes con Hipomagnesia Hipercalciuria y Nefrocalcinosis Familiar HFHNC con mutaciones

Dianas dependientes de andrógenos involucradas en procesos de daño y regeneración renal capaces de promover la progresión hacia la enfermedad renal crónica y el desarrollo de enfermedad cronica de riñon y cáncer.

Kidney Integration sofware: Developing a new tool for diagnostic and decision making treatments for Kidney Tumours (KINESICS)

Kidney and sex hormones: novel insights into development and progression of the metabolic syndrome

Ultrasecuenciación de RNAm y microRNAs en exosomas de pacientes con Hipomagnesia Hipercalciuria y Nefrocalcinosis Familiar HFHNC con mutaciones

Dianas dependientes de andrógenos involucradas en procesos de daño y regeneración renal capaces de promover la progresión hacia la enfermedad renal crónica y el desarrollo de enfermedad cronica de riñon y cáncer.

Kidney Integration sofware: Developing a new tool for diagnostic and decision making treatments for Kidney Tumours (KINESICS)

Kidney and sex hormones: novel insights into development and progression of the metabolic syndrome

Kidney and sex hormones: Novel insights into development and progression of the metabolic syndrome

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin, Concepció Jacobs Cachá, Andrea Caballero Garralda
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 266200
Reference: SAF2011-29506
Duration: 01/01/2012 - 31/12/2014

Promoting regeneration versus tubulointerstitial fibrosis in progressive renal disease: Novel molecular pathways

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin, Maria Teresa Salcedo Allende, Concepció Jacobs Cachá
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 18000
Reference: SENEFRO-2012-01
Duration: 06/10/2012 - 05/10/2014

Role of the kidney androgen-regulated protein (KAP) in the pathophysiology of the cardiometabolic syndrome

IP: Anna Meseguer Navarro
Collaborators: Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13500
Reference: PRED/IR-HUVH/14/2009
Duration: 01/01/2010 - 31/12/2013

Kidney and sex hormones: novel insights into development and progression of the metabolic syndrome

Kidney and sex hormones: Novel insights into development and progression of the metabolic syndrome

Promoting regeneration versus tubulointerstitial fibrosis in progressive renal disease: Novel molecular pathways

Role of the kidney androgen-regulated protein (KAP) in the pathophysiology of the cardiometabolic syndrome

Kidney and sex hormones: Novel insights into development and progression of the metabolic syndrome

Promoting regeneration versus tubulointerstitial fibrosis in progressive renal disease: Novel molecular pathways

Role of the kidney androgen-regulated protein (KAP) in the pathophysiology of the cardiometabolic syndrome

Acción androgénica y función renal: Implicación de la kidney androgen-regulated protein (KAP)

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin, Maria Teresa Salcedo Allende, Thais Cuadros Arasa
Funding agency: Instituto de Salud Carlos III
Funding: 441045
Reference: PI081351
Duration: 01/01/2009 - 31/12/2011

Acción andrógénica y función renal: Implicación de la Kidney androgen-regulated protein (KAP)

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin, Maria Teresa Salcedo Allende, Thais Cuadros Arasa, Concepció Jacobs Cachá
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 18000
Reference: SENEFRO/01/08
Duration: 01/02/2009 - 31/01/2011

Role of the kidney androgen-regulated protein (KAP) in the pathophysiology of the cardiometabolic syndrome

Implicacions del receptor del virus de l'hepatitis A humà (hHAVcr-1) en el desenvolupament i la progressió del carcinoma renal. Valor com a marcador diagnòstic i pronòstic en els carcinomes de bufeta i renals

IP: Anna Meseguer Navarro
Collaborators: Santiago Ramon y Cajal Agüeras, Joan Morote Robles, Enric Trilla Herrera, Thais Cuadros Arasa
Funding agency: Fundació La Marató de TV3
Funding: 204625
Reference: TV3/052410
Duration: 01/01/2006 - 30/04/2010

Acción androgénica y función renal: Implicación de la kidney androgen-regulated protein (KAP)

Acción andrógénica y función renal: Implicación de la Kidney androgen-regulated protein (KAP)

Las ciclofilinas en el fracaso renal agudo tóxico. Identificación de biomarcadores pronósticos y de posibles dianas terapéuticas.

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 38200
Reference: FMMA/01/2005
Duration: 11/09/2006 - 10/09/2009

Implicacions del receptor del virus de l'hepatitis A humà (hHAVcr-1) en el desenvolupament i la progressió del carcinoma renal. Valor com a marcador diagnòstic i pronòstic en els carcinomes de bufeta i renals

Implicación de la ciclofilina B (CYBP) y de las proteínas que con ella interaccionan, en el daño renal agudo

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin, Thais Cuadros Arasa
Funding agency: Fundación Renal Iñigo Alvarez de Toledo
Funding: 18000
Reference: FRIAT_01_2007
Duration: 01/01/2008 - 31/12/2009

Acción androgénica y función renal: Implicación de la kidney androgen-regulated protein (KAP)

Mecanismes moleculars implicats en la nefroxicitat produïda per Ciclospirina A (CsA) i FK506 en el túbul proximal renal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2005FI 00195
Duration: 01/01/2005 - 31/12/2008

Mecanismos de Neuroprotección mediada por Receptores de Estrógenos de Membrana

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 31350
Reference: JCI-2005-1469-1
Duration: 01/11/2006 - 30/11/2008

Las ciclofilinas en el fracaso renal agudo tóxico. Identificación de biomarcadores pronósticos y de posibles dianas terapéuticas.

Mecanismos de protección en la toxicidad renal producida por ciclosporina A(CsA): Función de las ciclofilinas (CypA/CypB) y de la Kidney androgen-regulated protein (KAP)

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 173740
Reference: SAF2005-05167
Duration: 15/10/2005 - 14/10/2008

Mecanismes moleculars implicats en la nefroxicitat produïda per Ciclospirina A (CsA) i FK506 en el túbul proximal renal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2005FI 00195
Duration: 01/01/2005 - 31/12/2008

Mecanismos de Neuroprotección mediada por Receptores de Estrógenos de Membrana

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 31350
Reference: JCI-2005-1469-1
Duration: 01/11/2006 - 30/11/2008

Las ciclofilinas en el fracaso renal agudo tóxico. Identificación de biomarcadores pronósticos y de posibles dianas terapéuticas.

Mecanismos de protección en la toxicidad renal producida por ciclosporina A(CsA): Función de las ciclofilinas (CypA/CypB) y de la Kidney androgen-regulated protein (KAP)

Generación d'animals transgènics i KNOCK-OUTS pel gen de la Kidney androgen-regulated protein (KAP). Aplicació d'aquests models per a l'estudi de la toxicitat renal per ciclosporina (CsA).

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/05/2002
Duration: 01/01/2003 - 31/12/2006

Mecanismes de regulació transcripcional del gen que codifica per a la Kidney Androgen-regulated Protein (KAP) en relació a la seva especifitat de teixit i control hormonal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2003FI 00132
Duration: 01/01/2003 - 31/12/2006

Mecanismes moleculars implicats en la nefroxicitat produïda per Ciclospirina A (CsA) i FK506 en el túbul proximal renal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2005FI 00195
Duration: 01/01/2005 - 31/12/2008

Mecanismos de Neuroprotección mediada por Receptores de Estrógenos de Membrana

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 31350
Reference: JCI-2005-1469-1
Duration: 01/11/2006 - 30/11/2008

Generación d'animals transgènics i KNOCK-OUTS pel gen de la Kidney androgen-regulated protein (KAP). Aplicació d'aquests models per a l'estudi de la toxicitat renal per ciclosporina (CsA).

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/05/2002
Duration: 01/01/2003 - 31/12/2006

Mecanismes de regulació transcripcional del gen que codifica per a la Kidney Androgen-regulated Protein (KAP) en relació a la seva especifitat de teixit i control hormonal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2003FI 00132
Duration: 01/01/2003 - 31/12/2006

Mecanismes moleculars implicats en la nefroxicitat produïda per Ciclospirina A (CsA) i FK506 en el túbul proximal renal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2005FI 00195
Duration: 01/01/2005 - 31/12/2008

Mecanismos de protección en la toxicidad renal producida por ciclosporina A(CsA): Función de las ciclofilinas (CypA/CypB) y de la Kidney androgen-regulated protein (KAP)

Mecanismes de regulació transcripcional del gen SA i caracterització i funció de la proteïna en la matriu mitocondrial

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding:
Reference: PRED_IR_HUVH_2001_04
Duration: 01/01/2002 - 31/12/2004

Generación d'animals transgènics i KNOCK-OUTS pel gen de la Kidney androgen-regulated protein (KAP). Aplicació d'aquests models per a l'estudi de la toxicitat renal per ciclosporina (CsA).

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/05/2002
Duration: 01/01/2003 - 31/12/2006

Mecanismes de regulació transcripcional del gen que codifica per a la Kidney Androgen-regulated Protein (KAP) en relació a la seva especifitat de teixit i control hormonal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2003FI 00132
Duration: 01/01/2003 - 31/12/2006

Nefrotoxicitat aguda per CsA en pacients sotmesos a trasplantament. Bases moleculars i implicació del gen que codifica ara la Kidney androgen-regulated Protein

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació La Marató de TV3
Funding: 114065.73
Reference: TV3/002230
Duration: 22/01/2001 - 21/01/2004

Mecanismes de regulació transcripcional del gen SA i caracterització i funció de la proteïna en la matriu mitocondrial

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding:
Reference: PRED_IR_HUVH_2001_04
Duration: 01/01/2002 - 31/12/2004

Generación d'animals transgènics i KNOCK-OUTS pel gen de la Kidney androgen-regulated protein (KAP). Aplicació d'aquests models per a l'estudi de la toxicitat renal per ciclosporina (CsA).

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/05/2002
Duration: 01/01/2003 - 31/12/2006

Mecanismes de regulació transcripcional del gen que codifica per a la Kidney Androgen-regulated Protein (KAP) en relació a la seva especifitat de teixit i control hormonal

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: AGAUR
Funding:
Reference: 2003FI 00132
Duration: 01/01/2003 - 31/12/2006

Regulación androgénica del gen SA en riñón e implicaciones en el control de la presión arterial. Identificación y caracterización funcional y bioquímica de la proteína SA

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia y Tecnología
Funding: 74381.26
Reference: SAF2000-0158
Duration: 01/11/2000 - 01/11/2003

Mecanismes de regulació transcripcional del gen SA i caracterització i funció de la proteïna en la matriu mitocondrial

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding:
Reference: PRED_IR_HUVH_2001_04
Duration: 01/01/2002 - 31/12/2004

Regulación androgénica del gen SA en riñón e implicaciones en el control de la presión arterial. Identificación y caracterización funcional y bioquímica de la proteína SA

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia y Tecnología
Funding: 74381.26
Reference: SAF2000-0158
Duration: 01/11/2000 - 01/11/2003

Nefrotoxicitat aguda per CsA en pacients sotmesos a trasplantament. Bases moleculars i implicació del gen que codifica ara la Kidney androgen-regulated Protein

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació La Marató de TV3
Funding: 114065.73
Reference: TV3/002230
Duration: 22/01/2001 - 21/01/2004

Mecanismos moleculares implicados en la nefrotoxicidad producida por Ciclosporina A (CsA) y FK506 en el túbulo proximal renal.

IP: Anna Meseguer Navarro
Collaborators: Joan López Hellin
Funding agency: Instituto de Salud Carlos III
Funding: 154675
Reference: PI020829
Duration: 06/11/2002 - 06/11/2005

Regulación androgénica del gen SA en riñón e implicaciones en el control de la presión arterial. Identificación y caracterización funcional y bioquímica de la proteína SA

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia y Tecnología
Funding: 74381.26
Reference: SAF2000-0158
Duration: 01/11/2000 - 01/11/2003

Nefrotoxicitat aguda per CsA en pacients sotmesos a trasplantament. Bases moleculars i implicació del gen que codifica ara la Kidney androgen-regulated Protein

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Fundació La Marató de TV3
Funding: 114065.73
Reference: TV3/002230
Duration: 22/01/2001 - 21/01/2004

Regulación androgénica del gen SA en riñón e implicaciones en el control de la presión arterial. Identificación y caracterización funcional y bioquímica de la proteína SA

IP: Anna Meseguer Navarro
Collaborators: -
Funding agency: Ministerio de Ciencia y Tecnología
Funding: 74381.26
Reference: SAF2000-0158
Duration: 01/11/2000 - 01/11/2003

Publications

Behavior of SelectMDx and Prostate-specific Antigen Density in the Challenging Scenario of Prostate Imaging-Reporting and Data System Category 3 Lesions.

PMID: 34602313
Journal: EUROPEAN UROLOGY
Year: 2022
Reference: Eur Urol. 2022 Jan;81(1):124-125. doi: 10.1016/j.eururo.2021.09.019. Epub 2021 Sep 30.
Impact factor: 20.096
Publication type: Letter whit IF
Authors: Morote, Juan; Diaz, Fernando; Celma, Anna; Planas, Jacques; Trilla, Enrique et al.
DOI: 10.1016/j.eururo.2021.09.019

Evaluating the impact of the learning curve on the perioperative outcomes of robot-assisted radical cystectomy with intracorporeal urinary diversion.

PMID: 34840098
Journal: Actas Urologicas Espanolas
Year: 2022
Reference: Actas Urol Esp (Engl Ed). 2022 Jan-Feb;46(1):57-62. doi: 10.1016/j.acuroe.2021.05.004. Epub 2021 Nov 25.
Impact factor: 0.994
Publication type: Paper in national publication
Authors: Trilla, E; Raventos, C X; Salvador, C; Lopez-Molina, C; Carrion, A; Campistol, M; Pinero, A; Lozano, F et al.
DOI: 10.1016/j.acuroe.2021.05.004

Reconciling short-term clinical and Immunological outcomes of SARS-CoV-2 vaccination in Solid Organ Transplant recipients.

PMID: 34554648
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2022
Reference: Am J Transplant. 2022 Feb;22(2):673-675. doi: 10.1111/ajt.16855. Epub 2021 Oct 5.
Impact factor: 8.086
Publication type: Letter or abstract
Authors: Toapanta, Nestor; Esperalba, Juliana; Campos-Varela, Isabel; Pont, Teresa; Len, Oscar; Campins, Magda; Moreso, Francesc; Crespo, Elena; Munoz, Marina; Lopez, Manuel et al.
DOI: 10.1111/ajt.16855

Is Tumor Budding a New Predictor for Early Cystectomy in pT1 High-Grade Bladder Cancer?

PMID: 34352790
Journal: UROLOGIA INTERNATIONALIS
Year: 2022
Reference: Urol Int. 2022;106(2):154-162. doi: 10.1159/000517543. Epub 2021 Aug 5.
Impact factor: 2.089
Publication type: Paper in international publication
Authors: Raventos Busquets, Carles X; Semidey, M Eugenia; Lozano Palacio, Fernando; Carrion Puig, Albert; Aula Olivar, Ana; De Torres Ramirez, Ines M; Trilla Herrera, Enrique et al.
DOI: 10.1159/000517543

Clinical and genetic characterization of a cohort of proteinuric patients with biallelic CUBN variants.

PMID: 34610128
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2021
Reference: Nephrol Dial Transplant. 2021 Oct 5. pii: 6381717. doi: 10.1093/ndt/gfab285.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Domingo-Gallego, Andrea, Pybus, Marc, Madariaga, Leire, Pinero-Fernandez, Juan Alberto, Gonzalez-Pastor, Sara, Lopez-Gonzalez, Mercedes, Simarro-Rueda, Esther, Quintanilla-Mata, Maria Luisa, Matoses-Ruiperez, Maria Luisa, Ejarque-Vila, Laia et al.
DOI: 10.1093/ndt/gfab285

Multidimensional inflammatory and immunological endotypes of idiopathic focal segmental glomerulosclerosis and their association with treatment outcomes.

PMID: 34221390
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Dec 14;14(7):1826-1834. doi: 10.1093/ckj/sfaa265. eCollection 2021 Jul.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Roca, Neus, Madrid, Alvaro, Lopez, Mercedes, Fraga, Gloria, Jatem, Elias, Gonzalez, Jorge, Martinez, Cristina, Segarra, Alfons et al.
DOI: 10.1093/ckj/sfaa265

Nutritional status and volume control in adolescents on chronic hemodialysis.

PMID: 33988730
Journal: PEDIATRIC NEPHROLOGY
Year: 2021
Reference: Pediatr Nephrol. 2021 Nov;36(11):3733-3740. doi: 10.1007/s00467-021-05089-6. Epub 2021 May 14.
Impact factor: 3.714
Publication type: Paper in international publication
Authors: Paglialonga, Fabio, Consolo, Silvia, Brambilla, Marta, Caporale, Olga, Gual, Alejandro Cruz, Grassi, Maria Rosa, Montini, Giovanni et al.
DOI: 10.1007/s00467-021-05089-6

Novel Dent Disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function.

PMID: 33987651
Journal: HUMAN MOLECULAR GENETICS
Year: 2021
Reference: Hum Mol Genet. 2021 Jul 9;30(15):1413-1428. doi: 10.1093/hmg/ddab131.
Impact factor: 6.15
Publication type: Paper in international publication
Authors: Duran, Monica, Burballa, Carla, Cantero-Recasens, Gerard, Butnaru, Cristian M, Malhotra, Vivek, Ariceta, Gema, Sarro, Eduard, Meseguer, Anna et al.
DOI: 10.1093/hmg/ddab131

Emergence Delirium: Can Corticosteroids Contribute to It?

PMID: 33133750
Journal: Journal of pediatric intensive care
Year: 2020
Reference: J Pediatr Intensive Care. 2020 Dec;9(4):304-306. doi: 10.1055/s-0040-1709655. Epub 2020 Apr 17.
Impact factor: 0
Publication type: Letter or abstract
Authors: Esmel-Vilomara, Roger, Cruz, Alejandro, Inoriza, Cristina, Andreu, Eva, Munar, Francisca et al.
DOI: 10.1055/s-0040-1709655

Long-term outcome in a case series of Denys-Drash syndrome.

PMID: 31807296
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2019 Mar 16;12(6):836-839. doi: 10.1093/ckj/sfz022. eCollection 2019 Dec.
Impact factor: 2.975
Publication type: Paper in international publication
Authors: Roca, Neus, Munoz, Marina, Cruz, Alejandro, Vilalta, Ramon, Lara, Enrique, Ariceta, Gema et al.
DOI: 10.1093/ckj/sfz022

Prediabetes is a risk factor for cardiovascular disease following renal transplantation.

PMID: 31611066
Journal: KIDNEY INTERNATIONAL
Year: 2019
Reference: Kidney Int. 2019 Dec;96(6):1374-1380. doi: 10.1016/j.kint.2019.06.026. Epub 2019 Aug 14.
Impact factor: 8.306
Publication type: Paper in international publication
Authors: Porrini, Esteban, Diaz, Juan Manuel, Moreso, Francesc, Lauzurrica, Ricardo, Ibernon, Meritxel, Torres, Irene Silva, Ruiz, Rocio Benitez, Rodriguez Rodriguez, Ana Elena, Mallen, Patricia Delgado, Bayes-Genis, Beatriz et al.
DOI: 10.1016/j.kint.2019.06.026

A patient with suspected non-ST elevation acute myocardial infarction and remarkably high brain natriuretic peptide levels.

PMID: 26440456
Journal: INTERNATIONAL JOURNAL OF CARDIOLOGY
Year: 2016
Reference: Int J Cardiol. 2016 Jan 1;202:485-7. doi: 10.1016/j.ijcard.2015.09.048. Epub 2015 Sep 25.
Impact factor: 4.036
Publication type: Paper in international publication
Authors: Baneras, Jordi, Buera, Irene, Oristrell, Gerard, Sansano, Irene, Fort, Joan, Ibernon, Meritxell, Marti, Gerard, Barrabes, Jose A, Dorado, David Garcia et al.
DOI: 10.1016/j.ijcard.2015.09.048

Clinical evolution of post-transplant diabetes mellitus.

PMID: 26538615
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2016
Reference: Nephrol Dial Transplant. 2016 Mar;31(3):495-505. doi: 10.1093/ndt/gfv368. Epub 2015 Nov 3.
Impact factor: 4.085
Publication type: Paper in international publication
Authors: Ruiz, Juan C, Porrini, Esteban L, Diaz, Jose M, Moreso, Francisco, Delgado Mallen, Patricia I, Silva Torres, Irene, Ibernon, Meritxell, Bayes-Genis, Beatriz, Benitez-Ruiz, Rocio, Lampreabe, Ildefonso et al.
DOI: 10.1093/ndt/gfv368

Renal Biopsy in Type 2 Diabetic Patients.

PMID: 26239461
Journal: Journal of Clinical Medicine
Year: 2015
Reference: J Clin Med. 2015 May 18;4(5):998-1009. doi: 10.3390/jcm4050998.
Impact factor: 0
Publication type: Review in international publication
Authors: Seron, Daniel, Ramos, Natalia, Espinel, Eugenia, Agraz, Irene, Ibernon, Meritxell, Fort, Joan et al.
DOI: 10.3390/jcm4050998

Low serum mannose-binding lectin levels are associated with inflammation and apoptosis in early surveillance allograft biopsies.

PMID: 25073029
Journal: TRANSPL IMMUNOL
Year: 2014
Reference: Transpl Immunol. 2014 Sep;31(3):152-6. doi: 10.1016/j.trim.2014.07.001. Epub 2014 Jul 26.
Impact factor: 1.832
Publication type: Paper in international publication
Authors: Ibernon, M, Moreso, F, O'Valle, F, Grinyo, J M, Moral, R G, Seron, D et al.
DOI: 10.1016/j.trim.2014.07.001

Hypertension in chronic kidney disease: the influence of renal transplantation.

PMID: 24770618
Journal: TRANSPLANTATION
Year: 2014
Reference: Transplantation. 2014 Sep 15;98(5):537-42. doi: 10.1097/TP.0000000000000103.
Impact factor: 3.535
Publication type: Paper in international publication
Authors: Azancot, Maria A, Ramos, Natalia, Moreso, Francesc J, Ibernon, Meritxell, Espinel, Eugenia, Torres, Irina B, Fort, Joan, Seron, Daniel et al.
DOI: 10.1097/TP.0000000000000103

Innate immunity in renal transplantation: The role of mannose-binding lectin.

PMID: 24321303
Journal: TRANSPLANT REV-ORLAN
Year: 2014
Reference: Transplant Rev (Orlando). 2014 Jan;28(1):21-5. doi: 10.1016/j.trre.2013.10.006. Epub 2013 Oct 26.
Impact factor: 2.66
Publication type: Paper in international publication
Authors: Ibernon, Meritxell, Moreso, Francesc, Seron, Daniel et al.
DOI: 10.1016/j.trre.2013.10.006

Subclinical rejection in renal transplants is associated with low serum mannose-binding lectin levels.

PMID: 25018901
Journal: Kidney international supplements
Year: 2011
Reference: Kidney Int Suppl (2011). 2011 Aug;1(2):36-39. doi: 10.1038/kisup.2011.10.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ibernon, Meritxell, Moreso, Francesc, Seron, Daniel et al.
DOI: 10.1038/kisup.2011.10

Thesis

Identification of time- and sex-dependent pathways involved in renal ischemia-reperfusion injury in a porcine model. Link to renal cancer.

PhD student: Stephane Nemours
Director/s: Anna Meseguer Navarro
University: Universitat Autònoma de Barcelona
Year: 2020

Desarrollo de modelos celulares de la enfermedad de Dent para la identificación de los mecanismos fisiopatológicos que subyacen a la progresión de la enfermedad

PhD student: Mónica Durán Fernández
Director/s: Anna Meseguer Navarro, Gema Ariceta Iraola
University: Universitat Autònoma de Barcelona
Year: 2020

The role of STAT3 phosphorylation state in clear cell renal cell carcinoma (ccRCC)

PhD student: Jazmine Paola Arevalo Bautista
Director/s: Anna Meseguer Navarro
University: Universitat Autònoma de Barcelona
Year: 2019

Exosomes in uterine aspirates: characterization and identification of diagnostic and prognostic biomarkers in endometrial cancer

PhD student: Irene Campoy Moncayo
Director/s: Antonio Gil Moreno, Eva Colas Ortega, Jaume Reventós Puigjaner
University: Universitat Autònoma de Barcelona
Year: 2017

Mecanismes moleculars implicats en la nefrotoxicitt per ciclosporina A (CsA): Estudi dels efectes de la CsA en les vies ERK i PI3K

PhD student: Eduard Sarro Tauler
Director/s:
University: Universitat Autònoma de Barcelona
Year: 2008

Blog

News

Dr. Gerard Cantero receives a grant from the Mizutani Foundation for GlycoScience in Japan to study Dent's disease

The researcher of the Renal Pathophysiology group at VHIR investigates the role of ClC-5 protein in the development of this rare kidney disease.

A new donation of € 15,000 from Hipofam boosts research in familial hypomagnesemia at Vall d'Hebron

The association renews its commitment to the research of the Renal Pathophysiology group of VHIR in this rare disease that affects the kidneys.

Dra. Anna Meseguer a la inauguració del nou Hub de tractaments contra malalties rares

Dr. Anna Meseguer highlights the importance of research at the inauguration of a new Hub for the development of innovative medic

The head of the Renal Pathophysiology group at VHIR was part of a round table on how research can help to meet the needs of patients with rare diseases.

Job offers

Data Entry - Kidney Physiopathology Group.

Start date:

27/09/2022

End date:

11/10/2022

Document: Download

Postdoctoral researcher - The Renal Physiopathology Group

Start date:

17/06/2022

End date:

01/07/2022

Document: Download

Data Entry

Start date:

23/02/2022

End date:

09/03/2022

Document: Download