About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.
IP: Maria Jose Soler Romeo Collaborators: Mario Alonso Narvaez Barros, Pamela Dominguez Baez, Sheila Bermejo Garcia, Alejandra Planas Vilaseca, Concepció Jacobs Cachá, Juan Carlos León Román Funding agency: Instituto de Salud Carlos III Funding: 122210 Reference: PI21/01292 Duration: 01/01/2022 - 30/06/2026
IP: Oriol Bestard Matamoros Collaborators: Estudio de la eficacia inmunosupresora de una nueva proteÃna de fusión dual Hybri-2 que bloquea las señales de co-estimulaciÃ, Elena Isabel Crespo Gimeno, Maria Antonia Emilia Meneghini, Estudio de la eficacia inmunosupresora de una nueva proteÃna de fusión dual Hybri-2 que bloquea las señales de co-estimulacià Funding agency: Fundación Renal Iñigo Alvarez de Toledo Funding: 105699.31 Reference: FRIAT/PROJECTES/2019/BESTARD Duration: 01/04/2020 - 31/03/2024
IP: Oriol Bestard Matamoros Collaborators: HORUS: Casting light on HOst-cytomegaloviRUs interaction in Solid organ transplantation, Elena Isabel Crespo Gimeno Funding agency: EUROPEAN COMMISSION Funding: 392651.25 Reference: HORUS_HE-HLTH-DISEASE21 Duration: 01/11/2022 - 31/10/2027
IP: Marta Aurora Rubiera Del Fueyo Collaborators: Maria Victoria Sala Sanz de Madrid, Cristina Guirao Martinez, Claudia Meza Burgos, Federica Rizzo, Ester Sanchez Gavilan, David Rodriguez Luna Funding agency: EUROPEAN COMMISSION Funding: 567950 Reference: VALIDATE_HE-HLTH-DISEASE21 Duration: 01/05/2022 - 30/04/2026
PMID: 38106814 Journal: TRANSPLANT INTERNATIONAL Year: 2023 Reference: Transpl Int. 2023 Dec 1;36:12406. doi: 10.3389/ti.2023.12406. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Bestard, Oriol; Naesens, Maarten; Pagliazzi, Angelica et al. DOI: 10.3389/ti.2023.12406
PMID: 38147137 Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Year: 2023 Reference: J Am Soc Nephrol. 2023 Dec 26. doi: 10.1681/ASN.0000000000000287. Impact factor: Publication type: Paper in international publication Authors: Abbadessa, Giovanni; Ali, Nicole; Bestard, Oriol; Brar, Amarpali; Cruzado, Josep M; Dudek, Markus; Gaber, A Osama; Lee, Helen; Lepine, Lucie; Montgomery, Robert A et al. DOI: 10.1681/ASN.0000000000000287
PMID: 38152017 Journal: AMERICAN JOURNAL OF TRANSPLANTATION Year: 2023 Reference: Am J Transplant. 2023 Nov 29:S1600-6135(23)00723-2. doi: 10.1016/j.ajt.2023.09.021. Impact factor: Publication type: Paper in international publication Authors: Alberici, Federico; Ansari, Mohammed Javeed; Augustine, Joshua; Benken, Scott; Bestard, Oriol; Bhati, Chandra; Chang, Anthony; Concepcion, Beatrice P; Donovan, Michael J; Gallon, Lorenzo et al. DOI: 10.1016/j.ajt.2023.09.021
PMID: 35384924 Journal: TRANSPLANTATION Year: 2022 Reference: Transplantation. 2022 Jul 1;106(7):1430-1439. doi: 10.1097/TP.0000000000004119. Epub 2022 Apr 1. Impact factor: 4.939 Publication type: Paper in international publication Authors: Mazuecos, Auxiliadora, Villanego, Florentino, Zarraga, Sofia, Lopez, Veronica, Oppenheimer, Federico, Llinas-Mallol, Laura, Moina, Inigo, Alcalde, Guillermo, Sanchez-Alvarez, Emilio, Pascual, Julio et al. DOI: 10.1097/TP.0000000000004119
PMID: 35373449 Journal: CTS-Clinical and Translational Science Year: 2022 Reference: Clin Transl Sci. 2022 Jun;15(6):1544-1555. doi: 10.1111/cts.13276. Epub 2022 Apr 19. Impact factor: 4.689 Publication type: Paper in international publication Authors: Charco, Ramon, Dopazo, Cristina, Bilbao, Itxarone, Garcia, Sonia, Gomez-Gavara, Concepcion, Caralt, Mireia, Campos-Varela, Isabel, Castells, Lluis, Hidalgo, Ernest, Moreso, Francisco et al. DOI: 10.1111/cts.13276
PMID: 35373130 Journal: Kidney360 Year: 2022 Reference: Kidney360. 2021 Dec 3;3(2):293-306. doi: 10.34067/KID.0006612021. eCollection 2022 Feb 24. Impact factor: 0 Publication type: Paper in international publication Authors: Avello, Alejandro, Lightstone, Liz, Turner-Stokes, Tabitha, Griffith, Megan, Torras, Joan, Martinez Valenzuela, Laura, Bestard, Oriol, Geddes, Colin, Flossmann, Oliver, Budge, Kelly L et al. DOI: 10.34067/KID.0006612021
PMID: 35320154 Journal: TRANSPLANTATION Year: 2022 Reference: Transplantation. 2022 May 1;106(5):1012-1023. doi: 10.1097/TP.0000000000004075. Epub 2022 Apr 26. Impact factor: 4.939 Publication type: Paper in international publication Authors: Bemelman, Frederike J, du Buf-Vereijken, Peggy W G, van Ginneken, Betty, Maas, Nanda, Vogt, Liffert, van Jaarsveld, Brigit C, Klingenberg-Salahova, Farah, Verhofstede, Sabine, Vervloet, Marc G, Nurmohamed, Azam et al. DOI: 10.1097/TP.0000000000004075
PMID: 34174006 Journal: Transplant Infectious Disease Year: 2021 Reference: Transpl Infect Dis. 2021 Aug;23(4):e13677. doi: 10.1111/tid.13677. Epub 2021 Jul 12. Impact factor: 2.228 Publication type: Letter or abstract Authors: Garcia-Garcia, Sonia, Los-Arcos, Ibai, Moreso, Francesc, Berastegui, Cristina, Castells, Lluis, Gorgas Torner, Maria Q, Miarons, Marta, Larrosa-Garcia, Maria et al. DOI: 10.1111/tid.13677
PMID: 33359528 Journal: KIDNEY INTERNATIONAL Year: 2021 Reference: Kidney Int. 2021 Jul;100(1):196-205. doi: 10.1016/j.kint.2020.12.015. Epub 2020 Dec 24. Impact factor: 10.612 Publication type: Paper in international publication Authors: Blosser, Christopher, Zuniga, Sandra Carias, Soler, Maria Jose, Moreso, Francesc, Mithani, Zain, Ortiz-Melo, David, Jaimes, Edgar A, Gutgarts, Victoria, Lum, Erik, Danovitch, Gabriel M et al. DOI: 10.1016/j.kint.2020.12.015
PMID: 34088718 Journal: Clinical Journal of the American Society of Nephrology Year: 2021 Reference: Clin J Am Soc Nephrol. 2021 Jul;16(7):1061-1072. doi: 10.2215/CJN.18961220. Epub 2021 Jun 4. Impact factor: 8.237 Publication type: Paper in international publication Authors: Soler, Maria Jose, Noordzij, Marlies, Abramowicz, Daniel, de Arriba, Gabriel, Basile, Carlo, van Buren, Marjolijn, Covic, Adrian, Crespo, Marta, Duivenvoorden, Raphael, Massy, Ziad et al. DOI: 10.2215/CJN.18961220
PMID: 34098555 Journal: KIDNEY & BLOOD PRESSURE RESEARCH Year: 2021 Reference: Kidney Blood Press Res. 2021;46(4):452-459. doi: 10.1159/000515714. Epub 2021 Jun 7. Impact factor: 2.687 Publication type: Paper in international publication Authors: Agraz, Irene, Roman, Juan Leon, Garcia-Carro, Clara, Gabaldon, Alejandra, Torres, Irina, Bury, Roxana, Baldallo, Cinthia, Seron, Daniel, Soler, Maria Jose, Vergara, Ander et al. DOI: 10.1159/000515714
PMID: 31598700 Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION Year: 2020 Reference: Nephrol Dial Transplant. 2020 Feb 1;35(2):222-226. doi: 10.1093/ndt/gfz199. Impact factor: 4.531 Publication type: Paper in international publication Authors: Rychlik, Ivan, Soler, Maria J, Stevens, Kate, Spasovski, Goce, Wanner, Christoph, Massy, Ziad, Goumenos, Dimitrios, Fliser, Danilo, Zoccali, Carmine, Blankestijn, Peter J et al. DOI: 10.1093/ndt/gfz199
PMID: 31203229 Journal: JOURNAL OF RHEUMATOLOGY Year: 2020 Reference: J Rheumatol. 2020 Mar;47(3):407-414. doi: 10.3899/jrheum.190065. Epub 2019 Jun 15. Impact factor: 3.35 Publication type: Paper in international publication Authors: Garcia-Vives, Eloi, Segarra-Medrano, Alfons, Martinez-Valle, Ferran, Agraz, Irene, Solans-Laque, Roser et al. DOI: 10.3899/jrheum.190065
PMID: 31071220 Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION Year: 2020 Reference: Nephrol Dial Transplant. 2020 Jan 1;35(1):10-17. doi: 10.1093/ndt/gfz051. Impact factor: 4.531 Publication type: Editorail in international publication Authors: Wanner, Christoph, Wiecek, Andrzej, Zoccali, Carmine, Unwin, Robert, Capasso, Giovambattista, Trepiccione, Francesco, Stevens, Kathryn I, Soler, Maria Jose, Viggiano, Davide, Wagner, Carsten A et al. DOI: 10.1093/ndt/gfz051
PMID: 32085620 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2020 Reference: Int J Mol Sci. 2020 Feb 18;21(4). pii: ijms21041372. doi: 10.3390/ijms21041372. Impact factor: 4.556 Publication type: Paper in international publication Authors: Garcia-Vives, Eloi, Sole, Cristina, Moline, Teresa, Vidal, Marta, Agraz, Irene, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al. DOI: 10.3390/ijms21041372
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
An international study involving the Hospital del Mar Research Institute and VHIR shows that there are substantial differences between men and women in the energy metabolism of of renal tubular cells.
Dr. Conxita Jacobs' research has been awarded in the clinical project category, while Dr. Anna Meseguer's research has been recognised in the basic research category.
