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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Team

Anna Rosell Novel

Anna Rosell Novel

Head of group
Neurovascular Diseases
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José Alvarez Sabin

José Alvarez Sabin

Senior researcher
Neurovascular Diseases
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Mercedes Arrue Gonzalo

Mercedes Arrue Gonzalo

Research technician
Neurovascular Diseases
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Anna Bonaterra Pastra

Anna Bonaterra Pastra

Research technician
Neurovascular Diseases
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Elena Pala Vila

Elena Pala Vila

Postdoctoral researcher
Neurovascular Diseases
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Alejandro Ballve Martin

Alejandro Ballve Martin

Neurovascular Diseases
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Anna Rosell Novel

Anna Rosell Novel

Head of group
Neurovascular Diseases
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José Alvarez Sabin

José Alvarez Sabin

Senior researcher
Neurovascular Diseases
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Mercedes Arrue Gonzalo

Mercedes Arrue Gonzalo

Research technician
Neurovascular Diseases
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Anna Bonaterra Pastra

Anna Bonaterra Pastra

Research technician
Neurovascular Diseases
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Elena Pala Vila

Elena Pala Vila

Postdoctoral researcher
Neurovascular Diseases
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Alejandro Ballve Martin

Alejandro Ballve Martin

Neurovascular Diseases
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Research lines

L1 Biomarkers

The use of plasma biomarkers is becoming increasingly popular in several fields of medicine. In fact, decision-making processes using biomarkers is widely accepted in medical situations such as initiating lipid lowering therapies (LDL), diagnosing acute myocardial infarction (troponins), and ruling out pulmonary embolism suspicions (D-dimer), among others. Therefore we really believe that biochemical markers of stroke, will really open “a window to the brain…”. In fact, in this research line we aim to answer relevant clinical questions through the use of biomarkers. Our main Objectives using mainly plasma proteins are: 1.- To predict stroke risk 2.- To make stroke diagnosis 3.- To differentiate stroke subtypes 4.- To establish evolution and prognosis 5.- To use Biomarkers as treatment end-points Some of our findings might have therapeutic implications since biological markers described by the group such as MMP-9 are well associated with Blood Brain Barrier disruption. In this direction, we have described MMP-9 predicting haemorrhagic complications among stroke patients receiving thrombolytic treatment. These approaches might contribute to increase safety of reperfusion treatments. The impact of this research line is clear, since articles like this (Circulation 2003) have been cited more than 180 times since its publication. The study of these molecules will also have diagnostic implications because we have proposed the biochemical diagnostic of stroke by means of the identification of a biomarkers panel that distinguish between a stroke and other stroke-mimicking conditions. This might contribute to refer only to real stroke patients to the stroke centres, saving huge resources to the system. These two examples, identification of biomarkers to predict tPA related bleedings and a stroke diagnostic test are examples of translational research in which the Neurovascular Research Lab is filing patents to be licensed to Biotech companies able to develop diagnostic kits in which our biomarkers might be placed and used in the clinical practice. That might close the circle of applied research. Reviews of our group in which you may find detailed info about those biomarkers: Foerch C, Montaner J, Furie KL, Ning MM, Lo EH. Searching for oracles? Blood biomarkers in acute stroke Neurology. 2009;73(5):393-9. Montaner J. Blood biomarkers to guide stroke thrombolysis. Front Biosci (Elite Ed). 2009 Jun 1;1:200-208. García-Berrocoso T, Fernández-Cadenas I, Delgado P, Rosell A, Montaner J. Blood Biomarkers to Identify Stroke Etiologies. Therapy 2010 (in press). Projects We are involved in several projects with public or private funding supporting our research on stroke biomarkers. One of such exciting projects is FIS PI 08/361 “Identificación y uso de biomarcadores pronósticos en el ictus isquémico”, aiming to identify biomarkers that predict main causes of stroke worsening (Infarct growth, cardiac complications, hemorrhagic transformation, infections, recurrence or new vascular events) to guide Stroke Unit allocation and stay of our patients. International Collaborations Discovery and validation of good candidate biomarkers, requires multidisciplinary approaches and replication in well designed multicentric and international studies. For that purpose we are actively collaborating with well known stroke research leading groups: - Eng Lo, Xiaoing Wang, Ming Ming Ning (Boston, USA). - Jean Charles Sanchez, Natacha Turck (Geneva, Switzerland). - Denis Vivien, Carine Ali, Eduardo Anglés-Cano (Caen, France). Research Tools and Techniques We are using a combination of discovery techniques and biological human and animal samples to identify new stroke-related biomarkers: One example is the “protein arrays”. In our laboratory, we have been using these new technologies and we actually use the SearchLight Assays (Aushon Biosystems) that allows us to study more than 170 human proteins and also many candidates from different animal species. We offer access to our technology to other groups. For more information, please refer to http://www.lin-bcn.com/ Also those biomarkers may be specifically tested not only as circulating markers in plasma or serum but in the components of interest of the Neurovascular Unit, that we may dissect by using the LCM Leica LMD6000 microscope, for Laser Capture microdissection. An example in which combine both thecniques may be found at: Cuadrado E, Rosell A, Penalba A, Slevin M, Alvarez-Sabin J, Ortega-Aznar A, Montaner J. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined Laser Microdissection and Protein Array Study. Journal of Proteome Research 2009;8(6):3191-3197. Biobanks All these results have been possible since the development of a “blood library” including more than 2000 stroke samples and a “brain library” that allowed us to describe for the first time the “human stroke proteome” with the outstanding collaboration of so many patients, relatives and clinicians of the Stroke Unit.

IP: Joan Montaner Villalonga, Anna Penalba Morenilla

L3 Acute Therapy

BACKGROUND The only approved stroke treatment so far is the acute thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) when administered within 3-4.5 hours after symptoms onset. However, a reduced number of patients (5-8%) profit by this treatment, primarily because of the narrow therapeutic time-window and the risk of brain bleedings beyond thromrbolytic therapy to achieve the recanalization of the occluded artery. Moreover, the inflammatory response that accompanied necrotic brain injury contributes to aggravate acutely the progression of ischemic pathology. Inflammatory and brain damaged cells release a variety of cytotoxic agents including cytokines, MMPs and ROS which induce more cell damage as well as disruption of BBB and brain edema. Thereby, it would be desirable to improve the efficacy and safety for thrombolytic therapy of stroke using combined anti-inflammatory strategies that may ameliorate the ischemic injury and means the best therapy translated at the clinical level. Our research, conducted on experimental models of cerebral ischemia, is focused on the development of neuroprotective strategies aimed to salvage ischemic brain tissue by means complementary to reperfusion. Our goal is to find out a multimodal treatment that combines the administration of tPA together with other co-agents (as simvastatin and/or anti-aggregants with anti-inflammatory and neuro-protective properties) in attempt to obtain the most therapeutic benefice in the acute phase of ischemic stroke. EXPERIMENTAL MODELS AND TECHNIQUES Ischemic stroke has a complex pathophysiology involving the interplay of many different cells and tissues. Animal models of ischemic stroke are procedures inducing cerebral ischemia, which mimicked satisfactorily this cerebrovascular disease. Therefore, research stroke conducted on animal models has been shown essential for treatment approach of ischemic stroke. Intra-arterial Suture Occlusion Model of Focal Cerebral Ischemia Infarction in the territory of the middle cerebral artery (MCA) is induced by extracranial vascular occlusion on rat. A heat-blunted 4/0 nylon-monofilament is used to block the origin of MCA during 90 or 120 min and then, the monofilament is removed and reperfusion is allowed during the followed 24, 48 or 72 h. This model mimics a clinical situation where recanalization of the occluded artery takes place, allowing test neuroprotectants that could be potentially co-administered with reperfusion agents like tPA. Embolic Model of Focal Cerebral Ischemia The stroke animal model by clot embolism has a large scientific interest in the clinical field because the high incidence of human thrombotic stroke and the use of reperfusion therapy with tPA, which can be assay on this model. Thromboembolic occlusion at the proximal level of MCA is achieved by injection of a rich fibrin clot through the internal carotid artery in the rat. Clots are previously performed using arterial blood from a donor rat. Thrombolytic therapy with tPA (9 mg/Kg) is administered by tail vein infusion (2 mg/mL;75 ?l/min) at different times points (2, 3, 4 hours) after occlusion. Relative Cerebral Blood Flow (rCBF) is measured in the cortex supplied by the MCA by continuous Laser Doppler flowmetry (LDF) to ensure the successful of the artery occlusion or reperfusion in these models. To examine the grade of infarction on rats, analysis of the infarct volume is evaluated using 2,3,5-triphenyltetrazolium chloride (TTC) staining and neurological score is assayed with a 9-point neurological at baseline (1-2 h) and each 24 h after occlusion. NMR Imaging Bruker-BIOSPEC 70/30 USR, 7 T Preclinical MRI System is used for the neuroimaging studies. Neuroimaging studies are conducted in vivo to valuate the cytotoxic edema and ischemic lesion (DWI, ADC map and T2WI) in the acute phase. Specific sequences are performed to assess Brain-Blood Barrier disruption (DCE) and occurrences of intracranial hemorrhages (T2*WI). Angiography is performed to document MCA occlusion or recanalization.

IP: Joan Montaner Villalonga

L4 Neurorepair

New therapies beyond the hyperacute phase of stroke are needed to be able to treat much more patients in delayed phases of this devastating disease. The idea that neurovascular plasticity contributes to stroke recovery can be a powerful concept for stroke therapy. Obviously, the therapeutic time window for interventions based on promoting recovery would be much larger than those for targeting acute stroke. In this context, long-term neuroreparative therapies will have to target the two essential phenomena to achieve brain neurorecovery after stroke: to restore the cerebral blood flow and to promote Neuroregeneration. To achieve these major goals, both angiogenesis and neurogenesis need to be enhanced in the ischemic brain. Classically, the formation of new blood vessels was thought to be mediated exclusively by embryogenic vasculogenesis followed by the sprouting of endothelial cells from preexisting vessels during angiogenesis. In the last decade, this standard dogma was overturned with the identification of the existence of circulating bone marrow-derived endothelial progenitor cells (EPCs). These cells are capable of differentiating, ex vivo, into endothelial-phenotyped cells, and now comprise a new model for endothelial generation and vessel repair (Asahara et al., 1997). These cells comprise a potential cell-based and growth-factor source of an alternate approach to enhance angio-neurogenic responses. In fact, newborn neurons (neurogenesis) and new vascular components (angiogenesis) form a microenvironment that has been termed the neurovascular niche [Ohab et al., 2006] were angiogenesis and neurogenesis are linked thorough specific growth factors. Angiogenesis and neurogenesis occur endogenously after stroke. Our goal is to study these two complex phenomena both in experimental and human studies to finally potentiate them correctly to improve brain function and neurorecovery after stroke. Experimental Models and Techniques In vivo stroke models: Cerebral ischemia affecting the cortical territory of the Middle Cerebral Artery (MCA) is occluded at the level of the M1 portion (distal occlusion). This model has been chosen because presents very low mortality rates allowing long-term studies. Besides, the infarct is restricted to the cortex with clear boundary areas with normal cerebral blood flow and never affects neuroblast-rich areas such as the subventricular zone (then, both angiogenesis and neurogenesis can occur). Functional outcome is assessed by the cylinder and corner tests which have been reported to be appropriate test for this type of cortical infarcts. Besides, histology and immunohistochemistry studies are conducted to evaluate brain repair and angio-neurogenic processes. Endothelial Progenitor Cell Cultures: EPCs are obtained from the Mononuclear cell fraction of human blood and from mouse spleen. MNCs are cultured in fibronectin-coated plates with complete cell culture medium EGM-2MV. Both in human and murine cell cultures yield an early EPC population (also called Circulating Angiogenic Cells) obtained at day 4-7 after plating and late outgrowth EPC colonies (also called Endothelial Colony Forming Cells) appear from day 10 as colonies with high proliferation capacity and tubulogenic capacity. In vitro Oxygen-Glucose Deprivation: endothelial cells and Endothelial progenitor cells are challenged to a transitory Oxygen and Glucose deprivation to study their angio-vasculogenic responses to ischemia and to test how potential treatments that could modify these responses. Angiogenesis-related techniques: angio-vasculogenic mechanisms are studied in a variety of in vitro assays including Matrigel® tubulogenesis, cell migration using trans-well assays or cell adhesion to a mature monolayer of endothelial cells. Our studies focus on the angio-vasculogenic responses of both Endothelial Progenitor Cells and mature endothelial cells such as the human cell line of microvascular endothelial cells (hCMEC/D3). NMR Imaging: Bruker-BIOSPEC 70/30 USR, 7 T Preclinical MRI System is used for the neuroimaging studies. Neuroimaging studies are conducted in vivo to follow-up the ischemic lesion. Specific sequences are performed to assess axonal degeneration/regeneration and changes in cerebral blood flow and angiogenesis.

IP: Anna Rosell Novel

L5 Cerebral Amyloid Angiopathy

Current project: Involment of proteolytic systems in the progression of Cerebral Amyloid Angiopathy Cerebral amyloid angiopathy (CAA) is produced by the accumulation of ß-amyloid protein within the meningeal and brain vessels. It is the second leading cause of cerebral hemorrhages. However, nowadays, factors related to brain bleedings following amyloid deposition are largely unknown. The understanding of the mollecular mechanisms that lead to cerebral hemorrhage may be the basis for future treatments. Previous evidences of our group have shown that Matrix Metal•loproteinases (MMPs) are related to brain bleeding. Now, we aim to investigate the relationship between these proteolytic systems and the appearance of intracraneal hemorrages in CAA. Our study includes: 1) The identification of both tissue and plasma biomarkers for the diagnosis and prognosis of CAA-related hemorrhages. 2) The search of the genetic markers related to proteolytic systems that could determine the risk of suffering a recurrence in CAA. We are studying a cohort of probable CAA patients that have been recruited in Hospital Vall d’Hebron in collaboration with the Stroke Project of the Cerebrovascular Diseases Study Group (Spanish Society of Neurology). 3) The study of MMPs role in ß-amyloid stimulated vascular cells in vitro. Cultured cells of the neurovascular unit are challenged with different ß-amyloid peptides and the implication of MMPs in ß-amyloid cleavage and cell toxicity are studied using cellular and molecular biology methodology. For this purpose, we use the human cerebral endothelial cell line hCMEC/D3, primary cultures of human leptomeningeal smooth muscle cells and rat/mouse glial and neuronal cultures. Thioflavin-S staining of fibillar ß-amyloid within brain vessels of CAA patient’s sections. Related bibliography: 1) Hernández-Guillamon M, Delgado P, Ortega L, Pares M, Rosell A, García-Bonilla L, Fernández-Cadenas I, Borrell-Pagès M, Boada M, Montaner J. Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. J Neurosci Res. 2009 Jul;87(9):2115-25. 2) Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Lo EH, Montaner J. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke. 2006 Jun;37(6):1399-406. 3) Alvarez-Sabín J, Delgado P, Abilleira S, Molina CA, Arenillas J, Ribó M, Santamarina E, Quintana M, Monasterio J, Montaner J. Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke. 2004 Jun;35(6):1316-22. 4) Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Ribó M, Quintana M, Alvarez-Sabín J. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation. 2003 Feb 4;107(4):598-603. Collaborations: Mercè Boada Fundació ACE, Barcelona, Spain. www.fundacioace.com/ Jorge Ghiso and Agueda Rostagno Pathology Dept. Langone Medical Center. NYU New York, US. Ignacio Romero Life Science Dept. Open University. Milton Keynes, UK.

IP: Maria Mar Hernandez Guillamon

Projects

Sol·licitud PFIS

IP: Anna Rosell Novel
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: FI17/00073
Duration: 08/01/2018 - 07/06/2022

Nueva estrategia para el manejo del ictus cardioembólico combinando biomarcadores pronósticos y neuroprotectores.

IP: Joan Montaner Villalonga
Collaborators: Elena Pala Vila
Funding agency: Fundació Institut de Recerca HUVH
Funding: 47268
Reference: 2018/VHIR/PALA
Duration: 01/04/2019 - 31/03/2022

Recerca en demencia mixta per malaltia d'Alzheimer i cerebrovascular

IP: Maria Pilar Delgado Martínez
Collaborators: Jesús Pizarro Gonzálvez
Funding agency: Instituto de Salud Carlos III
Funding: 41200
Reference: CM20/00218
Duration: 01/01/2021 - 31/12/2022

PI19. Demencia mixta por enfermedad de Alzheimer y cerebrovascular: un estudio clínico y experimental.

IP: Maria Pilar Delgado Martínez
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 60000
Reference: INT20/00084
Duration: 01/06/2021 - 31/12/2022

Projecte: Targeting stroke: new biomarkers and therapeutic targets of stroke through multi-omic techniques

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: IFI17/00012
Duration: 01/01/2018 - 31/12/2021

Sol·licitud PFIS

IP: Anna Rosell Novel
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: FI17/00073
Duration: 08/01/2018 - 07/06/2022

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IP: Maria Mar Hernandez Guillamon
Collaborators: Laia Perez Lasarte
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: VHIR/PREDOC/2017/MARAZUELA
Duration: 01/07/2018 - 30/06/2021

Nueva estrategia para el manejo del ictus cardioembólico combinando biomarcadores pronósticos y neuroprotectores.

IP: Joan Montaner Villalonga
Collaborators: Elena Pala Vila
Funding agency: Fundació Institut de Recerca HUVH
Funding: 47268
Reference: 2018/VHIR/PALA
Duration: 01/04/2019 - 31/03/2022

Progressió de la malaltia de petit vas cerebral: factors de risc, mecanismes implicats i conseqüències clíniques

IP: Maria Pilar Delgado Martínez
Collaborators: Laia Perez Lasarte
Funding agency: AGAUR
Funding: 21146.88
Reference: 2017 FI_B 00064
Duration: 01/03/2017 - 29/02/2020

Sol·licitud de la Dra. Mar Hernández dels contractes Miguel Servet II

IP: Joan Montaner Villalonga
Collaborators: Maria Mar Hernandez Guillamon, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 101250
Reference: CPII17/00010
Duration: 01/01/2018 - 31/12/2020

Sol·licitud PFIS

IP: Anna Rosell Novel
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: FI17/00073
Duration: 08/01/2018 - 07/06/2022

Projecte: Targeting stroke: new biomarkers and therapeutic targets of stroke through multi-omic techniques

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: IFI17/00012
Duration: 01/01/2018 - 31/12/2021

Búsqueda de nuevas terapias neuroreparadoras tras el ictus basadas en la modulación de la angiogénesis, el estudio de sus bases moleculares y el papel de las células endoteliales progenitoras (EPCs).

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 91125
Reference: CPII15/00003
Duration: 16/02/2016 - 15/02/2019

Sol·licitud Juan Rodés

IP: Joan Montaner Villalonga
Collaborators: Alejandro Bustamante Rangel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 135000
Reference: JR16/00008
Duration: 01/01/2017 - 30/09/2019

Progressió de la malaltia de petit vas cerebral: factors de risc, mecanismes implicats i conseqüències clíniques

IP: Maria Pilar Delgado Martínez
Collaborators: Laia Perez Lasarte
Funding agency: AGAUR
Funding: 21146.88
Reference: 2017 FI_B 00064
Duration: 01/03/2017 - 29/02/2020

Sol·licitud de la Dra. Mar Hernández dels contractes Miguel Servet II

IP: Joan Montaner Villalonga
Collaborators: Maria Mar Hernandez Guillamon, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 101250
Reference: CPII17/00010
Duration: 01/01/2018 - 31/12/2020

GENE-rtPA. New Device to improve the rt-PA treatment of ischemic stroke patients using GENEtic information (GENE-rtPA)

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 23500
Reference: EUIN2013-51119
Duration: 15/10/2014 - 31/12/2018

Stroke-Biotargets: Potencial terapèutic de nous biomarcadors d’isquèmia cerebral. Grup de recerca: Malalties Neurovasculars Investigador responsable/Director de Tesi: Joan Montaner

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: AGAUR
Funding: 48600
Reference: 2015 FI_B 00952
Duration: 01/02/2015 - 31/01/2018

Estudio de la angiogénesis en pacientes en rehabilitación después del ictus: búsqueda de marcadores de recuperación funcional e identificación de nuevas dianas terapéuticas

IP: Anna Rosell Novel
Collaborators: Laia Perez Lasarte
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-3
Duration: 16/02/2015 - 15/02/2018

Incorporació a l'àrea de Neurociències

IP: Joan Montaner Villalonga
Collaborators: Yolanda Riba Llena, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 135000
Reference: JR15/00032
Duration: 01/01/2016 - 31/12/2018

GENE-rtPA. New Device to improve the rt-PA treatment of ischemic stroke patients using GENEtic information (GENE-rtPA)

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 23500
Reference: EUIN2013-51119
Duration: 15/10/2014 - 31/12/2018

Role of Apolipoproteins (ApoE, ApoJ and ApoA-1) in Cerebral Amyloid Angiopathy: study of â-amyloid traffic across the blood brain barrier

IP: Joan Montaner Villalonga
Collaborators: Maria Mar Hernandez Guillamon, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 202500
Reference: MS12/03259
Duration: 01/01/2013 - 31/12/2017

Stroke-Biotargets: Potencial terapèutic de nous biomarcadors d’isquèmia cerebral. Grup de recerca: Malalties Neurovasculars Investigador responsable/Director de Tesi: Joan Montaner

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: AGAUR
Funding: 48600
Reference: 2015 FI_B 00952
Duration: 01/02/2015 - 31/01/2018

Estudio de la angiogénesis en pacientes en rehabilitación después del ictus: búsqueda de marcadores de recuperación funcional e identificación de nuevas dianas terapéuticas

IP: Anna Rosell Novel
Collaborators: Laia Perez Lasarte
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-3
Duration: 16/02/2015 - 15/02/2018

GENE-rtPA. New Device to improve the rt-PA treatment of ischemic stroke patients using GENEtic information (GENE-rtPA)

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 23500
Reference: EUIN2013-51119
Duration: 15/10/2014 - 31/12/2018

Silent clinical infarction detection and bimarkers associated with the risk of stroke in hypertensive Spanish population

IP: José Alvarez Sabin
Collaborators: Maria Pilar Delgado Martínez, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00136
Duration: 16/02/2010 - 15/02/2016

Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs)

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00265
Duration: 16/02/2010 - 15/02/2016

Identificación de Biomarcadores Plasmáticos en el Ictus y sus Aplicaciones en Angiopatía Amiloide Cerebral

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 54000
Reference: FI12/00089
Duration: 03/09/2012 - 02/09/2016

GENE-rtPA. New Device to improve the rt-PA treatment of ischemic stroke patients using GENEtic information (GENE-rtPA)

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 23500
Reference: EUIN2013-51119
Duration: 15/10/2014 - 31/12/2018

Silent clinical infarction detection and bimarkers associated with the risk of stroke in hypertensive Spanish population

IP: José Alvarez Sabin
Collaborators: Maria Pilar Delgado Martínez, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00136
Duration: 16/02/2010 - 15/02/2016

Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs)

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00265
Duration: 16/02/2010 - 15/02/2016

Biomarcadores en el ictus: optimizando las fases del proceso de traslación, desde el descubrimiento a su uso rutinario

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Fundació Institut de Recerca HUVH
Funding: 45135
Reference: PRED-VHIR-2011-09
Duration: 02/01/2012 - 01/01/2015

GENE-rtPA. New Device to improve the rt-PA treatment of ischemic stroke patients using GENEtic information (GENE-rtPA)

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 23500
Reference: EUIN2013-51119
Duration: 15/10/2014 - 31/12/2018

Silent clinical infarction detection and bimarkers associated with the risk of stroke in hypertensive Spanish population

IP: José Alvarez Sabin
Collaborators: Maria Pilar Delgado Martínez, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00136
Duration: 16/02/2010 - 15/02/2016

Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs)

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00265
Duration: 16/02/2010 - 15/02/2016

Beneficio del tratamiento trombolítico combinado con simvastatina en modelos de isquemia cerebral en roedores

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 54000
Reference: FI10/00508
Duration: 10/09/2010 - 09/09/2014

Identificación de nuevos biomaracadorse pronósticos en el ictus isquémico

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 54000
Reference: FI09/00017
Duration: 01/09/2009 - 31/08/2013

Silent clinical infarction detection and bimarkers associated with the risk of stroke in hypertensive Spanish population

IP: José Alvarez Sabin
Collaborators: Maria Pilar Delgado Martínez, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00136
Duration: 16/02/2010 - 15/02/2016

Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs)

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00265
Duration: 16/02/2010 - 15/02/2016

Beneficio del tratamiento trombolítico combinado con simvastatina en modelos de isquemia cerebral en roedores

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 54000
Reference: FI10/00508
Duration: 10/09/2010 - 09/09/2014

GRECOSAS: Genotipando el riesgo de REcurrencia en el ictus y resistencia a Clopidogrel o ASpirina. Hacia una prevención secundaria personalizada.

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 30000
Reference: POST/IR-HUVH/3/2008
Duration: 09/01/2009 - 08/01/2012

Identificación de nuevos biomaracadorse pronósticos en el ictus isquémico

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 54000
Reference: FI09/00017
Duration: 01/09/2009 - 31/08/2013

Silent clinical infarction detection and bimarkers associated with the risk of stroke in hypertensive Spanish population

IP: José Alvarez Sabin
Collaborators: Maria Pilar Delgado Martínez, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00136
Duration: 16/02/2010 - 15/02/2016

Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs)

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00265
Duration: 16/02/2010 - 15/02/2016

Regulación de la traducción en la tolerancia a la isquemia cerebral

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 147628.8
Reference: CD07/00255
Duration: 01/01/2008 - 31/12/2011

GRECOSAS: Genotipando el riesgo de REcurrencia en el ictus y resistencia a Clopidogrel o ASpirina. Hacia una prevención secundaria personalizada.

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 30000
Reference: POST/IR-HUVH/3/2008
Duration: 09/01/2009 - 08/01/2012

Identificación de nuevos biomaracadorse pronósticos en el ictus isquémico

IP: Joan Montaner Villalonga
Collaborators: Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 54000
Reference: FI09/00017
Duration: 01/09/2009 - 31/08/2013

Silent clinical infarction detection and bimarkers associated with the risk of stroke in hypertensive Spanish population

IP: José Alvarez Sabin
Collaborators: Maria Pilar Delgado Martínez, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 243000
Reference: MS09/00136
Duration: 16/02/2010 - 15/02/2016

Genética de las enfermedades cerebrovasculares

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 27000
Reference: FI05/00081
Duration: 15/02/2006 - 14/02/2010

Angiopatía amieloide cerebral (AAC)

IP: Joan Montaner Villalonga
Collaborators: Maria Mar Hernandez Guillamon
Funding agency: Instituto de Salud Carlos III
Funding: 148377.88
Reference: CD06/00028
Duration: 01/01/2007 - 31/12/2010

Geno-tPA: Búsqueda de patrones genéticos predictivos de la evolución del paciente con ictus isquémico después del tratamiento con t-PA

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding:
Reference: PRED/IR-HUVH/13/2006
Duration: 01/01/2007 - 31/12/2010

Regulación de la traducción en la tolerancia a la isquemia cerebral

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 147628.8
Reference: CD07/00255
Duration: 01/01/2008 - 31/12/2011

Aplicación de las tecnologías de la información y comunicación al ámbito sanitario, proyecto TELEICTUS

IP: José Alvarez Sabin
Collaborators: -
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 38206
Reference: PMSC/2008
Duration: 30/10/2009 - 31/12/2009

Hemorragia cerebral en el adulto de edad avanzada

IP: Joan Montaner Villalonga
Collaborators: Maria Pilar Delgado Martínez
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM05/00065
Duration: 18/01/2006 - 18/01/2009

Genética de las enfermedades cerebrovasculares

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 27000
Reference: FI05/00081
Duration: 15/02/2006 - 14/02/2010

Angiopatía amieloide cerebral (AAC)

IP: Joan Montaner Villalonga
Collaborators: Maria Mar Hernandez Guillamon
Funding agency: Instituto de Salud Carlos III
Funding: 148377.88
Reference: CD06/00028
Duration: 01/01/2007 - 31/12/2010

Optimización de las técnicas de recanalización precoz en el ictus isquémico

IP: José Alvarez Sabin
Collaborators: Marc Ribó Jacobi
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM04/00211
Duration: 01/02/2005 - 31/01/2008

Hemorragia cerebral en el adulto de edad avanzada

IP: Joan Montaner Villalonga
Collaborators: Maria Pilar Delgado Martínez
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM05/00065
Duration: 18/01/2006 - 18/01/2009

Genética de las enfermedades cerebrovasculares

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 27000
Reference: FI05/00081
Duration: 15/02/2006 - 14/02/2010

Angiopatía amieloide cerebral (AAC)

IP: Joan Montaner Villalonga
Collaborators: Maria Mar Hernandez Guillamon
Funding agency: Instituto de Salud Carlos III
Funding: 148377.88
Reference: CD06/00028
Duration: 01/01/2007 - 31/12/2010

Optimización de las técnicas de recanalización precoz en el ictus isquémico

IP: José Alvarez Sabin
Collaborators: Marc Ribó Jacobi
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM04/00211
Duration: 01/02/2005 - 31/01/2008

Hemorragia cerebral en el adulto de edad avanzada

IP: Joan Montaner Villalonga
Collaborators: Maria Pilar Delgado Martínez
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM05/00065
Duration: 18/01/2006 - 18/01/2009

Genética de las enfermedades cerebrovasculares

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 27000
Reference: FI05/00081
Duration: 15/02/2006 - 14/02/2010

Identificación de biomarcadores de isquemia cerebral mediante análisis de expresión génica y proteica de diferentes poblaciones celulares en core y penumbra tras el ictus en humanos

IP: Joan Montaner Villalonga
Collaborators: Anna Rosell Novel
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding:
Reference: EX-2006-0766
Duration: 01/06/2006 - 30/09/2007

Ministerio de Ciencia

Angiogenesis en la fase hiperaguda de la isquemia cerebral y su relación con la sobreinfección de metaloproteasas de matriz

IP: José Alvarez Sabin
Collaborators: Anna Rosell Novel
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/08/2002
Duration: 01/01/2003 - 31/12/2006

Optimización de las técnicas de recanalización precoz en el ictus isquémico

IP: José Alvarez Sabin
Collaborators: Marc Ribó Jacobi
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM04/00211
Duration: 01/02/2005 - 31/01/2008

Hemorragia cerebral en el adulto de edad avanzada

IP: Joan Montaner Villalonga
Collaborators: Maria Pilar Delgado Martínez
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM05/00065
Duration: 18/01/2006 - 18/01/2009

Genética de las enfermedades cerebrovasculares

IP: Joan Montaner Villalonga
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 27000
Reference: FI05/00081
Duration: 15/02/2006 - 14/02/2010

Influencia de las metaloproteasas de matriz y angiogénesis en la isquemia cerebral

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: SR 01/F060
Duration: 04/02/2002 - 03/03/2005

Angiogenesis en la fase hiperaguda de la isquemia cerebral y su relación con la sobreinfección de metaloproteasas de matriz

IP: José Alvarez Sabin
Collaborators: Anna Rosell Novel
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/08/2002
Duration: 01/01/2003 - 31/12/2006

Optimización de las técnicas de recanalización precoz en el ictus isquémico

IP: José Alvarez Sabin
Collaborators: Marc Ribó Jacobi
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: CM04/00211
Duration: 01/02/2005 - 31/01/2008

Influencia de las metaloproteasas de matriz en las complicaciones hemorrágicas tras el tratamiento trombolítico en el ictus isquémico.

IP: Joan Montaner Villalonga
Collaborators: Pilar Chacón Castro, José Alvarez Sabin, Marc Ribó Jacobi, Carlos Molina Cateriano, Manuel Quintana Luque
Funding agency: Instituto de Salud Carlos III
Funding: 33005
Reference: PI020773
Duration: 06/11/2002 - 06/11/2005

Influencia de las metaloproteasas de matriz y angiogénesis en la isquemia cerebral

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: SR 01/F060
Duration: 04/02/2002 - 03/03/2005

Angiogenesis en la fase hiperaguda de la isquemia cerebral y su relación con la sobreinfección de metaloproteasas de matriz

IP: José Alvarez Sabin
Collaborators: Anna Rosell Novel
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/08/2002
Duration: 01/01/2003 - 31/12/2006

Influencia de las metaloproteasas de matriz en las complicaciones hemorrágicas tras el tratamiento trombolítico en el ictus isquémico.

IP: Joan Montaner Villalonga
Collaborators: Pilar Chacón Castro, José Alvarez Sabin, Marc Ribó Jacobi, Carlos Molina Cateriano, Manuel Quintana Luque
Funding agency: Instituto de Salud Carlos III
Funding: 33005
Reference: PI020773
Duration: 06/11/2002 - 06/11/2005

Monitorización continua de la glucemia en el ictus tratado con tPA. Relación entre la glucemia en el momento de la reperfusión y el pronóstico.

IP: José Alvarez Sabin
Collaborators: Marc Ribó Jacobi, Manuel Quintana Luque
Funding agency: Instituto de Salud Carlos III
Funding: 72450
Reference: PI030139
Duration: 01/01/2004 - 28/11/2006

Influencia de las metaloproteasas de matriz y angiogénesis en la isquemia cerebral

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: SR 01/F060
Duration: 04/02/2002 - 03/03/2005

Angiogenesis en la fase hiperaguda de la isquemia cerebral y su relación con la sobreinfección de metaloproteasas de matriz

IP: José Alvarez Sabin
Collaborators: Anna Rosell Novel
Funding agency: Fundació Institut de Recerca HUVH
Funding: 13000
Reference: PRED/IR-HUVH/08/2002
Duration: 01/01/2003 - 31/12/2006

Papel de las metaloproteinasas en el desarrollo de edema en la fase aguda de la hemorragia intracerebral y en los fenomenos de reparacion y remodelacion posteriores.

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga, Alex Rovira Cañellas, Carlos Molina Cateriano
Funding agency: Instituto de Salud Carlos III
Funding: 30741.77
Reference: 01/1389
Duration: 17/07/2001 - 31/12/2003

Influencia de las metaloproteasas de matriz en las complicaciones hemorrágicas tras el tratamiento trombolítico en el ictus isquémico.

IP: Joan Montaner Villalonga
Collaborators: Pilar Chacón Castro, José Alvarez Sabin, Marc Ribó Jacobi, Carlos Molina Cateriano, Manuel Quintana Luque
Funding agency: Instituto de Salud Carlos III
Funding: 33005
Reference: PI020773
Duration: 06/11/2002 - 06/11/2005

Influencia de las metaloproteasas de matriz y angiogénesis en la isquemia cerebral

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga
Funding agency: Instituto de Salud Carlos III
Funding:
Reference: SR 01/F060
Duration: 04/02/2002 - 03/03/2005

Papel de las metaloproteinasas en el desarrollo de edema en la fase aguda de la hemorragia intracerebral y en los fenomenos de reparacion y remodelacion posteriores.

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga, Alex Rovira Cañellas, Carlos Molina Cateriano
Funding agency: Instituto de Salud Carlos III
Funding: 30741.77
Reference: 01/1389
Duration: 17/07/2001 - 31/12/2003

Influencia de las metaloproteasas de matriz en las complicaciones hemorrágicas tras el tratamiento trombolítico en el ictus isquémico.

IP: Joan Montaner Villalonga
Collaborators: Pilar Chacón Castro, José Alvarez Sabin, Marc Ribó Jacobi, Carlos Molina Cateriano, Manuel Quintana Luque
Funding agency: Instituto de Salud Carlos III
Funding: 33005
Reference: PI020773
Duration: 06/11/2002 - 06/11/2005

Papel de las metaloproteinasas en el desarrollo de edema en la fase aguda de la hemorragia intracerebral y en los fenomenos de reparacion y remodelacion posteriores.

IP: José Alvarez Sabin
Collaborators: Joan Montaner Villalonga, Alex Rovira Cañellas, Carlos Molina Cateriano
Funding agency: Instituto de Salud Carlos III
Funding: 30741.77
Reference: 01/1389
Duration: 17/07/2001 - 31/12/2003

Publications

Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease.

PMID: 34514662
Journal: BRAIN PATHOLOGY
Year: 2022
Reference: Brain Pathol. 2022 Jan;32(1):e13016. doi: 10.1111/bpa.13016. Epub 2021 Sep 12.
Impact factor: 6.508
Publication type: Paper in international publication
Authors: Camacho, Jessica; Rabano, Alberto; Marazuela, Paula; Bonaterra-Pastra, Anna; Serna, Garazi; Moline, Teresa; Ramon Y Cajal, Santiago; Martinez-Saez, Elena; Hernandez-Guillamon, Mar et al.
DOI: 10.1111/bpa.13016

Interictal brain activity changes in temporal lobe epilepsy: A quantitative electroencephalogram analysis.

PMID: 34687043
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2022
Reference: Acta Neurol Scand. 2022 Feb;145(2):239-248. doi: 10.1111/ane.13543. Epub 2021 Oct 22.
Impact factor: 3.209
Publication type: Paper in international publication
Authors: Fonseca, Elena; Quintana, Manuel; Seijo-Raposo, Ivan; Ortiz de Zarate, Zurine; Abraira, Laura; Santamarina, Estevo; Toledo, Manuel; Alvarez-Sabin, Jose et al.
DOI: 10.1111/ane.13543

Herpes simplex encephalitis in the context of immune checkpoint inhibitors: a complex interplay.

PMID: 34988947
Journal: ACTA NEUROLOGICA BELGICA
Year: 2022
Reference: Acta Neurol Belg. 2022 Jun;122(3):823-825. doi: 10.1007/s13760-021-01864-2. Epub 2022 Jan 6.
Impact factor: 2.396
Publication type: Letter or abstract
Authors: Lallana, Sofia; Sanchez-Tejerina, Daniel; Auger, Cristina; Callejo, Ana; Rio, Jordi; Cobo-Calvo, Alvaro et al.
DOI: 10.1007/s13760-021-01864-2

Erratum to: Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment.

PMID: 35137910
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 May 25;37(6):1199. doi: 10.1093/ndt/gfab339.
Impact factor: 5.992
Publication type: Letter or abstract
Authors: Kurganaite, Justina; Pepin, Marion; Ferreira, Ana Carina; Arici, Mustafa; Bachmann, Maie; Barbieri, Michelangela; Bumblyte, Inga Arune; Carriazo, Sol; Delgado, Pilar; Garneata, Liliana et al.
DOI: 10.1093/ndt/gfab339

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function.

PMID: 35083225
Journal: Frontiers in Cell and Developmental Biology
Year: 2021
Reference: Front Cell Dev Biol. 2022 Jan 10;9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021.
Impact factor: 6.684
Publication type: Review in international publication
Authors: Coccia, Elena, Sole, Montse, Comella, Joan X et al.
DOI: 10.3389/fcell.2021.826037

Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke.

PMID: 34899582
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Nov 25;12:767484. doi: 10.3389/fneur.2021.767484. eCollection 2021.
Impact factor: 4.003
Publication type: Paper in international publication
Authors: Tejada, Pedro Ignacio, Garcia-Rodriguez, Nicolas, Rodriguez, Susana, Buxo, Xavi, Perez-Mesquida, Maria Engracia, Beseler, Maria Rosario, Salom, Juan B, Perez, Laura M, Inzitari, Marco, Otero-Villaverde, Sergio et al.
DOI: 10.3389/fneur.2021.767484

Overnight switch from levetiracetam to brivaracetam. Safety and tolerability.

PMID: 34901817
Journal: Epilepsy & behavior reports
Year: 2021
Reference: Epilepsy Behav Rep. 2021 Nov 14;16:100504. doi: 10.1016/j.ebr.2021.100504. eCollection 2021.
Impact factor: 0
Publication type: Paper in international publication
Authors: Abraira, L, Salas-Puig, J, Quintana, M, Seijo-Raposo, I M, Santamarina, E, Fonseca, E, Toledo, M et al.
DOI: 10.1016/j.ebr.2021.100504

Systematic CT perfusion acquisition in acute stroke increases vascular occlusion detection and thrombectomy rates.

PMID: 34857668
Journal: Journal of NeuroInterventional Surgery
Year: 2021
Reference: J Neurointerv Surg. 2021 Dec 2. pii: neurintsurg-2021-018241. doi: 10.1136/neurintsurg-2021-018241.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Requena, Manuel, Diaz, Facundo, Boned, Sandra, Garcia-Tornel, Alvaro, Muchada, Marian, Deck, Matias, Lozano, Prudencio, Rodriguez-Villatoro, Noelia, Juega, Jesus et al.
DOI: 10.1136/neurintsurg-2021-018241

Management of acute stroke. Specific nursing care and treatments in the stroke unit.

PMID: 33153769
Journal: NEUROLOGIA
Year: 2020
Reference: Neurologia. 2020 Nov 2. pii: S0213-4853(20)30291-7. doi: 10.1016/j.nrl.2020.07.025.
Impact factor: 2.283
Publication type: Review in national publication
Authors: Rodriguez-Luna, D, Sanjuan, E, Pancorbo, O, Santana, K, Minarro, O, Sala, V, Muchada, M, Boned, S, Juega, J M, Pagola, J et al.
DOI: 10.1016/j.nrl.2020.07.025

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.

PMID: 33146036
Journal: CEPHALALGIA
Year: 2020
Reference: Cephalalgia. 2020 Nov;40(13):1410-1421. doi: 10.1177/0333102420965157.
Impact factor: 4.868
Publication type: Paper in international publication
Authors: Caronna, Edoardo, Ballve, Alejandro, Llaurado, Arnau, Gallardo, Victor Jose, Maria Ariton, Diana, Lallana, Sofia, Maza, Samuel Lopez, Gadea, Marta Olive, Quibus, Laura, Restrepo, Juan Luis et al.
DOI: 10.1177/0333102420965157

The mediating role of epileptic seizures, irritability, and depression on quality of life in people with epilepsy.

PMID: 33129044
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Dec;113:107511. doi: 10.1016/j.yebeh.2020.107511. Epub 2020 Oct 24.
Impact factor: 2.508
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Quintana, Manuel, Abraira, Laura, Seijo-Raposo, Ivan, Santamarina, Estevo, Toledo, Manuel, Fonseca, Elena, Campos-Fernandez, Daniel et al.
DOI: 10.1016/j.yebeh.2020.107511

(1)H NMR serum metabolomic profiling of patients at risk of cardiovascular diseases performing stress test.

PMID: 33082494
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Oct 20;10(1):17838. doi: 10.1038/s41598-020-74880-6.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Lema, Camila, Andres, Mireia, Aguade-Bruix, Santiago, Consegal, Marta, Rodriguez-Sinovas, Antonio, Benito, Begona, Ferreira-Gonzalez, Ignacio, Barba, Ignasi et al.
DOI: 10.1038/s41598-020-74880-6

BRIVA-LIFE-A multicenter retrospective study of the long-term use of brivaracetam in clinical practice.

PMID: 30506559
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2019
Reference: Acta Neurol Scand. 2019 Apr;139(4):360-368. doi: 10.1111/ane.13059. Epub 2018 Dec 27.
Impact factor: 2.852
Publication type: Paper in international publication
Authors: Villanueva, Vicente, Lopez-Gonzalez, Francisco Javier, Mauri, Jose Angel, Rodriguez-Uranga, Juan, Olive-Gadea, Marta, Montoya, Javier, Ruiz-Gimenez, Jesus, Zurita, Jorge, Abril, J, Toledo, M et al.
DOI: 10.1111/ane.13059

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics.

PMID: 31877821
Journal: Pharmaceutics
Year: 2019
Reference: Pharmaceutics. 2019 Dec 21;12(1). pii: pharmaceutics12010016. doi: 10.3390/pharmaceutics12010016.
Impact factor: 4.773
Publication type: Paper in international publication
Authors: Rosell, Anna, Zhang, Yajie, Garcia-Gabilondo, Miguel, Roig, Anna et al.
DOI: 10.3390/pharmaceutics12010016

Implementation of a protocol for direct stroke patient transfer and mobilization of a stroke team to reduce times to reperfusion.

PMID: 31777209
Journal: Emergencias
Year: 2019
Reference: Emergencias. 2019 Dic;31(6):385-390.
Impact factor: 3.35
Publication type: Paper in international publication
Authors: Sanjuan Menendez, Estela, Giron Espot, Pilar, Calleja Macho, Laura, Rodriguez-Samaniego, Maria Teresa, Santana Roman, Katherine E, Rubiera Del Fueyo, Marta et al.
DOI:

The ADAN Scale: A proposed scale for prehospital use to identify status epilepticus.

PMID: 30565357
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2019
Reference: Eur J Neurol. 2019 May;26(5):760-e55. doi: 10.1111/ene.13885. Epub 2019 Jan 20.
Impact factor: 4.621
Publication type: Paper in international publication
Authors: Requena, Manuel, Fonseca, Elena, Olive, Marta, Abraira, Laura, Quintana, Manuel, Mazuela, Gonzalo, Toledo, Manuel, Salas-Puig, Xavier, Santamarina, Estevo et al.
DOI: 10.1111/ene.13885

Anger Assessment in Patients Treated With Brivaracetam.

PMID: 29194113
Journal: CLINICAL NEUROPHARMACOLOGY
Year: 2018
Reference: Clin Neuropharmacol. 2018 Jan/Feb;41(1):6-9. doi: 10.1097/WNF.0000000000000258.
Impact factor: 1.37
Publication type: Paper in international publication
Authors: Toledo, Manuel, Ortega, Gemma, Abraira, Laura, Marti, Gloria, Quintana, Manuel, Mazuela, Gonzalo, Santamarina, Estevo, Salas-Puig, Xavier et al.
DOI: 10.1097/WNF.0000000000000258

Cost of status epilepticus (SE): Effects of delayed treatment and SE duration.

PMID: 30384104
Journal: EPILEPSY & BEHAVIOR
Year: 2018
Reference: Epilepsy Behav. 2018 Dec;89:8-14. doi: 10.1016/j.yebeh.2018.09.046. Epub 2018 Oct 26.
Impact factor: 2.6
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Parejo, Beatriz, Abraira, Laura, Gutierrez-Viedma, Alvaro, Alpuente, Alicia, Abarrategui, Belen, Toledo, Manuel, Mazuela, Gonzalo, Salas-Puig, Xavier, Garcia-Morales, Irene et al.
DOI: 10.1016/j.yebeh.2018.09.046

Primary hypothyroidism in a child leads to pituitary hyperplasia: A case report and literature review.

PMID: 30334955
Journal: MEDICINE
Year: 2018
Reference: Medicine (Baltimore). 2018 Oct;97(42):e12703. doi: 10.1097/MD.0000000000012703.
Impact factor: 2.028
Publication type: Paper in international publication
Authors: Cao, Junguo, Lei, Ting, Zhang, Chaochao, Ma, Chengyuan, Huang, Haiyan, Chen, Fan et al.
DOI: 10.1097/MD.0000000000012703

Reliability of the early syndromic diagnosis in adults with new-onset epileptic seizures: A retrospective study of 116 patients attended in the emergency room.

PMID: 30172139
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Oct;61:158-163. doi: 10.1016/j.seizure.2018.08.016. Epub 2018 Aug 18.
Impact factor: 2.839
Publication type: Clinical guide
Authors: Toledo, M, Salas Puig, X, Abraira Del Fresno, L, Fonseca Hernandez, E, Olive Gadea, M, Requena Ruiz, M, Quintana, M, Santamarina Perez, E, Alvarez Sabin, J et al.
DOI: 10.1016/j.seizure.2018.08.016

Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral beta-amyloidosis.

PMID: 29116115
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Nov 7;7(1):14637. doi: 10.1038/s41598-017-15215-w.
Impact factor: 4.259
Publication type: Paper in international publication
Authors: Fernandez-de-Retana, Sofia, Cano-Sarabia, Mary, Marazuela, Paula, Sanchez-Quesada, Jose Luis, Garcia-Leon, Annabel, Montanola, Alex, Montaner, Joan, Maspoch, Daniel, Hernandez-Guillamon, Mar et al.
DOI: 10.1038/s41598-017-15215-w

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease.

PMID: 28941727
Journal: NEUROBIOLOGY OF AGING
Year: 2017
Reference: Neurobiol Aging. 2017 Dec;60:116-128. doi: 10.1016/j.neurobiolaging.2017.08.028. Epub 2017 Sep 5.
Impact factor: 5.117
Publication type: Paper in international publication
Authors: Fernandez-de Retana, Sofia, Montanola, Alex, Marazuela, Paula, De La Cuesta, Maialen, Batlle, Aina, Fatar, Marc, Grudzenski, Saskia, Montaner, Joan, Hernandez-Guillamon, Mar et al.
DOI: 10.1016/j.neurobiolaging.2017.08.028

Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study.

PMID: 28716979
Journal: STROKE
Year: 2017
Reference: Stroke. 2017 Sep;48(9):2419-2425. doi: 10.1161/STROKEAHA.117.017076. Epub 2017 Jul 17.
Impact factor: 6.032
Publication type: Paper in international publication
Authors: Cardona, Pedro, Cano, Luis, Quesada, Helena, Terceno, Mikel, Silva, Yolanda, Castellanos, Mar, Garces, Moises, Reverte, Silvia, Ustrell, Xavier, Mares, Rafael et al.
DOI: 10.1161/STROKEAHA.117.017076

Endovascular treatment improves cognition after stroke: A secondary analysis of REVASCAT trial.

PMID: 27940648
Journal: NEUROLOGY
Year: 2017
Reference: Neurology. 2017 Jan 17;88(3):245-251. doi: 10.1212/WNL.0000000000003517. Epub 2016 Dec 9.
Impact factor: 8.32
Publication type: Clinical Trials
Authors: Lopez-Cancio, Elena, Jovin, Tudor G, Cobo, Erik, Cerda, Neus, Jimenez, Marta, Gomis, Meritxell, Hernandez-Perez, Maria, Caceres, Cynthia, Cardona, Pere, Lara, Blanca et al.
DOI: 10.1212/WNL.0000000000003517

Semi-automatic measuring of arteriovenous relation as a possible silent brain infarction risk index in hypertensive patients.

PMID: 27311989
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2016
Reference: Arch Soc Esp Oftalmol. 2016 Nov;91(11):513-519. doi: 10.1016/j.oftal.2016.05.001. Epub 2016 Jun 13.
Impact factor: 0
Publication type: Paper in national publication
Authors: Vazquez Dorrego, X M, Manresa Dominguez, J M, Heras Tebar, A, Fores, R, Girona Marce, A, Alzamora Sas, M T, Delgado Martinez, P, Riba-Llena, I, Ugarte Anduaga, J, Beristain Iraola, A et al.
DOI: 10.1016/j.oftal.2016.05.001

High daytime and nighttime ambulatory pulse pressure predict poor cognitive function and mild cognitive impairment in hypertensive individuals.

PMID: 25966945
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2016
Reference: J Cereb Blood Flow Metab. 2016 Jan;36(1):253-63. doi: 10.1038/jcbfm.2015.90.
Impact factor: 5.407
Publication type: Paper in international publication
Authors: Montaner, Joan, Riba-Llena, Iolanda, Nafria, Cristina, Filomena, Josefina, Tovar, Jose L, Vinyoles, Ernest, Mundet, Xavier, Jarca, Carmen I, Vilar-Bergua, Andrea, Delgado, Pilar et al.
DOI: 10.1038/jcbfm.2015.90

Blood and CSF biomarkers in brain subcortical ischemic vascular disease: involved pathways and clinical applicability.

PMID: 25899297
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2016
Reference: J Cereb Blood Flow Metab. 2016 Jan;36(1):55-71. doi: 10.1038/jcbfm.2015.68.
Impact factor: 5.407
Publication type: Paper in international publication
Authors: Vilar-Bergua, A, Riba-Llena, I, Nafria, C, Bustamante, A, Llombart, V, Delgado, P, Montaner, J et al.
DOI: 10.1038/jcbfm.2015.68

N-terminal pro-brain natriuretic peptide and subclinical brain small vessel disease.

PMID: 27956564
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Dec 13;87(24):2533-2539. Epub 2016 Nov 9.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Vilar-Bergua, Andrea, Riba-Llena, Iolanda, Penalba, Anna, Jimenez-Balado, Joan, Montaner, Joan, Delgado, Pilar, Cruz, Luz Maria et al.
DOI: 10.1212/WNL.0000000000003423

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives.

PMID: 26597154
Journal: Journal of the American Heart Association
Year: 2015
Reference: J Am Heart Assoc. 2015 Nov 23;4(11). pii: JAHA.115.002669. doi: 10.1161/JAHA.115.002669.
Impact factor: 4.306
Publication type: Paper in international publication
Authors: Delgado, Pilar, Montaner, Joan, Libert, Claude, Vilar-Bergua, Andrea, Riba-Llena, Iolanda, Vanhooren, Valerie, Dewaele, Sylviane, Penalba, Anna et al.
DOI: 10.1161/JAHA.115.002669

Small cortical infarcts: prevalence, determinants, and cognitive correlates in the general population.

PMID: 26043763
Journal: International Journal of Stroke
Year: 2015
Reference: Int J Stroke. 2015 Oct;10 Suppl A100:18-24. doi: 10.1111/ijs.12543. Epub 2015 Jun 4.
Impact factor: 3.833
Publication type: Paper in international publication
Authors: Riba-Llena, Iolanda, Koek, Marcel, Verhaaren, Benjamin F J, Vrooman, Henri A, van der Lugt, Aad, Hofman, Albert, Ikram, M Arfan, Vernooij, Meike W et al.
DOI: 10.1111/ijs.12543

B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis.

PMID: 25765726
Journal: STROKE
Year: 2015
Reference: Stroke. 2015 May;46(5):1187-95. doi: 10.1161/STROKEAHA.114.008311. Epub 2015 Mar 12.
Impact factor: 5.723
Publication type: Review in international publication
Authors: Etgen, Thorleif, Llombart, Victor, Antolin-Fontes, Albert, Bustamante, Alejandro, Giralt, Dolors, Rost, Natalia S, Furie, Karen, Shibazaki, Kensaku, Biteker, Murat, Castillo, Jose et al.
DOI: 10.1161/STROKEAHA.114.008311

Short-Term Blood Pressure Variability Relates to the Presence of Subclinical Brain Small Vessel Disease in Primary Hypertension.

PMID: 26101344
Journal: HYPERTENSION
Year: 2015
Reference: Hypertension. 2015 Sep;66(3):634-40; discussion 445. doi: 10.1161/HYPERTENSIONAHA.115.05440. Epub 2015 Jun 22.
Impact factor: 6.48
Publication type: Paper in international publication
Authors: Filomena, Josefina, Tovar, Jose L, Mundet, Xavier, Castane, Xavier, Vilar, Andrea, Lopez-Rueda, Antonio, Jimenez-Balado, Joan, Cartanya, Anna, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/HYPERTENSIONAHA.115.05440

Role of lipoprotein-associated phospholipase A activity for the prediction of silent brain infarcts in women.

PMID: 25463126
Journal: ATHEROSCLEROSIS
Year: 2014
Reference: Atherosclerosis. 2014 Dec;237(2):811-5. doi: 10.1016/j.atherosclerosis.2014.11.003. Epub 2014 Nov 10.
Impact factor: 3.971
Publication type: Paper in international publication
Authors: Riba-Llena, Iolanda, Penalba, Anna, Pelegri, Dolors, Vilar, Andrea, Jarca, Carme I, Filomena, Josefina, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1016/j.atherosclerosis.2014.11.003

Prevalence and associated factors of silent brain infarcts in a Mediterranean cohort of hypertensives.

PMID: 24958500
Journal: HYPERTENSION
Year: 2014
Reference: Hypertension. 2014 Sep;64(3):658-63. doi: 10.1161/HYPERTENSIONAHA.114.03563. Epub 2014 Jun 23.
Impact factor: 7.632
Publication type: Clinical Trials
Authors: Delgado, Pilar, Riba-Llena, Iolanda, Tovar, Jose L, Jarca, Carmen I, Mundet, Xavier, Lopez-Rueda, Antonio, Orfila, Francesc, Llussa, Judit, Manresa, Josep M, Alvarez-Sabin, Jose et al.
DOI: 10.1161/HYPERTENSIONAHA.114.03563

Brain proteomics identifies possible simvastatin targets in acute phase of stroke in a rat embolic model.

PMID: 24661059
Journal: J NEUROCHEM
Year: 2014
Reference: J Neurochem. 2014 Jul;130(2):301-12. doi: 10.1111/jnc.12719. Epub 2014 Apr 30.
Impact factor: 4.244
Publication type: Paper in international publication
Authors: Campos-Martorell, Mireia, Salvador, Nelida, Monge, Marta, Canals, Francesc, Garcia-Bonilla, Lidia, Hernandez-Guillamon, Mar, Ayuso, Maria Irene, Chacon, Pilar, Rosell, Anna, Alcazar, Alberto et al.
DOI: 10.1111/jnc.12719

Genes involved in hemorrhagic transformations that follow recombinant t-PA treatment in stroke patients.

PMID: 23556447
Journal: PHARMACOGENOMICS
Year: 2013
Reference: Pharmacogenomics. 2013 Apr;14(5):495-504. doi: 10.2217/pgs.13.19.
Impact factor: 3.857
Publication type: Paper in international publication
Authors: Fernandez-Cadenas, Israel, Rio-Espinola, Alberto Del, Domingues-Montanari, Sophie, Mendioroz, Maite, Fernandez-Morales, Jessica, Penalba, Anna, Rubiera, Marta, Hernandez-Guillamon, Mar, Rosell, Anna, Delgado, Pilar et al.
DOI: 10.2217/pgs.13.19

Letter by Riba-Llena et al Regarding Article, "Not Listened or Not Reported Rather Than Silent Stroke"

PMID: 23329208
Journal: STROKE
Year: 2013
Reference: Stroke. 2013 Apr;44(4):e42. doi: 10.1161/STROKEAHA.112.681817. Epub 2013 Jan 17.
Impact factor: 6.158
Publication type: Letter whit IF
Authors: Riba-Llena, Iolanda, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/STROKEAHA.112.681817

A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke.

PMID: 23280790
Journal: ANNALS OF NEUROLOGY
Year: 2012
Reference: Ann Neurol. 2012 Nov;72(5):716-29. doi: 10.1002/ana.23664.
Impact factor: 11.089
Publication type: Paper in international publication
Authors: Mendioroz, Maite, del Rio-Espinola, Alberto, Fernandez-Cadenas, Israel, Giralt, Dolors, Quiroga, Adoracion, Gutierrez-Agullo, Maria, Quintana, Manuel, Fernandez-Alvarez, Patricia, Domingues-Montanari, Sophie, Canovas, D et al.
DOI: 10.1002/ana.23664

Cognitive assessment protocol design in the ISSYS (Investigating Silent Strokes in hYpertensives: A magnetic resonance imaging Study).

PMID: 22836018
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2012
Reference: J Neurol Sci. 2012 Nov 15;322(1-2):79-81. doi: 10.1016/j.jns.2012.06.015. Epub 2012 Jul 24.
Impact factor: 2.353
Publication type: Paper in international publication
Authors: Riba, I, Jarca, C I, Mundet, X, Tovar, J L, Orfila, F, Nafria, C, Raga, A, Girona, A, Fernandez-Lara, P, Castane, X et al.
DOI: 10.1016/j.jns.2012.06.015

Evidence for the efficacy of statins in animal stroke models: a meta-analysis.

PMID: 22548274
Journal: JOURNAL OF NEUROCHEMISTRY
Year: 2012
Reference: J Neurochem. 2012 Jul;122(2):233-43. doi: 10.1111/j.1471-4159.2012.07773.x. Epub 2012 May 21.
Impact factor: 4.061
Publication type: Review in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1471-4159.2012.07773.x

Lipoprotein-Associated Phospholipase A(2) Activity Is Associated with Large-Artery Atherosclerotic Etiology and Recurrent Stroke in TIA Patients.

PMID: 22178747
Journal: CEREBROVASCULAR DISEASES
Year: 2012
Reference: Cerebrovasc Dis. 2012;33(2):150-8. Epub 2011 Dec 14.
Impact factor: 2.723
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1159/000334193

A panel of biomarkers including caspase-3 and d-dimer may differentiate acute stroke from stroke-mimicking conditions in the emergency department.

PMID: 21198992
Journal: JOURNAL OF INTERNAL MEDICINE
Year: 2011
Reference: J Intern Med. 2011 Aug;270(2):166-74. doi: 10.1111/j.1365-2796.2010.02329.x. Epub 2010 Dec 27.
Impact factor: 5.935
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1365-2796.2010.02329.x

Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.

PMID: 21122033
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2011
Reference: Eur J Neurol. 2011 Jun;18(6):826-35. doi: 10.1111/j.1468-1331.2010.03243.x. Epub 2010 Dec 1.
Impact factor: 3.765
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1468-1331.2010.03243.x

Effect of atorvastatin on lipoprotein (a) and interleukin-10: A randomized placebo-controlled trial.

PMID: 21131223
Journal: DIABETES & METABOLISM
Year: 2011
Reference: Diabetes Metab. 2011 Apr;37(2):124-30. Epub 2010 Dec 4.
Impact factor: 3.033
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1016/j.diabet.2010.08.006

Lipoprotein-associated phospholipase A(2) testing usefulness among patients with symptomatic intracranial atherosclerotic disease.

PMID: 21620406
Journal: ATHEROSCLEROSIS
Year: 2011
Reference: Atherosclerosis. 2011 Sep;218(1):181-7. Epub 2011 May 5.
Impact factor: 4.086
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.atherosclerosis.2011.04.031

Reperfusion therapy for acute stroke improves outcome by decreasing neuroinflammation.

PMID: 24323553
Journal: Translational stroke research
Year: 2010
Reference: Transl Stroke Res. 2010 Dec;1(4):261-7. doi: 10.1007/s12975-010-0038-0. Epub 2010 Aug 28.
Impact factor: 0
Publication type: Paper in international publication
Authors: Montaner, Joan, Salat, David, Garcia-Berrocoso, Teresa, Molina, Carlos A, Chacon, Pilar, Ribo, Marc, Alvarez-Sabin, Jose, Rosell, Anna et al.
DOI: 10.1007/s12975-010-0038-0

The I/D polymorphism of the ACE1 gene is not associated with ischaemic stroke in Spanish individuals.

PMID: 20402757
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2010
Reference: Eur J Neurol. 2010 Nov;17(11):1390-2.
Impact factor: 2.51
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1468-1331.2010.03022.x

Evolution of lipid profile, liver function, and pattern of plasma fatty acids according to the type of lipid emulsion administered in parenteral nutrition in the early postoperative period after digestive surgery.

PMID: 19420283
Journal: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
Year: 2009
Reference: JPEN J Parenter Enteral Nutr. 2009 Sep-Oct;33(5):501-12.
Impact factor: 1.97
Publication type: Paper in international publication
Authors: Puiggros, C, Sanchez, J, Chacon, P, Sabin, P, Bou, R, Planas, M, Rosello, J et al.
DOI: 10.1177/0148607109333001

Ezetimibe as monotherapy in the treatment of hypercholesterolemia in children and adolescents.

PMID: 19694195
Journal: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Year: 2009
Reference: J Pediatr Endocrinol Metab. 2009 Jun;22(6):487-92.
Impact factor: 0.938
Publication type: Paper in international publication
Authors: Yeste, Diego, Chacon, Pilar, Clemente, Maria, Albisu, M A, Gussinye, Miquel, Carrascosa, Antonio et al.
DOI:

Changes in lipid profile between flare and remission of patients with systemic lupus erythematosus: a prospective study.

PMID: 19531751
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2009
Reference: J Rheumatol. 2009 Aug;36(8):1639-45.
Impact factor: 3.282
Publication type: Paper in international publication
Authors: Urquizu-Padilla, Maria, Balada, Eva, Chacon, Pilar, Perez, Eduardo Hermosilla, Vilardell-Tarres, Miquel, Ordi-Ros, Josep et al.
DOI: 10.3899/jrheum.081097

C-reactive protein gene C1444T polymorphism and risk of recurrent ischemic events in patients with symptomatic intracranial atherostenoses.

PMID: 19494488
Journal: CEREBROVASCULAR DISEASES
Year: 2009
Reference: Cerebrovasc Dis. 2009;28(1):95-102.
Impact factor: 3.041
Publication type: Paper in international publication
Authors: Arenillas, Juan F, Massot, Andreu, Alvarez-Sabin, Jose, Fernandez-Cadenas, Israel, del Rio-Espinola, Albert, Chacon, Pilar, Quintana, Manuel, Molina, Carlos A, Rovira, Alex, Montaner, Joan et al.
DOI: 10.1159/000222660

Thesis

Els biomarcadors sanguinis com a eines per a la prevenció del ictus associat a la fibril·lació auricular

PhD student: Elena Pala Vila
Director/s: Joan Montaner Villalonga, Alejandro Bustamante Rangel
University: Universitat Autònoma de Barcelona
Year: 2022

Noves estratègies per a la predicció i prevenció de la pneumònia associada a l'ictus

PhD student: Julia Faura Llorens
Director/s: Alejandro Bustamante Rangel, Joan Montaner Villalonga
University: Universitat Autònoma de Barcelona
Year: 2021

The unique role of Angiogenin in neuroprotection and neurorepair after cerebral ischemia

PhD student: Ting Lei (Santiago)
Director/s: Anna Rosell Novel
University: Universitat Autònoma de Barcelona
Year: 2021

Búsqueda de nuevos biomarcadores en la angiopatía amiloide cerebral

PhD student: Paula Marazuela Fuentes
Director/s: Maria Mar Hernandez Guillamon
University: Universitat Autònoma de Barcelona
Year: 2021

Progresión de la enfermedad de pequeño vaso cerebral: factores de riesgo, mecanismos implicados y consecuencias clínicas

PhD student: Joan Jimenez Balado
Director/s: Maria Pilar Delgado Martínez
University: Universitat Autònoma de Barcelona
Year: 2020

Estado de mal epiléptico. Diagnóstico y pronóstico

PhD student: Gloria Monts. González Cuevas
Director/s: Estevo Santamarina Pérez
University: Universitat Autònoma de Barcelona
Year: 2020

Magnetic Nanomaterials for angiogenic therapies after stroke.

PhD student: Yajie Zhang
Director/s: Anna Rosell Novel
University: Universitat Autònoma de Barcelona
Year: 2020

Efecto de variaciones sobre ApoA-I y ApoJ recombinantes como aproximación terapéutica en el contexto de la Beta-amiloidosis cerebral

PhD student: Sofia Fernandez De Re Alda
Director/s: Maria Mar Hernandez Guillamon
University: Universitat Autònoma de Barcelona
Year: 2018

Modulació de marcadors de neuroreparació en teràpies rehabilitadores després de l'ictus i en un model pre-clínic d'isquèmia cerebral

PhD student: Marina Gabriel Salazar
Director/s: Anna Rosell Novel
University: Universitat Autònoma de Barcelona
Year: 2018

Potencial terapèutic de nous biomarcadors d'isquèmia cerebral

PhD student: Alba Simats Oriol
Director/s: Joan Montaner Villalonga, Teresa Garcia Berrocoso
University: Universitat Autònoma de Barcelona
Year: 2018

Human Autonomic and Respiratory Responses to Direct Electrical Cortical Stimulation

PhD student: Nuria Lacuey Lecumberri
Director/s: José Alvarez Sabin
University: Universitat Autònoma de Barcelona
Year: 2018

Impacto de los cambios y el curso de la presión arterial mediante monitorización intensiva en la evolución clínica y radiológica tras una hemorragia intracerebral aguda

PhD student: Mª Socorro Piñeiro Santos
Director/s: José Alvarez Sabin, David Rodriguez Luna, Carlos Molina Cateriano
University: Universitat Autònoma de Barcelona
Year: 2017

Utilidad de los biomarcadores en el diagnóstico de la enfermedad cerebrovascular silente

PhD student: Andrea Vilar Bergua
Director/s: Maria Pilar Delgado Martínez
University: Universitat Autònoma de Barcelona
Year: 2016

Condicionantes pronósticos del ictus isquémico: utilidad de los biomarcadores sanguíneos en su predicción

PhD student: Alejandro Bustamante Rangel
Director/s: Joan Montaner Villalonga, Carlos Molina Cateriano
University: Universitat Autònoma de Barcelona
Year: 2016

Aplicaciones proteómicas para el descubrimiento de biomarcadores diagnósticos en ictus

PhD student: Victor Llombart Sebastià
Director/s: Joan Montaner Villalonga, Maria Mar Hernandez Guillamon
University: Universitat de Barcelona
Year: 2016

Identificación de biomarcadores en el ictus hemorrágico y su estudio funcional en modelos experimentales

PhD student: Cristina Merino Zamorano
Director/s: Joan Montaner Villalonga
University: Universitat Autònoma de Barcelona
Year: 2016

Prevalencia y determinantes de las lesiones vasculares cerebrales definidas por resonancia magnética y estudio de la función cognitiva en problación adulta hipertensa y general

PhD student: Yolanda Riba Llena
Director/s: Joan Montaner Villalonga, Maria Pilar Delgado Martínez
University: Universitat Autònoma de Barcelona
Year: 2015

Dual role of matrix metalloproteinases in brain injury and neurorepais after cerebral ischemia

PhD student: Feifei Ma
Director/s: Joan Montaner Villalonga, Anna Rosell Novel
University: Universitat Autònoma de Barcelona
Year: 2015

Identificación y uso de biomarcadores pronósticos en el ictus isquémico

PhD student: Teresa Garcia Berrocoso
Director/s: Joan Montaner Villalonga, Israel Fernandez Cadenas, Maria Pilar Delgado Martínez
University: Universitat Autònoma de Barcelona
Year: 2014

Les cèl·lules progenitores endotelials com a tractament neuroreparador angio-vasculogènic en la isquèmia cerebral modulat per la metal·loproteïnasa de matriu 9

PhD student: Anna Morancho Retana
Director/s: Anna Rosell Novel, Joan Montaner Villalonga
University: Universitat Autònoma de Barcelona
Year: 2014

Eficàcia i seguretat de la Simvastatina administrada en la fase aguda de la isquèmia cerebral experimental

PhD student: Mireia Campos Martorell
Director/s: Joan Montaner Villalonga, Maria Mar Hernandez Guillamon
University: Universitat Autònoma de Barcelona
Year: 2014

Magnetic nanoparticles suspensions for cell tracking, imaging and therapeutics in ischemia treatments.

PhD student: Elisa Carenza
Director/s: Anna Rosell Novel
University: Universitat Autònoma de Barcelona
Year: 2014

Marcadores biológicos tras la hemorragia intracerebral y su relación con la evolución clínico-radiológica.

PhD student: Maria Pilar Delgado Martínez
Director/s:
University: Universitat Autònoma de Barcelona
Year: 2006

Proyecto Geno-tPA:Influencia del background genético en la seguridad y eficacia del tratamiento con t-PA en pacientes con ictus isquémico

PhD student: Israel Fernandez Cadenas
Director/s:
University: Universitat Autònoma de Barcelona
Year: 2006

Les Metal·loproteïnases de Matriu en el Parènquima Cerebral: Implicació en la Isquèmia Cerebral Humana

PhD student: Anna Rosell Novel
Director/s:
University: Universitat Autònoma de Barcelona
Year: 2005

aterosclerosis intracraneal de gran vaso: progresión y recurrencia clínica

PhD student: Juan Francisco Arenillas Lara
Director/s:
University: Universitat Autònoma de Barcelona
Year: 2003

Job offers

Clinical Researcher-Neurovascular diseases group.
Start date:
28/03/2022
End date:
11/04/2022
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Research Technician-Neurovascular Lab.
Start date:
16/03/2022
End date:
31/03/2022
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Research Technician-Neurovascular Research Laboratory (Animal).
Start date:
13/01/2022
End date:
14/02/2022
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