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Malalties Neurovasculars

L'ictus és una emergència mèdica i una de les principals causes de mort i discapacitat a tot el món, que afecta milions de persones. En aquest context, el 2001 es va crear el Laboratori de Recerca Neurovascular, centrat en la recerca biomèdica de l'ictus des d'una perspectiva bàsica i translacional, cobrint totes les etapes de la malaltia: des de la prevenció i el tractament fins a la recuperació. 

Avui dia el nostre equip està format per un grup d'investigadors altament motivats que inclou científics clínics i bàsics, amb líders de grup involucrats en projectes —nacionals i internacionals, amb finançament públic o privat— per a la recerca sobre biomarcadors per a la presa de decisions clíniques en l'ictus, la presència d'infarts silents, l'avaluació de la cognició i el deteriorament cognitiu, desenvolupant models experimentals d'isquèmia cerebral, provant nous tractaments complementaris a la reperfusió, i desenvolupant estudis sobre l’angiopatia amiloide cerebral, neurorreparació tissular o rehabilitació postictus.

Els estudis complementaris sobre la demència vascular i la malaltia d'Alzheimer relacionada amb la proteïna ß-amiloide també s'han inclòs com a part de la nostra recerca en els últims anys.
 

Equip

Anna Rosell Novel

Anna Rosell Novel

Cap de grup
Malalties neurovasculars
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José Alvarez Sabin

José Alvarez Sabin

Investigador/a sènior
Malalties neurovasculars
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Maria Mar Hernandez Guillamon

Maria Mar Hernandez Guillamon

Investigador/a principal
Malalties neurovasculars
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Antonio Palasi Franco

Antonio Palasi Franco

Tècnic de recerca
Malalties neurovasculars
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Berta Paez Montserrat

Berta Paez Montserrat

Investigador/a predoctoral
Malalties neurovasculars
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Cristina Giménez Paños

Cristina Giménez Paños

Investigador/a predoctoral
Malalties neurovasculars
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Anna Rosell Novel

Anna Rosell Novel

Cap de grup
Malalties neurovasculars
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José Alvarez Sabin

José Alvarez Sabin

Investigador/a sènior
Malalties neurovasculars
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Maria Mar Hernandez Guillamon

Maria Mar Hernandez Guillamon

Investigador/a principal
Malalties neurovasculars
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Antonio Palasi Franco

Antonio Palasi Franco

Tècnic de recerca
Malalties neurovasculars
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Berta Paez Montserrat

Berta Paez Montserrat

Investigador/a predoctoral
Malalties neurovasculars
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Cristina Giménez Paños

Cristina Giménez Paños

Investigador/a predoctoral
Malalties neurovasculars
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Línies de recerca

L1 Biomarkers

The use of plasma biomarkers is becoming increasingly popular in several fields of medicine. In fact, decision-making processes using biomarkers is widely accepted in medical situations such as initiating lipid lowering therapies (LDL), diagnosing acute myocardial infarction (troponins), and ruling out pulmonary embolism suspicions (D-dimer), among others.


Therefore we really believe that biochemical markers of stroke, will really open “a window to the brain…”. In fact, in this research line we aim to answer relevant clinical questions through the use of biomarkers.


Our main Objectives using mainly plasma proteins are:


1.- To predict stroke risk

2.- To make stroke diagnosis

3.- To differentiate stroke subtypes

4.- To establish evolution and prognosis

5.- To use Biomarkers as treatment end-points


Some of our findings might have therapeutic implications since biological markers described by the group such as MMP-9 are well associated with Blood Brain Barrier disruption. In this direction, we have described MMP-9 predicting haemorrhagic complications among stroke patients receiving thrombolytic treatment. These approaches might contribute to increase safety of reperfusion treatments. The impact of this research line is clear, since articles like this (Circulation 2003) have been cited more than 180 times since its publication.


The study of these molecules will also have diagnostic implications because we have proposed the biochemical diagnostic of stroke by means of the identification of a biomarkers panel that distinguish between a stroke and other stroke-mimicking conditions. This might contribute to refer only to real stroke patients to the stroke centres, saving huge resources to the system.


These two examples, identification of biomarkers to predict tPA related bleedings and a stroke diagnostic test are examples of translational research in which the Neurovascular Research Lab is filing patents to be licensed to Biotech companies able to develop diagnostic kits in which our biomarkers might be placed and used in the clinical practice. That might close the circle of applied research.


Reviews of our group in which you may find detailed info about those biomarkers:


Foerch C, Montaner J, Furie KL, Ning MM, Lo EH.

      Searching for oracles? Blood biomarkers in acute stroke

      Neurology. 2009;73(5):393-9.


Montaner J.

      Blood biomarkers to guide stroke thrombolysis.

      Front Biosci (Elite Ed). 2009 Jun 1;1:200-208.


García-Berrocoso T, Fernández-Cadenas I, Delgado P, Rosell A, Montaner J.

      Blood Biomarkers to Identify Stroke Etiologies.

      Therapy 2010 (in press).



Projects

We are involved in several projects with public or private funding supporting our research on stroke biomarkers. One of such exciting projects is FIS PI 08/361 “Identificación y uso de biomarcadores pronósticos en el ictus isquémico”, aiming to identify biomarkers that predict main causes of stroke worsening (Infarct growth, cardiac complications, hemorrhagic transformation, infections, recurrence or new vascular events) to guide Stroke Unit allocation and stay of our patients.


International Collaborations

Discovery and validation of good candidate biomarkers, requires multidisciplinary approaches and replication in well designed multicentric and international studies. For that purpose we are actively collaborating with well known stroke research leading groups:


- Eng Lo, Xiaoing Wang, Ming Ming Ning (Boston, USA).

- Jean Charles Sanchez, Natacha Turck (Geneva, Switzerland).

- Denis Vivien, Carine Ali, Eduardo Anglés-Cano (Caen, France).


Research Tools and Techniques

We are using a combination of discovery techniques and biological human and animal samples to identify new stroke-related biomarkers:


One example is the “protein arrays”. In our laboratory, we have been using these new technologies and we actually use the SearchLight Assays (Aushon Biosystems) that allows us to study more than 170 human proteins and also many candidates from different animal species. We offer access to our technology to other groups. For more information, please refer to http://www.lin-bcn.com/


Also those biomarkers may be specifically tested not only as circulating markers in plasma or serum but in the components of interest of the Neurovascular Unit, that we may dissect by using the LCM Leica LMD6000 microscope, for Laser Capture microdissection. An example in which combine both thecniques may be found at:


Cuadrado E, Rosell A, Penalba A, Slevin M, Alvarez-Sabin J, Ortega-Aznar A,  Montaner J. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined Laser Microdissection and Protein Array  Study. Journal of Proteome Research 2009;8(6):3191-3197.


Biobanks

All these results have been possible since the development of a “blood library” including more than 2000 stroke samples and a “brain library” that allowed us to describe for the first time the “human stroke proteome” with the outstanding collaboration of so many patients, relatives and clinicians of the Stroke Unit.


IP: Joan Montaner Villalonga, Anna Penalba Morenilla

L3 Acute Therapy

BACKGROUND


The only approved stroke treatment so far is the acute thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) when administered within 3-4.5 hours after symptoms onset. However, a reduced number of patients (5-8%) profit by this treatment, primarily because of the narrow therapeutic time-window and the risk of brain bleedings beyond thromrbolytic therapy to achieve the recanalization of the occluded artery. Moreover, the inflammatory response that accompanied necrotic brain injury contributes to aggravate acutely the progression of ischemic pathology. Inflammatory and brain damaged cells release a variety of cytotoxic agents including cytokines, MMPs and ROS which induce more cell damage as well as disruption of BBB and brain edema.


Thereby, it would be desirable to improve the efficacy and safety for thrombolytic therapy of stroke using combined anti-inflammatory strategies that may ameliorate the ischemic injury and means the best therapy translated at the clinical level.


Our research, conducted on experimental models of cerebral ischemia, is focused on the development of neuroprotective strategies aimed to salvage ischemic brain tissue by means complementary to reperfusion. Our goal is to find out a multimodal treatment that combines the administration of tPA together with other co-agents (as simvastatin and/or anti-aggregants with anti-inflammatory and neuro-protective properties) in attempt to obtain the most therapeutic benefice in the acute phase of ischemic stroke.


EXPERIMENTAL MODELS AND TECHNIQUES


Ischemic stroke has a complex pathophysiology involving the interplay of many different cells and tissues. Animal models of ischemic stroke are procedures inducing cerebral ischemia, which mimicked satisfactorily this cerebrovascular disease. Therefore, research stroke conducted on animal models has been shown essential for treatment approach of ischemic stroke.


Intra-arterial Suture Occlusion Model of Focal Cerebral Ischemia

Infarction in the territory of the middle cerebral artery (MCA) is induced by extracranial vascular occlusion on rat. A heat-blunted 4/0 nylon-monofilament is used to block the origin of MCA during 90 or 120 min and then, the monofilament is removed and reperfusion is allowed during the followed 24, 48 or 72 h.

This model mimics a clinical situation where recanalization of the occluded artery takes place, allowing test neuroprotectants that could be potentially co-administered with reperfusion agents like tPA.


Embolic Model of Focal Cerebral Ischemia

The stroke animal model by clot embolism has a large scientific interest in the clinical field because the high incidence of human thrombotic stroke and the use of reperfusion therapy with tPA, which can be assay on this model. Thromboembolic occlusion at the proximal level of MCA is achieved by injection of a rich fibrin clot through the internal carotid artery in the rat. Clots are previously performed using arterial blood from a donor rat. Thrombolytic therapy with tPA (9 mg/Kg) is administered by tail vein infusion (2 mg/mL;75 ?l/min) at different times points (2, 3, 4 hours) after occlusion.


Relative Cerebral Blood Flow (rCBF) is measured in the cortex supplied by the MCA by continuous Laser Doppler flowmetry (LDF) to ensure the successful of the artery occlusion or reperfusion in these models.  To examine the grade of infarction on rats, analysis of the infarct volume is evaluated using 2,3,5-triphenyltetrazolium chloride (TTC) staining and neurological score is assayed with a 9-point neurological at baseline (1-2 h) and each 24 h after occlusion.


NMR Imaging

Bruker-BIOSPEC 70/30 USR, 7 T Preclinical MRI System is used for the neuroimaging studies. Neuroimaging studies are conducted in vivo to valuate the cytotoxic edema and ischemic lesion (DWI, ADC map and T2WI) in the acute phase. Specific sequences are performed to assess Brain-Blood Barrier disruption (DCE) and occurrences of intracranial hemorrhages (T2*WI). Angiography is performed to document MCA occlusion or recanalization.

IP: Joan Montaner Villalonga

L4 Neurorepair

New therapies beyond the hyperacute phase of stroke are needed to be able to treat much more patients in delayed phases of this devastating disease. The idea that neurovascular plasticity contributes to stroke recovery can be a powerful concept for stroke therapy. Obviously, the therapeutic time window for interventions based on promoting recovery would be much larger than those for targeting acute stroke.  In this context, long-term neuroreparative therapies will  have to target the two essential phenomena to achieve brain neurorecovery after stroke: to restore the cerebral blood flow and to promote Neuroregeneration.


To achieve these major goals, both angiogenesis and neurogenesis need to be enhanced in the ischemic brain.


Classically, the formation of new blood vessels was thought to be mediated exclusively by embryogenic vasculogenesis followed by the sprouting of endothelial cells from preexisting vessels during angiogenesis. In the last decade, this standard dogma was overturned with the identification of the existence of circulating bone marrow-derived endothelial progenitor cells (EPCs). These cells are capable of differentiating, ex vivo, into endothelial-phenotyped cells, and now comprise a new model for endothelial generation and vessel repair (Asahara et al., 1997). These cells comprise a potential cell-based and growth-factor source of an alternate approach to enhance angio-neurogenic responses. In fact, newborn neurons (neurogenesis) and new vascular components (angiogenesis) form a microenvironment that has been termed the neurovascular niche [Ohab et al., 2006] were angiogenesis and neurogenesis are linked thorough specific growth factors.


Angiogenesis and neurogenesis occur endogenously after stroke. Our goal is to study these two complex phenomena both in experimental and human studies to finally potentiate them correctly to improve brain function and neurorecovery after stroke.


Experimental Models and Techniques


In vivo stroke models:

Cerebral ischemia affecting the cortical territory of the Middle Cerebral Artery (MCA) is occluded at the level of the M1 portion (distal occlusion). This model has been chosen because presents very low mortality rates allowing long-term studies. Besides, the infarct is restricted to the cortex with clear boundary areas with normal cerebral blood flow and never affects neuroblast-rich areas such as the subventricular zone (then, both angiogenesis and neurogenesis can occur).


Functional outcome is assessed by the cylinder and corner tests which have been reported to be appropriate test for this type of cortical infarcts. Besides, histology and immunohistochemistry studies are conducted to evaluate brain repair and angio-neurogenic processes.

                 

Endothelial Progenitor Cell Cultures:

EPCs are obtained from the Mononuclear cell fraction of human blood and from mouse spleen. MNCs are cultured in fibronectin-coated plates with complete cell culture medium EGM-2MV.

   

Both in human and murine cell cultures yield an early EPC population (also called Circulating Angiogenic Cells) obtained at day 4-7 after plating and late outgrowth EPC colonies (also called Endothelial Colony Forming Cells) appear from day 10 as colonies with high proliferation capacity and tubulogenic capacity.


In vitro Oxygen-Glucose Deprivation: endothelial cells and Endothelial progenitor cells are challenged to a transitory Oxygen and Glucose deprivation to study their angio-vasculogenic responses to ischemia and to test how potential treatments that could modify these responses.


Angiogenesis-related techniques: angio-vasculogenic mechanisms are studied in a variety of in vitro assays including Matrigel® tubulogenesis, cell migration using trans-well assays or cell adhesion to a mature monolayer of endothelial cells. Our studies focus on the angio-vasculogenic responses of both Endothelial Progenitor Cells and mature endothelial cells such as the human cell line of microvascular endothelial cells (hCMEC/D3).

   

NMR Imaging: Bruker-BIOSPEC 70/30 USR, 7 T Preclinical MRI System is used for the neuroimaging studies. Neuroimaging studies are conducted in vivo to follow-up the ischemic lesion. Specific sequences are performed to assess axonal degeneration/regeneration and changes in cerebral blood flow and angiogenesis.


IP: Anna Rosell Novel

L5 Cerebral Amyloid Angiopathy

Current project: 

Involment of proteolytic systems in the progression of Cerebral Amyloid Angiopathy


Cerebral amyloid angiopathy (CAA) is produced by the accumulation of ß-amyloid protein within the meningeal and brain vessels. It is the second leading cause of cerebral hemorrhages. However, nowadays, factors related to brain bleedings following amyloid deposition are largely unknown. The understanding of the mollecular mechanisms that lead to cerebral hemorrhage may be the basis for future treatments.

Previous evidences of our group have shown that Matrix Metal•loproteinases (MMPs) are related to brain bleeding. Now, we aim to investigate the relationship between these proteolytic systems and the appearance of intracraneal hemorrages in CAA.


Our study includes:


1) The identification of both tissue and plasma biomarkers for the diagnosis and prognosis of CAA-related hemorrhages.


2) The search of the genetic markers related to proteolytic systems that could determine the risk of suffering a recurrence in CAA.


We are studying a cohort of probable CAA patients that have been recruited in Hospital Vall d’Hebron in collaboration with the Stroke Project of the Cerebrovascular Diseases Study Group (Spanish Society of Neurology).


3) The study of MMPs role in ß-amyloid stimulated vascular cells in vitro.


Cultured cells of the neurovascular unit are challenged with different ß-amyloid peptides and the implication of MMPs in ß-amyloid cleavage and cell toxicity are studied using cellular and molecular biology methodology.


For this purpose, we use the human cerebral endothelial cell line hCMEC/D3, primary cultures of human leptomeningeal smooth muscle cells and rat/mouse glial and neuronal cultures.



Thioflavin-S staining of fibillar ß-amyloid within brain vessels of CAA patient’s sections.



Related bibliography:


1)  Hernández-Guillamon M, Delgado P, Ortega L, Pares M, Rosell A, García-Bonilla  L, Fernández-Cadenas I, Borrell-Pagès M, Boada M, Montaner J. Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. J Neurosci Res. 2009 Jul;87(9):2115-25.


2) Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Lo EH, Montaner J. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke. 2006 Jun;37(6):1399-406.


3)  Alvarez-Sabín J, Delgado P, Abilleira S, Molina CA, Arenillas J, Ribó M, Santamarina E, Quintana M, Monasterio J, Montaner J. Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke. 2004 Jun;35(6):1316-22.


4) Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Ribó M, Quintana M, Alvarez-Sabín J. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation. 2003 Feb 4;107(4):598-603.



Collaborations:

Mercè Boada

Fundació ACE, Barcelona, Spain.

www.fundacioace.com/


Jorge Ghiso and Agueda Rostagno

Pathology Dept. Langone Medical Center. NYU

New York, US.


Ignacio Romero

Life Science Dept. Open University.

Milton Keynes, UK.

IP: Maria Mar Hernandez Guillamon

Projectes

Neurovascular

IP: Anna Rosell Novel
Col·laboradors: -
Entitat finançadora: Fundació Institut de Recerca HUVH
Finançament: 160000
Referència: ROSELL/BOOST/2024
Durada: 15/11/2024 - 14/11/2028

PReDICT: Pediatric Stroke Rare Disorders: Integrative Diagnosis and Treatment using Multi-Omics and Deep Learning

IP: Belen Perez Dueñas
Col·laboradors: Marta Codina Solà, Maria Mar Hernandez Guillamon, Anna Rosell Novel, David Gómez Andrés
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 185165.07
Referència: PMPER24/00021
Durada: 01/01/2025 - 31/12/2026

Tejiendo Ciencia

IP: Ariadna Laguna Tuset
Col·laboradors: Anna Santamaria Margalef, Maria Mar Hernandez Guillamon, Sara Mas Assens
Entitat finançadora: Fundación Española Ciencia y Tecnología (FECYT)
Finançament: 15000
Referència: FCT-2023-19804
Durada: 01/12/2024 - 30/11/2025

Administració endovascular de nanomaterials terapèutics per la recuperació de l’ictus.

IP: Anna Rosell Novel
Col·laboradors: Anna Penalba Morenilla, Kerrie Adrián Campbell, Miguel García Gabilondo
Entitat finançadora: Fundació La Marató de TV3
Finançament: 173750
Referència: 202333-30
Durada: 22/04/2024 - 21/04/2027

Publicacions

Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis.

PMID: 38368420
Revista: Cell Death Discovery
Any: 2024
Referència: Cell Death Discov. 2024 Feb 17;10(1):85. doi: 10.1038/s41420-024-01857-z.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Asensio, Victor; Canellas, Guillem; Capo, Toni; Carcel-Marquez, Jara; Carrera, Caty; Cullell, Natalia; Diaz, Rosa M; Fernandez-Cadenas, Israel; Fernandez-Perez, Isabel; Fleischer, Aarne et al.
DOI: 10.1038/s41420-024-01857-z

Retraction Note: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage.

PMID: 38409072
Revista: Stem Cell Research & Therapy
Any: 2024
Referència: Stem Cell Res Ther. 2024 Feb 27;15(1):50. doi: 10.1186/s13287-024-03667-7.
Factor d'impacte:
Tipus de publicació: Altres (cartes a l'editor, abstracts, correccions, etc.)
Autors: Bugno, Paulina; Duban-Deweer, Sophie; Garcia-Gabilondo, Miguel; Gosselet, Fabien; Grayston, Alba; Hachani, Johan; Kanda, Takashi; Kowalska, Agnieszka; Loiola, Rodrigo Azevedo; Mysiorek, Caroline et al.
DOI: 10.1186/s13287-024-03667-7

Exploratory study of blood biomarkers in patients with post-stroke epilepsy.

PMID: 38557165
Revista: European Stroke Journal
Any: 2024
Referència: Eur Stroke J. 2024 Apr 1:23969873241244584. doi: 10.1177/23969873241244584.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Abraira, Laura; Alvarez Sabin, Jose; Becerra, Juan Luis; Bustamante, Alejandro; Campos-Fernandez, Daniel; Ciurans, Jordi; Fonseca, Elena; Grau-Lopez, Laia; Jimenez, Marta; Lallana, Sofia et al.
DOI: 10.1177/23969873241244584

Retraction Notice: Rapid synthesis of water-dispersible superparamagnetic iron oxide nanoparticles by a microwave-assisted route for safe labeling of endothelial progenitor cells.

PMID: 38569792
Revista: Acta Biomaterialia
Any: 2024
Referència: Acta Biomater. 2024 Apr 1;178:366. doi: 10.1016/j.actbio.2024.03.009.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Barcelo, Veronica; Carenza, Elisa; Montaner, Joan; Morancho, Anna; Roig, Anna; Rosell, Anna et al.
DOI: 10.1016/j.actbio.2024.03.009

Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study.

PMID: 36404260
Revista: Journal of Geriatric Oncology
Any: 2023
Referència: J Geriatr Oncol. 2023 Jan;14(1):101401. doi: 10.1016/j.jgo.2022.10.016. Epub 2022 Nov 18.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arnan, Montserrat; Bonanad, Santiago; Casado, Alfonso; Cruz-Jentoft, Alfonso J; de la Rubia, Javier; Encinas, Cristina; Fernandez, Patricia; Gironella, Mercedes; Gonzalez, Bernardo; Hernandez-Rivas, Jose Angel et al.
DOI: 10.1016/j.jgo.2022.10.016

Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy.

PMID: 36357555
Revista: Brain Imaging and Behavior
Any: 2023
Referència: Brain Imaging Behav. 2023 Feb;17(1):35-43. doi: 10.1007/s11682-022-00738-2. Epub 2022 Nov 10.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Abraira, Laura; Fonseca, Elena; Pareto, Deborah; Quintana, Manuel; Rovira, Alex; Santamarina, Estevo; Sarria-Estrada, Silvana; Toledo, Manuel; Tortajada, Carlos; Turon, Marc et al.
DOI: 10.1007/s11682-022-00738-2

Intensive 90-day textile wearable Holter monitoring: an alternative to detect paroxysmal atrial fibrillation in selected patients with cryptogenic stroke.

PMID: 35882656
Revista: HEART AND VESSELS
Any: 2023
Referència: Heart Vessels. 2023 Jan;38(1):114-121. doi: 10.1007/s00380-022-02141-9. Epub 2022 Jul 27.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Arenillas, Juan F; Boned, Sandra; Cabezas, Juan Antonio; De Lera-Alfonso, Mercedes; de Torres, Reyes; Deck, Matias; Dorado, Laura; Francisco-Pascual, Jaume; Garcia-Tornel, Alvaro et al.
DOI: 10.1007/s00380-022-02141-9

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference.

PMID: 35894842
Revista: EUROPACE
Any: 2023
Referència: Europace. 2023 Feb 8;25(1):6-27. doi: 10.1093/europace/euac062.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arbelo, Elena; Boriani, Giuseppe; Boveda, Serge; Buckley, Claire M; Camm, A John; Casadei, Barbara; Chua, Winnie; Dagres, Nikolaos; Daniel Zink, Matthias; de Melis, Mirko et al.
DOI: 10.1093/europace/euac062

Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia.

PMID: 36501107
Revista: Nutrients
Any: 2022
Referència: Nutrients. 2022 Nov 29;14(23):5077. doi: 10.3390/nu14235077.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Cadiz-Gurrea, Maria de la Luz; Garcia-Rodriguez, Paula; Leyva-Jimenez, Francisco Javier; Ma, Feifei; Menendez-Valladares, Paloma; Montaner, Joan; Najar, Ana M; Perez-Sanchez, Soledad; Ramiro, Laura; Rio, Carmen Del et al.
DOI: 10.3390/nu14235077

[Interarm blood pressure difference: Concordance between two methods of automatic simultaneous measurement and between visits reproducibility].

PMID: 36423568
Revista: Atencion Primaria
Any: 2022
Referència: Aten Primaria. 2022 Dec;54(12):102514. doi: 10.1016/j.aprim.2022.102514. Epub 2022 Nov 21.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Albaladejo, Raquel; Martinez, Luis Miguel; Martinez-Sanchez, Nuria; Palasi, Antonio; Pera, Guillem; Toran, Pere et al.
DOI: 10.1016/j.aprim.2022.102514

Bioevaluation of magnetic mesoporous silica rods: cytotoxicity, cell uptake and biodistribution in zebrafish and rodents.

PMID: 36380961
Revista: RSC Advances
Any: 2022
Referència: RSC Adv. 2022 Nov 7;12(49):31878-31888. doi: 10.1039/d2ra05750f. eCollection 2022 Nov 3.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Gich, Marti; Grayston, Alba; Grzelak, Jan; Roher, Nerea; Roig, Anna; Rosell, Anna; Teles, Mariana et al.
DOI: 10.1039/d2ra05750f

Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas.

PMID: 36259411
Revista: STROKE
Any: 2022
Referència: Stroke. 2022 Dec;53(12):3728-3740. doi: 10.1161/STROKEAHA.122.040768. Epub 2022 Oct 19.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Abad, Fontcuberta; Abidi, El; Abilleira, Sonia; Adell, Vanessa Dr; Agamez, Segovia; Agramunt, Nuria; Aguilo, Oriol; Ajenjo, Prieto; Alaez, San Juan; Alami, Khlifi et al.
DOI: 10.1161/STROKEAHA.122.040768

Neurological presentations of COVID-19: Findings from the Spanish Society of Neurology neuroCOVID-19 registry.

PMID: 33636661
Revista: JOURNAL OF THE NEUROLOGICAL SCIENCES
Any: 2021
Referència: J Neurol Sci. 2021 Apr 15;423:117283. doi: 10.1016/j.jns.2020.117283. Epub 2020 Dec 19.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Abildua, Maria Jose Abenza; Abildua, Maria Jose Abenza; Aguirre, Maria Elena Erro; Alonso, Hortenia; Alvarez, Eric Freire; Alvarez, Javier Villacieros; Andres, Jose Miguel Lainez; Atienza, Saida; Beitia, Garazi Agirre; Borja, Sergio et al.
DOI: 10.1016/j.jns.2020.117283

Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke.

PMID: 34899582
Revista: Frontiers in Neurology
Any: 2021
Referència: Front Neurol. 2021 Nov 25;12:767484. doi: 10.3389/fneur.2021.767484. eCollection 2021.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Beseler, Maria Rosario; Buxo, Xavi; Garcia-Rodriguez, Nicolas; Inzitari, Marco; Martin-Mourelle, Rosa; Miranda-Artieda, Zuberoa Maite; Molleda, Mercedes; Olive-Gadea, Marta; Otero-Villaverde, Sergio; Penalba, Anna et al.
DOI: 10.3389/fneur.2021.767484

Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment.

PMID: 34718757
Revista: NEPHROLOGY DIALYSIS TRANSPLANTATION
Any: 2021
Referència: Nephrol Dial Transplant. 2021 Dec 28;37(Supplement_2):ii23-ii32. doi: 10.1093/ndt/gfab262.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Andrade, Alexandre; Arici, Mustafa; Arici, Mustafa; Bachman, Maie; Bachmann, Maie; Barbieri, Michelangela; Barbieri, Michelangela; Batinic, Bojan; Bikbov, Boris; Blankestijn, Peter et al.
DOI: 10.1093/ndt/gfab262

Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage.

PMID: 34702368
Revista: Stem Cell Research & Therapy
Any: 2021
Referència: Stem Cell Res Ther. 2021 Oct 26;12(1):552. doi: 10.1186/s13287-021-02608-y.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bugno, Paulina; Duban-Deweer, Sophie; Garcia-Gabilondo, Miguel; Gosselet, Fabien; Grayston, Alba; Hachani, Johan; Kanda, Takashi; Kowalska, Agnieszka; Loiola, Rodrigo Azevedo; Mazurek, Maciej Piotr et al.
DOI: 10.1186/s13287-021-02608-y

Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome.

PMID: 33585816
Revista: Brain communications
Any: 2020
Referència: Brain Commun. 2020 Jun 4;2(2):fcaa078. doi: 10.1093/braincomms/fcaa078. eCollection 2020.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Avila-Gomez, Paulo; Bashir, Saima; Bustamante, Alejandro; Campos, Francisco; Castillo, Jose; Correa-Paz, Clara; Dopico-Lopez, Antonio; Fernandez-Susavila, Hector; Gubern, Carme; Hervella, Pablo et al.
DOI: 10.1093/braincomms/fcaa078

Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples.

PMID: 33224099
Revista: Frontiers in Neurology
Any: 2020
Referència: Front Neurol. 2020 Nov 3;11:589628. doi: 10.3389/fneur.2020.589628. eCollection 2020.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Attia, John; Bivard, Andrew; Bustamante, Alejandro; Cadenas, Israel Fernandez; Chan, Jilly; Choi, Philip; Cloud, Geoffrey; Draxler, Dominik F; Garcia-Esperon, Carlos; Gyawali, Prajwal et al.
DOI: 10.3389/fneur.2020.589628

SAA (Serum Amyloid A): A Novel Predictor of Stroke-Associated Infections.

PMID: 33161846
Revista: STROKE
Any: 2020
Referència: Stroke. 2020 Dec;51(12):3523-3530. doi: 10.1161/STROKEAHA.120.030064. Epub 2020 Nov 9.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Azurmendi Gil, Leire; Boned, Sandra; Bustamante, Alejandro; Faura, Julia; Fluri, Felix; Katan, Mira; Lapierre-Fetaud, Vanessa; Luft, Andreas; Montaner, Joan; Sanchez, Jean-Charles et al.
DOI: 10.1161/STROKEAHA.120.030064

Risk of Atrial Fibrillation, Ischemic Stroke and Cognitive Impairment: Study of a Population Cohort >/=65 Years of Age.

PMID: 33149596
Revista: Vascular health and risk management
Any: 2020
Referència: Vasc Health Risk Manag. 2020 Oct 28;16:445-454. doi: 10.2147/VHRM.S276477. eCollection 2020.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Ballesta-Ors, Juan; Bustamante, Alejandro; Clua-Espuny, Jose-Luis; Clua-Queralt, Josep; Gentille-Lorente, Delicia; Lechuga-Duran, Inigo; Lorman-Carbo, Blanca; Montaner, Joan; Munoz, Miguel Angel; Muria-Subirats, Eulalia et al.
DOI: 10.2147/VHRM.S276477

Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.

PMID: 31984233
Revista: European stroke journal
Any: 2019
Referència: Eur Stroke J. 2019 Sep;4(3):254-262. doi: 10.1177/2396987319844690. Epub 2019 Apr 20.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bath, Philip Mw; Bathula, Raj; Christensen, Hanne; Colam, Bridget; Cordonnier, Charlotte; Demotes-Mainard, Jacques; Durand-Zaleski, Isabelle; Gluud, Christian; Jakobsen, Janus Christian; Kallmunzer, Bernd et al.
DOI: 10.1177/2396987319844690

Usefulness of TNFR1 as biomarker of intracranial aneurysm in patients with spontaneous subarachnoid hemorrhage.

PMID: 31915532
Revista: Future science OA
Any: 2019
Referència: Future Sci OA. 2019 Nov 5;6(1):FSO431. doi: 10.2144/fsoa-2019-0090.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bustamante, Alejandro; Canhao, Patricia; de Torres, Reyes; Fragata, Isabel; Mancha, Fernando; Montaner, Joan et al.
DOI: 10.2144/fsoa-2019-0090

Diabetic retinopathy as an independent predictor of subclinical cardiovascular disease: baseline results of the PRECISED study.

PMID: 31908800
Revista: BMJ Open Diabetes Research & Care
Any: 2019
Referència: BMJ Open Diabetes Res Care. 2019 Dec 29;7(1):e000845. doi: 10.1136/bmjdrc-2019-000845. eCollection 2019.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Aguade-Bruix, Santiago; Baneras, Jordi; Boixadera, Anna; Ferreira, Ignacio; Garcia-Arumi, Jose; Garcia-Dorado, David; Genesca, Joan; Gonzalez-Alujas, Teresa; Gutierrez, Laura; Hernandez, Cristina et al.
DOI: 10.1136/bmjdrc-2019-000845

Antibiotic treatment for pneumonia complicating stroke: Recommendations from the pneumonia in stroke consensus (PISCES) group.

PMID: 31903430
Revista: European stroke journal
Any: 2019
Referència: Eur Stroke J. 2019 Dec;4(4):318-328. doi: 10.1177/2396987319851335. Epub 2019 May 27.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bustamante, Alejandro; Chamorro, Angel; Garau, Javier; Jeans, Adam R; Kalra, Lalit; Katan, Mira; Kishore, Amit K; Langhorne, Peter; Meisel, Andreas; Montaner, Joan et al.
DOI: 10.1177/2396987319851335

First assessment of the clinical impact and confirmation of the diagnostic ability of the 18F-FDG-PET/CTA prosthetic valve endocarditis. New data supports initial results

PMID: NOPMID022
Revista: EUROPEAN HEART JOURNAL
Any: 2018
Referència: First assessment of the clinical impact and confirmation of the diagnostic ability of the [...]. EUR HEART J. 39(s1)450
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Aguade Bruix, Santiago; Almirante Gragera, Benito; Castell Conesa, Joan; Cuellar Calabria, Hug; Fernández Hidalgo, Nuria; Ferreira González, Ignacio; García-Dorado García, David; González Alujas, Teresa; Maisterra Santos, Olga; Pizzi , Maria Nazarena et al.
DOI: 10.1093/eurheartj/ehy565.P2274

Incorporating Biomarkers Into a Stroke Research Career.

PMID: 30571440
Revista: STROKE
Any: 2018
Referència: Stroke. 2018 Dec;49(12):e329-e331. doi: 10.1161/STROKEAHA.118.022915.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: De Marchis, Gian Marco; Elkind, Mitchell S V; Garcia-Berrocoso, Teresa; Katan, Mira et al.
DOI: 10.1161/STROKEAHA.118.022915

Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson's Disease: A Pilot Study.

PMID: 30515291
Revista: Parkinsons Disease
Any: 2018
Referència: Parkinsons Dis. 2018 Nov 1;2018:8691495. doi: 10.1155/2018/8691495. eCollection 2018.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; De Fabregues, Oriol; Ferre, Alex; Quintana, Manuel; Romero, Odile et al.
DOI: 10.1155/2018/8691495

Author response: Usefulness of ADAMTS13 to predict response to recanalization therapies in acute ischemic stroke.

PMID: 30397046
Revista: NEUROLOGY
Any: 2018
Referència: Neurology. 2018 Nov 6;91(19):899. doi: 10.1212/WNL.0000000000006466.
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Bustamante, Alejandro; Montaner, Joan et al.
DOI: 10.1212/WNL.0000000000006466

GISCOME - Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study.

PMID: 31008316
Revista: European stroke journal
Any: 2017
Referència: Eur Stroke J. 2017 Sep;2(3):229-237. doi: 10.1177/2396987317704547. Epub 2017 Apr 19.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bevan, Steve; Fernandez-Cadenas, Israel; Hankey, Graeme J; Jern, Christina; Jimenez-Conde, Jordi; Jood, Katarina; Lee, Jin-Moo; Lemmens, Robin; Levi, Christopher; Lindgren, Arne et al.
DOI: 10.1177/2396987317704547

Erratum to "Safety, efficacy and outcome-related factors of perampanel over 12months in a real-world setting: The FYDATA study" [Epilepsy Res. 126 (2016) 201-210].

PMID: 28017504
Revista: EPILEPSY RESEARCH
Any: 2017
Referència: Epilepsy Res. 2017 Jan;129:174-175. doi: 10.1016/j.eplepsyres.2016.12.005. Epub 2016 Dec 22.
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Baigesr, J J; Camacho, J L; Campos, D; Carreno, M; Castillo, A; Esteve, P; Flores, J; Garces, M; Giner, P; Gomez, J B et al.
DOI: 10.1016/j.eplepsyres.2016.12.005

Principles of precision medicine in stroke.

PMID: 27919057
Revista: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Any: 2017
Referència: J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):54-61. doi: 10.1136/jnnp-2016-314587. Epub 2016 Oct 19.
Factor d'impacte:
Tipus de publicació: Revisió en revista nacional
Autors: Arenillas, Juan F; Brown, Scott; Feldmann, Edward; Hinman, Jason D; Leung, Thomas W; Liebeskind, David S; Montaner, Joan; Muir, Keith W; Rost, Natalia S et al.
DOI: 10.1136/jnnp-2016-314587

Profiling and identification of new proteins involved in brain ischemia using MALDI-imaging-mass-spectrometry.

PMID: 27888142
Revista: Journal of Proteomics
Any: 2017
Referència: J Proteomics. 2017 Jan 30;152:243-253. doi: 10.1016/j.jprot.2016.11.014. Epub 2016 Nov 22.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bronsoms, Silvia; Canals, Francesc; Faura, Julia; Feifei, Ma; Garcia-Berrocoso, Teresa; Hernandez-Guillamon, Mar; Llombart, Victor; Montaner, Joan; Morancho, Anna; Rosell, Anna et al.
DOI: 10.1016/j.jprot.2016.11.014

Reply to letter "Remarks on cerebral infarct from another point of view".

PMID: 25064157
Revista: NEUROLOGIA
Any: 2016
Referència: Neurologia. 2016 Mar;31(2):136. doi: 10.1016/j.nrl.2014.06.001. Epub 2014 Jul 23.
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Alonso de Lecinana, M; Caniego, J L; Casado, I; Davalos, A; Diez Tejedor, E; Egido, J A; Martinez-Vila, E; Masjuan, J; Ribo, M et al.
DOI: 10.1016/j.nrl.2014.06.001

The Spanish Neurological Society official clinical practice guidelines in epilepsy.

PMID: 24636132
Revista: NEUROLOGIA
Any: 2016
Referència: Neurologia. 2016 Mar;31(2):121-9. doi: 10.1016/j.nrl.2013.12.020. Epub 2014 Mar 11.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Lopez Gonzalez, F J; Mauri Llerda, J A; Mercade Cerda, J M; Salas Puig, X; Sancho Rieger, J; Toledo Argani, M et al.
DOI: 10.1016/j.nrl.2013.12.020

Admission troponin-I predicts subsequent cardiac complications and mortality in acute stroke patients.

PMID: 31008281
Revista: European stroke journal
Any: 2016
Referència: Eur Stroke J. 2016 Sep;1(3):205-212. doi: 10.1177/2396987316654337. Epub 2016 Jun 21.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Blanco-Grau, Albert; Bustamante, Alejandro; Diaz-Fernandez, Belen; Garcia-Berrocoso, Teresa; Montaner, Joan; Pagola, Jorge; Penalba, Anna; Rubiera, Marta et al.
DOI: 10.1177/2396987316654337

Semi-automatic measuring of arteriovenous relation as a possible silent brain infarction risk index in hypertensive patients.

PMID: 27311989
Revista: Archivos de la Sociedad Espanola de Oftalmologia
Any: 2016
Referència: Arch Soc Esp Oftalmol. 2016 Nov;91(11):513-519. doi: 10.1016/j.oftal.2016.05.001. Epub 2016 Jun 13.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Alzamora Sas, M T; Barandiaran Martirena, I; Beristain Iraola, A; Delgado Martinez, P; Fores, R; Girona Marce, A; Heras Tebar, A; Manresa Dominguez, J M; Riba-Llena, I; Ruiz Bilbao, S M et al.
DOI: 10.1016/j.oftal.2016.05.001

Occult anterograde flow is an under-recognized but crucial predictor of early recanalization with intravenous tissue-type plasminogen activator.

PMID: 25700286
Revista: STROKE
Any: 2015
Referència: Stroke. 2015 Apr;46(4):968-75. doi: 10.1161/STROKEAHA.114.008648. Epub 2015 Feb 19.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Ahn, Seong Hwan; d'Esterre, Christopher D; Demchuk, Andrew M; Fainardi, Enrico; Goyal, Mayank; Hill, Michael D; Lee, Ting Y; Menon, Bijoy K; Najm, Mohammed; Qazi, Emmad M et al.
DOI: 10.1161/STROKEAHA.114.008648

Twelve-Month Clinical and Quality-of-Life Outcomes in the Interventional Management of Stroke III Trial.

PMID: 25858239
Revista: STROKE
Any: 2015
Referència: Stroke. 2015 May;46(5):1321-7. doi: 10.1161/STROKEAHA.115.009180. Epub 2015 Apr 9.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Anderson, Craig; Broderick, Joseph P; Carrozzella, Janice; Demchuk, Andrew M; Engelter, Stefan T; Foster, Lydia D; Goyal, Mayank; Hill, Michael D; Janis, L Scott; Jauch, Edward C et al.
DOI: 10.1161/STROKEAHA.115.009180

Outcomes measured by mortality rates, quality of life and degree of autonomy in the first year in stroke units in Spain.

PMID: 25889480
Revista: HEALTH QUAL LIFE OUT
Any: 2015
Referència: Health Qual Life Outcomes. 2015 Mar 17;13:36. doi: 10.1186/s12955-015-0230-8.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Amandi, Mariano Rebollo; Alvarez-Sabin, Jose; Arenillas Lara, Juan Francisco; Becerra, Virginia; Casado Naranjo, Ignacio; Casado, Miguel Angel; Castillo Sanchez, Jose; Escribano Soriano, Bernardo; Gallego Cullere, Jaime; Gonzalez Rodriguez, Carmen et al.
DOI: 10.1186/s12955-015-0230-8

Prognosis in epilepsy: initiating long-term drug therapy.

PMID: 24745309
Revista: NEUROLOGIA
Any: 2015
Referència: Neurologia. 2015 Jul-Aug;30(6):367-74. doi: 10.1016/j.nrl.2014.03.003. Epub 2014 Apr 16.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Becerra Cunat, J L; Lopez Gonzalez, F J; Mauri Llerda, J A; Mercade Cerda, J M; Molins Albanell, A; Parra Gomez, J; Salas Puig, X; Viteri Torres, C et al.
DOI: 10.1016/j.nrl.2014.03.003

Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage.

PMID: 25287269
Revista: EUROPEAN NEUROLOGY
Any: 2014
Referència: Eur Neurol. 2014;72(3-4):203-8. doi: 10.1159/000362269. Epub 2014 Sep 13.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Boned-Riera, Sandra; Carcamo, Daniel A; Coscojuela, Pilar; Flores, Alan; Meler, Pilar; Molina, Carlos A; Muchada, Marian; Pagola, Jorge; Pineiro, Socorro et al.
DOI: 10.1159/000362269

Impact of time to treatment on tissue-type plasminogen activator-induced recanalization in acute ischemic stroke.

PMID: 25104845
Revista: STROKE
Any: 2014
Referència: Stroke. 2014 Sep;45(9):2734-8. doi: 10.1161/STROKEAHA.114.006222. Epub 2014 Aug 7.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Boned, Sandra; Flores, Alan; Meler, Pilar; Molina, Carlos A; Muchada, Marian; Pagola, Jorge; Ribo, Marc; Rodriguez-Luna, David; Rubiera, Marta et al.
DOI: 10.1161/STROKEAHA.114.006222

Baseline National Institutes of Health stroke scale-adjusted time window for intravenous tissue-type plasminogen activator in acute ischemic stroke.

PMID: 24603070
Revista: STROKE
Any: 2014
Referència: Stroke. 2014 Apr;45(4):1059-63. doi: 10.1161/STROKEAHA.113.004307. Epub 2014 Mar 6.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Flores, Alan; Kallas, Julia; Meler, Pilar; Molina, Carlos A; Muchada, Marian; Pagola, Jorge; Ribo, Marc; Rodriguez-Luna, David; Rubiera, Marta et al.
DOI: 10.1161/STROKEAHA.113.004307

Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment.

PMID: 23044408
Revista: NEUROLOGIA
Any: 2014
Referència: Neurologia. 2014 Jul-Aug;29(6):353-70. doi: 10.1016/j.nrl.2012.07.009. Epub 2012 Oct 6.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Alonso de Lecinana, M; Alvarez-Sabin, J; Arenillas, J; Calleja, S; Casado, I; Castellanos, M; Castillo, J; Davalos, A; Diaz-Otero, F; Diez Tejedor, E et al.
DOI: 10.1016/j.nrl.2012.07.009

The role of citicoline in neuroprotection and neurorepair in ischemic stroke.

PMID: 24961534
Revista: Brain sciences
Any: 2013
Referència: Brain Sci. 2013 Sep 23;3(3):1395-414. doi: 10.3390/brainsci3031395.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Roman, Gustavo C et al.
DOI: 10.3390/brainsci3031395

ADAMTS proteoglycanases in the physiological and pathological central nervous system.

PMID: 24176075
Revista: Journal of Neuroinflammation
Any: 2013
Referència: J Neuroinflammation. 2013 Oct 31;10:133. doi: 10.1186/1742-2094-10-133.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Emery, Evelyne; Kanninen, Katja; Koistinaho, Jari; Lemarchant, Sighild; Montaner, Joan; Pruvost, Mathilde; Vivien, Denis et al.
DOI: 10.1186/1742-2094-10-133

Cardioembolic stroke diagnosis using blood biomarkers.

PMID: 24527683
Revista: Current cardiology reviews
Any: 2013
Referència: Curr Cardiol Rev. 2013 Nov;9(4):340-52.
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Bustamante, Alejandro; Fernandez-Cadenas, Israel; Garcia-Berrocoso, Teresa; Llombart, Victor; Montaner, Joan et al.
DOI:

B-type natriuretic peptides and mortality after stroke: a systematic review and meta-analysis.

PMID: 24186915
Revista: NEUROLOGY
Any: 2013
Referència: Neurology. 2013 Dec 3;81(23):1976-85. doi: 10.1212/01.wnl.0000436937.32410.32. Epub 2013 Nov 1.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Bustamante, Alejandro; Chen, Xingyong; Etgen, Thorleif; Garcia-Berrocoso, Teresa; Giralt, Dolors; Jensen, Jesper K; Montaner, Joan; Saritas, Ayhan; Sharma, Jagdish C; Shibazaki, Kensaku et al.
DOI: 10.1212/01.wnl.0000436937.32410.32

Guidelines for the preventive treatment of ischaemic stroke and TIA (I). Update on risk factors and life style.

PMID: 21890241
Revista: NEUROLOGIA
Any: 2012
Referència: Neurologia. 2012 Nov-Dec;27(9):560-74. doi: 10.1016/j.nrl.2011.06.002. Epub 2011 Sep 3.
Factor d'impacte:
Tipus de publicació: Revisió en revista nacional
Autors: Alonso de Lecinana, M; Alonso de Lecinana, Maria; Alvarez-Sabin, J; Alvarez-Sabin, Jose; Alvarez-Sabin, Jose; Arenillas, J; Arenillas, Juan; Calleja, S; Calleja, Sergio; Casado, I et al.
DOI: 10.1016/j.nrl.2011.06.002

[Translation and validation of the Spanish version of the EAT-10 (Eating Assessment Tool-10) for the screening of dysphagia].

PMID: 23588456
Revista: Nutricion Hospitalaria
Any: 2012
Referència: Nutr Hosp. 2012 Nov-Dec;27(6):2048-54. doi: 10.3305/nh.2012.27.6.6100.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Araujo, K; Barcons, N; Burgos, R; Cardenas, G; Perez-Portabella, C; Puiggros, C; Romagosa, A; Sarto, B; Segurola, H; Vazquez, C et al.
DOI: 10.3305/nh.2012.27.6.6100

Biological markers of nephrotic syndrome: a few steps forward in the long way.

PMID: 23013941
Revista: NEFROLOGIA
Any: 2012
Referència: Nefrologia. 2012;32(5):558-72. doi: 10.3265/Nefrologia.pre2012.Jun.11396.
Factor d'impacte:
Tipus de publicació: Revisió en revista nacional
Autors: Agraz-Pamplona, Irene; Arbos-Via, M Antonia; Carnicer-Caceres, Clara; Ostos-Roldan, Elena; Quiles-Perez, M Teresa; Segarra-Medrano, Alfonso et al.
DOI: 10.3265/Nefrologia.pre2012.Jun.11396

A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke.

PMID: 23280790
Revista: ANNALS OF NEUROLOGY
Any: 2012
Referència: Ann Neurol. 2012 Nov;72(5):716-29. doi: 10.1002/ana.23664.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, J; Arboix, A; Arenillas, J F; Aymerich, N; Canovas, D; Castellanos, Mar; Chacon, Pilar; Cocho, D; Cuadrado-Godia, Elisa; de Vilanova, Arnau et al.
DOI: 10.1002/ana.23664

Thrombolysis improves 90-day functional outcome in acute ischaemic stroke, even in very older people.

PMID: 21447524
Revista: Evidence-based medicine
Any: 2011
Referència: Evid Based Med. 2011 Oct;16(5):136-7. doi: 10.1136/ebm1302. Epub 2011 Mar 29.
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Rubiera, Marta et al.
DOI: 10.1136/ebm1302

A panel of biomarkers including caspase-3 and d-dimer may differentiate acute stroke from stroke-mimicking conditions in the emergency department.

PMID: 21198992
Revista: JOURNAL OF INTERNAL MEDICINE
Any: 2011
Referència: J Intern Med. 2011 Aug;270(2):166-74. doi: 10.1111/j.1365-2796.2010.02329.x. Epub 2010 Dec 27.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1365-2796.2010.02329.x

[Endovenous thrombolysis in a district hospital using the telestroke system].

PMID: 21748711
Revista: REVISTA DE NEUROLOGIA
Any: 2011
Referència: Rev Neurol. 2011 Aug 1;53(3):139-45.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Alvarez-Sabin, J; Brugues, J; Molina, C A; Pedragosa, A; Ribo, M et al.
DOI:

[Stroke health care plan (ICTUS II. 2010).]

PMID: 21163236
Revista: NEUROLOGIA
Any: 2011
Referència: Neurologia. 2011 Sep;26(7):383-96. Epub 2010 Nov 3.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.nrl.2010.05.008

Intra-arterial Administration of Microbubbles and Continuous 2-MHz Ultrasound Insonation to Enhance Intra-arterial Thrombolysis.

PMID: 19226340
Revista: JOURNAL OF NEUROIMAGING
Any: 2010
Referència: J Neuroimaging. 2010 Jul;20(3):224-7. doi: 10.1111/j.1552-6569.2008.00357.x. Epub 2009 Feb 13.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: ; ; ; ; ; et al.
DOI: 10.1111/j.1552-6569.2008.00357.x

Blood biomarkers in cardioembolic stroke.

PMID: 21804778
Revista: Curr Cardiol Rev
Any: 2010
Referència: Curr Cardiol Rev. 2010 Aug;6(3):194-201.
Factor d'impacte:
Tipus de publicació: Carta o abstract
Autors: Delgado, Pilar; Fernandez-Cadenas, Israel; Garcia-Berrocoso, Teresa; Montaner, Joan; Rosell, Anna et al.
DOI: 10.2174/157340310791658767

Novel human pathological mutations. Gene symbol: NOTCH3. Disease: CADASIL.

PMID: 21488300
Revista: HUMAN GENETICS
Any: 2010
Referència: Hum Genet. 2010 Apr;127(4):474.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: del Rio-Espinola, A; Domingues-Montanari, S; Fernandez, M T; Fernandez-Cadenas, I; Fernandez-Morales, J; Garcia-Patos, V; Gutierrez-Agullo, M; Maisterra, O; Mendioroz, M; Montaner, J et al.
DOI:

Novel human pathological mutations. Gene symbol: NOTCH3. Disease: CADASIL.

PMID: 21488283
Revista: HUMAN GENETICS
Any: 2010
Referència: Hum Genet. 2010 Apr;127(4):473-4.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: del Rio-Espinola, A; Delgado, P; Domingues-Montanari, S; Fernandez, M T; Fernandez-Cadenas, I; Fernandez-Morales, J; Gutierrez-Agullo, M; Mendioroz, M; Montaner, J; Sole, E et al.
DOI:

[Primary and secondary prevention of stroke: a guideline]

PMID: 19464713
Revista: MEDICINA CLINICA
Any: 2009
Referència: Med Clin (Barc). 2009 Nov 21;133(19):754-62.
Factor d'impacte:
Tipus de publicació: Revisió o editorial en revista nacional
Autors: Abilleira Castells, Sonia; Alonso Coello, Pablo; Alvarez-Sabin, Jose; Armario Garcia, Pedro; Arrieta Anton, Enrique; Borras Perez, Francesc Xavier; Gil Nunez, Antonio; Maranon Fernandez, Eugenio; Marti Canales, Juan Carlos; Morales Ortiz, Ana et al.
DOI: 10.1016/j.medcli.2009.02.037

Impact of a telemedicine system on acute stroke care in a community hospital.

PMID: 19590033
Revista: JOURNAL OF TELEMEDICINE AND TELECARE
Any: 2009
Referència: J Telemed Telecare. 2009;15(5):260-3.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alonso, Francisco; Alvarez-Sabin, Jose; Martin, M Cruz; Molina, Carlos A; Pedragosa, Angels; Ribo, Marc; Sanclemente, Carmen et al.
DOI: 10.1258/jtt.2009.090102

Blood biomarkers to guide stroke thrombolysis.

PMID: 19482637
Revista: FRONTIERS IN BIOSCIENCE
Any: 2009
Referència: Front Biosci (Elite Ed). 2009 Jun 1;1:200-8.
Factor d'impacte:
Tipus de publicació: Revisió en revista internacional
Autors: Montaner, Joan et al.
DOI:

Is it time to reassess the SITS-MOST criteria for thrombolysis?: A comparison of patients with and without SITS-MOST exclusion criteria.

PMID: 19423853
Revista: STROKE
Any: 2009
Referència: Stroke. 2009 Jul;40(7):2568-71.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Delgado, Pilar; Delgado-Mederos, Raquel; Maisterra, Olga; Molina, Carlos A; Ortega, Gemma; Ribo, Marc; Rubiera, Marta; Santamarina, Estevo et al.
DOI: 10.1161/STROKEAHA.108.538587

MRI findings in aphasic status epilepticus.

PMID: 18522643
Revista: EPILEPSIA
Any: 2008
Referència: Epilepsia. 2008 Aug;49(8):1465-9. doi: 10.1111/j.1528-1167.2008.01620.x. Epub 2008 Jun 3.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Munuera, Josep; Rovira, Alex; Rovira, Rosa; Sueiras, Maria; Toledo, Manuel et al.
DOI: 10.1111/j.1528-1167.2008.01620.x

Lack of evidence for arterial ischemia in transient global amnesia.

PMID: 18187686
Revista: STROKE
Any: 2008
Referència: Stroke. 2008 Feb;39(2):476-9. doi: 10.1161/STROKEAHA.107.498303. Epub 2008 Jan 10.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Grive, Elisenda; Pujadas, Francesc; Quintana, Manuel; Rovira, Alex; Toledo, Manuel et al.
DOI: 10.1161/STROKEAHA.107.498303

Stroke patients with cardiac atrial septal abnormalities: differential infarct patterns on DWI.

PMID: 17032383
Revista: JOURNAL OF NEUROIMAGING
Any: 2006
Referència: J Neuroimaging. 2006 Oct;16(4):334-40. doi: 10.1111/j.1552-6569.2006.00056.x.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Alvarez-Sabin, Jose; Gonzalez-Alujas, M Teresa; Molina, Carlos A; Munoz, Veronica; Ribo, Marc; Rovira, Alex; Rubiera, Marta; Santamarina, Estevo et al.
DOI: 10.1111/j.1552-6569.2006.00056.x

[Functional outcome after one year follow-up in cryptogenetic brain infarction and patent foramen ovale].

PMID: 15860167
Revista: MEDICINA CLINICA
Any: 2005
Referència: Med Clin (Barc). 2005 Apr 23;124(15):561-5. doi: 10.1157/13074135.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Alvarez Sabin, Jose; Evangelista, Arturo; Gonzalez Alujas, M Teresa; Molina, Carlos A; Munoz, Veronica; Quintana, Manuel; Rovira, Alex; Rubiera, Marta; Santamarina, Esteban et al.
DOI: 10.1157/13074135

[Recurrent Transient Global Amnesia, a manifestation of ischemic cerebrovascular disease].

PMID: 16185544
Revista: MEDICINA CLINICA
Any: 2005
Referència: Med Clin (Barc). 2005 Sep 24;125(10):361-5. doi: 10.1157/13079167.
Factor d'impacte:
Tipus de publicació: Article en revista nacional
Autors: Alvarez-Sabin, Jose; Lara, Noemi; Pujadas, Francesc; Purroy, Francisco; Quintana, Manuel; Toledo, Manuel et al.
DOI: 10.1157/13079167

Tesis

Estudi dels factors de risc genètics associats a l'ictus isquèmic.

Doctorand: Jara Cárcel Marquez
Director/s: Israel Fernandez Cadenas
Universitat: Universitat Autònoma de Barcelona
Any: 2023

Estudi del metabolisme lipídic perifèric i l'apolipoproteïna J en l'angiopatia amiloide cerebral

Doctorand: Anna Bonaterra Pastra, Anna Bonaterra Pastra
Director/s: Maria Mar Hernandez Guillamon
Universitat:
Any: 2023

Els biomarcadors sanguinis com a eines per a la prevenció del ictus associat a la fibril·lació auricular

Doctorand: Elena Pala Vila
Director/s: Joan Montaner Villalonga, Alejandro Bustamante Rangel
Universitat: Universidad Autònoma de Barcelona
Any: 2022

Noves estratègies per a la predicció i prevenció de la pneumònia associada a l'ictus

Doctorand: Julia Faura Llorens
Director/s: Alejandro Bustamante Rangel, Joan Montaner Villalonga
Universitat: Universidad Autònoma de Barcelona
Any: 2021

The unique role of Angiogenin in neuroprotection and neurorepair after cerebral ischemia

Doctorand: Ting Lei (Santiago)
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2021

Búsqueda de nuevos biomarcadores en la angiopatía amiloide cerebral

Doctorand: Paula Marazuela Fuentes
Director/s: Maria Mar Hernandez Guillamon
Universitat: Universidad Autònoma de Barcelona
Any: 2021

Progresión de la enfermedad de pequeño vaso cerebral: factores de riesgo, mecanismos implicados y consecuencias clínicas

Doctorand: Joan Jimenez Balado
Director/s: Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2020

Estado de mal epiléptico. Diagnóstico y pronóstico

Doctorand: Gloria Monts. González Cuevas
Director/s: Estevo Santamarina Pérez
Universitat: Universidad Autònoma de Barcelona
Any: 2020

Magnetic Nanomaterials for angiogenic therapies after stroke.

Doctorand: Yajie Zhang
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2020

Efecto de variaciones sobre ApoA-I y ApoJ recombinantes como aproximación terapéutica en el contexto de la Beta-amiloidosis cerebral

Doctorand: Sofia Fernandez De Re Alda
Director/s: Maria Mar Hernandez Guillamon
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Modulació de marcadors de neuroreparació en teràpies rehabilitadores després de l'ictus i en un model pre-clínic d'isquèmia cerebral

Doctorand: Marina Gabriel Salazar
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Potencial terapèutic de nous biomarcadors d'isquèmia cerebral

Doctorand: Alba Simats Oriol
Director/s: Joan Montaner Villalonga, Teresa Garcia Berrocoso
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Human Autonomic and Respiratory Responses to Direct Electrical Cortical Stimulation

Doctorand: Nuria Lacuey Lecumberri, Nuria Lacuey Lecumberri, Nuria Lacuey Lecumberri
Director/s: José Alvarez Sabin
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Impacto de los cambios y el curso de la presión arterial mediante monitorización intensiva en la evolución clínica y radiológica tras una hemorragia intracerebral aguda

Doctorand: Mª Socorro Piñeiro Santos
Director/s: José Alvarez Sabin, David Rodriguez Luna, Carlos Molina Cateriano
Universitat: Universidad Autònoma de Barcelona
Any: 2017

Utilidad de los biomarcadores en el diagnóstico de la enfermedad cerebrovascular silente

Doctorand: Andrea Vilar Bergua
Director/s: Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2016

Condicionantes pronósticos del ictus isquémico: utilidad de los biomarcadores sanguíneos en su predicción

Doctorand: Alejandro Bustamante Rangel
Director/s: Joan Montaner Villalonga, Carlos Molina Cateriano
Universitat: Universidad Autònoma de Barcelona
Any: 2016

Aplicaciones proteómicas para el descubrimiento de biomarcadores diagnósticos en ictus

Doctorand: Victor Llombart Sebastià
Director/s: Joan Montaner Villalonga, Maria Mar Hernandez Guillamon
Universitat: Universitat de Barcelona
Any: 2016

Identificación de biomarcadores en el ictus hemorrágico y su estudio funcional en modelos experimentales

Doctorand: Cristina Merino Zamorano
Director/s: Joan Montaner Villalonga
Universitat: Universidad Autònoma de Barcelona
Any: 2016

Prevalencia y determinantes de las lesiones vasculares cerebrales definidas por resonancia magnética y estudio de la función cognitiva en problación adulta hipertensa y general

Doctorand: Yolanda Riba Llena
Director/s: Joan Montaner Villalonga, Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2015

Dual role of matrix metalloproteinases in brain injury and neurorepais after cerebral ischemia

Doctorand: Feifei Ma
Director/s: Joan Montaner Villalonga, Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2015

Les cèl·lules progenitores endotelials com a tractament neuroreparador angio-vasculogènic en la isquèmia cerebral modulat per la metal·loproteïnasa de matriu 9

Doctorand: Anna Morancho Retana
Director/s: Anna Rosell Novel, Joan Montaner Villalonga
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Identificación y uso de biomarcadores pronósticos en el ictus isquémico

Doctorand: Teresa Garcia Berrocoso
Director/s: Joan Montaner Villalonga, Israel Fernandez Cadenas, Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Eficàcia i seguretat de la Simvastatina administrada en la fase aguda de la isquèmia cerebral experimental

Doctorand: Mireia Campos Martorell
Director/s: Joan Montaner Villalonga, Maria Mar Hernandez Guillamon
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Magnetic nanoparticles suspensions for cell tracking, imaging and therapeutics in ischemia treatments.

Doctorand: Elisa Carenza
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Marcadores biológicos tras la hemorragia intracerebral y su relación con la evolución clínico-radiológica.

Doctorand: Maria Pilar Delgado Martínez
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2006

Proyecto Geno-tPA:Influencia del background genético en la seguridad y eficacia del tratamiento con t-PA en pacientes con ictus isquémico

Doctorand: Israel Fernandez Cadenas
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2006

Les Metal·loproteïnases de Matriu en el Parènquima Cerebral: Implicació en la Isquèmia Cerebral Humana

Doctorand: Anna Rosell Novel
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2005

aterosclerosis intracraneal de gran vaso: progresión y recurrencia clínica

Doctorand: Juan Francisco Arenillas Lara
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2003

Actualitat

Notícies

El 15 de març s’ha celebrat una Jornada de Portes Obertes on la ciutadania ha pogut conèixer les noves instal·lacions i alguns dels projectes dels nostres grups.

El debat s’ha centrat en l’evolució de la investigació i l’assistència de la malaltia, el paper d’infermeria, i l’experiència dels pacients.

Durant tres dies, s’ha celebrat el III Congrés d’Ictus de la xarxa nacional RICORS-ICTUS i un simposi centrat en l’hemorràgia cerebral.