About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35713496 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Jun 17. pii: 6609769. doi: 10.1093/rheumatology/keac361. Impact factor: 7.58 Publication type: Paper in international publication Authors: Prieto-Gonzalez, Sergio, Matas-Garcia, Ana, Guillen-Del-Castillo, Alfredo, Kisluk, Boris, Selva-O'Callaghan, Albert, Espinosa, Gerard, Milisenda, Jose C, Simeon-Aznar, Carmen Pilar, Grau-Junyent, Josep Maria, Garrabou, Gloria et al. DOI: 10.1093/rheumatology/keac361
PMID: 35691226 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2022 Reference: Semin Arthritis Rheum. 2022 Aug;55:152033. doi: 10.1016/j.semarthrit.2022.152033. Epub 2022 May 28. Impact factor: 5.532 Publication type: Paper in international publication Authors: Freire, Mayka, Chamorro, Antonio-J, Perales Fraile, Isabel, Madronero Vuelta, Ana Belen, Sanchez Trigo, Sabela, Tolosa Vilella, Carles, Fonollosa Pla, Vicent, Simeon Aznar, Carmen Pilar, Herranz Marin, Maria Teresa, Trapiella Martinez, Luis et al. DOI: 10.1016/j.semarthrit.2022.152033
PMID: 35626355 Journal: Diagnostics Year: 2022 Reference: Diagnostics (Basel). 2022 May 11;12(5). pii: diagnostics12051200. doi: 10.3390/diagnostics12051200. Impact factor: 3.706 Publication type: Review in international publication Authors: Matas-Garcia, Ana, Milisenda, Jose C, Espinosa, Gerard, Cuatrecasas, Miriam, Selva-O'Callaghan, Albert, Grau, Josep Maria, Prieto-Gonzalez, Sergio et al. DOI: 10.3390/diagnostics12051200
PMID: 35628558 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 May 20;23(10). pii: ijms23105748. doi: 10.3390/ijms23105748. Impact factor: 5.924 Publication type: Paper in international publication Authors: Mariscal, Anais, Zamora, Carlos, Diaz-Torne, Cesar, Ortiz, M Angels, Agustin, Juan Jose de, Reina, Delia, Estrada, Paula, Moya, Patricia, Corominas, Hector, Vidal, Silvia et al. DOI: 10.3390/ijms23105748
PMID: 33541851 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2021 Reference: J Investig Allergol Clin Immunol. 2021 Dec 21;31(6):461-470. doi: 10.18176/jiaci.0675. Epub 2020 Feb 5. Impact factor: Publication type: Review in international publication Authors: Escribese, M M; Labrador-Horrillo, M; Longo, N; Luengo-Sanchez, O; Matheu, V; Matito, A; Mayorga, C; Pascal, M; Perez-Gordo, M; Seoane-Reula, M E et al. DOI: 10.18176/jiaci.0675
PMID: 33493294 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Oct 2;60(10):4538-4547. doi: 10.1093/rheumatology/keab027. Impact factor: Publication type: Paper in international publication Authors: Garcia-Vives, Eloi; Harty, Len; Jayne, David; Rodriguez-Palomares, J F; Solans-Laque, Roser et al. DOI: 10.1093/rheumatology/keab027
PMID: 33020895 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2021 Reference: Clin Exp Immunol. 2021 Feb;203(2):209-218. doi: 10.1111/cei.13530. Epub 2020 Nov 2. Impact factor: Publication type: Paper in international publication Authors: Amengual, Ma Jose; Feijoo, Carlos; Loureiro-Amigo, Jose; Marin, Ana; Monsalvez, Victor; Oristrell, Joaquim; Segarra, Alfons; Solans, Roser; Tolosa, Carles; Valenzuela, Ma Pau et al. DOI: 10.1111/cei.13530
PMID: 32730636 Journal: BRITISH JOURNAL OF DERMATOLOGY Year: 2021 Reference: Br J Dermatol. 2021 Jan;184(1):167-168. doi: 10.1111/bjd.19425. Epub 2020 Sep 2. Impact factor: Publication type: Letter or abstract Authors: Aguilera Peiro, P; Baliu-Pique, C; Bonfill Orti, M; Curto Barredo, L; Exposito-Serrano, V; Fernandez Chico, N; Figueras Nart, I; Gimenez-Arnau, A; Gomez Armayones, S; Guilabert Vidal, A et al. DOI: 10.1111/bjd.19425
PMID: 31873754 Journal: RHEUMATOLOGY Year: 2020 Reference: Rheumatology (Oxford). 2020 Sep 1;59(9):2350-2359. doi: 10.1093/rheumatology/kez578. Impact factor: 5.606 Publication type: Paper in international publication Authors: Sanchez-Guerrero, Jorge, Brito-Zeron, Pilar, Acar-Denizli, Nihan, Ng, Wan-Fai, Bootsma, Hendrika, Nakamura, Hideki, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele et al. DOI: 10.1093/rheumatology/kez578
PMID: 32441643 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2020 Reference: Clin Exp Rheumatol. 2020 Mar-Apr;38 Suppl 124(2):112-119. Epub 2020 May 21. Impact factor: 3.319 Publication type: Paper in international publication Authors: Calderon-Goercke, Monica, Castaneda, Santos, Aldasoro, Vicente, Villa, Ignacio, Prieto-Pena, Diana, Atienza-Mateo, Belen, Patino, Esther, Moriano, Clara, Romero-Yuste, Susana, Narvaez, Javier et al. DOI:
PMID: 32843099 Journal: ARTHRITIS RESEARCH & THERAPY Year: 2020 Reference: Arthritis Res Ther. 2020 Aug 25;22(1):196. doi: 10.1186/s13075-020-02287-9. Impact factor: 4.103 Publication type: Paper in international publication Authors: Julia, Antonio, Avila, Gabriela, Celis, Raquel, Sanmarti, Raimon, Ramirez, Julio, Marsal, Sara, Canete, Juan D et al. DOI: 10.1186/s13075-020-02287-9
PMID: 32766318 Journal: Journal of Immunology Research Year: 2020 Reference: J Immunol Res. 2020 Jul 16;2020:6292631. doi: 10.1155/2020/6292631. eCollection 2020. Impact factor: 3.327 Publication type: Paper in international publication Authors: Baucells, Andres, Martinez, Maria Angeles, Alvarado-Cardenas, Marcelo, Mariscal, Anais, Martinez-Martinez, Laura, Juarez, Candido, Selva-O'Callaghan, Albert et al. DOI: 10.1155/2020/6292631
PMID: 30442823 Journal: JOURNAL OF RHEUMATOLOGY Year: 2019 Reference: J Rheumatol. 2019 Mar;46(3):279-284. doi: 10.3899/jrheum.180355. Epub 2018 Nov 15. Impact factor: 3.634 Publication type: Paper in international publication Authors: Mosca, Marta, Bauhammer, Jutta, Miehle, Nikolaus, Parisi, Simone, Cavagna, Lorenzo, Codullo, Veronica, Montecucco, Carlomaurizio, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Nieto-Gonzalez, Juan Carlos et al. DOI: 10.3899/jrheum.180355
PMID: 30535994 Journal: CLINICAL RHEUMATOLOGY Year: 2019 Reference: Clin Rheumatol. 2019 Apr;38(4):1117-1124. doi: 10.1007/s10067-018-4390-x. Epub 2018 Dec 7. Impact factor: 2.293 Publication type: Paper in international publication Authors: Chamorro, A J, Todoli-Parra, Jose A, Rodriguez-Carballeira, Monica, Espinosa-Garriga, Gerard, Colunga-Arguelles, Dolores, Ortego-Centeno, Norberto, Trapiella-Martinez, Luis, Rodero-Roldan, Maria M, Pla-Salas, Xavier, Perales-Fraile, Isabel et al. DOI: 10.1007/s10067-018-4390-x
PMID: 30222111 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Investig Allergol Clin Immunol. 2019;29(5):338-348. doi: 10.18176/jiaci.0323. Epub 2018 Sep 17. Impact factor: 3.802 Publication type: Review in international publication Authors: Ferrer Puga, M, Silvestre Salvador, F J, Sastre, J, Ortiz de Frutos, J, Miquel Miquel, F J, Gimenez Arnau, A M, Valero Santiago, A, Bartra Tomas, J, Jauregui Presa, I, Labrador-Horrillo, M et al. DOI: 10.18176/jiaci.0323
PMID: 30273709 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 Mar;143(3):864-879. doi: 10.1016/j.jaci.2018.08.049. Epub 2018 Sep 29. Impact factor: 14.11 Publication type: Paper in international publication Authors: Okubo, Ken, Bousquet, Jean, Hellings, Peter W, Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J, Anto, Josep M, Bachert, Claus, Bateman, Eric D et al. DOI: 10.1016/j.jaci.2018.08.049
PMID: 30044938 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2018 Reference: N Engl J Med. 2018 Jul 26;379(4):352-362. doi: 10.1056/NEJMoa1716995. Impact factor: 79.258 Publication type: Clinical Trials Authors: Aygoren-Pursun, Emel, Bygum, Anette, Grivcheva-Panovska, Vesna, Magerl, Markus, Graff, Jochen, Maurer, Marcus, Cicardi, Marco, Sheridan, William, Collis, Phil, Fang, Lei et al. DOI: 10.1056/NEJMoa1716995
PMID: 30048251 Journal: Current Opinion in Allergy and Clinical Immunology Year: 2018 Reference: Curr Opin Allergy Clin Immunol. 2018 Oct;18(5):370-376. doi: 10.1097/ACI.0000000000000472. Impact factor: 3.544 Publication type: Review in international publication Authors: Sala-Cunill, Anna, Guilarte, Mar, Cardona, Victoria et al. DOI: 10.1097/ACI.0000000000000472
PMID: 30033702 Journal: Emergencias Year: 2018 Reference: Emergencias. 2018 Ago;30(4):268-277. Impact factor: 3.608 Publication type: Paper in international publication Authors: Pinera Salmeron, Pascual, Delgado Romero, Julio, Dominguez Ortega, Javier, Labrador Horrillo, Moises, Alvarez Gutierrez, Francisco J, Martinez Moragon, Eva, Plaza Moral, Vicente, Alvarez Rodriguez, Cesareo, Miguel Franco, Jose et al. DOI:
PMID: 30005858 Journal: AUTOIMMUNITY REVIEWS Year: 2018 Reference: Autoimmun Rev. 2018 Sep;17(9):900-905. doi: 10.1016/j.autrev.2018.03.015. Epub 2018 Jul 11. Impact factor: 8.745 Publication type: Review in national publication Authors: Sanz Perez, I, Martinez Valle, F, Guillen Del Castillo, A, Roque Perez, A, Cuellar Calabria, H, Pizzi, M N, Fernandez Codina, A, Callejas Moragas, E, Orozco Galvez, O, Fonollosa Pla, V et al. DOI: 10.1016/j.autrev.2018.03.015
PMID: 27609533 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2017 Reference: J Investig Allergol Clin Immunol. 2017;27(2):98-103. doi: 10.18176/jiaci.0110. Epub 2016 Sep 9. Impact factor: 2.131 Publication type: Paper in international publication Authors: Cardona, V, Pastor-Vargas, C, Cuesta-Herranz, J, Moreno-Perez, N, Luengo-Sanchez, O, Munoz-Garcia, E et al. DOI: 10.18176/jiaci.0110
PMID: 27439141 Journal: ALLERGY Year: 2017 Reference: Allergy. 2017 Jan;72(1):35-42. doi: 10.1111/all.12989. Epub 2016 Aug 15. Impact factor: 6.335 Publication type: Paper in international publication Authors: Luengo, Olga, Cardona, Victoria, Labrador, Moises et al. DOI: 10.1111/all.12989
PMID: 27269294 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2017 Reference: Ann Rheum Dis. 2017 Jan;76(1):196-202. doi: 10.1136/annrheumdis-2015-208918. Epub 2016 Jun 7. Impact factor: 12.384 Publication type: Paper in international publication Authors: Diaz-Gonzalez, Federico, DelaRosa, Olga, Alvaro-Gracia, Jose M, Jover, Juan A, Garcia-Vicuna, Rosario, Carreno, Luis, Alonso, Alberto, Marsal, Sara, Blanco, Francisco, Martinez-Taboada, Victor M et al. DOI: 10.1136/annrheumdis-2015-208918
PMID: 27258623 Journal: BRITISH JOURNAL OF DERMATOLOGY Year: 2017 Reference: Br J Dermatol. 2017 Mar;176(3):643-649. doi: 10.1111/bjd.14776. Epub 2016 Oct 3. Impact factor: 4.317 Publication type: Paper in international publication Authors: Rivera, Raquel, Garcia-Doval, I, Hernandez, M V, Vanaclocha, F, Sellas, A, de la Cueva, P, Montero, D, Rodriguez, Basilio, Erausquin, Celia, Rua, Inigo et al. DOI: 10.1111/bjd.14776
PMID: 26607825 Journal: ACTA DIABETOLOGICA Year: 2016 Reference: Acta Diabetol. 2016 Oct;53(5):857-8. doi: 10.1007/s00592-015-0818-9. Epub 2015 Nov 25. Impact factor: 3.074 Publication type: Letter or abstract Authors: Jose, Antonio San, Formiga, Francesc, Agusti, Antonia et al. DOI: 10.1007/s00592-015-0818-9
PMID: 27050764 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2016 Reference: Clin Exp Rheumatol. 2016 Sep-Oct;34(6 Suppl 102):S41-S45. Epub 2016 Apr 1. Impact factor: 2.495 Publication type: Paper in international publication Authors: Garcia-Lozano, Jose-Raul, Conde-Jaldon, Marta, Ortego-Centeno, Norberto, Gonzalez-Leon, Rocio, Espinosa, Gerard, Grana-Gil, Genaro, Sanchez-Burson, Juan, Julia, Maria Rosa, Solans, Roser, Blanco, Ricardo et al. DOI:
PMID: 25480887 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2016 Reference: Ann Rheum Dis. 2016 Feb;75(2):382-9. doi: 10.1136/annrheumdis-2014-206008. Epub 2014 Dec 5. Impact factor: 12.384 Publication type: Paper in international publication Authors: Praprotnik, Sonja, Sumida, Takayuki, Nishiyama, Sumusu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Meiners, Petra, Brito-Zeron, Pilar, Vitali, Claudio et al. DOI: 10.1136/annrheumdis-2014-206008
PMID: 25433020 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2016 Reference: Ann Rheum Dis. 2016 Feb;75(2):348-55. doi: 10.1136/annrheumdis-2014-206418. Epub 2014 Nov 28. Impact factor: 9.27 Publication type: Paper in international publication Authors: Ramos-Casals, M, Retamozo, S, Gheitasi, H, Morera-Morales, M L, Brito-Zeron, P, Kostov, B, Solans, R, Fraile, G, Casanovas, A, Rascon, F J et al. DOI: 10.1136/annrheumdis-2014-206418
PMID: 25641891 Journal: JOURNAL OF RHEUMATOLOGY Year: 2015 Reference: J Rheumatol. 2015 Apr;42(4):695-701. doi: 10.3899/jrheum.140949. Epub 2015 Feb 1. Impact factor: 3.187 Publication type: Paper in international publication Authors: Ortiz-Fernandez, Lourdes, Garcia-Lozano, Jose-Raul, Montes-Cano, Marco-Antonio, Conde-Jaldon, Marta, Ortego-Centeno, Norberto, Garcia-Hernandez, Francisco-Jose, Espinosa, Gerard, Grana-Gil, Genaro, Sanchez-Burson, Juan, Blanco, Ricardo et al. DOI: 10.3899/jrheum.140949
PMID: 25752415 Journal: MOLECULAR GENETICS AND METABOLISM Year: 2015 Reference: Mol Genet Metab. 2015 Apr;114(4):580-3. doi: 10.1016/j.ymgme.2015.02.004. Epub 2015 Feb 21. Impact factor: 2.625 Publication type: Paper in international publication Authors: Perez-Lopez, Jordi, Selva-O'Callaghan, Albert, Grau-Junyent, Josep M, Gallego-Galindo, Luis, Coll, M Josep, Garcia-Morillo, Salvador, Torralba-Cabeza, Miguel A, Vilardell-Tarres, Miquel et al. DOI: 10.1016/j.ymgme.2015.02.004
PMID: 26266361 Journal: MEDICINE Year: 2015 Reference: Medicine (Baltimore). 2015 Aug;94(32):e1275. doi: 10.1097/MD.0000000000001275. Impact factor: 5.723 Publication type: Paper in international publication Authors: DeTorres, Ines, Solans-Laque, Roser, Fraile-Rodriguez, Guadalupe, Casanovas-Martinez, Arnau, Lopez-Dupla, Miguel, Robles-Marhuenda, Angel, Barragan-Gonzalez, Maria Jesus, Cid, Maria Cinta, Prieto-Gonzalez, Sergio, Brito-Zeron, Pilar et al. DOI: 10.1097/MD.0000000000001275
PMID: 25209656 Journal: GUT Year: 2015 Reference: Gut. 2015 Sep;64(9):1379-88. doi: 10.1136/gutjnl-2013-306236. Epub 2014 Sep 10. Impact factor: 13.319 Publication type: Paper in international publication Authors: Vicario, Maria, Gonzalez-Castro, Ana M, Martinez, Cristina, Lobo, Beatriz, Pigrau, Marc, Guilarte, Mar, de Torres, Ines, Mosquera, Jose L, Fortea, Marina, Sevillano-Aguilera, Cesar et al. DOI: 10.1136/gutjnl-2013-306236
PMID: 24625627 Journal: ANN RHEUM DIS Year: 2014 Reference: Ann Rheum Dis. 2014 Jul;73(7):1433-4. doi: 10.1136/annrheumdis-2013-205156. Epub 2014 Mar 13. Impact factor: 9.27 Publication type: Letter or abstract Authors: Ortiz-Fernandez, Lourdes, Conde-Jaldon, Marta, Garcia-Lozano, Jose Raul, Montes-Cano, Marco Antonio, Ortego-Centeno, Norberto, Castillo-Palma, Maria Jesus, Espinosa, Gerard, Grana-Gil, Genaro, Sanchez-Burson, Juan, Gonzalez-Gay, Miguel Angel et al. DOI: 10.1136/annrheumdis-2013-205156
PMID: 24919468 Journal: ANN RHEUM DIS Year: 2014 Reference: Ann Rheum Dis. 2014 Sep;73(9):1742-5. doi: 10.1136/annrheumdis-2014-205261. Epub 2014 Jun 11. Impact factor: 9.27 Publication type: Paper in international publication Authors: Narvaez, J, Gomez-Vaquero, C, Martinez-Taboada, V M, Ortego-Centeno, N, Sopena, B, Monfort, J, Garcia-Villanueva, M J, Caminal-Montero, L, de Miguel, E, Blanco, R et al. DOI: 10.1136/annrheumdis-2014-205261
PMID: 24952504 Journal: NAT IMMUNOL Year: 2014 Reference: Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22. Impact factor: 24.973 Publication type: Paper in international publication Authors: Martin-Sanchez, Fatima, Gomez, Ana I, Martinez, Carlos M, Amores-Iniesta, Joaquin, Compan, Vincent, Barbera-Cremades, Maria, Yague, Jordi, Ruiz-Ortiz, Estibaliz, Anton, Jordi, Bujan, Segundo et al. DOI: 10.1038/ni.2919
PMID: 25019531 Journal: PLOS ONE Year: 2014 Reference: PLoS One. 2014 Jul 14;9(7):e102100. doi: 10.1371/journal.pone.0102100. eCollection 2014. Impact factor: 3.534 Publication type: Paper in international publication Authors: Solans, Roser, Fanlo, Patricia, Carballeira, Monica Rodriguez, Camps, Teresa, Castaneda, Santos, Martin, Javier, Gonzalez-Escribano, Maria Francisca, Barnosi-Marin, Ana Celia, Gonzalez-Gay, Miguel Angel, Grana-Gil, Genaro et al. DOI: 10.1371/journal.pone.0102100
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The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.