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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Publications

Management of anaphylaxis due to COVID-19 vaccines in the elderly.

PMID: 33811358
Journal: ALLERGY
Year: 2021
Reference: Allergy. 2021 Oct;76(10):2952-2964. doi: 10.1111/all.14838.
Impact factor: 13.146
Publication type: Paper in international publication
Authors: Bosnic-Anticevich, Sinthia, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, M Beatrice, Czarlewski, Wienczyslawa et al.
DOI: 10.1111/all.14838

Hypoglycemia as an onset form of hypophysial infiltration by lymphoma.

PMID: 32423687
Journal: MEDICINA CLINICA
Year: 2021
Reference: Med Clin (Barc). 2021 Apr 9;156(7):362-363. doi: 10.1016/j.medcli.2020.01.040. Epub 2020 May 16.
Impact factor: 1.725
Publication type: Letter or abstract
Authors: Vega-Cano, Sharela, Cordero-Vazquez, Efrain, Mestre-Torres, Jaume et al.
DOI: 10.1016/j.medcli.2020.01.040

The diagnosis and management of allergic reactions in patients sensitized to non-specific lipid transfer proteins.

PMID: 33655502
Journal: ALLERGY
Year: 2021
Reference: Allergy. 2021 Aug;76(8):2433-2446. doi: 10.1111/all.14797. Epub 2021 Mar 27.
Impact factor: 13.146
Publication type: Review in international publication
Authors: Skypala, Isabel J, Bartra, Joan, Ebo, Didier G, Antje Faber, Margaretha, Fernandez-Rivas, Montserrat, Gomez, Francisca, Luengo, Olga, Till, Stephen J, Asero, Riccardo, Barber, Domingo et al.
DOI: 10.1111/all.14797

Corrigendum to 'Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation' [AUTREV 19-5 (2020) 102507].

PMID: 33766615
Journal: AUTOIMMUNITY REVIEWS
Year: 2021
Reference: Autoimmun Rev. 2021 May;20(5):102793. doi: 10.1016/j.autrev.2021.102793. Epub 2021 Mar 22.
Impact factor: 9.754
Publication type: Letter or abstract
Authors: Rubio-Rivas, Manuel, Corbella, Xavier, Guillen-Del-Castillo, Alfredo, Vilella, Carles Tolosa, Arguelles, Dolores Colunga, Aznar, Carmen Pilar Simeon, Pla, Vicent Fonollosa, Trigo, Sabela Sanchez, de la Puebla Gimenez, Rafael Angel Fernandez, Argibay, Ana et al.
DOI: 10.1016/j.autrev.2021.102793

2019 ARIA Care pathways for allergen immunotherapy.

PMID: 30955224
Journal: ALLERGY
Year: 2019
Reference: Allergy. 2019 Nov;74(11):2087-2102. doi: 10.1111/all.13805. Epub 2019 Jul 15.
Impact factor: 6.771
Publication type: Paper in international publication
Authors: Wallace, D, Caraballo, L, Cardona, V, Casale, T, Cecchi, L, Chu, D K, Costa, E, Cruz, A A, Czarlewski, W, Durham, S R et al.
DOI: 10.1111/all.13805

[Prevalence of ten Immune-mediated inflammatory diseases (IMID) in Spain].

PMID: 30907380
Journal: Revista Espanola de Salud Publica
Year: 2019
Reference: Rev Esp Salud Publica. 2019 Mar 25;93.
Impact factor: 0.635
Publication type: Letter or abstract
Authors: Arraiza, Antonio, Casado, Paloma, Codesido, Maria, Pascual, Cesar, Saldana, Roberto, Gil, Angel, Palau, Javier, Hinojosa, Joaquin, Marsal, Sara, Puig, Lluis et al.
DOI:

Autoreactive B-Lymphocytes in SLE and RA patients: Isolation and characterisation using extractable nuclear and citrullinated antigens bound to immunobeads.

PMID: 30893475
Journal: EUROPEAN JOURNAL OF IMMUNOLOGY
Year: 2019
Reference: Eur J Immunol. 2019 Jul;49(7):1107-1116. doi: 10.1002/eji.201848065. Epub 2019 Apr 2.
Impact factor: 4.695
Publication type: Paper in international publication
Authors: Medina-Varo, Fermin, Rodriguez, Carmen, Anez, Gustavo A, Campos-Caro, Antonio, Rodriguez-Bayona, Beatriz, de la Varga-Martinez, Raquel et al.
DOI: 10.1002/eji.201848065

Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis.

PMID: 30872671
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Mar 14;9(1):4579. doi: 10.1038/s41598-019-40874-2.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Arostegui, Juan I, Rabionet, Raquel, Remesal, Agustin, Mensa-Vilaro, Anna, Murias, Sara, Alcobendas, Rosa, Gonzalez-Roca, Eva, Ruiz-Ortiz, Estibaliz, Anton, Jordi, Iglesias, Estibaliz et al.
DOI: 10.1038/s41598-019-40874-2

Novel evidences of atypical manifestations in cryopyrin-associated periodic syndromes.

PMID: 28079503
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2017
Reference: Clin Exp Rheumatol. 2017 Nov-Dec;35 Suppl 108(6):27-31. Epub 2017 Jan 9.
Impact factor: 2.634
Publication type: Paper in international publication
Authors: Bujan-Rivas, Segundo, Basagana, Maria, Sena, Francisca, Mendez, Maria, Dordal, Maria Teresa, Gonzalez-Roca, Eva, Ruiz-Ortiz, Estibaliz, Mensa-Vilaro, Anna, Plaza, Susana, Modesto, Consuelo et al.
DOI:

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.

PMID: 28041642
Journal: AMERICAN JOURNAL OF HUMAN GENETICS
Year: 2017
Reference: Am J Hum Genet. 2017 Jan 5;100(1):64-74. doi: 10.1016/j.ajhg.2016.11.013. Epub 2016 Dec 29.
Impact factor: 9.025
Publication type: Paper in international publication
Authors: Schonau, Verena, Monach, Paul A, Castaneda, Santos, Solans, Roser, Morado, Inmaculada C, Narvaez, Javier, Ramentol-Sintas, Marc, Pease, Colin T, Dasgupta, Bhaskar, Watts, Richard et al.
DOI: 10.1016/j.ajhg.2016.11.013

Treatment and management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: all roads lead to Rome.

PMID: 28052319
Journal: BRITISH JOURNAL OF PHARMACOLOGY
Year: 2017
Reference: Br J Pharmacol. 2017 Mar;174(5):345-369. doi: 10.1111/bph.13702. Epub 2017 Feb 1.
Impact factor: 5.491
Publication type: Review in national publication
Authors: Castro-Marrero, Jesus, Saez-Francas, Naia, Santillo, Dafna, Alegre, Jose et al.
DOI: 10.1111/bph.13702

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

PMID: 27999855
Journal: Journal of Nutrition Health & Aging
Year: 2017
Reference: J Nutr Health Aging. 2017;21(1):92-104. doi: 10.1007/s12603-016-0803-1.
Impact factor: 2.772
Publication type: Paper in international publication
Authors: Siciliano, P, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I et al.
DOI: 10.1007/s12603-016-0803-1

The diagnosis and classification of polymyositis.

PMID: 24461380
Journal: J AUTOIMMUN
Year: 2014
Reference: J Autoimmun. 2014 Feb-Mar;48-49:118-21. doi: 10.1016/j.jaut.2014.01.025. Epub 2014 Jan 22.
Impact factor: 7.018
Publication type: Review in international publication
Authors: Milisenda, J C, Selva-O'Callaghan, A, Grau, J M et al.
DOI: 10.1016/j.jaut.2014.01.025

Basal functional status predicts three-month mortality after a heart failure hospitalization in elderly patients - The prospective RICA study.

PMID: 24452223
Journal: INT J CARDIOL
Year: 2014
Reference: Int J Cardiol. 2014 Mar 1;172(1):127-31. doi: 10.1016/j.ijcard.2013.12.169. Epub 2014 Jan 8.
Impact factor: 6.175
Publication type: Paper in international publication
Authors: Formiga, Francesc, Chivite, David, Conde, Alicia, Ruiz-Laiglesia, Fernando, Franco, Alvaro Gonzalez, Bocanegra, Carmen Perez, Manzano, Luis, Perez-Barquero, Manuel Montero et al.
DOI: 10.1016/j.ijcard.2013.12.169

An inter-rater reliability study of the prescribing indicated medications quality indicators of the Assessing Care Of Vulnerable Elders (ACOVE) 3 criteria as a potentially inappropriate prescribing tool.

PMID: 24438879
Journal: ARCH GERONTOL GERIAT
Year: 2014
Reference: Arch Gerontol Geriatr. 2014 May-Jun;58(3):460-4. doi: 10.1016/j.archger.2013.12.006. Epub 2014 Jan 2.
Impact factor: 1.525
Publication type: Paper in international publication
Authors: San-Jose, Antonio, Agusti, Antonia, Vidal, Xavier, Barbe, Jose, Torres, Olga H, Ramirez-Duque, Nieves, Garcia, Juana, Fernandez-Moyano, Antonio, Lopez-Soto, Alfonso, Formiga, Francesc et al.
DOI: 10.1016/j.archger.2013.12.006

The 'Sparing Phenomenon' of Purpuric Rash over Tattooed Skin.

PMID: 24356492
Journal: DERMATOLOGY
Year: 2014
Reference: Dermatology. 2014;228(1):27-30. doi: 10.1159/000356779. Epub 2013 Dec 14.
Impact factor: 1.685
Publication type: Paper in international publication
Authors: Pinal-Fernandez, Iago, Solans-Laque, Roser et al.
DOI: 10.1159/000356779

Blog

News

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.

The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.