About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35460231 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Apr 23. pii: 6572805. doi: 10.1093/rheumatology/keac252. Impact factor: 7.58 Publication type: Paper in international publication Authors: Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Sanz-Martinez, Maria Teresa et al. DOI: 10.1093/rheumatology/keac252
PMID: 35452853 Journal: AUTOIMMUNITY REVIEWS Year: 2022 Reference: Autoimmun Rev. 2022 Jun;21(6):103101. doi: 10.1016/j.autrev.2022.103101. Epub 2022 Apr 20. Impact factor: 9.754 Publication type: Review in international publication Authors: Jarne-Borras, Marina, Miro-Mur, Francesc, Anunciacion-Llunell, Ariadna, Alijotas-Reig, Jaume et al. DOI: 10.1016/j.autrev.2022.103101
PMID: 35432370 Journal: Frontiers in Immunology Year: 2022 Reference: Front Immunol. 2022 Mar 31;13:873019. doi: 10.3389/fimmu.2022.873019. eCollection 2022. Impact factor: 7.561 Publication type: Paper in international publication Authors: Olivera-Ardid, Sara, Bello-Gil, Daniel, Tuzikov, Alexander, Araujo, Ricardo N, Ferrero-Alves, Yara, Garcia Figueroa, Blanca Esther, Labrador-Horrillo, Moises, Garcia-Perez, Ana L, Bovin, Nicolai, Manez, Rafael et al. DOI: 10.3389/fimmu.2022.873019
PMID: 34147248 Journal: MEDICINA CLINICA Year: 2022 Reference: Med Clin (Barc). 2022 Apr 8;158(7):301-307. doi: 10.1016/j.medcli.2021.03.005. Epub 2021 May 6. Impact factor: 1.725 Publication type: Paper in national publication Authors: Cardona-Pascual, Ignacio, Berlana, David, Martinez-Valle, Ferran, Campany-Herrero, David, Montoro-Ronsano, Jose Bruno et al. DOI: 10.1016/j.medcli.2021.03.005
PMID: 34597274 Journal: JOURNAL OF CLINICAL INVESTIGATION Year: 2021 Reference: J Clin Invest. 2021 Dec 1;131(23). pii: 152386. doi: 10.1172/JCI152386. Impact factor: 14.808 Publication type: Paper in international publication Authors: O'Byrne, Sheila M, Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Nafria-Jimenez, Beatriz, Hov, Johannes R, Migeotte, Isabelle, Renieri, Alessandra et al. DOI: 10.1172/JCI152386
PMID: 34096881 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2021 Reference: Ann Rheum Dis. 2021 Apr 1. pii: annrheumdis-2021-219884. doi: 10.1136/annrheumdis-2021-219884. Impact factor: 19.103 Publication type: Paper in international publication Authors: Distler, J H W, Acosta-Herrera, Marialbert, Kerick, Martin, Lopez-Isac, Elena, Assassi, Shervin, Beretta, Lorenzo, Simeon-Aznar, Carmen Pilar, Ortego-Centeno, Norberto, Proudman, Susanna M, Hunzelmann, Nicolas et al. DOI: 10.1136/annrheumdis-2021-219884
PMID: 34090714 Journal: Clinica e investigacion en arteriosclerosis : publ Year: 2021 Reference: Clin Investig Arterioscler. 2021 Nov-Dec;33(6):289-295. doi: 10.1016/j.arteri.2021.03.004. Epub 2021 Jun 3. Impact factor: 0 Publication type: Paper in national publication Authors: Perez, Enrique Ruiz, Albarran, Olga Gonzalez, Puebla, Mercedes Herranz, Robles, Carolina Puertas, Anguila, Silvia Campos, Ruiz, Joan Lima, Ruiz, Armando Raul Guerra, Hernandez, Jose Luis Hernandez, Lario, Jose Vicente Garcia, Busto, Pablo Gonzalez et al. DOI: 10.1016/j.arteri.2021.03.004
PMID: 33493333 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Oct 2;60(10):4558-4567. doi: 10.1093/rheumatology/keab032. Impact factor: 7.58 Publication type: Paper in international publication Authors: Hinrichs, Anneline, Gandolfo, Saviana, Hashimoto, Kunio, Hernandez-Molina, Gabriela, Hofauer, Benedikt, Mendieta-Zeron, Samara, Rasmussen, Astrid, Sandhya, Pulukool, Sene, Damien, Trevisani, Virginia Fernandes Moca et al. DOI: 10.1093/rheumatology/keab032
PMID: 31033231 Journal: ARTHRITIS CARE & RESEARCH Year: 2020 Reference: Arthritis Care Res (Hoboken). 2020 Jun;72(6):822-828. doi: 10.1002/acr.23910. Epub 2020 May 14. Impact factor: 4.056 Publication type: Paper in international publication Authors: Nolla, Joan M, Fernandez-Carballido, Cristina, Martin-Martinez, Maria A, Garcia-Gomez, Carmen, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Barril, Sara Marsal, Steiner, Martina, Munoz, Santiago et al. DOI: 10.1002/acr.23910
PMID: 32546599 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2020 Reference: Ann Rheum Dis. 2020 Sep;79(9):1234-1242. doi: 10.1136/annrheumdis-2019-216599. Epub 2020 Jun 16. Impact factor: 16.102 Publication type: Paper in international publication Authors: Miller, Frederick W, Milisenda, Jose Cesar, Grau-Junyent, Josep Maria, Selva-O'Callaghan, Albert, Carrion-Ribas, Carme, Paik, Julie J, Albayda, Jemima, Christopher-Stine, Lisa, Lloyd, Thomas E, Corse, Andrea M et al. DOI: 10.1136/annrheumdis-2019-216599
PMID: 32534273 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2020 Reference: Semin Arthritis Rheum. 2020 Aug;50(4):776-790. doi: 10.1016/j.semarthrit.2020.03.007. Epub 2020 Jun 1. Impact factor: 4.751 Publication type: Paper in international publication Authors: Selva-O'Callaghan, A, Romero-Bueno, F, Diaz Del Campo, P, Trallero-Araguas, E, Ruiz-Rodriguez, J C, Castellvi, I, Rodriguez-Nieto, M J, Martinez-Becerra, M J, Sanchez-Pernaute, O, Pinal-Fernandez, I et al. DOI: 10.1016/j.semarthrit.2020.03.007
PMID: 32504166 Journal: International Journal of Clinical Pharmacy Year: 2020 Reference: Int J Clin Pharm. 2020 Aug;42(4):1184-1189. doi: 10.1007/s11096-020-01072-7. Epub 2020 Jun 5. Impact factor: 1.616 Publication type: Paper in international publication Authors: Campany-Herrero, David, Larrosa-Garcia, Maria, Lalueza-Broto, Pilar, Rivera-Sanchez, Lucas, Espinosa-Pereiro, Juan, Mestre-Torres, Jaume, Pigrau-Serrallach, Carles et al. DOI: 10.1007/s11096-020-01072-7
PMID: 30789151 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2019 Reference: Clin Exp Rheumatol. 2019 Sep-Oct;37(5):774-782. Epub 2019 Feb 15. Impact factor: 3.238 Publication type: Paper in international publication Authors: Garcia-Gomez, Carmen, Martin-Martinez, Maria A, Fernandez-Carballido, Cristina, Castaneda, Santos, Gonzalez-Juanatey, Carlos, Sanchez-Alonso, Fernando, Gonzalez-Fernandez, Maria J, Sanmarti, Raimon, Garcia-Vadillo, Jesus A, Fernandez-Gutierrez, Benjamin et al. DOI:
PMID: 30620291 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2019 Reference: Clin Exp Rheumatol. 2019 Sep-Oct;37(5):731-739. Epub 2019 Jan 3. Impact factor: 3.238 Publication type: Paper in international publication Authors: Martin-Martinez, Maria A, Castaneda, Santos, Gonzalez-Juanatey, Carlos, Sanchez-Alonso, Fernando, Garcia-Gomez, Carmen, Lopez-Gonzalez, Ruth, Babio-Herraiz, Jesus, Juan-Mas, Antonio, Sanchez-Gonzalez, Carmen O, Romera-Baures, Montserrat et al. DOI:
PMID: 31557429 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2019 Reference: N Engl J Med. 2019 Dec 5;381(23):2199-2208. doi: 10.1056/NEJMoa1906190. Epub 2019 Sep 26. Impact factor: 70.67 Publication type: Paper in international publication Authors: Heels-Ansdell, Diane, Thabane, Lehana, Walter, Stephen D, Devereaux, P J, HEALTH investigators, Guerra Farfan, Ernesto Melchor, Teixidor Serra, Jordi, Tomás Hernández, Jordi, Molero García, Vicent, Selga Marsà, Jordi et al. DOI: 10.1056/NEJMoa1906190
PMID: 31533337 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2019 Reference: Int J Mol Sci. 2019 Sep 17;20(18). pii: ijms20184601. doi: 10.3390/ijms20184601. Impact factor: 4.183 Publication type: Paper in international publication Authors: Torres-Salido, Maria Teresa, Sanchis, Mireia, Sole, Cristina, Moline, Teresa, Vidal, Marta, Vidal, Xavier, Sola, Anna, Hotter, Georgina, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al. DOI: 10.3390/ijms20184601
PMID: 29775498 Journal: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY Year: 2018 Reference: J Eur Acad Dermatol Venereol. 2018 Oct;32(10):1791-1795. doi: 10.1111/jdv.15078. Epub 2018 Jun 8. Impact factor: 4.287 Publication type: Paper in international publication Authors: Alvarez, A, Armegol, P, Barbera, M J, Esperalba, J, Vall-Mayans, M, Mota-Foix, M, Fernandez, C, Arando, M et al. DOI: 10.1111/jdv.15078
PMID: 29768139 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2018 Reference: N Engl J Med. 2018 May 17;378(20):1908-1919. doi: 10.1056/NEJMoa1706314. Impact factor: 79.258 Publication type: Paper in international publication Authors: Livneh, Avi, Brogan, Paul, Cattalini, Marco, Obici, Laura, Lheritier, Karine, Speziale, Antonio, Junge, Guido, Gul, Ahmet, Constantin, Tamas, Bujan-Rivas, Segundo et al. DOI: 10.1056/NEJMoa1706314
PMID: 29770505 Journal: JOURNAL OF SLEEP RESEARCH Year: 2018 Reference: J Sleep Res. 2018 Dec;27(6):e12703. doi: 10.1111/jsr.12703. Epub 2018 May 16. Impact factor: 3.433 Publication type: Paper in international publication Authors: Castro-Marrero, Jesus, Zaragoza, Maria C, Gonzalez-Garcia, Sergio, Aliste, Luisa, Saez-Francas, Naia, Romero, Odile, Fernandez de Sevilla, Tomas, Alegre, Jose, Ferre, Alex et al. DOI: 10.1111/jsr.12703
PMID: 29745871 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2018 Reference: Clin Exp Rheumatol. 2018 Nov-Dec;36 Suppl 115(6):40-44. Epub 2018 May 3. Impact factor: 3.201 Publication type: Paper in international publication Authors: Nieto, Javier, Solanich, Xavier, Martinez-Valle, Ferran, Fonseca, Eva, Munoz, Francisco Jose, Fraile, Guadalupe, de Escalante, Begona, Boldova, Rafael, Hurtado, Robert, Espinosa, Gerard et al. DOI:
PMID: 28980912 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2017 Reference: Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):98-105. Epub 2017 Sep 21. Impact factor: 2.634 Publication type: Paper in international publication Authors: Iniesta Arandia, Nerea, Simeon-Aznar, Carmen Pilar, Guillen Del Castillo, Alfredo, Colunga Arguelles, Dolores, Rubio-Rivas, Manuel, Trapiella Martinez, Luis, Garcia Hernandez, Francisco Jose, Saez Comet, Luis, Egurbide Arberas, Maria Victoria, Ortego-Centeno, Norberto et al. DOI:
PMID: 28980905 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2017 Reference: Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):89-97. Epub 2017 Sep 18. Impact factor: 2.634 Publication type: Review in international publication Authors: Marin Ballve, Adela, Pla Salas, Xavier, Madronero Vuelta, Ana Belen, Ruiz Munoz, Manuel, Fonollosa Pla, Vicent, Simeon Aznar, Carmen Pilar, Rios Blanco, Juan Jose, Vargas Hitos, Jose Antonio, Saez Comet, Luis, Egurbide Arberas, Maria Victoria et al. DOI:
PMID: 28934835 Journal: RHEUMATOLOGY Year: 2017 Reference: Rheumatology (Oxford). 2017 Apr 1;56(4):628. doi: 10.1093/rheumatology/kew415. Impact factor: 4.818 Publication type: Paper in international publication Authors: Pardos-Gea, Jose et al. DOI: 10.1093/rheumatology/kew415
PMID: 28918450 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2017 Reference: Rheumatol Int. 2017 Nov;37(11):1817-1823. doi: 10.1007/s00296-017-3814-2. Epub 2017 Sep 16. Impact factor: 1.824 Publication type: Paper in international publication Authors: Sellas I Fernandez, Agusti, Juanola Roura, Xavier, Alonso Ruiz, Alberto, Rosas, Jose, Medina Luezas, Julio, Collantes Estevez, Eduardo, Abad Hernandez, Miguel Angel, Carrasco Benitez, Virginia, Fisac, Cesar et al. DOI: 10.1007/s00296-017-3814-2
PMID: 27326983 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2016 Reference: J Investig Allergol Clin Immunol. 2016 Jun;26(3):161-7. doi: 10.18176/jiaci.0037. Impact factor: 2.131 Publication type: Paper in international publication Authors: Pinero-Saavedra, M, Rubio, M, Caballero, T, Lopez-Serrano, M C, Cimbollek, S, Gonzalez-Quevedo, T, Guilarte, M, Marcos, C, Larco, J I, Baeza, M L et al. DOI: 10.18176/jiaci.0037
PMID: 27250623 Journal: Archivos de prevencion de riesgos laborales Year: 2016 Reference: Arch Prev Riesgos Labor. 2016 Jan-Mar;19(1):15-21. doi: 10.12961/aprl.2016.19.1.03. Impact factor: 0 Publication type: Paper in national publication Authors: Carreras Valls, Rosa, Olive Cristany, Victoria, Bretau Vinas, Frederic, Subirats Cid, Pilar, Sanchez Flores, Eugenia, Villegas Rodriguez, Sonia, Guixeras Campos, Assumpcio, Torrecillas Mota, Susana, Barroso Reinon, Sonia, Serra Pujadas, Consol et al. DOI: 10.12961/aprl.2016.19.01.3
PMID: 27213830 Journal: Arthritis & Rheumatology Year: 2016 Reference: Arthritis Rheumatol. 2016 Nov;68(11):2795-2805. doi: 10.1002/art.39763. Impact factor: 6.009 Publication type: Paper in international publication Authors: Rigante, Donato, Russo, Ricardo, Pachlopnik Schmid, Jana, Lane, Thirusha, Martini, Alberto, Ruperto, Nicolino, Frenkel, Joost, Gattorno, Marco, Consolini, Rita, Boros, Christina et al. DOI: 10.1002/art.39763
PMID: 27111665 Journal: Arthritis & Rheumatology Year: 2016 Reference: Arthritis Rheumatol. 2016 Sep;68(9):2338-44. doi: 10.1002/art.39730. Impact factor: 6.009 Publication type: Paper in national publication Authors: Santaniello, Alessandro, Lopez-Isac, Elena, Martin, Jose-Ezequiel, Assassi, Shervin, Simeon, Carmen P, Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltran, Emma, Narvaez, Javier et al. DOI: 10.1002/art.39730
PMID: 26343462 Journal: COMPREHENSIVE PSYCHIATRY Year: 2015 Reference: Compr Psychiatry. 2015 Oct;62:13-9. doi: 10.1016/j.comppsych.2015.06.010. Epub 2015 Jun 17. Impact factor: 2.252 Publication type: Paper in international publication Authors: Saez-Francas, Naia, Calvo, Natalia, Alegre, Jose, Castro-Marrero, Jesus, Ramirez, Nicolas, Hernandez-Vara, Jorge, Casas, Miguel et al. DOI: 10.1016/j.comppsych.2015.06.010
PMID: 26081942 Journal: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING Year: 2015 Reference: Eur J Nucl Med Mol Imaging. 2015 Oct;42(11):1778-1779. doi: 10.1007/s00259-015-3108-4. Epub 2015 Jun 17. Impact factor: 5.383 Publication type: Paper in international publication Authors: Martinez-Valle, Fernando, Gironella, Mercedes, Riveiro-Barciela, Mar, Lorenzo-Bosquet, Carles et al. DOI: 10.1007/s00259-015-3108-4
PMID: 25806935 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2015 Reference: N Engl J Med. 2015 Mar 26;372(13):1273-4. doi: 10.1056/NEJMc1500688#SA1. Impact factor: 55.873 Publication type: Letter whit IF Authors: Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Labrador-Horrillo, Moises et al. DOI: 10.1056/NEJMc1500688#SA1
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PMID: 25580506 Journal: ANN MED Year: 2014 Reference: Ann Med. 2014 Dec;46(8):607-18. doi: 10.3109/07853890.2014.949300. Impact factor: 4.733 Publication type: Review in international publication Authors: Cabanas, R, Campos, A, Cimbollek, S, Gomez-Traseira, C, Quevedo, T Gonzalez, Guilarte, M, Jurado-Palomo, J, Lobera, T, Lopez-Serrano, M C, Marcos, C et al. DOI:
PMID: 25634237 Journal: INT ARCH ALLERGY IMM Year: 2014 Reference: Int Arch Allergy Immunol. 2014;165(4):244-6. doi: 10.1159/000371418. Epub 2015 Jan 29. Impact factor: 2.433 Publication type: Paper in international publication Authors: Corominas, Merce, Postigo, Idoia, Cardona, Victoria, Lleonart, Ramon, Romero-Pinel, Lucia, Martinez, Jorge et al. DOI: 10.1159/000371418
PMID: 25250172 Journal: Clinical and Translational Allergy Year: 2014 Reference: Clin Transl Allergy. 2014 Sep 8;4:28. doi: 10.1186/2045-7022-4-28. eCollection 2014. Impact factor: 0 Publication type: Letter or abstract Authors: Luengo, Olga, Cardona, Victoria et al. DOI: 10.1186/2045-7022-4-28
PMID: 24989080 Journal: ALLERGY Year: 2014 Reference: Allergy. 2014 Oct;69(10):1397-404. doi: 10.1111/all.12475. Epub 2014 Aug 16. Impact factor: 5.995 Publication type: Paper in international publication Authors: Papadopoulos, N G, Worm, M, Moneret-Vautrin, A, Scherer, K, Lang, R, Fernandez-Rivas, M, Cardona, V, Kowalski, M L, Jutel, M, Poziomkowska-Gesicka, I et al. DOI: 10.1111/all.12475
PMID: 22076442 Journal: HUMAN MOLECULAR GENETICS Year: 2012 Reference: Hum Mol Genet. 2012 Feb 15;21(4):926-33. Epub 2011 Nov 10. Impact factor: 7.636 Publication type: Paper in international publication Authors: Vaqueiro, Ines, Bossini-Castillo, Lara, Martin, Jose-Ezequiel, Broen, Jasper, Gorlova, Olga, Simeon, Carmen P, Beretta, Lorenzo, Vonk, Madelon C, Callejas, Jose Luis, Castellvi, Ivan et al. DOI: 10.1093/hmg/ddr522
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PMID: 22742541 Journal: TISSUE ANTIGENS Year: 2012 Reference: Tissue Antigens. 2012 Sep;80(3):254-8. doi: 10.1111/j.1399-0039.2012.01915.x. Epub 2012 Jun 29. Impact factor: 2.588 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1111/j.1399-0039.2012.01915.x
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
