Eva Colas Ortega Sóc investigadora principal del Grup de Recerca Biomèdica en Ginecologia, on dirigeixo el grup de recerca translacional. El meu interès se centra a aportar solucions a necessitats clíniques no cobertes en ginecologia, principalment en càncer d'endometri i endometriosi. Treballem en la recerca de biomarcadors per oferir solucions innovadores i models preclínics per millorar la medicina personalitzada. Institucions de les que formen part Cap de grup Recerca biomèdica en ginecologia Vall Hebron Institut de Recerca LinkedIn Twitter Orcid Email Eva Colas Ortega LinkedIn Twitter Orcid Email Institucions de les que formen part Cap de grup Recerca biomèdica en ginecologia Vall Hebron Institut de Recerca Sóc investigadora principal del Grup de Recerca Biomèdica en Ginecologia, on dirigeixo el grup de recerca translacional. El meu interès se centra a aportar solucions a necessitats clíniques no cobertes en ginecologia, principalment en càncer d'endometri i endometriosi. Treballem en la recerca de biomarcadors per oferir solucions innovadores i models preclínics per millorar la medicina personalitzada.
Sóc biòloga de formació i he estat totalment dedicada a la investigació del càncer d'endometri durant els últims 16 anys. Des del 2017 lidero el meu propi equip al Grup de Recerca Biomèdica en Ginecologia (VHIR) i la meva recerca se centra en la implantació del diagnòstic molecular i la medicina personalitzada en ginecologia, principalment en càncer d'endometri (CE) i endometriosi. Al llarg de la meva carrera professional, he participat en el desenvolupament dels primers models murins derivats dels pacients (PDX) de CE, i avui el meu grup és propietari d'un dels biobancs PDX més grans d'Europa, que utilitzem nosaltres, els nostres socis i les empreses farmacèutiques per avaluar tractaments pels pacients de CE. És important destacar que també he crescut com a científica dedicada a la investigació de biomarcadors en líquids ginecològics. Vaig treballar en el desenvolupament del primer kit molecular per diagnosticar el CE. Avui dia sóc la coordinadora en l'àmbit europeu d'un estudi multicèntric per desenvolupar un diagnòstic no invasiu del CE (ERA PerMed), i sóc fundadora d'una spin-off (MiMARK Diagnostics S.L.) que té com a objectiu desenvolupar solucions innovadores per a la salut de la dona. En resum, tinc un total de 73 articles científics amb factor d'impacte; 17 d'ells com a autora principal; i sóc inventora de 4 patents. La meva capacitat científica i de lideratge queda demostrada per la direcció de 12 tesis doctorals, 6 de les quals ja han estat defensades, dues d'elles premiades. He participat en 32 projectes de recerca competitius, sent en 13 d'ells investigadora principal, i he participat activament en xarxes de càncer nacionals (CIBERONC) i internacionals (ENITEC). He estat docent en estudis de grau i màster els darrers 7 anys; i fa 10 anys que formo part del Comitè de Direcció de la Societat Catalana de Biologia.
Línies de recerca Endometrial Cancer and Endometriosis Research Research team: Dr. Eva Colas (Principal researcher) Dr. Cristian Moiola (Post-doctoral researcher) Dr. Eva Coll (PhD student) Dr. Carlos López (PhD student) Dr. Carina Masferrer (PhD student) Dr. Beatriz Villafranca (PhD student) Dr. Melek Denizli (Technician) Dr. Marta Rebull (Technician) Dr. Aida Soler (Technician) Dr. Antonio Gil-Moreno (Principal researcher) Dra. Silvia Cabrera (Clinical associated investigator) Dr. Angel García (Clinical associated investigator) Dr. Armando Reques (Clinical associated investigator) Dra. Elena Suárez (Clinical associated investigator) Dra. Mireia Armengol (Clinical associated investigator/resident) Research focus IMPLEMENTATION OF MOLECULAR DIAGNOSTICS IN ENDOMETRIAL CANCER Early detection is directly related to an increased survival for endometrial cancer patients. Diagnosis of endometrial cancer initiates with the presence of symptoms, i.e. an abnormal vaginal bleeding, and 1 of every 10 women with this symptom will have an endometrial cancer. In order to improve early detection, we aim to improve the process of diagnosis by implementing molecular markers in proximal bodily fluids. Thus, we expect to minimize invasiveness whilst increase accuracy on the newly developed methods of diagnosis. In this research line, the group has two ongoing projects: Proteomic biomarkers for an improved diagnosis in uterine aspirates. Exploitation of pap-smears as an untapped source of biomarkers of endometrial cancer. PREVENTING DISTANT AND LOCAL DISSEMINATION OF ENDOMETRIAL CANCER CELLS Once a patient is diagnosed, the presence of prognostic factors are used to classify patients according to their risk of recurrence, which directly affects their clinical management. However, up to 20% of patients diagnosed at early stages, and up to 50% of patients diagnosed in advanced stages will suffer a relapse without means of predicting it. We aim to understand the mechanisms of local and distant tumour dissemination to develop strategies that prevent tumour relapse. Moreover, we aim to design tools to better estimate the risk of recurrence of endometrial cancer patients. In this research line, the group has two ongoing projects: Understanding the molecular mechanisms associated to local and distant dissemination via studying the MELF component and the exosomes derived from the tumor. Deciphering biomarkers of recurrence in endometrial cancer. DEVELOPING INDIVIDUALIZED TREATMENT FOR ENDOMETRIAL CANCER PATIENTS Nowadays, adjuvant treatment of metastatic or recurrent endometrial cancer patients is restricted to few therapeutic options, mostly based on radiotherapy and conventional chemotherapy regimens. Advances in understanding the molecular landscape of endometrial cancer have arisen the development of targeted therapies. However, responses to these targeted therapies are modest, probably due to the underestimation of the heterogeneity found in cancer, misrepresentation of low frequent subtypes of cancer, as well as the lack of clinically relevant models to perform pre-clinical studies, among other issues. The group aims to develop clinically relevant models and design experimental treatments in order to increase the response rate of patients. In this research line, the group has 2 ongoing projects: The U-CAN platform of endometrial cancer PDX models to perform preclinical studies. Identification of new experimental therapies. Real-time oncology. MOLECULAR DIAGNOSIS AND RECURRENCE PREDICTION IN ENDOMETRIOSIS Endometriosis is an estrogen dependent disease that affects approximately 15% of women in reproductive age. Although endometriosis is considered a benign disease, characterized by the presence of uterine tissue outside the uterus, it causes strong pain and, often, infertility. So far, the gold standard method to diagnose endometriosis is laparoscopy, an invasive technique and there are no methods for early diagnose of the disease. In addition, patients undergoing surgery as a definitive treatment of endometriosis might recur without means of predicting it. In this research line, the group has 2 ongoing projects: Assess the potential of angiogenic factors to diagnose and predict recurrence in endometriosis. Identification of biomarkers to predict recurrence in endometrioma using a proteomic and transcriptomic approach. IP: Eva Colas Ortega Projectes Approaching personalized treatment in endometrial cancer patients unveiling the intratumour heterogeneity IP: Eva Colas Ortega Col·laboradors: Beatriz Villafranca Magdalena, Miriam Izquierdo Sans Entitat finançadora: Instituto de Salud Carlos III Finançament: 19895 Referència: MV23/00016 Durada: 08/07/2024 - 20/12/2024 BIOBANCOS Y BIOMODELOS IP: Isabel Novoa Garcia Col·laboradors: Joaquim Vives Armengol, Anna Duarri Piqué, Eva Colas Ortega, Oriol Bestard Matamoros, Marta Rosal Fontana, Carmen Espejo Ruiz, Marielle Esteves Coelho, Juan Jose Gonzalez Lopez, Sheyla Pascual Martín, Alejandro Tomasello Weitz Entitat finançadora: Instituto de Salud Carlos III Finançament: 137460 Referència: PT23/00040 Durada: 01/01/2024 - 31/12/2026 Desarrollo de CEMARK-Px, un método in vitro para el diagnóstico objetivo y preciso del tipo y grado histológico del cáncer de endometrio en fluido uterino IP: Eva Colas Ortega Col·laboradors: Vicente Bebia Conesa, Silvia Cabrera Diaz, Antonio Gil Moreno, Marta Rebull Santamaria, Ana Luzarraga Aznar, Irene De la Calle Fuentes, Melek Denizli, Lourdes Elena Salazar Huayna Entitat finançadora: Instituto de Salud Carlos III Finançament: 278300 Referència: DTS23/00091 Durada: 01/01/2024 - 31/12/2025 Development of a non-invasive ivd for endometrial cancer screening on high-risk populations IP: Eva Colas Ortega Col·laboradors: Antonio Gil Moreno, Irene De la Calle Fuentes Entitat finançadora: Ministerio de Ciencia e Innovación-MICINN Finançament: 201869.5 Referència: CPP2022-009817 Durada: 01/10/2023 - 30/09/2026 Paginació Pàgina actual 1 Page 2 Page 3 Page 4 Page 5 … Pàgina següent › Última pàgina »
