Miquel Vila Bover Sóc investigador ICREA i dirigeixo el Grup de Recerca en Malalties Neurodegeneratives del Vall d’Hebron Institut de Recerca (VHIR) Institucions de les que formen part Cap de grup Malalties neurodegeneratives Vall Hebron Institut de Recerca Email Miquel Vila Bover Email Institucions de les que formen part Cap de grup Malalties neurodegeneratives Vall Hebron Institut de Recerca Sóc investigador ICREA i dirigeixo el Grup de Recerca en Malalties Neurodegeneratives del Vall d’Hebron Institut de Recerca (VHIR)
Sóc llicenciat en Medicina i Cirurgia per la Universitat de Barcelona (1993) i Doctor en Neurociències per la Universitat de Paris 6 (1998). El meu treball de doctorat realitzat al laboratori de neurologia experimental de l’Hospital de la Salpêtrière de Paris (1993-98) va contribuir a establir el nucli subtalàmic com a principal diana terapèutica per al tractament quirúrgic de la malaltia de Parkinson amb estimulació cerebral profunda. De 1998 a 2005 vaig treballar a la Unitat de Transtorns del Moviment de la Universitat de Columbia de Nova York (USA), inicialment com a investigador postdoctoral i des de 2001 com a Professor titular de neurologia d’aquesta universitat, centrat en l’estudi dels mecanismes de mort neuronal en la malaltia de Parkinson per identificar noves dianes terapèutiques per aquesta malaltia. L’any 2006 em vaig traslladar a Barcelona com a Professor d’Investigació ICREA (Institució Catalana de Recerca i Estudis Avançats) per fundar i dirigir un nou grup de recerca en malalties neurodegeneratives al Vall d’Hebron Institut de Recerca (VHIR). Des de llavors, el nostre grup s’ha consolidat com a referent en l’estudi de la malaltia de Parkinson i forma part del Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED) i de l’Aligning Science Across Parkinson’s Collaborative Research Network (ASAP-CRN). També sóc professor associat a la Universitat Autonòma de Barcelona, investigador principal del CIBERNED, investigador principal coordinador de l'ASAP-CRN i membre dels Comitès de Direcció de la World Parkinson Coalition i del Basic Science Special Interest Group de la International Parkinson and Movement Disorder Society.
Línies de recerca Role of mitochondria in Parkinson's disease Mitochondria are highly dynamic organelles with complex structural features that play several important cellular functions, such as the production of energy by oxidative phosphorylation, the regulation of calcium homeostasis, or the control of programmed cell death. Given its essential role in neuronal viability, alterations in mitochondrial biology can lead to neuron dysfunction and cell death. Defects in mitochondrial respiration have long been implicated in the etiology and pathogenesis of Parkinson's disease (PD). However, the role of mitochondria in PD extends well beyond defective respiration and also involves perturbations in mitochondrial dynamics, leading to alterations in mitochondrial morphology, intracellular trafficking, or quality control. Whether a primary or secondary event, mitochondrial dysfunction holds promise as a potential therapeutic target to halt the progression of dopaminergic neurodegeneration in PD. IP: Miquel Vila Bover Alpha-synuclein involvement in Parkinson's disease Formation and accumulation of abnormal protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson’s disease (PD), the aggregation-prone protein á-synuclein accumulates in several areas of the central and peripheral nervous system. Pathological á-synuclein accumulation in PD can result from (i) abnormally increased á-synuclein expression, (ii) defective intracellular clearance of á-synuclein protein, (iii) progressive self-propagation and spreading of pathological á-synuclein between interconnected brain areas. Targeting á-synuclein pathological changes may provide therapeutic benefit to delay, halt or prevent neuronal dysfunction and degeneration in PD. IP: Miquel Vila Bover Neuromelanin and Parkinson's disease In Parkinson's disease (PD), there is a selective degeneration of neurons that contain a dark-brown pigment called neuromelanin, especially dopaminergic neurons of the substantia nigra, which leads to the classical motor symptoms of the disease. However, the physiological significance of neuromelanin and its potential contribution to PD pathogenesis remain unknown. IP: Miquel Vila Bover Identification of biomarkers of prodromal Parkinson's disease Despite intensive efforts towards understanding the aetiology/pathogenesis of Parkinson's disease (PD) and the development of novel therapeutic approaches for this neurodegenerative condition, the current treatment for PD remains symptomatic and yet far from modifying disease onset or progression. Before the manifestation of the classical motor symptoms, PD patients present with non-motor symptoms in a prodromal phase. The identification of deregulated molecular pathways or genes in peripheral blood and/or cerebrospinal fluid from these prodromal patients may help develop potential biomarkers for the early detection, diagnosis, risk assessment and/or progression of PD, which are currently lacking, as well as to stratify patients at very early stages to apply more specific, personalized disease-modifying treatments. IP: Miquel Vila Bover, Ariadna Laguna Tuset Paginació Pàgina actual 1 Page 2 Pàgina següent › Última pàgina » Projectes Neuromelanin and PD: mechanisms and therapeutic perspectives IP: Miquel Vila Bover Col·laboradors: - Entitat finançadora: Michael J. Fox Foundation Finançament: 441200 Referència: MJF/NETWORKS/2024/VILA Durada: 01/07/2025 - 30/06/2027 Neurodegeneratives IP: Miquel Vila Bover Col·laboradors: - Entitat finançadora: Fundació Institut de Recerca HUVH Finançament: 160000 Referència: VILA/BOOST/2024 Durada: 15/11/2024 - 14/11/2028 Red de Investigación MitoNED: (Dis)función mitocondrial en enfermedades neurodegenerativas IP: Miquel Vila Bover Col·laboradors: - Entitat finançadora: Ministerio de Ciencia e Innovación-MICINN Finançament: 0.01 Referència: RED2022-134786-T Durada: 01/06/2023 - 31/05/2025 Malalties neurodegeneratives IP: Miquel Vila Bover Col·laboradors: Jorge Hernández Vara, Malalties neurodegeneratives , Marta Martínez Vicente, Jordi Bove Badell, Eddie Pradas Gracia, Maria Camprodon Gomez, Laura Castillo Ribelles, Oriol de Fabregues-Boixar Nebot, Javier Hoyo Pérez, Ariadna Laguna Tuset, Maria Sellés Altés, Marta González Sepúlveda, Joana Margalida Cladera Sastre, Annabelle Parent, Daniela Samaniego Toro, Malalties neurodegeneratives Entitat finançadora: Agència Gestió Ajuts Universitaris i de Recerca Finançament: 40000 Referència: 2021 SGR 00784 Durada: 01/01/2022 - 30/06/2025 Paginació Pàgina actual 1 Page 2 Page 3 Page 4 Page 5 … Pàgina següent › Última pàgina »
