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Malalties Neurovasculars

L'ictus és una emergència mèdica i una de les principals causes de mort i discapacitat a tot el món, que afecta milions de persones. En aquest context, el 2001 es va crear el Laboratori de Recerca Neurovascular, centrat en la recerca biomèdica de l'ictus des d'una perspectiva bàsica i translacional, cobrint totes les etapes de la malaltia: des de la prevenció i el tractament fins a la recuperació. 

Avui dia el nostre equip està format per un grup d'investigadors altament motivats que inclou científics clínics i bàsics, amb líders de grup involucrats en projectes —nacionals i internacionals, amb finançament públic o privat— per a la recerca sobre biomarcadors per a la presa de decisions clíniques en l'ictus, la presència d'infarts silents, l'avaluació de la cognició i el deteriorament cognitiu, desenvolupant models experimentals d'isquèmia cerebral, provant nous tractaments complementaris a la reperfusió, i desenvolupant estudis sobre l’angiopatia amiloide cerebral, neurorreparació tissular o rehabilitació postictus.

Els estudis complementaris sobre la demència vascular i la malaltia d'Alzheimer relacionada amb la proteïna ß-amiloide també s'han inclòs com a part de la nostra recerca en els últims anys.
 

Equip

Anna Rosell Novel

Anna Rosell Novel

Cap de grup
Malalties neurovasculars
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José Alvarez Sabin

José Alvarez Sabin

Investigador/a sènior
Malalties neurovasculars
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Maria Mar Hernandez Guillamon

Maria Mar Hernandez Guillamon

Investigador/a principal
Malalties neurovasculars
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Anna Bonaterra Pastra

Anna Bonaterra Pastra

Investigador/a postdoctoral
Malalties neurovasculars
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Antonio Palasi Franco

Antonio Palasi Franco

Tècnic de recerca
Malalties neurovasculars
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Berta Paez Montserrat

Berta Paez Montserrat

Investigador/a predoctoral
Malalties neurovasculars
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Anna Rosell Novel

Anna Rosell Novel

Cap de grup
Malalties neurovasculars
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José Alvarez Sabin

José Alvarez Sabin

Investigador/a sènior
Malalties neurovasculars
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Maria Mar Hernandez Guillamon

Maria Mar Hernandez Guillamon

Investigador/a principal
Malalties neurovasculars
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Anna Bonaterra Pastra

Anna Bonaterra Pastra

Investigador/a postdoctoral
Malalties neurovasculars
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Antonio Palasi Franco

Antonio Palasi Franco

Tècnic de recerca
Malalties neurovasculars
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Berta Paez Montserrat

Berta Paez Montserrat

Investigador/a predoctoral
Malalties neurovasculars
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Línies de recerca

L1 Biomarkers

The use of plasma biomarkers is becoming increasingly popular in several fields of medicine. In fact, decision-making processes using biomarkers is widely accepted in medical situations such as initiating lipid lowering therapies (LDL), diagnosing acute myocardial infarction (troponins), and ruling out pulmonary embolism suspicions (D-dimer), among others.


Therefore we really believe that biochemical markers of stroke, will really open “a window to the brain…”. In fact, in this research line we aim to answer relevant clinical questions through the use of biomarkers.


Our main Objectives using mainly plasma proteins are:


1.- To predict stroke risk

2.- To make stroke diagnosis

3.- To differentiate stroke subtypes

4.- To establish evolution and prognosis

5.- To use Biomarkers as treatment end-points


Some of our findings might have therapeutic implications since biological markers described by the group such as MMP-9 are well associated with Blood Brain Barrier disruption. In this direction, we have described MMP-9 predicting haemorrhagic complications among stroke patients receiving thrombolytic treatment. These approaches might contribute to increase safety of reperfusion treatments. The impact of this research line is clear, since articles like this (Circulation 2003) have been cited more than 180 times since its publication.


The study of these molecules will also have diagnostic implications because we have proposed the biochemical diagnostic of stroke by means of the identification of a biomarkers panel that distinguish between a stroke and other stroke-mimicking conditions. This might contribute to refer only to real stroke patients to the stroke centres, saving huge resources to the system.


These two examples, identification of biomarkers to predict tPA related bleedings and a stroke diagnostic test are examples of translational research in which the Neurovascular Research Lab is filing patents to be licensed to Biotech companies able to develop diagnostic kits in which our biomarkers might be placed and used in the clinical practice. That might close the circle of applied research.


Reviews of our group in which you may find detailed info about those biomarkers:


Foerch C, Montaner J, Furie KL, Ning MM, Lo EH.

      Searching for oracles? Blood biomarkers in acute stroke

      Neurology. 2009;73(5):393-9.


Montaner J.

      Blood biomarkers to guide stroke thrombolysis.

      Front Biosci (Elite Ed). 2009 Jun 1;1:200-208.


García-Berrocoso T, Fernández-Cadenas I, Delgado P, Rosell A, Montaner J.

      Blood Biomarkers to Identify Stroke Etiologies.

      Therapy 2010 (in press).



Projects

We are involved in several projects with public or private funding supporting our research on stroke biomarkers. One of such exciting projects is FIS PI 08/361 “Identificación y uso de biomarcadores pronósticos en el ictus isquémico”, aiming to identify biomarkers that predict main causes of stroke worsening (Infarct growth, cardiac complications, hemorrhagic transformation, infections, recurrence or new vascular events) to guide Stroke Unit allocation and stay of our patients.


International Collaborations

Discovery and validation of good candidate biomarkers, requires multidisciplinary approaches and replication in well designed multicentric and international studies. For that purpose we are actively collaborating with well known stroke research leading groups:


- Eng Lo, Xiaoing Wang, Ming Ming Ning (Boston, USA).

- Jean Charles Sanchez, Natacha Turck (Geneva, Switzerland).

- Denis Vivien, Carine Ali, Eduardo Anglés-Cano (Caen, France).


Research Tools and Techniques

We are using a combination of discovery techniques and biological human and animal samples to identify new stroke-related biomarkers:


One example is the “protein arrays”. In our laboratory, we have been using these new technologies and we actually use the SearchLight Assays (Aushon Biosystems) that allows us to study more than 170 human proteins and also many candidates from different animal species. We offer access to our technology to other groups. For more information, please refer to http://www.lin-bcn.com/


Also those biomarkers may be specifically tested not only as circulating markers in plasma or serum but in the components of interest of the Neurovascular Unit, that we may dissect by using the LCM Leica LMD6000 microscope, for Laser Capture microdissection. An example in which combine both thecniques may be found at:


Cuadrado E, Rosell A, Penalba A, Slevin M, Alvarez-Sabin J, Ortega-Aznar A,  Montaner J. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined Laser Microdissection and Protein Array  Study. Journal of Proteome Research 2009;8(6):3191-3197.


Biobanks

All these results have been possible since the development of a “blood library” including more than 2000 stroke samples and a “brain library” that allowed us to describe for the first time the “human stroke proteome” with the outstanding collaboration of so many patients, relatives and clinicians of the Stroke Unit.


IP: Joan Montaner Villalonga, Anna Penalba Morenilla

L3 Acute Therapy

BACKGROUND


The only approved stroke treatment so far is the acute thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) when administered within 3-4.5 hours after symptoms onset. However, a reduced number of patients (5-8%) profit by this treatment, primarily because of the narrow therapeutic time-window and the risk of brain bleedings beyond thromrbolytic therapy to achieve the recanalization of the occluded artery. Moreover, the inflammatory response that accompanied necrotic brain injury contributes to aggravate acutely the progression of ischemic pathology. Inflammatory and brain damaged cells release a variety of cytotoxic agents including cytokines, MMPs and ROS which induce more cell damage as well as disruption of BBB and brain edema.


Thereby, it would be desirable to improve the efficacy and safety for thrombolytic therapy of stroke using combined anti-inflammatory strategies that may ameliorate the ischemic injury and means the best therapy translated at the clinical level.


Our research, conducted on experimental models of cerebral ischemia, is focused on the development of neuroprotective strategies aimed to salvage ischemic brain tissue by means complementary to reperfusion. Our goal is to find out a multimodal treatment that combines the administration of tPA together with other co-agents (as simvastatin and/or anti-aggregants with anti-inflammatory and neuro-protective properties) in attempt to obtain the most therapeutic benefice in the acute phase of ischemic stroke.


EXPERIMENTAL MODELS AND TECHNIQUES


Ischemic stroke has a complex pathophysiology involving the interplay of many different cells and tissues. Animal models of ischemic stroke are procedures inducing cerebral ischemia, which mimicked satisfactorily this cerebrovascular disease. Therefore, research stroke conducted on animal models has been shown essential for treatment approach of ischemic stroke.


Intra-arterial Suture Occlusion Model of Focal Cerebral Ischemia

Infarction in the territory of the middle cerebral artery (MCA) is induced by extracranial vascular occlusion on rat. A heat-blunted 4/0 nylon-monofilament is used to block the origin of MCA during 90 or 120 min and then, the monofilament is removed and reperfusion is allowed during the followed 24, 48 or 72 h.

This model mimics a clinical situation where recanalization of the occluded artery takes place, allowing test neuroprotectants that could be potentially co-administered with reperfusion agents like tPA.


Embolic Model of Focal Cerebral Ischemia

The stroke animal model by clot embolism has a large scientific interest in the clinical field because the high incidence of human thrombotic stroke and the use of reperfusion therapy with tPA, which can be assay on this model. Thromboembolic occlusion at the proximal level of MCA is achieved by injection of a rich fibrin clot through the internal carotid artery in the rat. Clots are previously performed using arterial blood from a donor rat. Thrombolytic therapy with tPA (9 mg/Kg) is administered by tail vein infusion (2 mg/mL;75 ?l/min) at different times points (2, 3, 4 hours) after occlusion.


Relative Cerebral Blood Flow (rCBF) is measured in the cortex supplied by the MCA by continuous Laser Doppler flowmetry (LDF) to ensure the successful of the artery occlusion or reperfusion in these models.  To examine the grade of infarction on rats, analysis of the infarct volume is evaluated using 2,3,5-triphenyltetrazolium chloride (TTC) staining and neurological score is assayed with a 9-point neurological at baseline (1-2 h) and each 24 h after occlusion.


NMR Imaging

Bruker-BIOSPEC 70/30 USR, 7 T Preclinical MRI System is used for the neuroimaging studies. Neuroimaging studies are conducted in vivo to valuate the cytotoxic edema and ischemic lesion (DWI, ADC map and T2WI) in the acute phase. Specific sequences are performed to assess Brain-Blood Barrier disruption (DCE) and occurrences of intracranial hemorrhages (T2*WI). Angiography is performed to document MCA occlusion or recanalization.

IP: Joan Montaner Villalonga

L4 Neurorepair

New therapies beyond the hyperacute phase of stroke are needed to be able to treat much more patients in delayed phases of this devastating disease. The idea that neurovascular plasticity contributes to stroke recovery can be a powerful concept for stroke therapy. Obviously, the therapeutic time window for interventions based on promoting recovery would be much larger than those for targeting acute stroke.  In this context, long-term neuroreparative therapies will  have to target the two essential phenomena to achieve brain neurorecovery after stroke: to restore the cerebral blood flow and to promote Neuroregeneration.


To achieve these major goals, both angiogenesis and neurogenesis need to be enhanced in the ischemic brain.


Classically, the formation of new blood vessels was thought to be mediated exclusively by embryogenic vasculogenesis followed by the sprouting of endothelial cells from preexisting vessels during angiogenesis. In the last decade, this standard dogma was overturned with the identification of the existence of circulating bone marrow-derived endothelial progenitor cells (EPCs). These cells are capable of differentiating, ex vivo, into endothelial-phenotyped cells, and now comprise a new model for endothelial generation and vessel repair (Asahara et al., 1997). These cells comprise a potential cell-based and growth-factor source of an alternate approach to enhance angio-neurogenic responses. In fact, newborn neurons (neurogenesis) and new vascular components (angiogenesis) form a microenvironment that has been termed the neurovascular niche [Ohab et al., 2006] were angiogenesis and neurogenesis are linked thorough specific growth factors.


Angiogenesis and neurogenesis occur endogenously after stroke. Our goal is to study these two complex phenomena both in experimental and human studies to finally potentiate them correctly to improve brain function and neurorecovery after stroke.


Experimental Models and Techniques


In vivo stroke models:

Cerebral ischemia affecting the cortical territory of the Middle Cerebral Artery (MCA) is occluded at the level of the M1 portion (distal occlusion). This model has been chosen because presents very low mortality rates allowing long-term studies. Besides, the infarct is restricted to the cortex with clear boundary areas with normal cerebral blood flow and never affects neuroblast-rich areas such as the subventricular zone (then, both angiogenesis and neurogenesis can occur).


Functional outcome is assessed by the cylinder and corner tests which have been reported to be appropriate test for this type of cortical infarcts. Besides, histology and immunohistochemistry studies are conducted to evaluate brain repair and angio-neurogenic processes.

                 

Endothelial Progenitor Cell Cultures:

EPCs are obtained from the Mononuclear cell fraction of human blood and from mouse spleen. MNCs are cultured in fibronectin-coated plates with complete cell culture medium EGM-2MV.

   

Both in human and murine cell cultures yield an early EPC population (also called Circulating Angiogenic Cells) obtained at day 4-7 after plating and late outgrowth EPC colonies (also called Endothelial Colony Forming Cells) appear from day 10 as colonies with high proliferation capacity and tubulogenic capacity.


In vitro Oxygen-Glucose Deprivation: endothelial cells and Endothelial progenitor cells are challenged to a transitory Oxygen and Glucose deprivation to study their angio-vasculogenic responses to ischemia and to test how potential treatments that could modify these responses.


Angiogenesis-related techniques: angio-vasculogenic mechanisms are studied in a variety of in vitro assays including Matrigel® tubulogenesis, cell migration using trans-well assays or cell adhesion to a mature monolayer of endothelial cells. Our studies focus on the angio-vasculogenic responses of both Endothelial Progenitor Cells and mature endothelial cells such as the human cell line of microvascular endothelial cells (hCMEC/D3).

   

NMR Imaging: Bruker-BIOSPEC 70/30 USR, 7 T Preclinical MRI System is used for the neuroimaging studies. Neuroimaging studies are conducted in vivo to follow-up the ischemic lesion. Specific sequences are performed to assess axonal degeneration/regeneration and changes in cerebral blood flow and angiogenesis.


IP: Anna Rosell Novel

L5 Cerebral Amyloid Angiopathy

Current project: 

Involment of proteolytic systems in the progression of Cerebral Amyloid Angiopathy


Cerebral amyloid angiopathy (CAA) is produced by the accumulation of ß-amyloid protein within the meningeal and brain vessels. It is the second leading cause of cerebral hemorrhages. However, nowadays, factors related to brain bleedings following amyloid deposition are largely unknown. The understanding of the mollecular mechanisms that lead to cerebral hemorrhage may be the basis for future treatments.

Previous evidences of our group have shown that Matrix Metal•loproteinases (MMPs) are related to brain bleeding. Now, we aim to investigate the relationship between these proteolytic systems and the appearance of intracraneal hemorrages in CAA.


Our study includes:


1) The identification of both tissue and plasma biomarkers for the diagnosis and prognosis of CAA-related hemorrhages.


2) The search of the genetic markers related to proteolytic systems that could determine the risk of suffering a recurrence in CAA.


We are studying a cohort of probable CAA patients that have been recruited in Hospital Vall d’Hebron in collaboration with the Stroke Project of the Cerebrovascular Diseases Study Group (Spanish Society of Neurology).


3) The study of MMPs role in ß-amyloid stimulated vascular cells in vitro.


Cultured cells of the neurovascular unit are challenged with different ß-amyloid peptides and the implication of MMPs in ß-amyloid cleavage and cell toxicity are studied using cellular and molecular biology methodology.


For this purpose, we use the human cerebral endothelial cell line hCMEC/D3, primary cultures of human leptomeningeal smooth muscle cells and rat/mouse glial and neuronal cultures.



Thioflavin-S staining of fibillar ß-amyloid within brain vessels of CAA patient’s sections.



Related bibliography:


1)  Hernández-Guillamon M, Delgado P, Ortega L, Pares M, Rosell A, García-Bonilla  L, Fernández-Cadenas I, Borrell-Pagès M, Boada M, Montaner J. Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. J Neurosci Res. 2009 Jul;87(9):2115-25.


2) Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Lo EH, Montaner J. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke. 2006 Jun;37(6):1399-406.


3)  Alvarez-Sabín J, Delgado P, Abilleira S, Molina CA, Arenillas J, Ribó M, Santamarina E, Quintana M, Monasterio J, Montaner J. Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke. 2004 Jun;35(6):1316-22.


4) Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Ribó M, Quintana M, Alvarez-Sabín J. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation. 2003 Feb 4;107(4):598-603.



Collaborations:

Mercè Boada

Fundació ACE, Barcelona, Spain.

www.fundacioace.com/


Jorge Ghiso and Agueda Rostagno

Pathology Dept. Langone Medical Center. NYU

New York, US.


Ignacio Romero

Life Science Dept. Open University.

Milton Keynes, UK.

IP: Maria Mar Hernandez Guillamon

Projectes

Influencia de factores clínicos, marcadores de neuroimagen y parámetros de laboratorio en el control de la presión arterial tras una hemorragia intracerebral aguda

IP: David Rodriguez Luna
Col·laboradors: Anna Bonaterra Pastra, Noelia Rodríguez Villatoro, Manuel Requena Ruiz, Olalla Pancorbo Rosal
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 40000
Referència: PI23/01061
Durada: 01/01/2024 - 31/12/2026

Papel de la proteína MFGE8 como potencial biomarcador y diana terapéutica en la angiopatía amiloide cerebral

IP: Maria Mar Hernandez Guillamon
Col·laboradors: -
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 208750
Referència: PI23/00082
Durada: 01/01/2024 - 31/12/2026

Beca VHIR PhD

IP: Anna Rosell Novel
Col·laboradors: Sira Rodrigo Bosch, Laia Perez Lasarte, Marta Kinga Klimczak , Marta Kinga Klimczak
Entitat finançadora: Fundació Institut de Recerca HUVH
Finançament: 69188.74
Referència: VPHD/MARTA_K
Durada: 15/05/2023 - 14/05/2026

Proyecto colaborativo europeo-latinoamericano y caribeño sobre medicina personalizada para el estudio de trastornos neurológicos

IP: Maria Mar Hernandez Guillamon
Col·laboradors: Anna Penalba Morenilla, Jessica Camacho Soriano, Elena Antima Martinez Saez
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 174845
Referència: AC22/00051
Durada: 01/01/2023 - 31/12/2025

Publicacions

Retinoic Acid-Loaded Nanoparticles Promote Neurovascular Protection in Stroke.

PMID: 36912140
Revista: STROKE
Any: 2023
Referència: Stroke. 2023 Mar 13. doi: 10.1161/STROKEAHA.122.041839.
Factor d'impacte:
Tipus de publicació: Carta amb FI
Autors: Bernardino, Liliana; Cristovao, Ana; Ferreira, Lino; Ferreira, Raquel; Francisco, Vitor; Garcia-Gabilondo, Miguel; Grayston, Alba; Machado-Pereira, Marta; Marto, Joao; Rosell, Anna et al.
DOI: 10.1161/STROKEAHA.122.041839

Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke.

PMID: 37021149
Revista: European Stroke Journal
Any: 2023
Referència: Eur Stroke J. 2023 Mar;8(1):309-319. doi: 10.1177/23969873221145391. Epub 2022 Dec 21.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arnold, Marcel; Arnold, Markus; Bicvic, Antonela; Bonati, Leo H; Bracher, Katja; Bustamante, Alejandro; Cereda, Carlo; De Marchis, Gian Marco; Fischer, Urs; Foerch, Christian et al.
DOI: 10.1177/23969873221145391

C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke: An Individual Participant Data Meta-Analysis.

PMID: 37026458
Revista: STROKE
Any: 2023
Referència: Stroke. 2023 May;54(5):1289-1299. doi: 10.1161/STROKEAHA.122.040529. Epub 2023 Apr 7.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Gorey, Sarah; Harris, Katie; Hervella, Pablo; Iglesias-Rey, Ramon; Jern, Christina; Kelly, Peter J; Li, Linxin; McCabe, John J; Miyamoto, Nobukazu; Montaner, Joan et al.
DOI: 10.1161/STROKEAHA.122.040529

Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model.

PMID: 37036702
Revista: JAMA Neurology
Any: 2023
Referència: JAMA Neurol. 2023 Apr 10. doi: 10.1001/jamaneurol.2023.0611.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Abraira, Laura; Alvarez-Sabin, Jose; Baumann, Christian R; Bayona-Ortiz, Hernan; Bentes, Carla; Bicciato, Giulio; Brigo, Francesco; Conrad, Julian; Dohler, Nico; Duncan, John S et al.
DOI: 10.1001/jamaneurol.2023.0611

Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry.

PMID: 35508915
Revista: EUROPEAN JOURNAL OF HEART FAILURE
Any: 2022
Referència: Eur J Heart Fail. 2022 Jul;24(7):1253-1265. doi: 10.1002/ejhf.2525. Epub 2022 May 16.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Abboud, C S; Abd El-Nasser, M; Abdel-Hay, M; Abdelnaby, M; Abe, K; Abid, L; Aboal Vinas, J; Aboulenein, J; Aboyans, V; Abreu, J et al.
DOI: 10.1002/ejhf.2525

Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease.

PMID: 34514662
Revista: BRAIN PATHOLOGY
Any: 2022
Referència: Brain Pathol. 2022 Jan;32(1):e13016. doi: 10.1111/bpa.13016. Epub 2021 Sep 12.
Factor d'impacte: 6.508
Tipus de publicació: Article en revista internacional
Autors: Camacho, Jessica; Rabano, Alberto; Marazuela, Paula; Bonaterra-Pastra, Anna; Serna, Garazi; Moline, Teresa; Ramon Y Cajal, Santiago; Martinez-Saez, Elena; Hernandez-Guillamon, Mar et al.
DOI: 10.1111/bpa.13016

Interictal brain activity changes in temporal lobe epilepsy: A quantitative electroencephalogram analysis.

PMID: 34687043
Revista: ACTA NEUROLOGICA SCANDINAVICA
Any: 2022
Referència: Acta Neurol Scand. 2022 Feb;145(2):239-248. doi: 10.1111/ane.13543. Epub 2021 Oct 22.
Factor d'impacte: 3.209
Tipus de publicació: Article en revista internacional
Autors: Fonseca, Elena; Quintana, Manuel; Seijo-Raposo, Ivan; Ortiz de Zarate, Zurine; Abraira, Laura; Santamarina, Estevo; Toledo, Manuel; Alvarez-Sabin, Jose et al.
DOI: 10.1111/ane.13543

Herpes simplex encephalitis in the context of immune checkpoint inhibitors: a complex interplay.

PMID: 34988947
Revista: ACTA NEUROLOGICA BELGICA
Any: 2022
Referència: Acta Neurol Belg. 2022 Jun;122(3):823-825. doi: 10.1007/s13760-021-01864-2. Epub 2022 Jan 6.
Factor d'impacte: 2.396
Tipus de publicació: Carta o abstract
Autors: Lallana, Sofia; Sanchez-Tejerina, Daniel; Auger, Cristina; Callejo, Ana; Rio, Jordi; Cobo-Calvo, Alvaro et al.
DOI: 10.1007/s13760-021-01864-2

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function.

PMID: 35083225
Revista: Frontiers in Cell and Developmental Biology
Any: 2021
Referència: Front Cell Dev Biol. 2022 Jan 10;9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021.
Factor d'impacte: 6.684
Tipus de publicació: Revisió en revista internacional
Autors: Coccia, Elena, Sole, Montse, Comella, Joan X et al.
DOI: 10.3389/fcell.2021.826037

Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke.

PMID: 34899582
Revista: Frontiers in Neurology
Any: 2021
Referència: Front Neurol. 2021 Nov 25;12:767484. doi: 10.3389/fneur.2021.767484. eCollection 2021.
Factor d'impacte: 4.003
Tipus de publicació: Article en revista internacional
Autors: Tejada, Pedro Ignacio, Garcia-Rodriguez, Nicolas, Rodriguez, Susana, Buxo, Xavi, Perez-Mesquida, Maria Engracia, Beseler, Maria Rosario, Salom, Juan B, Perez, Laura M, Inzitari, Marco, Otero-Villaverde, Sergio et al.
DOI: 10.3389/fneur.2021.767484

Overnight switch from levetiracetam to brivaracetam. Safety and tolerability.

PMID: 34901817
Revista: Epilepsy & behavior reports
Any: 2021
Referència: Epilepsy Behav Rep. 2021 Nov 14;16:100504. doi: 10.1016/j.ebr.2021.100504. eCollection 2021.
Factor d'impacte: 0
Tipus de publicació: Article en revista internacional
Autors: Abraira, L, Salas-Puig, J, Quintana, M, Seijo-Raposo, I M, Santamarina, E, Fonseca, E, Toledo, M et al.
DOI: 10.1016/j.ebr.2021.100504

Systematic CT perfusion acquisition in acute stroke increases vascular occlusion detection and thrombectomy rates.

PMID: 34857668
Revista: Journal of NeuroInterventional Surgery
Any: 2021
Referència: J Neurointerv Surg. 2021 Dec 2. pii: neurintsurg-2021-018241. doi: 10.1136/neurintsurg-2021-018241.
Factor d'impacte: 5.836
Tipus de publicació: Article en revista internacional
Autors: Olive-Gadea, Marta, Requena, Manuel, Diaz, Facundo, Boned, Sandra, Garcia-Tornel, Alvaro, Muchada, Marian, Deck, Matias, Lozano, Prudencio, Rodriguez-Villatoro, Noelia, Juega, Jesus et al.
DOI: 10.1136/neurintsurg-2021-018241

Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.

PMID: 33173895
Revista:
Any: 2020
Referència: medRxiv. 2020 Nov 3:2020.10.29.20222257. doi: 10.1101/2020.10.29.20222257. Preprint.
Factor d'impacte:
Tipus de publicació: Altres (cartes a l'editor, abstracts, correccions, etc.)
Autors: Amini, Hajar; Ander, Bradley P; Arauz, Antonio; Arenillas, Juan Francisco; Arias-Rivas, Susana; Bang, Oh Young; Barboza, Miguel A; Bergmann, Kristy; Bradley, Joseph; Budde, John et al.
DOI: 10.1101/2020.10.29.20222257

Management of acute stroke. Specific nursing care and treatments in the stroke unit.

PMID: 33153769
Revista: NEUROLOGIA
Any: 2020
Referència: Neurologia. 2020 Nov 2. pii: S0213-4853(20)30291-7. doi: 10.1016/j.nrl.2020.07.025.
Factor d'impacte: 2.283
Tipus de publicació: Revisió en revista nacional
Autors: Rodriguez-Luna, D, Sanjuan, E, Pancorbo, O, Santana, K, Minarro, O, Sala, V, Muchada, M, Boned, S, Juega, J M, Pagola, J et al.
DOI: 10.1016/j.nrl.2020.07.025

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.

PMID: 33146036
Revista: CEPHALALGIA
Any: 2020
Referència: Cephalalgia. 2020 Nov;40(13):1410-1421. doi: 10.1177/0333102420965157.
Factor d'impacte: 4.868
Tipus de publicació: Article en revista internacional
Autors: Caronna, Edoardo, Ballve, Alejandro, Llaurado, Arnau, Gallardo, Victor Jose, Maria Ariton, Diana, Lallana, Sofia, Maza, Samuel Lopez, Gadea, Marta Olive, Quibus, Laura, Restrepo, Juan Luis et al.
DOI: 10.1177/0333102420965157

The mediating role of epileptic seizures, irritability, and depression on quality of life in people with epilepsy.

PMID: 33129044
Revista: EPILEPSY & BEHAVIOR
Any: 2020
Referència: Epilepsy Behav. 2020 Dec;113:107511. doi: 10.1016/j.yebeh.2020.107511. Epub 2020 Oct 24.
Factor d'impacte: 2.508
Tipus de publicació: Article en revista internacional
Autors: Olive-Gadea, Marta, Quintana, Manuel, Abraira, Laura, Seijo-Raposo, Ivan, Santamarina, Estevo, Toledo, Manuel, Fonseca, Elena, Campos-Fernandez, Daniel et al.
DOI: 10.1016/j.yebeh.2020.107511

BRIVA-LIFE-A multicenter retrospective study of the long-term use of brivaracetam in clinical practice.

PMID: 30506559
Revista: ACTA NEUROLOGICA SCANDINAVICA
Any: 2019
Referència: Acta Neurol Scand. 2019 Apr;139(4):360-368. doi: 10.1111/ane.13059. Epub 2018 Dec 27.
Factor d'impacte: 2.852
Tipus de publicació: Article en revista internacional
Autors: Villanueva, Vicente, Lopez-Gonzalez, Francisco Javier, Mauri, Jose Angel, Rodriguez-Uranga, Juan, Olive-Gadea, Marta, Montoya, Javier, Ruiz-Gimenez, Jesus, Zurita, Jorge, Abril, J, Toledo, M et al.
DOI: 10.1111/ane.13059

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics.

PMID: 31877821
Revista: Pharmaceutics
Any: 2019
Referència: Pharmaceutics. 2019 Dec 21;12(1). pii: pharmaceutics12010016. doi: 10.3390/pharmaceutics12010016.
Factor d'impacte: 4.773
Tipus de publicació: Article en revista internacional
Autors: Rosell, Anna, Zhang, Yajie, Garcia-Gabilondo, Miguel, Roig, Anna et al.
DOI: 10.3390/pharmaceutics12010016

Implementation of a protocol for direct stroke patient transfer and mobilization of a stroke team to reduce times to reperfusion.

PMID: 31777209
Revista: Emergencias
Any: 2019
Referència: Emergencias. 2019 Dic;31(6):385-390.
Factor d'impacte: 3.35
Tipus de publicació: Article en revista internacional
Autors: Sanjuan Menendez, Estela, Giron Espot, Pilar, Calleja Macho, Laura, Rodriguez-Samaniego, Maria Teresa, Santana Roman, Katherine E, Rubiera Del Fueyo, Marta et al.
DOI:

The ADAN Scale: A proposed scale for prehospital use to identify status epilepticus.

PMID: 30565357
Revista: EUROPEAN JOURNAL OF NEUROLOGY
Any: 2019
Referència: Eur J Neurol. 2019 May;26(5):760-e55. doi: 10.1111/ene.13885. Epub 2019 Jan 20.
Factor d'impacte: 4.621
Tipus de publicació: Article en revista internacional
Autors: Requena, Manuel, Fonseca, Elena, Olive, Marta, Abraira, Laura, Quintana, Manuel, Mazuela, Gonzalo, Toledo, Manuel, Salas-Puig, Xavier, Santamarina, Estevo et al.
DOI: 10.1111/ene.13885

Anger Assessment in Patients Treated With Brivaracetam.

PMID: 29194113
Revista: CLINICAL NEUROPHARMACOLOGY
Any: 2018
Referència: Clin Neuropharmacol. 2018 Jan/Feb;41(1):6-9. doi: 10.1097/WNF.0000000000000258.
Factor d'impacte: 1.37
Tipus de publicació: Article en revista internacional
Autors: Toledo, Manuel, Ortega, Gemma, Abraira, Laura, Marti, Gloria, Quintana, Manuel, Mazuela, Gonzalo, Santamarina, Estevo, Salas-Puig, Xavier et al.
DOI: 10.1097/WNF.0000000000000258

Cost of status epilepticus (SE): Effects of delayed treatment and SE duration.

PMID: 30384104
Revista: EPILEPSY & BEHAVIOR
Any: 2018
Referència: Epilepsy Behav. 2018 Dec;89:8-14. doi: 10.1016/j.yebeh.2018.09.046. Epub 2018 Oct 26.
Factor d'impacte: 2.6
Tipus de publicació: Article en revista internacional
Autors: Santamarina, Estevo, Parejo, Beatriz, Abraira, Laura, Gutierrez-Viedma, Alvaro, Alpuente, Alicia, Abarrategui, Belen, Toledo, Manuel, Mazuela, Gonzalo, Salas-Puig, Xavier, Garcia-Morales, Irene et al.
DOI: 10.1016/j.yebeh.2018.09.046

Primary hypothyroidism in a child leads to pituitary hyperplasia: A case report and literature review.

PMID: 30334955
Revista: MEDICINE
Any: 2018
Referència: Medicine (Baltimore). 2018 Oct;97(42):e12703. doi: 10.1097/MD.0000000000012703.
Factor d'impacte: 2.028
Tipus de publicació: Article en revista internacional
Autors: Cao, Junguo, Lei, Ting, Zhang, Chaochao, Ma, Chengyuan, Huang, Haiyan, Chen, Fan et al.
DOI: 10.1097/MD.0000000000012703

Reliability of the early syndromic diagnosis in adults with new-onset epileptic seizures: A retrospective study of 116 patients attended in the emergency room.

PMID: 30172139
Revista: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Any: 2018
Referència: Seizure. 2018 Oct;61:158-163. doi: 10.1016/j.seizure.2018.08.016. Epub 2018 Aug 18.
Factor d'impacte: 2.839
Tipus de publicació: Guia clínica
Autors: Toledo, M, Salas Puig, X, Abraira Del Fresno, L, Fonseca Hernandez, E, Olive Gadea, M, Requena Ruiz, M, Quintana, M, Santamarina Perez, E, Alvarez Sabin, J et al.
DOI: 10.1016/j.seizure.2018.08.016

Reported Prestroke Physical Activity Is Associated with Vascular Endothelial Growth Factor Expression and Good Outcomes after Stroke.

PMID: 28029607
Revista: Journal of Stroke & Cerebrovascular Diseases
Any: 2017
Referència: J Stroke Cerebrovasc Dis. 2017 Feb;26(2):425-430. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.004. Epub 2016 Oct 28.
Factor d'impacte:
Tipus de publicació: Article en revista internacional
Autors: Arenillas, Juan F; Campos, Francisco; Cortes, Jordi; Davalos, Antoni; de la Ossa, Natalia Perez; Dorado, Laura; Gomis, Meritxell; Hernandez-Perez, Maria; Lopez-Cancio, Elena; Millan, Monica et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2016.10.004

Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral beta-amyloidosis.

PMID: 29116115
Revista: Scientific Reports
Any: 2017
Referència: Sci Rep. 2017 Nov 7;7(1):14637. doi: 10.1038/s41598-017-15215-w.
Factor d'impacte: 4.259
Tipus de publicació: Article en revista internacional
Autors: Fernandez-de-Retana, Sofia, Cano-Sarabia, Mary, Marazuela, Paula, Sanchez-Quesada, Jose Luis, Garcia-Leon, Annabel, Montanola, Alex, Montaner, Joan, Maspoch, Daniel, Hernandez-Guillamon, Mar et al.
DOI: 10.1038/s41598-017-15215-w

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease.

PMID: 28941727
Revista: NEUROBIOLOGY OF AGING
Any: 2017
Referència: Neurobiol Aging. 2017 Dec;60:116-128. doi: 10.1016/j.neurobiolaging.2017.08.028. Epub 2017 Sep 5.
Factor d'impacte: 5.117
Tipus de publicació: Article en revista internacional
Autors: Fernandez-de Retana, Sofia, Montanola, Alex, Marazuela, Paula, De La Cuesta, Maialen, Batlle, Aina, Fatar, Marc, Grudzenski, Saskia, Montaner, Joan, Hernandez-Guillamon, Mar et al.
DOI: 10.1016/j.neurobiolaging.2017.08.028

Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study.

PMID: 28716979
Revista: STROKE
Any: 2017
Referència: Stroke. 2017 Sep;48(9):2419-2425. doi: 10.1161/STROKEAHA.117.017076. Epub 2017 Jul 17.
Factor d'impacte: 6.032
Tipus de publicació: Article en revista internacional
Autors: Cardona, Pedro, Cano, Luis, Quesada, Helena, Terceno, Mikel, Silva, Yolanda, Castellanos, Mar, Garces, Moises, Reverte, Silvia, Ustrell, Xavier, Mares, Rafael et al.
DOI: 10.1161/STROKEAHA.117.017076

Semi-automatic measuring of arteriovenous relation as a possible silent brain infarction risk index in hypertensive patients.

PMID: 27311989
Revista: Archivos de la Sociedad Espanola de Oftalmologia
Any: 2016
Referència: Arch Soc Esp Oftalmol. 2016 Nov;91(11):513-519. doi: 10.1016/j.oftal.2016.05.001. Epub 2016 Jun 13.
Factor d'impacte: 0
Tipus de publicació: Article en revista nacional
Autors: Vazquez Dorrego, X M, Manresa Dominguez, J M, Heras Tebar, A, Fores, R, Girona Marce, A, Alzamora Sas, M T, Delgado Martinez, P, Riba-Llena, I, Ugarte Anduaga, J, Beristain Iraola, A et al.
DOI: 10.1016/j.oftal.2016.05.001

High daytime and nighttime ambulatory pulse pressure predict poor cognitive function and mild cognitive impairment in hypertensive individuals.

PMID: 25966945
Revista: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Any: 2016
Referència: J Cereb Blood Flow Metab. 2016 Jan;36(1):253-63. doi: 10.1038/jcbfm.2015.90.
Factor d'impacte: 5.407
Tipus de publicació: Article en revista internacional
Autors: Montaner, Joan, Riba-Llena, Iolanda, Nafria, Cristina, Filomena, Josefina, Tovar, Jose L, Vinyoles, Ernest, Mundet, Xavier, Jarca, Carmen I, Vilar-Bergua, Andrea, Delgado, Pilar et al.
DOI: 10.1038/jcbfm.2015.90

Blood and CSF biomarkers in brain subcortical ischemic vascular disease: involved pathways and clinical applicability.

PMID: 25899297
Revista: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Any: 2016
Referència: J Cereb Blood Flow Metab. 2016 Jan;36(1):55-71. doi: 10.1038/jcbfm.2015.68.
Factor d'impacte: 5.407
Tipus de publicació: Article en revista internacional
Autors: Vilar-Bergua, A, Riba-Llena, I, Nafria, C, Bustamante, A, Llombart, V, Delgado, P, Montaner, J et al.
DOI: 10.1038/jcbfm.2015.68

N-terminal pro-brain natriuretic peptide and subclinical brain small vessel disease.

PMID: 27956564
Revista: NEUROLOGY
Any: 2016
Referència: Neurology. 2016 Dec 13;87(24):2533-2539. Epub 2016 Nov 9.
Factor d'impacte: 8.166
Tipus de publicació: Article en revista internacional
Autors: Vilar-Bergua, Andrea, Riba-Llena, Iolanda, Penalba, Anna, Jimenez-Balado, Joan, Montaner, Joan, Delgado, Pilar, Cruz, Luz Maria et al.
DOI: 10.1212/WNL.0000000000003423

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives.

PMID: 26597154
Revista: Journal of the American Heart Association
Any: 2015
Referència: J Am Heart Assoc. 2015 Nov 23;4(11). pii: JAHA.115.002669. doi: 10.1161/JAHA.115.002669.
Factor d'impacte: 4.306
Tipus de publicació: Article en revista internacional
Autors: Delgado, Pilar, Montaner, Joan, Libert, Claude, Vilar-Bergua, Andrea, Riba-Llena, Iolanda, Vanhooren, Valerie, Dewaele, Sylviane, Penalba, Anna et al.
DOI: 10.1161/JAHA.115.002669

Small cortical infarcts: prevalence, determinants, and cognitive correlates in the general population.

PMID: 26043763
Revista: International Journal of Stroke
Any: 2015
Referència: Int J Stroke. 2015 Oct;10 Suppl A100:18-24. doi: 10.1111/ijs.12543. Epub 2015 Jun 4.
Factor d'impacte: 3.833
Tipus de publicació: Article en revista internacional
Autors: Riba-Llena, Iolanda, Koek, Marcel, Verhaaren, Benjamin F J, Vrooman, Henri A, van der Lugt, Aad, Hofman, Albert, Ikram, M Arfan, Vernooij, Meike W et al.
DOI: 10.1111/ijs.12543

B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis.

PMID: 25765726
Revista: STROKE
Any: 2015
Referència: Stroke. 2015 May;46(5):1187-95. doi: 10.1161/STROKEAHA.114.008311. Epub 2015 Mar 12.
Factor d'impacte: 5.723
Tipus de publicació: Revisió en revista internacional
Autors: Etgen, Thorleif, Llombart, Victor, Antolin-Fontes, Albert, Bustamante, Alejandro, Giralt, Dolors, Rost, Natalia S, Furie, Karen, Shibazaki, Kensaku, Biteker, Murat, Castillo, Jose et al.
DOI: 10.1161/STROKEAHA.114.008311

Short-Term Blood Pressure Variability Relates to the Presence of Subclinical Brain Small Vessel Disease in Primary Hypertension.

PMID: 26101344
Revista: HYPERTENSION
Any: 2015
Referència: Hypertension. 2015 Sep;66(3):634-40; discussion 445. doi: 10.1161/HYPERTENSIONAHA.115.05440. Epub 2015 Jun 22.
Factor d'impacte: 6.48
Tipus de publicació: Article en revista internacional
Autors: Filomena, Josefina, Tovar, Jose L, Mundet, Xavier, Castane, Xavier, Vilar, Andrea, Lopez-Rueda, Antonio, Jimenez-Balado, Joan, Cartanya, Anna, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/HYPERTENSIONAHA.115.05440

Role of lipoprotein-associated phospholipase A activity for the prediction of silent brain infarcts in women.

PMID: 25463126
Revista: ATHEROSCLEROSIS
Any: 2014
Referència: Atherosclerosis. 2014 Dec;237(2):811-5. doi: 10.1016/j.atherosclerosis.2014.11.003. Epub 2014 Nov 10.
Factor d'impacte: 3.971
Tipus de publicació: Article en revista internacional
Autors: Riba-Llena, Iolanda, Penalba, Anna, Pelegri, Dolors, Vilar, Andrea, Jarca, Carme I, Filomena, Josefina, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1016/j.atherosclerosis.2014.11.003

Prevalence and associated factors of silent brain infarcts in a Mediterranean cohort of hypertensives.

PMID: 24958500
Revista: HYPERTENSION
Any: 2014
Referència: Hypertension. 2014 Sep;64(3):658-63. doi: 10.1161/HYPERTENSIONAHA.114.03563. Epub 2014 Jun 23.
Factor d'impacte: 7.632
Tipus de publicació: Assaig clínic
Autors: Delgado, Pilar, Riba-Llena, Iolanda, Tovar, Jose L, Jarca, Carmen I, Mundet, Xavier, Lopez-Rueda, Antonio, Orfila, Francesc, Llussa, Judit, Manresa, Josep M, Alvarez-Sabin, Jose et al.
DOI: 10.1161/HYPERTENSIONAHA.114.03563

Brain proteomics identifies possible simvastatin targets in acute phase of stroke in a rat embolic model.

PMID: 24661059
Revista: J NEUROCHEM
Any: 2014
Referència: J Neurochem. 2014 Jul;130(2):301-12. doi: 10.1111/jnc.12719. Epub 2014 Apr 30.
Factor d'impacte: 4.244
Tipus de publicació: Article en revista internacional
Autors: Campos-Martorell, Mireia, Salvador, Nelida, Monge, Marta, Canals, Francesc, Garcia-Bonilla, Lidia, Hernandez-Guillamon, Mar, Ayuso, Maria Irene, Chacon, Pilar, Rosell, Anna, Alcazar, Alberto et al.
DOI: 10.1111/jnc.12719

Genes involved in hemorrhagic transformations that follow recombinant t-PA treatment in stroke patients.

PMID: 23556447
Revista: PHARMACOGENOMICS
Any: 2013
Referència: Pharmacogenomics. 2013 Apr;14(5):495-504. doi: 10.2217/pgs.13.19.
Factor d'impacte: 3.857
Tipus de publicació: Article en revista internacional
Autors: Fernandez-Cadenas, Israel, Rio-Espinola, Alberto Del, Domingues-Montanari, Sophie, Mendioroz, Maite, Fernandez-Morales, Jessica, Penalba, Anna, Rubiera, Marta, Hernandez-Guillamon, Mar, Rosell, Anna, Delgado, Pilar et al.
DOI: 10.2217/pgs.13.19

Letter by Riba-Llena et al Regarding Article, "Not Listened or Not Reported Rather Than Silent Stroke"

PMID: 23329208
Revista: STROKE
Any: 2013
Referència: Stroke. 2013 Apr;44(4):e42. doi: 10.1161/STROKEAHA.112.681817. Epub 2013 Jan 17.
Factor d'impacte: 6.158
Tipus de publicació: Carta amb FI
Autors: Riba-Llena, Iolanda, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/STROKEAHA.112.681817

A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke.

PMID: 23280790
Revista: ANNALS OF NEUROLOGY
Any: 2012
Referència: Ann Neurol. 2012 Nov;72(5):716-29. doi: 10.1002/ana.23664.
Factor d'impacte: 11.089
Tipus de publicació: Article en revista internacional
Autors: Mendioroz, Maite, del Rio-Espinola, Alberto, Fernandez-Cadenas, Israel, Giralt, Dolors, Quiroga, Adoracion, Gutierrez-Agullo, Maria, Quintana, Manuel, Fernandez-Alvarez, Patricia, Domingues-Montanari, Sophie, Canovas, D et al.
DOI: 10.1002/ana.23664

Cognitive assessment protocol design in the ISSYS (Investigating Silent Strokes in hYpertensives: A magnetic resonance imaging Study).

PMID: 22836018
Revista: JOURNAL OF THE NEUROLOGICAL SCIENCES
Any: 2012
Referència: J Neurol Sci. 2012 Nov 15;322(1-2):79-81. doi: 10.1016/j.jns.2012.06.015. Epub 2012 Jul 24.
Factor d'impacte: 2.353
Tipus de publicació: Article en revista internacional
Autors: Riba, I, Jarca, C I, Mundet, X, Tovar, J L, Orfila, F, Nafria, C, Raga, A, Girona, A, Fernandez-Lara, P, Castane, X et al.
DOI: 10.1016/j.jns.2012.06.015

Evidence for the efficacy of statins in animal stroke models: a meta-analysis.

PMID: 22548274
Revista: JOURNAL OF NEUROCHEMISTRY
Any: 2012
Referència: J Neurochem. 2012 Jul;122(2):233-43. doi: 10.1111/j.1471-4159.2012.07773.x. Epub 2012 May 21.
Factor d'impacte: 4.061
Tipus de publicació: Revisió en revista internacional
Autors: , , , , , , , et al.
DOI: 10.1111/j.1471-4159.2012.07773.x

Lipoprotein-Associated Phospholipase A(2) Activity Is Associated with Large-Artery Atherosclerotic Etiology and Recurrent Stroke in TIA Patients.

PMID: 22178747
Revista: CEREBROVASCULAR DISEASES
Any: 2012
Referència: Cerebrovasc Dis. 2012;33(2):150-8. Epub 2011 Dec 14.
Factor d'impacte: 2.723
Tipus de publicació: Article en revista internacional
Autors: , , , , , , , , , et al.
DOI: 10.1159/000334193

A panel of biomarkers including caspase-3 and d-dimer may differentiate acute stroke from stroke-mimicking conditions in the emergency department.

PMID: 21198992
Revista: JOURNAL OF INTERNAL MEDICINE
Any: 2011
Referència: J Intern Med. 2011 Aug;270(2):166-74. doi: 10.1111/j.1365-2796.2010.02329.x. Epub 2010 Dec 27.
Factor d'impacte: 5.935
Tipus de publicació: Article en revista internacional
Autors: , , , , , , , , , et al.
DOI: 10.1111/j.1365-2796.2010.02329.x

Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.

PMID: 21122033
Revista: EUROPEAN JOURNAL OF NEUROLOGY
Any: 2011
Referència: Eur J Neurol. 2011 Jun;18(6):826-35. doi: 10.1111/j.1468-1331.2010.03243.x. Epub 2010 Dec 1.
Factor d'impacte: 3.765
Tipus de publicació: Article en revista internacional
Autors: , , , , , , , , , et al.
DOI: 10.1111/j.1468-1331.2010.03243.x

Effect of atorvastatin on lipoprotein (a) and interleukin-10: A randomized placebo-controlled trial.

PMID: 21131223
Revista: DIABETES & METABOLISM
Any: 2011
Referència: Diabetes Metab. 2011 Apr;37(2):124-30. Epub 2010 Dec 4.
Factor d'impacte: 3.033
Tipus de publicació: Article en revista internacional
Autors: , , , , , , , et al.
DOI: 10.1016/j.diabet.2010.08.006

Lipoprotein-associated phospholipase A(2) testing usefulness among patients with symptomatic intracranial atherosclerotic disease.

PMID: 21620406
Revista: ATHEROSCLEROSIS
Any: 2011
Referència: Atherosclerosis. 2011 Sep;218(1):181-7. Epub 2011 May 5.
Factor d'impacte: 4.086
Tipus de publicació: Article en revista internacional
Autors: , , , , , , , , , et al.
DOI: 10.1016/j.atherosclerosis.2011.04.031

Reperfusion therapy for acute stroke improves outcome by decreasing neuroinflammation.

PMID: 24323553
Revista: Translational stroke research
Any: 2010
Referència: Transl Stroke Res. 2010 Dec;1(4):261-7. doi: 10.1007/s12975-010-0038-0. Epub 2010 Aug 28.
Factor d'impacte: 0
Tipus de publicació: Article en revista internacional
Autors: Montaner, Joan, Salat, David, Garcia-Berrocoso, Teresa, Molina, Carlos A, Chacon, Pilar, Ribo, Marc, Alvarez-Sabin, Jose, Rosell, Anna et al.
DOI: 10.1007/s12975-010-0038-0

The I/D polymorphism of the ACE1 gene is not associated with ischaemic stroke in Spanish individuals.

PMID: 20402757
Revista: EUROPEAN JOURNAL OF NEUROLOGY
Any: 2010
Referència: Eur J Neurol. 2010 Nov;17(11):1390-2.
Factor d'impacte: 2.51
Tipus de publicació: Article en revista internacional
Autors: , , , , , , , , , et al.
DOI: 10.1111/j.1468-1331.2010.03022.x

Evolution of lipid profile, liver function, and pattern of plasma fatty acids according to the type of lipid emulsion administered in parenteral nutrition in the early postoperative period after digestive surgery.

PMID: 19420283
Revista: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
Any: 2009
Referència: JPEN J Parenter Enteral Nutr. 2009 Sep-Oct;33(5):501-12.
Factor d'impacte: 1.97
Tipus de publicació: Article en revista internacional
Autors: Puiggros, C, Sanchez, J, Chacon, P, Sabin, P, Bou, R, Planas, M, Rosello, J et al.
DOI: 10.1177/0148607109333001

Ezetimibe as monotherapy in the treatment of hypercholesterolemia in children and adolescents.

PMID: 19694195
Revista: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Any: 2009
Referència: J Pediatr Endocrinol Metab. 2009 Jun;22(6):487-92.
Factor d'impacte: 0.938
Tipus de publicació: Article en revista internacional
Autors: Yeste, Diego, Chacon, Pilar, Clemente, Maria, Albisu, M A, Gussinye, Miquel, Carrascosa, Antonio et al.
DOI:

Changes in lipid profile between flare and remission of patients with systemic lupus erythematosus: a prospective study.

PMID: 19531751
Revista: JOURNAL OF RHEUMATOLOGY
Any: 2009
Referència: J Rheumatol. 2009 Aug;36(8):1639-45.
Factor d'impacte: 3.282
Tipus de publicació: Article en revista internacional
Autors: Urquizu-Padilla, Maria, Balada, Eva, Chacon, Pilar, Perez, Eduardo Hermosilla, Vilardell-Tarres, Miquel, Ordi-Ros, Josep et al.
DOI: 10.3899/jrheum.081097

C-reactive protein gene C1444T polymorphism and risk of recurrent ischemic events in patients with symptomatic intracranial atherostenoses.

PMID: 19494488
Revista: CEREBROVASCULAR DISEASES
Any: 2009
Referència: Cerebrovasc Dis. 2009;28(1):95-102.
Factor d'impacte: 3.041
Tipus de publicació: Article en revista internacional
Autors: Arenillas, Juan F, Massot, Andreu, Alvarez-Sabin, Jose, Fernandez-Cadenas, Israel, del Rio-Espinola, Albert, Chacon, Pilar, Quintana, Manuel, Molina, Carlos A, Rovira, Alex, Montaner, Joan et al.
DOI: 10.1159/000222660

Tesis

Estudi dels factors de risc genètics associats a l'ictus isquèmic.

Doctorand: Jara Cárcel Marquez
Director/s: Israel Fernandez Cadenas
Universitat: Universitat Autònoma de Barcelona
Any: 2023

Estudi del metabolisme lipídic perifèric i l'apolipoproteïna J en l'angiopatia amiloide cerebral

Doctorand: Anna Bonaterra Pastra, Anna Bonaterra Pastra
Director/s: Maria Mar Hernandez Guillamon
Universitat:
Any: 2023

Els biomarcadors sanguinis com a eines per a la prevenció del ictus associat a la fibril·lació auricular

Doctorand: Elena Pala Vila
Director/s: Joan Montaner Villalonga, Alejandro Bustamante Rangel
Universitat: Universidad Autònoma de Barcelona
Any: 2022

Noves estratègies per a la predicció i prevenció de la pneumònia associada a l'ictus

Doctorand: Julia Faura Llorens
Director/s: Alejandro Bustamante Rangel, Joan Montaner Villalonga
Universitat: Universidad Autònoma de Barcelona
Any: 2021

The unique role of Angiogenin in neuroprotection and neurorepair after cerebral ischemia

Doctorand: Ting Lei (Santiago)
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2021

Búsqueda de nuevos biomarcadores en la angiopatía amiloide cerebral

Doctorand: Paula Marazuela Fuentes
Director/s: Maria Mar Hernandez Guillamon
Universitat: Universidad Autònoma de Barcelona
Any: 2021

Progresión de la enfermedad de pequeño vaso cerebral: factores de riesgo, mecanismos implicados y consecuencias clínicas

Doctorand: Joan Jimenez Balado
Director/s: Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2020

Estado de mal epiléptico. Diagnóstico y pronóstico

Doctorand: Gloria Monts. González Cuevas
Director/s: Estevo Santamarina Pérez
Universitat: Universidad Autònoma de Barcelona
Any: 2020

Magnetic Nanomaterials for angiogenic therapies after stroke.

Doctorand: Yajie Zhang
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2020

Efecto de variaciones sobre ApoA-I y ApoJ recombinantes como aproximación terapéutica en el contexto de la Beta-amiloidosis cerebral

Doctorand: Sofia Fernandez De Re Alda
Director/s: Maria Mar Hernandez Guillamon
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Modulació de marcadors de neuroreparació en teràpies rehabilitadores després de l'ictus i en un model pre-clínic d'isquèmia cerebral

Doctorand: Marina Gabriel Salazar
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Potencial terapèutic de nous biomarcadors d'isquèmia cerebral

Doctorand: Alba Simats Oriol
Director/s: Joan Montaner Villalonga, Teresa Garcia Berrocoso
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Human Autonomic and Respiratory Responses to Direct Electrical Cortical Stimulation

Doctorand: Nuria Lacuey Lecumberri, Nuria Lacuey Lecumberri, Nuria Lacuey Lecumberri
Director/s: José Alvarez Sabin
Universitat: Universidad Autònoma de Barcelona
Any: 2018

Impacto de los cambios y el curso de la presión arterial mediante monitorización intensiva en la evolución clínica y radiológica tras una hemorragia intracerebral aguda

Doctorand: Mª Socorro Piñeiro Santos
Director/s: José Alvarez Sabin, David Rodriguez Luna, Carlos Molina Cateriano
Universitat: Universidad Autònoma de Barcelona
Any: 2017

Utilidad de los biomarcadores en el diagnóstico de la enfermedad cerebrovascular silente

Doctorand: Andrea Vilar Bergua
Director/s: Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2016

Condicionantes pronósticos del ictus isquémico: utilidad de los biomarcadores sanguíneos en su predicción

Doctorand: Alejandro Bustamante Rangel
Director/s: Joan Montaner Villalonga, Carlos Molina Cateriano
Universitat: Universidad Autònoma de Barcelona
Any: 2016

Aplicaciones proteómicas para el descubrimiento de biomarcadores diagnósticos en ictus

Doctorand: Victor Llombart Sebastià
Director/s: Joan Montaner Villalonga, Maria Mar Hernandez Guillamon
Universitat: Universitat de Barcelona
Any: 2016

Identificación de biomarcadores en el ictus hemorrágico y su estudio funcional en modelos experimentales

Doctorand: Cristina Merino Zamorano
Director/s: Joan Montaner Villalonga
Universitat: Universidad Autònoma de Barcelona
Any: 2016

Prevalencia y determinantes de las lesiones vasculares cerebrales definidas por resonancia magnética y estudio de la función cognitiva en problación adulta hipertensa y general

Doctorand: Yolanda Riba Llena
Director/s: Joan Montaner Villalonga, Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2015

Dual role of matrix metalloproteinases in brain injury and neurorepais after cerebral ischemia

Doctorand: Feifei Ma
Director/s: Joan Montaner Villalonga, Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2015

Les cèl·lules progenitores endotelials com a tractament neuroreparador angio-vasculogènic en la isquèmia cerebral modulat per la metal·loproteïnasa de matriu 9

Doctorand: Anna Morancho Retana
Director/s: Anna Rosell Novel, Joan Montaner Villalonga
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Identificación y uso de biomarcadores pronósticos en el ictus isquémico

Doctorand: Teresa Garcia Berrocoso
Director/s: Joan Montaner Villalonga, Israel Fernandez Cadenas, Maria Pilar Delgado Martínez
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Eficàcia i seguretat de la Simvastatina administrada en la fase aguda de la isquèmia cerebral experimental

Doctorand: Mireia Campos Martorell
Director/s: Joan Montaner Villalonga, Maria Mar Hernandez Guillamon
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Magnetic nanoparticles suspensions for cell tracking, imaging and therapeutics in ischemia treatments.

Doctorand: Elisa Carenza
Director/s: Anna Rosell Novel
Universitat: Universidad Autònoma de Barcelona
Any: 2014

Marcadores biológicos tras la hemorragia intracerebral y su relación con la evolución clínico-radiológica.

Doctorand: Maria Pilar Delgado Martínez
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2006

Proyecto Geno-tPA:Influencia del background genético en la seguridad y eficacia del tratamiento con t-PA en pacientes con ictus isquémico

Doctorand: Israel Fernandez Cadenas
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2006

Les Metal·loproteïnases de Matriu en el Parènquima Cerebral: Implicació en la Isquèmia Cerebral Humana

Doctorand: Anna Rosell Novel
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2005

aterosclerosis intracraneal de gran vaso: progresión y recurrencia clínica

Doctorand: Juan Francisco Arenillas Lara
Director/s:
Universitat: Universidad Autònoma de Barcelona
Any: 2003

Actualitat

Notícies

Els grups de Malalties Cardiovasculars i de Malalties Neurovasculars del VHIR investigaran noves estratègies terapèutiques per a la insuficiència cardíaca, nanomedicina en ictus i prevenció de la toxicitat cardiovascular davant tractaments oncològics.

Per tal de conscienciar la població, la Comissió de Salut i Medi Ambient ha impulsat la instal·lació d’uns grans plafons situats als diferents vestíbuls de l’hospital en què es pot veure una silueta humana acompanyada dels 17 tipus de malalties que causa.

La recerca és fonamental per contrarestar els efectes de la pol·lució, que segons l’AEMPS, va ser la causa de més de 300.000 morts prematures a la UE el 2020.

Ofertes de treball

Study Coordinator - Neurovascular diseases group_20240057
Data d'inici:
12/02/2024
Data de fi:
26/02/2024
Document: Descarrega
2024001_Laboratory technician - Neurovascular diseases group
Data d'inici:
02/01/2024
Data de fi:
15/01/2024
Document: Descarrega
Laboratory Technician - Neurovascular Research Laboratory
Data d'inici:
07/12/2023
Data de fi:
21/12/2023
Document: Descarrega