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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Publications

Evaluating multiple sclerosis severity loci 30 years after a clinically isolated syndrome.

PMID: 39670111
Journal: Brain Communications
Year: 2024
Reference: Brain Commun. 2024 Dec 5;6(6):fcae443. doi: 10.1093/braincomms/fcae443. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Brownlee, Wallace; Chard, Declan; Chung, Karen; Ciccarelli, Olga; Haider, Lukas; Houlden, Henry; Kanber, Baris; Prados Carrasco, Ferran; Sahi, Nitin et al.
DOI: 10.1093/braincomms/fcae443

Improvements in quality of life of people with relapsing multiple sclerosis treated with cladribine tablets during the 2-year CLARIFY-MS study: a plain language summary.

PMID: 39676554
Journal: Neurodegenerative disease management
Year: 2024
Reference: Neurodegener Dis Manag. 2024 Dec 16:1-12. doi: 10.1080/17582024.2024.2429970.
Impact factor:
Publication type: Paper in international publication
Authors: Alexandri, Nektaria; Brieva, Luis; Brochet, Bruno; Hupperts, Raymond; Kubala Havrdova, Eva; Langdon, Dawn; Lechner-Scott, Jeannette; Maidal, Eva Maria; Montalban, Xavier; Nolting, Axel et al.
DOI: 10.1080/17582024.2024.2429970

Long-term follow-up of patients with a first clinical demyelinating event (clinically isolated syndrome) who received cladribine tablets in CLASSIC-MS: Findings for the ORACLE-MS cohort.

PMID: 39690897
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Dec 17:13524585241302170. doi: 10.1177/13524585241302170.
Impact factor:
Publication type: Paper in international publication
Authors: Aydemir, Aida; Borsi, Laszlo; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S; Giovannoni, Gavin; Leist, Thomas; Montalban, Xavier; Rammohan, Kottil et al.
DOI: 10.1177/13524585241302170

De-escalating and discontinuing disease-modifying therapies in multiple sclerosis.

PMID: 39707906
Journal: BRAIN
Year: 2024
Reference: Brain. 2024 Dec 21:awae409. doi: 10.1093/brain/awae409.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Androdias, Geraldine; Audoin, Bertrand; Bruijstens, Arlette L; Bsteh, Gabriel; Butzkueven, Helmut; Ciccarelli, Olga; Cobo-Calvo, Alvaro; Derfuss, Tobias; Di Pauli, Franziska et al.
DOI: 10.1093/brain/awae409

Retinal Changes After Acute and Late Optic Neuritis in Aquaporin-4 Antibody Seropositive NMOSD.

PMID: 37782525
Journal: JOURNAL OF NEURO-OPHTHALMOLOGY
Year: 2023
Reference: J Neuroophthalmol. 2023 Sep 29. doi: 10.1097/WNO.0000000000001991.
Impact factor:
Publication type: Paper in international publication
Authors: Aktas, Orhan; Albrecht, Philipp; Asseyer, Eva Susanna; Bereuter, Charlotte; Brandt, Alexander U; Chien, Claudia; Cobo-Calvo, Alvaro; Cobo-Calvo, Alvaro; Cook, Lawrence; Fontenelle, Mariana Andrade et al.
DOI: 10.1097/WNO.0000000000001991

Assessment of Upper Extremity Function in Multiple Sclerosis: Feasibility of a Digital Pinching Test.

PMID: 37782540
Journal: JMIR formative research
Year: 2023
Reference: JMIR Form Res. 2023 Oct 2;7:e46521. doi: 10.2196/46521.
Impact factor:
Publication type: Paper in international publication
Authors: Bernasconi, Corrado; Dondelinger, Frank; Elantkowski, Marcin; Graves, Jennifer S; Lindemann, Michael; Lipsmeier, Florian; Midaglia, Luciana; Montalban, Xavier; Zhang, Yan-Ping et al.
DOI: 10.2196/46521

Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI.

PMID: 37803817
Journal: JOURNAL OF MAGNETIC RESONANCE IMAGING
Year: 2023
Reference: J Magn Reson Imaging. 2023 Oct 6. doi: 10.1002/jmri.29046.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Alberich, Manel; Arrambide, Georgina; Auger, Cristina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaqui N; Cobo-Calvo, Alvaro; Cobo-Calvo, Alvaro; Coll, Llucia et al.
DOI: 10.1002/jmri.29046

The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.

PMID: 37813596
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2023
Reference: Neurol Neuroimmunol Neuroinflamm. 2023 Oct 9;10(6):e200169. doi: 10.1212/NXI.0000000000200169. Print 2023 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Louzi, Omar; Albrecht, Philipp; Aly, Lilian; Banze, Nicolas; Baumann, Carmen; Cabello, Sergio; Calabresi, Peter A; Ciccarelli, Olga; Feucht, Nikolaus; Garcia-Martin, Elena et al.
DOI: 10.1212/NXI.0000000000200169

Treatment satisfaction, safety, and tolerability of cladribine tablets in patients with highly active relapsing multiple sclerosis: CLARIFY-MS study 6-month interim analysis.

PMID: 35158476
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jan;57:103385. doi: 10.1016/j.msard.2021.103385. Epub 2021 Nov 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alexandri, Nektaria; Brochet, Bruno; Havrdova, Eva K; Hupperts, Raymond; Keller, Birgit; Langdon, Dawn; Lechner-Scott, Jeannette; Montalban, Xavier; Nolting, Axel; Patti, Francesco et al.
DOI: 10.1016/j.msard.2021.103385

Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis.

PMID: 34836608
Journal: REVUE NEUROLOGIQUE
Year: 2022
Reference: Rev Neurol (Paris). 2022 Jan-Feb;178(1-2):121-128. doi: 10.1016/j.neurol.2021.10.003. Epub 2021 Nov 4.
Impact factor:
Publication type: Review in international publication
Authors: Akhavan Sigari, A; Baratian, M; Blanco, Y; Etemadifar, M; Mahdavi, S; Maracy, M R; Nouri, H; Salari, M; Sedaghat, N; Sepulveda, M et al.
DOI: 10.1016/j.neurol.2021.10.003

Neurotoxicity-associated sinus bradycardia after chimeric antigen receptor T-cell therapy.

PMID: 35139240
Journal: HEMATOLOGICAL ONCOLOGY
Year: 2022
Reference: Hematol Oncol. 2022 Aug;40(3):482-487. doi: 10.1002/hon.2976. Epub 2022 Feb 16.
Impact factor:
Publication type: Letter or abstract
Authors: Barba, Pere; Bosch, Francesc; Cabirta, Alba; Carpio, Cecilia; Catala, Eva; Iacoboni, Gloria; Oristrell, Gerard; Tintore, Mar; Vidal-Jordana, Angela; Vilaseca, Andreu et al.
DOI: 10.1002/hon.2976

Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis.

PMID: 35105687
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2022
Reference: Neurol Neuroimmunol Neuroinflamm. 2022 Feb 1;9(2). pii: 9/2/e1143. doi: 10.1212/NXI.0000000000001143. Print 2022 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Beltran, Jordina; Bonastre, Merce; Carbonell-Mirabent, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Comabella, Manuel; Espejo, Carmen et al.
DOI: 10.1212/NXI.0000000000001143

Ibudilast: a paradigm shift for progressive MS?

PMID: 33268561
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Jan 26;96(4):141-142. doi: 10.1212/WNL.0000000000011312. Epub 2020 Dec 2.
Impact factor:
Publication type: Editorail in international publication
Authors: Barkhof, Frederik; Sormani, Maria Pia; Tur, Carmen et al.
DOI: 10.1212/WNL.0000000000011312

A R-Script for Generating Multiple Sclerosis Lesion Pattern Discrimination Plots.

PMID: 33445771
Journal: Brain Sciences
Year: 2021
Reference: Brain Sci. 2021 Jan 12;11(1). pii: brainsci11010090. doi: 10.3390/brainsci11010090.
Impact factor:
Publication type: Paper in international publication
Authors: Marschallinger, Hannes; Marschallinger, Robert; Sellner, Johann; Tur, Carmen et al.
DOI: 10.3390/brainsci11010090

Association of Gray Matter Atrophy Patterns with Clinical Phenotype and Progression in Multiple Sclerosis.

PMID: 33441452
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Mar 16;96(11):e1561-e1573. doi: 10.1212/WNL.0000000000011494. Epub 2021 Jan 13.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Bellenberg, Barbara; Bisecco, Alvino; Ciccarelli, Olga; Filippi, Massimo; Gallo, Antonio; Gobbi, Claudio; Kearney, Hugh; Lukas, Carsten; Matthews, Lucy et al.
DOI: 10.1212/WNL.0000000000011494

Mind the gap: from neurons to networks to outcomes in multiple sclerosis.

PMID: 33437067
Journal: Nature Reviews Neurology
Year: 2021
Reference: Nat Rev Neurol. 2021 Mar;17(3):173-184. doi: 10.1038/s41582-020-00439-8. Epub 2021 Jan 12.
Impact factor:
Publication type: Review in international publication
Authors: Alahmadi, Adnan A S; Audoin, Bertrand; Barkhof, F; Barkhof, Frederik; Charalambous, Thalis; Chard, Declan T; Ciccarelli, O; Ciccarelli, Olga; De Stefano, N; Enzinger, C et al.
DOI: 10.1038/s41582-020-00439-8

A validation study of manual atrophy measures in patients with Multiple Sclerosis.

PMID: 32246177
Journal: NEURORADIOLOGY
Year: 2020
Reference: Neuroradiology. 2020 Aug;62(8):955-964. doi: 10.1007/s00234-020-02401-3. Epub 2020 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Alyafeai, Rumaiza; Auger, Cristina; Cappelle, Sarah; Montalban, Xavier; Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1007/s00234-020-02401-3

Targeted resequencing reveals rare variants enrichment in multiple sclerosis susceptibility genes.

PMID: 32196808
Journal: HUMAN MUTATION
Year: 2020
Reference: Hum Mutat. 2020 Jul;41(7):1308-1320. doi: 10.1002/humu.24016. Epub 2020 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alcina, Antonio; Bosch, Elena; Comabella, Manuel; Eixarch, Herena; Fernandez, Oscar; Gil-Varea, Elia; Izquierdo, Guillermo; Llufriu, Sara; Malhotra, Sunny; Matesanz, Fuencisla et al.
DOI: 10.1002/humu.24016

Author response: Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis.

PMID: 32152239
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 Mar 10;94(10):456-457. doi: 10.1212/WNL.0000000000009065.
Impact factor:
Publication type: Letter or abstract
Authors: Otero-Romero, Susana; Perez-Hoyos, Santiago; Tintore, Mar et al.
DOI: 10.1212/WNL.0000000000009065

Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis.

PMID: 32139431
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: AJNR Am J Neuroradiol. 2020 Mar;41(3):461-463. doi: 10.3174/ajnr.A6481. Epub 2020 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, M; Auger, C; Garcia-Vidal, A; Montalban, X; Pareto, D; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.3174/ajnr.A6481

Usefulness of brain perfusion CT in focal-onset status epilepticus.

PMID: 31166616
Journal: EPILEPSIA
Year: 2019
Reference: Epilepsia. 2019 Jul;60(7):1317-1324. doi: 10.1111/epi.16063. Epub 2019 Jun 5.
Impact factor: 5.562
Publication type: Paper in international publication
Authors: Gonzalez-Cuevas, Montserrat, Coscojuela, Pilar, Santamarina, Estevo, Pareto, Deborah, Quintana, Manuel, Sueiras, Maria, Guzman, Lorena, Sarria, Silvana, Salas-Puig, Xavier, Toledo, Manuel et al.
DOI: 10.1111/epi.16063

Predictors of response to endovascular treatment of posterior circulation stroke.

PMID: 31153569
Journal: EUROPEAN JOURNAL OF RADIOLOGY
Year: 2019
Reference: Eur J Radiol. 2019 Jul;116:219-224. doi: 10.1016/j.ejrad.2019.05.001. Epub 2019 May 2.
Impact factor: 2.948
Publication type: Paper in international publication
Authors: Tomasello, Alejandro, Molina, Carlos, Rovira, Alex, Rubiera, Marta, Gramegna, Laura Ludovica, Requena, Manuel, Dinia, Lavinia, Melendez, Fernando, Hernandez, David, Coscojuela, Pilar et al.
DOI: 10.1016/j.ejrad.2019.05.001

Engaging across dimensions of diversity: A cross-national perspective on mHealth tools for managing relapsing remitting and progressive multiple sclerosis.

PMID: 31125754
Journal: Multiple Sclerosis and Related Disorders
Year: 2019
Reference: Mult Scler Relat Disord. 2019 Jul;32:123-132. doi: 10.1016/j.msard.2019.04.020. Epub 2019 Apr 16.
Impact factor: 2.725
Publication type: Paper in international publication
Authors: Simblett, Sara K, Evans, Joanne, Greer, Ben, Curtis, Hannah, Matcham, Faith, Radaelli, Marta, Mulero, Patricia, Arevalo, Maria Jesus, Polhemus, Ashley, Ferrao, Jose et al.
DOI: 10.1016/j.msard.2019.04.020

CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.

PMID: 31072955
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2019
Reference: J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):1027-1038. doi: 10.1136/jnnp-2018-318957. Epub 2019 May 9.
Impact factor: 8.327
Publication type: Paper in international publication
Authors: Taieb, Guillaume, Mulero, Patricia, Psimaras, Dimitri, van Oosten, Bob W, Seebach, Jorg D, Marignier, Romain, Pico, Fernando, Rigau, Valerie, Ueno, Yuji, Duflos, Claire et al.
DOI: 10.1136/jnnp-2018-318957

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis.

PMID: 29352526
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2018
Reference: Eur J Neurol. 2018 Feb;25(2):215-237. doi: 10.1111/ene.13536. Epub 2018 Jan 19.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, M P; Chandraratna, D; Clanet, M; Comi, G; Derfuss, T; Fazekas, F; Gold, R; Hartung, H P; Havrdova, E; Hemmer, B et al.
DOI: 10.1111/ene.13536

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

PMID: 29353550
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Feb;24(2):96-120. doi: 10.1177/1352458517751049. Epub 2018 Jan 20.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Chandraratna, Dhia; Clanet, Michel; Comi, Giancarlo; Derfuss, Tobias; Fazekas, Franz; Gold, Ralf; Hartung, Hans Peter; Havrdova, Eva; Hemmer, Bernhard et al.
DOI: 10.1177/1352458517751049

Bone morphogenetic proteins in multiple sclerosis: role in neuroinflammation.

PMID: 28249802
Journal: BRAIN BEHAVIOR AND IMMUNITY
Year: 2018
Reference: Brain Behav Immun. 2018 Feb;68:1-10. doi: 10.1016/j.bbi.2017.02.019. Epub 2017 Feb 27.
Impact factor:
Publication type: Review in national publication
Authors: Calvo-Barreiro, Laura; Eixarch, Herena; Espejo, Carmen; Montalban, Xavier et al.
DOI: 10.1016/j.bbi.2017.02.019

Deep grey matter volume loss drives disability worsening in multiple sclerosis.

PMID: 29331092
Journal: ANNALS OF NEUROLOGY
Year: 2018
Reference: Ann Neurol. 2018 Feb;83(2):210-222. doi: 10.1002/ana.25145. Epub 2018 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Alexander, Daniel C; Altmann, Daniel R; Barkhof, Frederik; Battaglini, Marco; Brownlee, Wallace; Cardoso, M Jorge; Cawley, Niamh; Chard, Declan; Ciccarelli, Olga; De Angelis, Floriana et al.
DOI: 10.1002/ana.25145

[Response to treatment with interferon beta in patients with multiple sclerosis. Validation of the Rio Score].

PMID: 27439483
Journal: REVISTA DE NEUROLOGIA
Year: 2016
Reference: Rev Neurol. 2016 Aug 16;63(4):145-50.
Impact factor: 0.684
Publication type: Paper in national publication
Authors: Montalban, X, Comabella, M, Rio, J, Rovira, A, Blanco, Y, Sainz, A, Perkal, H, Robles, R, Ramio-Torrenta, Ll, Diaz, R M et al.
DOI:

Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test.

PMID: 26216790
Journal: NEUROREHABILITATION AND NEURAL REPAIR
Year: 2016
Reference: Neurorehabil Neural Repair. 2016 May;30(4):373-83. doi: 10.1177/1545968315597070. Epub 2015 Jul 27.
Impact factor: 4.035
Publication type: Paper in international publication
Authors: Feys, Peter, Leone, Carmela, Severijns, Deborah, Dolezalova, Vendula, Baert, Ilse, Dalgas, Ulrik, Romberg, Anders, Bethoux, Francois, Maamagi, Heigo, Rasova, Kamila et al.
DOI: 10.1177/1545968315597070

Contribution of the symptomatic lesion in establishing MS diagnosis and prognosis.

PMID: 27566747
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 27;87(13):1368-74. doi: 10.1212/WNL.0000000000003144. Epub 2016 Aug 26.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Nos, Carlos, Arevalo, Maria Jesus, Vidal-Jordana, Angela, Castillo, Joaquin, Rodriguez-Acevedo, Breogan, Midaglia, Luciana, Mitjana, Raquel, Auger, Cristina, Sastre-Garriga, Jaume, Rovira, Alex et al.
DOI: 10.1212/WNL.0000000000003144

Neurofilament light chain level is a weak risk factor for the development of MS.

PMID: 27521440
Journal: NEUROLOGY
Year: 2016
Reference: Neurology. 2016 Sep 13;87(11):1076-84. doi: 10.1212/WNL.0000000000003085. Epub 2016 Aug 12.
Impact factor: 8.166
Publication type: Paper in international publication
Authors: Kappos, Ludwig, Sastre-Garriga, Jaume, Pareto, Deborah, Simon, Eva, Comabella, Manuel, Rio, Jordi, Nos, Carlos, Tur, Carmen, Castillo, Joaquin, Disanto, Giulio et al.
DOI: 10.1212/WNL.0000000000003085

Significant clinical worsening after natalizumab withdrawal: Predictive factors.

PMID: 25392320
Journal: Multiple Sclerosis Journal
Year: 2015
Reference: Mult Scler. 2015 May;21(6):780-5. doi: 10.1177/1352458514549401. Epub 2014 Nov 12.
Impact factor: 4.863
Publication type: Paper in international publication
Authors: Tintore, M, Tur, C, Perez-Miralles, F, Auger, C, Rio, J, Nos, C, Arrambide, G, Comabella, M, Galan, I, Castillo, J et al.
DOI: 10.1177/1352458514549401

Brain atrophy in natalizumab-treated patients: A 3-year follow-up.

PMID: 25392330
Journal: Multiple Sclerosis Journal
Year: 2015
Reference: Mult Scler. 2015 May;21(6):749-56. doi: 10.1177/1352458514556300. Epub 2014 Nov 12.
Impact factor: 4.863
Publication type: Paper in international publication
Authors: Rovira, A, Sastre-Garriga, J, Tur, C, Pareto, D, Vidal-Jordana, A, Auger, C, Rio, J, Huerga, E, Tintore, M, Montalban, X et al.
DOI: 10.1177/1352458514556300

Quantifying brain tissue volume in multiple sclerosis with automated lesion segmentation and filling.

PMID: 26740917
Journal: NeuroImage-Clinical
Year: 2015
Reference: Neuroimage Clin. 2015 Oct 28;9:640-7. doi: 10.1016/j.nicl.2015.10.012. eCollection 2015.
Impact factor: 2.526
Publication type: Paper in international publication
Authors: Valverde, Sergi, Oliver, Arnau, Roura, Eloy, Pareto, Deborah, Vilanova, Joan C, Ramio-Torrenta, Lluis, Sastre-Garriga, Jaume, Montalban, Xavier, Rovira, Alex, Llado, Xavier et al.
DOI: 10.1016/j.nicl.2015.10.012

Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta.

PMID: 26531701
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2015
Reference: J Neuroimmunol. 2015 Nov 15;288:98-101. doi: 10.1016/j.jneuroim.2015.09.007. Epub 2015 Sep 25.
Impact factor: 2.467
Publication type: Paper in international publication
Authors: Negrotto, Laura, Canto, Ester, Tintore, Mar, Montalban, Xavier, Comabella, Manuel, Rio, Jordi et al.
DOI: 10.1016/j.jneuroim.2015.09.007

HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-beta therapy in multiple sclerosis.

PMID: 24748646
Journal: J MED GENET
Year: 2014
Reference: J Med Genet. 2014 Jun;51(6):395-400. doi: 10.1136/jmedgenet-2014-102348. Epub 2014 Apr 19.
Impact factor: 5.636
Publication type: Paper in international publication
Authors: Nunez, Concepcion, Rio, Jordi, Fernandez-Arquero, Miguel, Arroyo, Rafael, Montalban, Xavier, Fernandez, Oscar, Oliver-Martos, Begona, Leyva, Laura, Comabella, Manuel, Urcelay, Elena et al.
DOI: 10.1136/jmedgenet-2014-102348

Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

PMID: 24793898
Journal: J NEUROIMMUNOL
Year: 2014
Reference: J Neuroimmunol. 2014 Jul 15;272(1-2):51-5. doi: 10.1016/j.jneuroim.2014.04.007. Epub 2014 Apr 16.
Impact factor: 2.786
Publication type: Paper in international publication
Authors: Moreno, Montserrat, Negrotto, Laura, Rio, Jordi, Moubarak, Rana, Martin, Isabel, Bustamante, Marta F, Comella, Joan X, Vidal-Jordana, Angela, Perez-Boza, Jennifer, Montalban, Xavier et al.
DOI: 10.1016/j.jneuroim.2014.04.007

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

PMID: 24328534
Journal: AUTOIMMUNITY
Year: 2014
Reference: Autoimmunity. 2014 Mar;47(2):127-33. doi: 10.3109/08916934.2013.866104. Epub 2013 Dec 12.
Impact factor: 2.754
Publication type: Paper in international publication
Authors: Mansilla, Maria Jose, Comabella, Manuel, Rio, Jordi, Castillo, Joaquin, Castillo, Mireia, Martin, Roland, Montalban, Xavier, Espejo, Carmen et al.
DOI: 10.3109/08916934.2013.866104

Evaluating the response to glatiramer acetate in relapsing-remitting multiple sclerosis (RRMS) patients.

PMID: 24622350
Journal: MULT SCLER J
Year: 2014
Reference: Mult Scler. 2014 Oct;20(12):1602-8. doi: 10.1177/1352458514527863. Epub 2014 Mar 12.
Impact factor: 4.863
Publication type: Paper in international publication
Authors: Montalban, Xavier, Vidal, Angela, Tur, Carmen, Nos, Carlos, Rio, Jordi, Rovira, Alex, Tintore, Mar, Sastre-Garriga, Jaume, Castillo, Joaquin, Auger, Cristina et al.
DOI: 10.1177/1352458514527863

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography.

PMID: 23402900
Journal: NEUROBIOLOGY OF AGING
Year: 2013
Reference: Neurobiol Aging. 2013 Jul;34(7):1790-8. doi: 10.1016/j.neurobiolaging.2012.12.027. Epub 2013 Feb 10.
Impact factor: 6.166
Publication type: Paper in international publication
Authors: Rojas, Santiago, Herance, Jose Raul, Gispert, Juan Domingo, Abad, Sergio, Torrent, Elia, Jimenez, Xavier, Pareto, Deborah, Perpina, Unai, Sarroca, Sara, Rodriguez, Elisenda et al.
DOI: 10.1016/j.neurobiolaging.2012.12.027

Cellular immune responses in multiple sclerosis patients treated with interferon-beta.

PMID: 23379429
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2013
Reference: Clin Exp Immunol. 2013 Mar;171(3):243-6. doi: 10.1111/cei.12016.
Impact factor: 3.409
Publication type: Paper in international publication
Authors: Bustamante, M F, Rio, J, Castro, Z, Sanchez, A, Montalban, X, Comabella, M et al.
DOI: 10.1111/cei.12016

Early brain pseudoatrophy while on natalizumab therapy is due to white matter volume changes.

PMID: 23319072
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Aug;19(9):1175-81. doi: 10.1177/1352458512473190. Epub 2013 Jan 14.
Impact factor: 4.472
Publication type: Paper in international publication
Authors: Vidal-Jordana, Angela, Sastre-Garriga, Jaume, Perez-Miralles, Francisco, Tur, Carmen, Tintore, Mar, Horga, Alejandro, Auger, Cristina, Rio, Jordi, Nos, Carlos, Edo, Mari C et al.
DOI: 10.1177/1352458512473190

Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients.

PMID: 23182615
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2013
Reference: J Neuroimmunol. 2013 Feb 15;255(1-2):102-4. doi: 10.1016/j.jneuroim.2012.10.016. Epub 2012 Nov 22.
Impact factor: 3.033
Publication type: Paper in international publication
Authors: Comabella, M, Rentzsch, K, Rio, J, Bustamante, M F, Borowski, K, Stoecker, W, Montalban, X et al.
DOI: 10.1016/j.jneuroim.2012.10.016

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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