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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Publications

The potential of patient-derived organoids in precision medicine of biliary tract cancer.

PMID: 37992681
Journal: Cell Reports Medicine
Year: 2023
Reference: Cell Rep Med. 2023 Nov 21;4(11):101294. doi: 10.1016/j.xcrm.2023.101294.
Impact factor:
Publication type: Paper in international publication
Authors: Macarulla, Teresa; Malagelada, Carolina; Martin Dominguez, Veronica; Santander, Cecilio; Tian, Tian V; Yanez-Bartolome, Mariana et al.
DOI: 10.1016/j.xcrm.2023.101294

Mutual modulation of gut microbiota and the immune system in type 1 diabetes models.

PMID: 38012160
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Nov 27;14(1):7770. doi: 10.1038/s41467-023-43652-x.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Fabiola; Arpa, Berta; Aunon, Pilar; Corral-Pujol, Marta; Cosovanu, Catalina; Egia-Mendikute, Leire; Garcia, Patricia; Garcia-Carro, Clara; Gutierrez, Eduardo; Manichanh, Chaysavanh et al.
DOI: 10.1038/s41467-023-43652-x

A Randomized Trial of Dolutegravir Plus Darunavir/Cobicistat as a Switch Strategy in HIV-1-Infected Patients With Resistance to at Least 2 Antiretroviral Classes.

PMID: 38023553
Journal: Open Forum Infectious Diseases
Year: 2023
Reference: Open Forum Infect Dis. 2023 Oct 31;10(11):ofad542. doi: 10.1093/ofid/ofad542. eCollection 2023 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Arpa, Berta; Bernal, Enrique; Clotet, Bonaventura; Corral-Pujol, Marta; Cosovanu, Catalina; Curran, Adria; Domingo, Pere; Egia-Mendikute, Leire; Gutierrez, Felix; Imaz, Arkaitz et al.
DOI: 10.1093/ofid/ofad542

The adjusted prevalence of hepatitis delta virus (HDV) in 25 countries and territories.

PMID: 38030035
Journal: JOURNAL OF HEPATOLOGY
Year: 2023
Reference: J Hepatol. 2023 Nov 27:S0168-8278(23)05285-6. doi: 10.1016/j.jhep.2023.10.043.
Impact factor:
Publication type: Paper in international publication
Authors: Arijs, Ingrid; Borruel, Natalia; Carney, Nicholas; Casellas, Francesc; Charlafti, Ilias; Ferrante, Marc; Fierens, Liselotte; Fiorino, Gionata; Gerold, Nathalie; Gross, Evelyn et al.
DOI: 10.1016/j.jhep.2023.10.043

Selective CCK receptor antagonism enhances accommodation and tolerance of intestinal gas in functional gut disorders.

PMID: 26416485
Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Year: 2016
Reference: J Gastroenterol Hepatol. 2016 Feb;31(2):288-93. doi: 10.1111/jgh.13177.
Impact factor: 3.322
Publication type: Paper in international publication
Authors: Lobo, Beatriz, Serra, Jordi, D'Amato, Massimo, Rovati, Lucio, Malagelada, Juan-R, Santos, Javier, Azpiroz, Fernando et al.
DOI: 10.1111/jgh.13177

Blog

News

Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.