Josep Castellví Vives Institucions de les que formen part Investigador/a principal Patologia molecular translacional Vall Hebron Institut de Recerca Email
Línies de recerca Study of CAP-dependent and CAP-independent signalling pathways in breast carcinomas. In previous works we studied several factors involved in cell signalling pathways that control cell growth. The found that the phosphorylated form of 4E-BP1 was the only factor that correlated with prognosis, and histologic aggressive features in several types of cancers. 4E-BP1 is a key regulator of CAP-dependent traslation and its main function is the inactivation of eIF4E. However, not all the aggressive tumors show activation of this factor. On the other hand, it has been shown that under hypoxia conditions cells the translation of some key factors can be regulated by CAP-independent pathways, mediated by factors known as ITAFs. The aim of our study is to find the CAP-depdendent/CAP-independent balance in tumors in relation to hypoxia, and evaluate its impact on prognosis. IP: Josep Castellví Vives Projectes Anys actiu Patologia molecular translacional IP: - Col·laboradors: Cleofé Romagosa Pérez-Portabell, Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Jessica Camacho Soriano, Carmela Iglesias i Felip, Josep Castellví Vives, Elena Muro Blanc, Marta Cano Galietero, Elena Antima Martinez Saez, Javier Hernandez Losa, Marta Sese Faustino, Vicente Peg Camara, Irene Sansano Valero, Trond Aasen , Konstantin Slobodnyuk , Stefan Hummer , Milena Marcela Riaño Rodriguez Entitat finançadora: AGAUR Finançament: 40000 Referència: 2021 SGR 01138 Durada: 01/01/2022 - 31/12/2024 Transcriptomic and (epi)genetic hallmarks of CNS-tropism in diffuse large B cell lymphoma IP: Marta Crespo Maull Col·laboradors: Carlota Pagès Geli, Josep Castellví Vives Entitat finançadora: Instituto de Salud Carlos III Finançament: 99220 Referència: PI21/01190 Durada: 01/01/2022 - 31/12/2024 Enhancing CD8+ Resident Memory T cell function to control and eliminate viral reservoirs IP: Meritxell Genesca Ferrer Col·laboradors: Vicente Descalzo Jorro, Josep Castellví Vives, Laura Mañalich Barrachina Entitat finançadora: Instituto de Salud Carlos III Finançament: 171820 Referència: PI20/00160 Durada: 01/01/2021 - 31/12/2023 New therapeutic approaches in head and neck cancer IP: Matilde Lleonart Pajarin Col·laboradors: Yoelsis Garcia Mayea, Jordi Temprana Salvador, Angel García Jiménez, Josep Castellví Vives, Cristina Mir Perez, Laia Josa Culleré, Marina Bataller Fernández Entitat finançadora: Instituto de Salud Carlos III Finançament: 183920 Referència: PI20/00556 Durada: 01/01/2021 - 31/12/2023 Paginació Pàgina actual 1 Page 2 Page 3 Page 4 Page 5 … Pàgina següent › Última pàgina »
