Muscle injury due to micro-rupture of muscle fibers by surgical intervention Muscle lesion will be generated by performing a transverse biopsy, using a 6 mm diameter trocar, at the level of the myotendinous junction of the medial gastrocnemius muscle of the right hind leg

Fed for 12 or 20 weeks with a hypercaloric diet combined with a glucose-fructose drink (high fat glucose-fructose diet, HFGFD), in which the degree of non-alcoholic steatohepatitis (NASH) + fibrosis that they develop is evaluated Combination effect of 2 factors: Genetic + Dietetic

Fed for 8 weeks with a hypercaloric diet combined with a glucose-fructose drink (high fat glucose-fructose diet, HFGFD), in which the degree of non-alcoholic steatohepatitis (NASH) develop is evaluated

This mouse has a specific deletion of the Nr1f3 gene in adipocytes, resulting in a knockout of the gene in white and brown adipose tissues. So far, no pheNoype has been described.

This mouse model generate spontaneous hipermutant small intestinal tumors and CRC tumors (when treated with DSS)

Induction of migraine by administration of a nitric oxide donor: A solution of nitroglycerin (10 mg / Kg) or vehicle will be injected intraperitoneally once a day on alternate days (1, 3, 5, 7 and 9 post-basal).or inflammatory mediators infuse under anesthesia a solution containing histamine (1 mM), serotonin (1 mM), bradykinin (1 mM) and prostaglandin E2 (100 μM) or vehicle in the duramater on alternate days on days 1, 3, 5, 7 and 9 of the procedure) Location of a wireless EEG/EMG recording implant on the skull that allows continuous neurophysiological recording to assess cortical activity, movement patterns and sleep/wake cycle Animals habituation to different variables that will be found during the behavior test

Metastasis model obtained by intravenous injection (human model)

Condral defect of 10mm2 surgically generated in the loading area of the medial and lateral femoral condyle

In DBA/2 J mice, mutations in two genes (GpnmbR150X and Tyrp1b) lead to iris disease with features of human iris atrophy and pigment dispersion syndrome. This strain of mice is used as an experimental model of POAG (primary open-angle glaucoma), as they develop a chronic progressive increase in IOP that causes retinal ganglion cell death. The increase in IOP in these animals begins at 10 months of age, and the pressure remains elevated until death. These animal models are very useful in elucidating the glaucoma pathogenesis and to identify potential therapeutic targets

Measurement of intraocular pressure (IOP), reading is obtained from the central cornea of each eye. is measured with a rebound tonometer (Tonolab, Icare, Espoo, Finland) specific adapted by mice or rat