Cancer cells will be injected subcutaneously since early tumor formation

APP/PS1 double transgenic mouse co-expressing 5 AD family mutations and additively increasing Aβ42 production. It is considered a model of accelerated production of amyloid plaques, showing Aβ plaques and neurodegeneration from three months and spatial memory deficits from 4-5 months (Oakley et al., 2006). Unlike APP23, this model does not show Aβ deposition in cerebral blood vessels.

Model generated by intramuscular injection of cyclosporine (CsA)

Dexamethasone induces intraocular hypertension and a degeneration of the optic nerve

The low-dose streptozotocin model has been widely used for years in numerous publications with excellent results. The main advantage of drug delivery-based models is that the degree of β-cell disruption can be regulated according to the dose of toxin administered. This diabetic rat constitutes a good model because it generates vascular dysfunction and retinal neurodegeneration similar to human pathogenesis and allows obtaining sufficient amounts of retinal RNA or protein for experimental procedures. 1 dose of 65 mg/kg of STZ solution intraperitoneally. A week after stabilization, weight and blood glucose are measured. If the injected rats have a blood glucose level of > 250 mg/dl, they are considered diabetic.

This model exhibits servere obesity and altered glucose homeostasis (glucose intolerance and insulin resistance) after being fed with a high fat diet (45% Kcal from fat) or very high fat diet (60 % kcal from fat).

Model generated by Implantation of subcutaneous isoproterenol release pump

Model generated by Implantation of subcutaneous angiotensin II release pump

The DKO rd8 is obtained by crossing the C57BL/6NJ strain (homozygous for the Crb1rd8 mutation, the B6.129S4-*Ccl2tm1Rol*/J strain (homozygous for the Ccl2tm1Rol (Ccl2-/-) mutation), and the B6. 129P-*Cx3cr1tm1Litt*/J strain (homozygous for the Cx3cr1tm1Litt (Cx3cr1-/-) mutation). Availability: Cryopreserved