About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35225224 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2022 Reference: Clin Exp Rheumatol. 2022 Feb;40(2):309-319. Epub 2022 Feb 25. Impact factor: 4.473 Publication type: Review in international publication Authors: Faghihi-Kashani, Sara, Scire, Carlo Alberto, Bonella, Francesco, Corte, Tamera J, Doyle, Tracy J, Fiorentino, David, Gonzalez-Gay, Miguel A, Hudson, Marie, Kuwana, Masataka, Lundberg, Ingrid E et al. DOI:
PMID: 34480833 Journal: Arthritis & Rheumatology Year: 2022 Reference: Arthritis Rheumatol. 2022 Mar;74(3):508-517. doi: 10.1002/art.41964. Epub 2022 Feb 1. Impact factor: 10.995 Publication type: Paper in international publication Authors: Pinal-Fernandez, Iago, Pak, Katherine, Huang, Wilson, Selva-O'Callaghan, Albert, Albayda, Jemima, Casciola-Rosen, Livia, Paik, Julie J, Tiniakou, Eleni, Mecoli, Christopher A, Lloyd, Thomas E et al. DOI: 10.1002/art.41964
PMID: 35188463 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2022 Reference: J Investig Allergol Clin Immunol. 2022 Feb;32(1):1-12. doi: 10.18176/jiaci.0769. Impact factor: 7.033 Publication type: Review in international publication Authors: Luengo, O, Labrador-Horrillo, M et al. DOI: 10.18176/jiaci.0769
PMID: 33146762 Journal: RHEUMATOLOGY INTERNATIONAL Year: 2022 Reference: Rheumatol Int. 2022 Mar;42(3):441-448. doi: 10.1007/s00296-020-04733-y. Epub 2020 Nov 4. Impact factor: 2.631 Publication type: Paper in international publication Authors: Reina Sanz, Delia, Moya Alvarado, Patricia, de Agustin de Oro, Juan Jose, Aparicio Espinar, Maria, Armengol Perez, Eulalia, Busquets Perez, Noemi, Carmona, Loreto, Casado Burgos, Enrique, Clavaguera Poch, Teresa, Cuervo Aguilera, Andrea et al. DOI: 10.1007/s00296-020-04733-y
PMID: 34071326 Journal: SENSORS Year: 2021 Reference: Sensors (Basel). 2021 May 28;21(11). pii: s21113746. doi: 10.3390/s21113746. Impact factor: 3.576 Publication type: Paper in international publication Authors: Capdevila, Lluis, Castro-Marrero, Jesus, Alegre, Jose, Ramos-Castro, Juan, Escorihuela, Rosa M et al. DOI: 10.3390/s21113746
PMID: 34069603 Journal: Medicina-Lithuania Year: 2021 Reference: Medicina (Kaunas). 2021 May 19;57(5). pii: medicina57050510. doi: 10.3390/medicina57050510. Impact factor: 2.43 Publication type: Paper in international publication Authors: Nacul, Luis, Authier, Francois Jerome, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid Bergliot, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta et al. DOI: 10.3390/medicina57050510
PMID: 34075090 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Jun 1;11(1):11462. doi: 10.1038/s41598-021-90797-0. Impact factor: 4.38 Publication type: Paper in international publication Authors: Julia, Antonio, Bonafonte-Pardas, Irene, Gomez, Antonio, Lopez-Lasanta, Maria, Lopez-Corbeto, Mireia, Martinez-Mateu, Sergio H, Llados, Jordi, Rodriguez-Nunez, Ivan, Myers, Richard M, Marsal, Sara et al. DOI: 10.1038/s41598-021-90797-0
PMID: 34025983 Journal: Clinical and Translational Allergy Year: 2021 Reference: Clin Transl Allergy. 2021 May 18;11(3):e12010. doi: 10.1002/clt2.12010. eCollection 2021 May. Impact factor: 5.871 Publication type: Review in international publication Authors: Faber, Margaretha A, Skypala, Isabel J, Asero, Ricardo, Barber, Domingo, Cecchi, Lorenzo, Diaz Perales, Arazeli, Hoffmann-Sommergruber, Karin, Pastorello, Elide A, Swoboda, Ines, Bartra, Joan et al. DOI: 10.1002/clt2.12010
PMID: 32194200 Journal: AUTOIMMUNITY REVIEWS Year: 2020 Reference: Autoimmun Rev. 2020 May;19(5):102507. doi: 10.1016/j.autrev.2020.102507. Epub 2020 Mar 17. Impact factor: 7.767 Publication type: Review in international publication Authors: Rubio-Rivas, Manuel, Corbella, Xavier, Guillen-Del-Castillo, Alfredo, Vilella, Carles Tolosa, Arguelles, Dolores Colunga, Argibay, Ana, Aznar, Carmen Pilar Simeon, Pla, Vicent Fonollosa, Trigo, Sabela Sanchez, Hitos, Jose Antonio Vargas et al. DOI: 10.1016/j.autrev.2020.102507
PMID: 32128023 Journal: World Allergy Organization Journal Year: 2020 Reference: World Allergy Organ J. 2020 Feb 25;13(2):100080. doi: 10.1016/j.waojou.2019.100080. eCollection 2020 Feb. Impact factor: 3.506 Publication type: Paper in international publication Authors: Antila, Martti, Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier et al. DOI: 10.1016/j.waojou.2019.100080
PMID: 31627910 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Allergy Clin Immunol. 2020 Jan;145(1):70-80.e3. doi: 10.1016/j.jaci.2019.06.049. Epub 2019 Oct 15. Impact factor: 10.228 Publication type: Review in international publication Authors: Menditto, Enrica, Bousquet, Jean, Schunemann, Holger J, Togias, Akdis, Bachert, Claus, Erhola, Martina, Hellings, Peter W, Klimek, Ludger, Pfaar, Oliver, Wallace, Dana et al. DOI: 10.1016/j.jaci.2019.06.049
PMID: 31530514 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Investig Allergol Clin Immunol. 2020;30(1):67. doi: 10.18176/jiaci.0444. Epub 2019 Sep 18. Impact factor: 3.488 Publication type: Paper in international publication Authors: Castillo Marchuet, M J, Luengo, O, Cardona, V et al. DOI: 10.18176/jiaci.0444
PMID: 31261500 Journal: MEDICINE Year: 2019 Reference: Medicine (Baltimore). 2019 Jun;98(26):e15947. doi: 10.1097/MD.0000000000015947. Impact factor: 1.87 Publication type: Paper in international publication Authors: Corominas, Hector, Alegre, Cayetano, Narvaez, Javier, Fernandez-Cid, Carlos Marras, Torrente-Segarra, Vicenc, Gomez, Manuel Rodriguez, Pan, Francisco Maceiras, Morla, Rosa Maria, Martinez, Fernando Jose Rodriguez, Gomez-Centeno, Antoni et al. DOI: 10.1097/MD.0000000000015947
PMID: 31253111 Journal: BMC PUBLIC HEALTH Year: 2019 Reference: BMC Public Health. 2019 Jun 28;19(1):840. doi: 10.1186/s12889-019-7225-z. Impact factor: 2.567 Publication type: Paper in international publication Authors: Castro-Marrero, Jesus, Faro, Monica, Zaragoza, Maria Cleofe, Aliste, Luisa, de Sevilla, Tomas Fernandez, Alegre, Jose et al. DOI: 10.1186/s12889-019-7225-z
PMID: 31253480 Journal: MEDICINA CLINICA Year: 2019 Reference: Med Clin (Barc). 2019 Dec 13;153(11):437-440. doi: 10.1016/j.medcli.2019.04.022. Epub 2019 Jun 26. Impact factor: 1.277 Publication type: Paper in national publication Authors: Milisenda, Jose C, Garcia, Ana Matas, Jou, Cristina, Pinal-Fernandez, Iago, O'Callaghan, Albert Selva, Grau, Josep Maria et al. DOI: 10.1016/j.medcli.2019.04.022
PMID: 31237427 Journal: Arthritis & Rheumatology Year: 2019 Reference: Arthritis Rheumatol. 2019 Dec;71(12):2081-2089. doi: 10.1002/art.41026. Epub 2019 Oct 21. Impact factor: 9.002 Publication type: Paper in international publication Authors: Ruiz-Moreno, Oscar, Atienza-Mateo, Belen, Martin-Varillas, Jose Luis, Calvo-Rio, Vanesa, Fernandez-Cid, Carlos, Aurrecoechea, Elena, Garcia-Arias, Miriam, Castaneda, Santos, Caracuel-Ruiz, Miguel A, Montilla-Morales, Carlos A et al. DOI: 10.1002/art.41026
PMID: 28887115 Journal: AMERICAN JOURNAL OF OPHTHALMOLOGY Year: 2018 Reference: Am J Ophthalmol. 2018 Mar;187:158-166. doi: 10.1016/j.ajo.2017.08.017. Epub 2017 Sep 6. Impact factor: 4.795 Publication type: Paper in international publication Authors: Russo, Ricardo, Susic, Gordana, Thatayatikom, Akaluck, Thomee, Caroline, Vastert, Sebastiaan, Bertin, John, Arostegui, Juan I, Rose, Carlos D, Wouters, Carine H, Ramanan, Athimalaipet V et al. DOI: 10.1016/j.ajo.2017.08.017
PMID: 29473763 Journal: Expert Review of Clinical Immunology Year: 2018 Reference: Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23. Impact factor: 3.436 Publication type: Paper in international publication Authors: Grau-Junyent, Josep Maria, Selva-O'Callaghan, Albert, Alvarado-Cardenas, Marcelo, Pinal-Fernandez, Iago, Trallero-Araguas, Ernesto, Milisenda, Jose Cesar, Martinez, Maria Angeles, Marin, Ana, Labrador-Horrillo, Moises, Juarez, Candido et al. DOI: 10.1080/1744666X.2018.1440206
PMID: 29461211 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2018 Reference: J Investig Allergol Clin Immunol. 2018;28(1):51-53. doi: 10.18176/jiaci.0206. Impact factor: 3.457 Publication type: Paper in international publication Authors: Peixoto, S, Monteiro, T, Carvalho, M, Santos, M, Matos, C, Bartolome, B, Labrador-Horrillo, M, Quaresma, M et al. DOI: 10.18176/jiaci.0206
PMID: 29461213 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2018 Reference: J Investig Allergol Clin Immunol. 2018;28(1):56-58. doi: 10.18176/jiaci.0208. Impact factor: 3.457 Publication type: Paper in international publication Authors: Miquel, S, Micozzi, S, Bartolome, B, Labrador-Horrillo, M, Roger, A, Prieto-Garcia, A, Basagana, M et al. DOI: 10.18176/jiaci.0208
PMID: 28432600 Journal: DRUGS & AGING Year: 2017 Reference: Drugs Aging. 2017 Jun;34(6):453-466. doi: 10.1007/s40266-017-0452-z. Impact factor: 2.769 Publication type: Paper in international publication Authors: Marquez, Paola H Ponte, Torres, Olga H, San-Jose, Anonio, Vidal, Xavier, Agusti, Antonia, Formiga, Francesc, Lopez-Soto, Alfonso, Ramirez-Duque, Nieves, Fernandez-Moyano, Antonio, Garcia-Moreno, Juana et al. DOI: 10.1007/s40266-017-0452-z
PMID: 28426925 Journal: Arthritis & Rheumatology Year: 2017 Reference: Arthritis Rheumatol. 2017 Sep;69(9):1914-1915. doi: 10.1002/art.40129. Epub 2017 Jul 11. Impact factor: 6.918 Publication type: Letter or abstract Authors: Bernal-Bello, David, Guillen-Del Castillo, Alfredo, Selva-O'Callaghan, Albert, Garcia de Tena, Jaime, Fonollosa-Pla, Vicent, Simeon-Aznar, Carmen Pilar et al. DOI: 10.1002/art.40129
PMID: 28410878 Journal: MOLECULAR GENETICS AND METABOLISM Year: 2017 Reference: Mol Genet Metab. 2017 Jun;121(2):138-149. doi: 10.1016/j.ymgme.2017.04.004. Epub 2017 Apr 9. Impact factor: 3.769 Publication type: Paper in international publication Authors: Perez-Lopez, Jordi, Morales-Conejo, Montserrat, Lopez-Rodriguez, Monica, Hermida-Ameijeiras, Alvaro, Molto-Abad, Marc et al. DOI: 10.1016/j.ymgme.2017.04.004
PMID: 28396659 Journal: Frontiers in Immunology Year: 2017 Reference: Front Immunol. 2017 Mar 27;8:299. doi: 10.3389/fimmu.2017.00299. eCollection 2017. Impact factor: 6.429 Publication type: Paper in international publication Authors: Tome, Adria, Yague, Jordi, Anton, Jordi, Hernandez-Rodriguez, Jose, Castellanos-Moreira, Raul, Espanol-Rego, Marta, Soriano, Alessandra, Ruiz-Ortiz, Estibaliz, Iglesias, Estibaliz, Bujan-Rivas, Segundo et al. DOI: 10.3389/fimmu.2017.00299
PMID: 26190206 Journal: Reumatologia clinica Year: 2016 Reference: Reumatol Clin. 2016 Mar-Apr;12(2):72-77. doi: 10.1016/j.reuma.2015.05.007. Epub 2015 Jul 17. Impact factor: 0 Publication type: Paper in national publication Authors: Faro, Monica, Saez-Francas, Naia, Castro-Marrero, Jesus, Aliste, Luisa, Fernandez de Sevilla, Tomas, Alegre, Jose et al. DOI: 10.1016/j.reuma.2015.05.007
PMID: 27033432 Journal: MEDICAL CLINICS OF NORTH AMERICA Year: 2016 Reference: Med Clin (Barc). 2016 Oct 7;147(7):313-5. doi: 10.1016/j.medcli.2016.02.024. Epub 2016 Mar 28. Impact factor: 2.333 Publication type: Paper in international publication Authors: Cardellach, Francesc, Vilardell, Miquel, Pujol, Ramon et al. DOI: 10.1016/j.medcli.2016.02.024
PMID: 27007234 Journal: JAMA Psychiatry Year: 2016 Reference: JAMA Psychiatry. 2016 May 1;73(5):497-505. doi: 10.1001/jamapsychiatry.2016.0129. Impact factor: 14.417 Publication type: Paper in international publication Authors: Georgieva, Lyudmila, McGrath, John J, Mills, Melinda C, Wray, Naomi R, Lee, S Hong, Andreassen, Ole A, Bramon, Elvira, Bruggeman, Richard, Buxbaum, Joseph D, Cairns, Murray J et al. DOI: 10.1001/jamapsychiatry.2016.0129
PMID: 26983453 Journal: RHEUMATOLOGY Year: 2016 Reference: Rheumatology (Oxford). 2016 Jun;55(6):1106-11. doi: 10.1093/rheumatology/kew035. Epub 2016 Mar 15. Impact factor: 4.524 Publication type: Paper in international publication Authors: Julia, Antonio, Gonzalez, Isidoro, Fernandez-Nebro, Antonio, Blanco, Francisco, Rodriguez, Luis, Gonzalez, Antonio, Canete, Juan D, Maymo, Joan, Alperi-Lopez, Mercedes, Olive, Alejandro et al. DOI: 10.1093/rheumatology/kew035
PMID: 25569641 Journal: MEDICINE Year: 2015 Reference: Medicine (Baltimore). 2015 Jan;94(1):e267. doi: 10.1097/MD.0000000000000267. Impact factor: 5.723 Publication type: Paper in international publication Authors: Erausquin, Celia, Rua-Figueroa, Inigo, Richi, Patricia, Lopez-Longo, Francisco Javier, Galindo, Maria, Calvo-Alen, Jaime, Olive-Marques, Alejandro, Loza-Santamaria, Estibaliz, Vicente, Sabina Perez, Bonilla, Gema et al. DOI: 10.1097/MD.0000000000000267
PMID: 25557950 Journal: GASTROENTEROLOGY Year: 2015 Reference: Gastroenterology. 2015 Apr;148(4):794-805. doi: 10.1053/j.gastro.2014.12.030. Epub 2014 Dec 31. Impact factor: 16.716 Publication type: Paper in international publication Authors: Alonso, Arnald, Domenech, Eugeni, Julia, Antonio, Panes, Julian, Garcia-Sanchez, Valle, Mateu, Pilar Nos, Gutierrez, Ana, Gomollon, Fernando, Mendoza, Juan L, Garcia-Planella, Esther et al. DOI: 10.1053/j.gastro.2014.12.030
PMID: 25542479 Journal: JOURNAL OF CLINICAL VIROLOGY Year: 2015 Reference: J Clin Virol. 2015 Jan;62:84-8. doi: 10.1016/j.jcv.2014.11.022. Epub 2014 Nov 22. Impact factor: 3.016 Publication type: Paper in international publication Authors: Vilardell-Tarres, M, Solans-Laque, R, Simeon-Aznar, C P, Selva-O'Callaghan, A, Balada, E, Ramentol, M, Felip, L, Ordi-Ros, J et al. DOI: 10.1016/j.jcv.2014.11.022
PMID: 25712812 Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM Year: 2015 Reference: Semin Arthritis Rheum. 2015 Jun;44(6):672-9. doi: 10.1016/j.semarthrit.2015.01.006. Epub 2015 Jan 23. Impact factor: 3.925 Publication type: Paper in international publication Authors: Vilardell-Tarres, Miquel, Ordi-Ros, Josep, Egri, Natalia, Cortes-Hernandez, Josefina et al. DOI: 10.1016/j.semarthrit.2015.01.006
PMID: 25196202 Journal: EUR J CLIN PHARMACOL Year: 2014 Reference: Eur J Clin Pharmacol. 2014 Nov;70(11):1385-93. doi: 10.1007/s00228-014-1746-2. Epub 2014 Sep 9. Impact factor: 2.697 Publication type: Paper in international publication Authors: Danes, I, Agusti, A, Vallano, A, Alerany, C, Martinez, J, Bosch, J A, Ferrer, A, Gratacos, L, Perez, A, Olmo, M et al. DOI: 10.1007/s00228-014-1746-2
PMID: 25179678 Journal: EUR J INTERN MED Year: 2014 Reference: Eur J Intern Med. 2014 Oct;25(8):710-6. doi: 10.1016/j.ejim.2014.07.011. Epub 2014 Aug 29. Impact factor: 2.3 Publication type: Paper in international publication Authors: San-Jose, Antonio, Agusti, Antonia, Vidal, Xavier, Formiga, Francesc, Lopez-Soto, Alfonso, Fernandez-Moyano, Antonio, Garcia, Juana, Ramirez-Duque, Nieves, Torres, Olga H, Barbe, Jose et al. DOI: 10.1016/j.ejim.2014.07.011
PMID: 24741583 Journal: Journal of immunology research Year: 2014 Reference: J Immunol Res. 2014;2014:290797. doi: 10.1155/2014/290797. Epub 2014 Feb 4. Impact factor: 3.53 Publication type: Paper in international publication Authors: Labrador-Horrillo, Moises, Martinez, Maria Angeles, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Balada, Eva, Vilardell-Tarres, Miquel, Juarez, Candido et al. DOI: 10.1155/2014/290797
PMID: 24238281 Journal: CLIN EXP RHEUMATOL Year: 2014 Reference: Clin Exp Rheumatol. 2014 Jan-Feb;32(1):113-6. Epub 2013 Nov 15. Impact factor: 2.973 Publication type: Paper in international publication Authors: Balada, Eva, Castro-Marrero, Jesus, Felip, Lledo, Ordi-Ros, Josep, Vilardell-Tarres, Miquel et al. DOI:
PMID: 22459412 Journal: JOINT BONE SPINE Year: 2012 Reference: Joint Bone Spine. 2012 Jul;79(4):415. doi: 10.1016/j.jbspin.2012.02.009. Epub 2012 Mar 27. Impact factor: 2.274 Publication type: Editorail in international publication Authors: , et al. DOI: 10.1016/j.jbspin.2012.02.009
PMID: 22429259 Journal: HAEMOPHILIA Year: 2012 Reference: Haemophilia. 2012 Sep;18(5):789-93. doi: 10.1111/j.1365-2516.2012.02772.x. Epub 2012 Mar 19. Impact factor: 2.597 Publication type: Paper in international publication Authors: , , , , et al. DOI: 10.1111/j.1365-2516.2012.02772.x
PMID: 22407130 Journal: HUMAN MOLECULAR GENETICS Year: 2012 Reference: Hum Mol Genet. 2012 Jun 15;21(12):2825-35. doi: 10.1093/hmg/dds099. Epub 2012 Mar 9. Impact factor: 7.636 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1093/hmg/dds099
PMID: 22415197 Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY Year: 2012 Reference: Am J Gastroenterol. 2012 May;107(5):736-46. doi: 10.1038/ajg.2011.472. Epub 2012 Mar 13. Impact factor: 7.282 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1038/ajg.2011.472
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.
