Enfermedades Sistémicas

El grupo de Enfermedades Sistémicas desarrolla una investigación traslacional basada en una serie de al menos 300 pacientes con lupus eritomatoso sistémico (LES), síndrome antifosfolipídico (SAF), esclerosis sistémica, vasculitis, dermatomiitis, síndrome de Sjörin o síndromes autoinflamatorios con el fin de conocer mejor su patogenia (tanto a nivel de regulación inmunológica como genética), estudiar su expresión clínica y biológica (mediante la detección de nuevos marcadores que ayuden a caracterizar cada una de las enfermedades autoinmunes propias), estudiar la morbimortalidad (a través de estudios epidemiológicos) y el análisis de la respuesta de los pacientes hacia los medicamentos. Con estos objetivos en mente, buscamos mejorar el diagnóstico, seguimiento clínico y la prognosis de nuestros pacientes.

Líneas de investigación

Immunologic lesional mechanisms in late adverse reactions against bioimplants.

The late clinical manifestations that arise when bioimplants are applied seem to have an immunologic basis. We are studying both the histological characteristics and the lesional mechanisms of the most frequently used implants. We try to analyze the role that bacteria may have in the induction and/or maintenance of these reactions and the possible correlation between particular HLA haplotypes and the adverse effects.

IP: Jaume Alijotas Reig

Predictive kit to detect the possible establishment of late adverse effects related to bioimplants used in clinical practice.

A high variability in the prevalence of adverse effects with an immunologic basis seems to be related with any implant used in clinical practice. We have managed to find a particular association of HLA haplotypes that increase the risk for developing these effects up to 600 times. We are nowadays working on setting up a safe and reliable biochip or kit which predicts this risk easily in a routine test.

IP: Jaume Alijotas Reig

Serological markers study in anaphylaxis.

We are performing a follow up study of different serological markers in patients who have suffered some anaphylactic episodes. The main goal consists on detecting anaphylaxis patients at the intensive care unit and to determine different serological and plasma markers, mainly tryptase and carboxypeptidase levels by means of a sandwich ELISA.

IP: Moisés Labrador Horrillo

Urinary biomarkers detection in lupus nephritis.

Our main goal in this project is to try to avoid the repeated renal biopsies needed for establishing both the diagnosis and the following up of patients who suffer with lupus nephritis. By using just urine from the patients, we want to find out whether there is one/some biomarker/s (MCP-1, TWEAK, NGAL, APRIL, RANTES,...) that allow us to establish particular diagnosis and prognosis criteria equally effective or even more accurate than those obtained with the renal biopsy.

IP: José Ordi Ros