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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Team

Carmen Alonso  Cotoner

Carmen Alonso Cotoner

Physiology and Pathophysiology of the Digestive Tract
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Carolina Malagelada Prats

Carolina Malagelada Prats

Physiology and Pathophysiology of the Digestive Tract
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Fco Javier Santos Vicente

Fco Javier Santos Vicente

Head of group
Physiology and Pathophysiology of the Digestive Tract
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Ana Maria Gonzalez Castro

Ana Maria Gonzalez Castro

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Elena Céspedes Martínez

Elena Céspedes Martínez

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Adriana Zucchiatti Llanos

Adriana Zucchiatti Llanos

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Carmen Alonso  Cotoner

Carmen Alonso Cotoner

Physiology and Pathophysiology of the Digestive Tract
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Carolina Malagelada Prats

Carolina Malagelada Prats

Physiology and Pathophysiology of the Digestive Tract
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Fco Javier Santos Vicente

Fco Javier Santos Vicente

Head of group
Physiology and Pathophysiology of the Digestive Tract
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Ana Maria Gonzalez Castro

Ana Maria Gonzalez Castro

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Elena Céspedes Martínez

Elena Céspedes Martínez

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Adriana Zucchiatti Llanos

Adriana Zucchiatti Llanos

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Research lines

Gut Microbiota

The human microbiome is the collective genomes of all microorganisms living at the multiple sites of the human body (oral cavity, skin, nasal cavity, gastrointestinal tract (GI) and vagina). Human (Homo sapiens) and their commensal microorganisms have evolved together over the last 200,000 years and have become dependent on one another. Interaction between humans and their symbiotic bacteria is essential to many aspects of normal ‘mammalian’ physiology, ranging from metabolic activity to immune homeostasis, and ecological or genetic changes that disturb this mutualism can result in disease. It reflects the evolutionary selection pressures acting at both the levels of the host and the microbial cells and has a direct profound impact on human health. This line of research aims at understanding the role of the gut microbiome in intestinal disorders using ‘omics approaches.


Our research group proposes a service-collaboration in Microbiome analysis.

You can find further information on our prices at the following URL.

IP: Chaysavanh Manichanh

Hypersensitivity and dysmotility of the gastrointestinal tract

Research has been focused on the origin and mechanisms of the disorders of digestive function. Major advancements have been achieved in relation to the diagnostic  methods to detect neuro-myopathic disorders of the digestive tract. Specifically, an overload test has been developed that increases the sensitivity of intestinal manometry to the detect small bowel motor dysfunction. Non-invasive evaluation of intestinal motility has been approached using an original program of endoluminal image analysis using computer learning techniques and automatic learning methods to videos obtained by means of capsule endoscopy. Furthermore, the possible mechanisms involved in symptoms without apparent cause have been investigated; specifically, the mechanism of abdominal distention has been identified by means of morpho-volumetric analysis of the abdominal; The effects of food and diet on gut function amnd perception in health and disease have been addressed.

IP: Hypersensitivity and dysmotility of the gastrointestinal tract

Inflammatory pathways in the gut and therapeutic targets

This research programme includes five projects (supported by Spanish and European public research agencies) aimed at the investigation of the cross-talk and effects of live bacteria of the gut microbiota on the intestinal mucosa. In addition, the programme includes four clinical/physiological studies that address the potential application of new knowledge gained in basic research on inflammatory bowel diseases.

IP: Inflammatory pathways in the gut and therapeutic targets

Neuro-Immuno-Gastroenterology

The irritable bowel syndrome (IBS), the group of microscopical enteritides, food allergy, gastrointestinal eosinophilopaties, and other functional disorders of the gastrointestinal tract represent more than 50% of digestive consultations. Clinical course is chronic and recurrent. However, sensitive and specific diagnostic biological markers are lacking and clinical management is suboptimal as well. Interestingly, a common finding in the intestine of these patients is the presence of barrier dysfunction, mucosal inflammation and immune activation. Moreover, this finding may be related to the onset and severity of some major clinical symptoms, particularly in IBS.

Therefore, our group pursues the detailed comprehension (genetic/gender, immunological, metabolic, cellular and molecular basis) of the mechanisms connecting environmental determinants (stress and infections) to the development of intestinal mucosal microscopical inflammation, with special focus in IBS.

Our approach includes experimental studies in animal models and humans as well, yet remains inherently translational in search for better targets helpful for the diagnosis, prevention and treatment of IBS and related disorders. In addition, preclinical and clinical assays are also being carried out.

IP: Fco Javier Santos Vicente

Projects

Interacción entre huésped-microbiota y defectos en la integridad de la mucosa intestinal implicados en el origen del daño glomerular en el síndrome nefrótico idiopático

IP: Cristina Martínez Martínez
Collaborators: Alejandro Cruz Gual, Alvaro Domingo Madrid Aris, Ana Maria Gonzalez Castro
Funding agency: Instituto de Salud Carlos III
Funding: 38585.07
Reference: PI21/00757
Duration: 01/01/2022 - 30/06/2026

Development of new oral biologics for Inflammatory Bowel Disease (IBD)

IP: Fco Javier Santos Vicente
Collaborators: Natalia Borruel Sainz, Ana Maria Gonzalez Castro
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 218513
Reference: CPP2022-009979
Duration: 01/12/2023 - 30/11/2026

Ministerio de Ciencia

New tool based on Artificial Intelligence and Biomarkers for early non-invasive diagnosis of Pancreatic Cancer - AI-Early PanC

IP: -
Collaborators: Santiago Pérez Hoyos, Joaquin Balsells Valls, Joan Dot Bach
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 293321
Reference: CPP2022-009592
Duration: 01/10/2023 - 30/09/2026

Ministerio de Ciencia

CFTR down regulation enhances pancreatic carcinogenesis and promotes cancer invasion and metastasis

IP: -
Collaborators: Raquel Ibañez Ferrer
Funding agency: Cystic Fibrosis Foundation
Funding: 300565.29
Reference: CFTR_CFF_RESEARCH GRANTS - FALL 2021
Duration: 01/05/2022 - 30/04/2025

Publications

European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.

PMID: 39754724
Journal: United European Gastroenterology Journal
Year: 2025
Reference: United European Gastroenterol J. 2025 Jan 4. doi: 10.1002/ueg2.12711.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Ariadna; Alcala-Gonzalez, Luis; Aziz, Imran; Barba, Elizabeth; Bonaz, Bruno; Carbone, Florencia; Corsetti, Maura; De Giorgio, Roberto; Drewes, Asbjorn Mohr; Dumitrascu, Dan et al.
DOI: 10.1002/ueg2.12711

Updated document on the management of functional dyspepsia by the Asociacion Espanola de Neurogastroenterologia y Motilidad (ASENEM) and Sociedad Espanola de Medicina Familiar y Comunitaria (semFYC).

PMID: 39812003
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2025
Reference: Rev Esp Enferm Dig. 2025 Jan 15;117. doi: 10.17235/reed.2025.10572/2024.
Impact factor:
Publication type: Paper in international publication
Authors: Alcala-Gonzalez, Luis Gerardo; Mendive, Juan Manuel; Santander Vaquero, Cecilio; Serra, Jordi; Serrano Falcon, Blanca et al.
DOI: 10.17235/reed.2025.10572/2024

Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.

PMID: 39956014
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
Year: 2025
Reference: Eur Neuropsychopharmacol. 2025 Feb 15;94:4-15. doi: 10.1016/j.euroneuro.2025.02.003.
Impact factor:
Publication type: Paper in international publication
Authors: Amoretti, Silvia; Bernardo, Miquel; Berrocoso, Esther; Butjosa, Anna; Cano-Escalera, Guillermo; Cuesta, Manuel Jesus; De-la-Camara, Concepcion; Elena, Rubio-Abadal; Farre, Adriana; Garcia-Rizo, Clemente et al.
DOI: 10.1016/j.euroneuro.2025.02.003

Chronic pancreatitis for the clinician: complications and special forms of the disease. Interdisciplinary position paper of the Catalan Society of Digestology (SCD) and the Catalan Pancreatic Society (SCPanc).

PMID: 35262306
Journal: Minerva gastroenterology
Year: 2024
Reference: Minerva Gastroenterol (Torino). 2024 Jun;70(2):208-224. doi: 10.23736/S2724-5985.22.03127-8. Epub 2022 Mar 8.
Impact factor:
Publication type: Paper in international publication
Authors: Ayuso, Juan R; Balsells, Joaquim; Boadas, Jaume; Busquets, Juli; Casteras, Anna; Concepcion, Mar; Cuatrecasas, Miriam; Fernandez Esparrach, Gloria; Fort, Esther; Garcia Borobia, Francisco et al.
DOI: 10.23736/S2724-5985.22.03127-8

Review document of the Spanish Association of Neurogastroenterology and Motility on the management of opioid-induced constipation.

PMID: 38305669
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2024
Reference: Rev Esp Enferm Dig. 2024 Feb 2. doi: 10.17235/reed.2024.10242/2024.
Impact factor:
Publication type: Paper in international publication
Authors: Alcedo, Javier; Barber, Claudia; Ciriza de Los Rios, Constanza; Serra, Jordi et al.
DOI: 10.17235/reed.2024.10242/2024

Effect of Iberogast (STW5) on tolerance to colonic gas in patients with irritable bowel syndrome: A randomized, double-blind, placebo control clinical trial.

PMID: 38361151
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2024
Reference: Neurogastroenterol Motil. 2024 Feb 15:e14765. doi: 10.1111/nmo.14765.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Ariadna; Benslaiman, Bouchra; Serra, Jordi et al.
DOI: 10.1111/nmo.14765

ABDOMINAL DISTENSION AND BLOATING; MECHANISTIC APPROACH FOR TAILORED MANAGEMENT.

PMID: 38527662
Journal: Gastroenterologia y Hepatologia
Year: 2024
Reference: Gastroenterol Hepatol. 2024 Mar 23:S0210-5705(24)00074-8. doi: 10.1016/j.gastrohep.2024.03.001.
Impact factor:
Publication type: Paper in international publication
Authors: Alcala-Gonzalez, Luis G; Caselles, Claudia Barber; Cayuelas, Ariadna Aguilar; Yanez, Francisca et al.
DOI: 10.1016/j.gastrohep.2024.03.001

Clinical significance of small bowel manometry patterns suggestive of intestinal obstruction.

PMID: 36102622
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Jan;35(1):e14462. doi: 10.1111/nmo.14462. Epub 2022 Sep 14.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Alcala-Gonzalez, Luis G; Azpiroz, Fernando; Malagelada, Carolina; Malagelada, Juan-Ramon; Mego, Marianela; Monrroy, Hugo et al.
DOI: 10.1111/nmo.14462

Benefit of extending the protocol for high resolution manometry according to the version 4.0 of the Chicago criteria. A multicenter study.

PMID: 36443930
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Mar;35(3):e14503. doi: 10.1111/nmo.14503. Epub 2022 Nov 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Ariadna; Alcala-Gonzalez, Luis G; Araujo, Isis K; Barba, Elizabeth; Barber, Claudia; Ezquerra-Duran, Alberto; Marin, Ingrid; Naves, Juan; Serra, Jordi et al.
DOI: 10.1111/nmo.14503

Evaluation of abdominal gas by plain abdominal radiographs.

PMID: 36194191
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Feb;35(2):e14485. doi: 10.1111/nmo.14485. Epub 2022 Oct 4.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Alcala-Gonzalez, Luis G; Azpiroz, Fernando; Barba, Elizabeth; Livovsky, Dan M; Quiroga, Sergio; Relea, Lucia et al.
DOI: 10.1111/nmo.14485

COVID-19 detection prior to motility examinations: Prospective evaluation of pre-test questionnaires and PCR-testing.

PMID: 36273655
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Nov;46(9):663-670. doi: 10.1016/j.gastrohep.2022.10.014. Epub 2022 Oct 20.
Impact factor:
Publication type: Paper in national publication
Authors: Aguilar, Ariadna; Serra, Jordi et al.
DOI: 10.1016/j.gastrohep.2022.10.014

Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.

PMID: 36364873
Journal: Nutrients
Year: 2022
Reference: Nutrients. 2022 Nov 2;14(21). pii: nu14214611. doi: 10.3390/nu14214611.
Impact factor:
Publication type: Paper in international publication
Authors: Avila-Galvez, Maria Angeles; Azpiroz, Fernando; Barber, Claudia; Bendezu, Rogger Alvaro; Espin, Juan Carlos; Guarner, Francisco; Guerin-Deremaux, Laetitia; Margolles, Abelardo; Sabater, Carlos; Vallejo, Fernando et al.
DOI: 10.3390/nu14214611

Artificial intelligence to improve polyp detection and screening time in colon capsule endoscopy.

PMID: 36314009
Journal: Frontiers in Medicine
Year: 2022
Reference: Front Med (Lausanne). 2022 Oct 13;9:1000726. doi: 10.3389/fmed.2022.1000726. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Gilabert, Pere; Laiz, Pablo; Malagelada, Carolina; Segui, Santi; Vitria, Jordi; Watson, Angus; Wenzek, Hagen et al.
DOI: 10.3389/fmed.2022.1000726

Intercontinental Gut Microbiome Variances in IBD.

PMID: 36142786
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Sep 17;23(18). pii: ijms231810868. doi: 10.3390/ijms231810868.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, Natalia; Manichanh, Chaysavanh; Mayorga, Luis; Serrano-Gomez, Gerard; Xie, Zixuan et al.
DOI: 10.3390/ijms231810868

The serotonin receptor 3E variant is a risk factor for female IBS-D.

PMID: 36121467
Journal: JOURNAL OF MOLECULAR MEDICINE-JMM
Year: 2022
Reference: J Mol Med (Berl). 2022 Nov;100(11):1617-1627. doi: 10.1007/s00109-022-02244-w. Epub 2022 Sep 19.
Impact factor:
Publication type: Paper in international publication
Authors: Andresen, Viola; Beltran, Caroll; Berens, Sabrina; Boeckxstaens, Guy; Bustamante, Mariona; Clarke, Gerard; Cryan, John F; D'Amato, Mauro; Dinan, Timothy G; Dong, Yuanjun et al.
DOI: 10.1007/s00109-022-02244-w

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

PMID: 35099124
Journal: United European Gastroenterology Journal
Year: 2021
Reference: United European Gastroenterol J. 2021 Sep;9(7):883-884. doi: 10.1002/ueg2.12090. Epub 2021 Jul 14.
Impact factor:
Publication type: Letter or abstract
Authors: Accarino, Anna; Barbara, Giovanni; Bor, Serhat; Coffin, Benoit; Corsetti, Maura; De Schepper, Heiko; Dickman, R; Drug, V; Dumitrascu, Dan; Enck, P et al.
DOI: 10.1002/ueg2.12090

A Fermented Milk Product Containing B. lactis CNCM I-2494 Improves the Tolerance of a Plant-Based Diet in Patients with Disorders of Gut-Brain Interactions.

PMID: 34960094
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Dec 18;13(12). pii: nu13124542. doi: 10.3390/nu13124542.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Barba, Elizabeth; Batet, Ferran Pinsach; Butler, John; Cotillard, Aurelie; Derrien, Muriel; Dornic, Quentin; Faurie, Jean-Michel; Guarner, Francisco; Lobo, Beatriz et al.
DOI: 10.3390/nu13124542

Identification of Lynch Syndrome Carriers among Patients with Small Bowel Adenocarcinoma.

PMID: 34944998
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Dec 20;13(24). pii: cancers13246378. doi: 10.3390/cancers13246378.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Lara; Alvarez-Urturi, Cristina; Balaguer, Francesc; Bayarri, Carolina; Bofill, Alex; Bujanda, Luis; Carballal, Sabela; Castells, Antoni; Castellvi-Bel, Sergi; Cuatrecasas, Miriam et al.
DOI: 10.3390/cancers13246378

Dysbiosis and relapse-related microbiome in inflammatory bowel disease: A shotgun metagenomic approach.

PMID: 34938418
Journal: Computational and Structural Biotechnology Journal
Year: 2021
Reference: Comput Struct Biotechnol J. 2021 Dec 2;19:6481-6489. doi: 10.1016/j.csbj.2021.11.037. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, Natalia; Casellas, Francesc; Guarner, Francisco; Machiels, Kathleen; Manichanh, Chaysavanh; Mayorga, Luis; Oyarzun, Inigo; Pozuelo, Marta; Roca, Joaquim; Serrano-Gomez, Gerard et al.
DOI: 10.1016/j.csbj.2021.11.037

Antibiotics as Major Disruptors of Gut Microbiota.

PMID: 33330122
Journal: Frontiers in Cellular and Infection Microbiology
Year: 2020
Reference: Front Cell Infect Microbiol. 2020 Nov 24;10:572912. doi: 10.3389/fcimb.2020.572912. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Bustos Fernandez, Luis; Cohen, Henry; Guarner, Francisco; Maruy, Aldo; Ramirez, Jaime; Sdepanian, Vera Lucia et al.
DOI: 10.3389/fcimb.2020.572912

Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome.

PMID: 33244004
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Nov 26;10(1):20706. doi: 10.1038/s41598-020-77176-x.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Azpiroz, Fernando; de Torres, Ines; Exposito, Elba; Farre, Ricard; Fortea, Marina; Gonzalez-Castro, Ana M; Guagnozzi, Danila; Lobo, Beatriz; Martinez, Cristina et al.
DOI: 10.1038/s41598-020-77176-x

Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry.

PMID: 32677040
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2020
Reference: Aliment Pharmacol Ther. 2020 Sep;52(5):798-807. doi: 10.1111/apt.15957. Epub 2020 Jul 17.
Impact factor:
Publication type: Paper in international publication
Authors: Alcedo, Javier; Arias, Ángel; Barrio, JesÃ.s; Casabona, Sergio; de la Riva, Susana; Guagnozzi, Danila; Guardiola-Arévalo, Antonio; Laserna-Mendieta, Emilio J; Lucendo, Alfredo J; Lund Krarup, Anne et al.
DOI: 10.1111/apt.15957

WCE polyp detection with triplet based embeddings.

PMID: 33130417
Journal: COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
Year: 2020
Reference: Comput Med Imaging Graph. 2020 Dec;86:101794. doi: 10.1016/j.compmedimag.2020.101794. Epub 2020 Oct 3.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Laiz, Pablo; Malagelada, Carolina; Segui, Santi; Vitria, Jordi; Wenzek, Hagen et al.
DOI: 10.1016/j.compmedimag.2020.101794

Efficacy, immunogenicity, and safety of a quadrivalent inactivated influenza vaccine in children aged 6-35months: A multi-season randomised placebo-controlled trial in the Northern and Southern Hemispheres.

PMID: 30558818
Journal: VACCINE
Year: 2019
Reference: Vaccine. 2019 Mar 22;37(13):1876-1884. doi: 10.1016/j.vaccine.2018.11.074. Epub 2018 Dec 14.
Impact factor:
Publication type: Paper in international publication
Authors: Ariza, Miguel; Borja-Tabora, Charissa Fay Corazon; Bravo, Lulu; Cutland, Clare; De Bruijn, Iris; de Castro, Jo-Anne; Diez-Domingo, Javier; Dupuy, Martin; Espiau Guarner, Maria; Gonzalez, Celia Diaz et al.
DOI: 10.1016/j.vaccine.2018.11.074

Healthcare Experience and their Relationship with Demographic, Disease and Healthcare-Related Variables: A Cross-Sectional Survey of Patients with Chronic Diseases Using the IEXPAC Scale.

PMID: 30430456
Journal: Patient-Patient Centered Outcomes Research
Year: 2019
Reference: Patient. 2019 Jun;12(3):307-317. doi: 10.1007/s40271-018-0345-1.
Impact factor:
Publication type: Paper in international publication
Authors: Casellas, Francesc; Cea-Calvo, Luis; de Toro, Javier; Fernandez, Gonzalo; Fuster-RuizdeApodaca, Maria J; Galindo, Maria J; Garcia-Vivar, Maria L; Guilabert, Mercedes; Hormigo-Pozo, Antonio; Marin-Jimenez, Ignacio et al.
DOI: 10.1007/s40271-018-0345-1

Efficacy and safety of Gelsectan for diarrhoea-predominant irritable bowel syndrome: A randomised, crossover clinical trial.

PMID: 31662866
Journal: United European Gastroenterology Journal
Year: 2019
Reference: United European Gastroenterol J. 2019 Oct;7(8):1093-1101. doi: 10.1177/2050640619862721. Epub 2019 Jul 3.
Impact factor:
Publication type: Paper in international publication
Authors: Burta, Ovidiu; Lenghel, Augustin; Petrisor, Diana Corina; Santos, Javier; Tiuca, Nicoleta; Trifan, Anca et al.
DOI: 10.1177/2050640619862721

A single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model of colitis.

PMID: 31628021
Journal: EBioMedicine
Year: 2019
Reference: EBioMedicine. 2019 Oct;48:630-641. doi: 10.1016/j.ebiom.2019.10.002. Epub 2019 Oct 15.
Impact factor:
Publication type: Paper in international publication
Authors: Lleal, Marina; Manichanh, Chaysavanh; Pozuelo, Marta; Santiago, Alba; Sarrabayrouse, Guillaume; Willamil, Joseane et al.
DOI: 10.1016/j.ebiom.2019.10.002

Diagnosis and Treatment of Rumination Syndrome.

PMID: 29902642
Journal: Clinical Gastroenterology and Hepatology
Year: 2018
Reference: Clin Gastroenterol Hepatol. 2018 Oct;16(10):1549-1555. doi: 10.1016/j.cgh.2018.05.049. Epub 2018 Jun 12.
Impact factor:
Publication type: Review in international publication
Authors: Barba, Elizabeth; Halland, Magnus; Pandolfino, John et al.
DOI: 10.1016/j.cgh.2018.05.049

Comparison between small bowel manometric patterns and full-thickness biopsy histopathology in severe intestinal dysmotility.

PMID: 28941004
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Mar;30(3). doi: 10.1111/nmo.13219. Epub 2017 Sep 22.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, A; Azpiroz, F; Boschetti, E; Cogliandro, R F; De Giorgio, R; Gori, A; Karunaratne, T B; Landolfi, S; Malagelada, C; Malagelada, J R et al.
DOI: 10.1111/nmo.13219

[Rumination syndrome: Diagnostic and therapeutic difficulties of a not so uncommon disorder].

PMID: 28460821
Journal: ANALES DE PEDIATRIA
Year: 2018
Reference: An Pediatr (Barc). 2018 Feb;88(2):100-105. doi: 10.1016/j.anpedi.2017.03.011. Epub 2017 Apr 29.
Impact factor:
Publication type: Paper in national publication
Authors: Accarino Garaventa, Anna; Alvarez Beltran, Marina; Azpiroz Vidaur, Fernando; Barba Orozco, Elisabeth; Gimenez Casado, Aida; Lopez Linan, Maria Jose; Segarra Canton, Oscar et al.
DOI: 10.1016/j.anpedi.2017.03.011

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

PMID: 30525861
Journal: Nutricion Hospitalaria
Year: 2018
Reference: Nutr Hosp. 2018 Dec 3;35(6):1450-1466.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, Rosa; Casellas, Francesc; Ciriza-de-Los-Rios, Constanza; Garcia-Manzanares, Alvaro; Lema-Marques, Beatriz; Marcos, Ascension; Polanco, Isabel; Puy-Portillo, Maria; Santos, Javier; Vazquez-Alferez, M feminine Del Carmen et al.
DOI:

Abnormal Barrier Function in Gastrointestinal Disorders.

PMID: 27995392
Journal: Handbook of experimental pharmacology
Year: 2017
Reference: Handb Exp Pharmacol. 2017;239:193-217. doi: 10.1007/164_2016_107.
Impact factor:
Publication type: Paper in international publication
Authors: Farre, Ricard; Vicario, Maria et al.
DOI: 10.1007/164_2016_107

High resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset.

PMID: 27935079
Journal: MUSCLE & NERVE
Year: 2017
Reference: Muscle Nerve. 2017 Sep;56(3):386-392. doi: 10.1002/mus.25507. Epub 2017 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Casal-Dominguez, Maria; Jubany, Lluis; Mego, Marianela; Pinal-Fernandez, Iago; Selva-O'Callaghan, Albert et al.
DOI: 10.1002/mus.25507

Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study.

PMID: 27958281
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2017
Reference: Am J Gastroenterol. 2017 Jan;112(1):120-131. doi: 10.1038/ajg.2016.569. Epub 2016 Dec 13.
Impact factor:
Publication type: Paper in international publication
Authors: Aicart, M; Alcain, G; Almela, P; Arguelles-Arias, F; Arias-Rivera, M L; Barreiro-de Acosta, M; Barrio, J; Beltran, B; Benitez, J M; Bermejo, F et al.
DOI: 10.1038/ajg.2016.569

Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function.

PMID: 27680592
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2017
Reference: J Clin Gastroenterol. 2017 Aug;51(7):619-625. doi: 10.1097/MCG.0000000000000723.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Guarner, Francisco; Manichanh, Chaysavanh; Mego, Marianela; Mendez, Sara; Molne, Laura; Nieto, Adoracion; Sailer, Manuela; Santos, Javier et al.
DOI: 10.1097/MCG.0000000000000723

Lessons learned--resolving the enigma of genetic factors in IBS.

PMID: 26726033
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2016
Reference: Nat Rev Gastroenterol Hepatol. 2016 Feb;13(2):77-87. doi: 10.1038/nrgastro.2015.206. Epub 2016 Jan 4.
Impact factor:
Publication type: Review in international publication
Authors: Bengtson, May-Bente; Demetriou, Christiana A; Friedman, Eitan; Gazouli, Maria; Kapur-Pojskic, Lejla; Mulak, Agata; Niesler, Beate; Nikcevic, Gordana; Santos, Javier; Wouters, Mira M et al.
DOI: 10.1038/nrgastro.2015.206

Systematic review with meta-analysis: diagnostic overlap of microscopic colitis and functional bowel disorders.

PMID: 26913568
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2016
Reference: Aliment Pharmacol Ther. 2016 Apr;43(8):851-862. doi: 10.1111/apt.13573. Epub 2016 Feb 24.
Impact factor:
Publication type: Review in international publication
Authors: Arias, A; Guagnozzi, D; Lucendo, A J et al.
DOI: 10.1111/apt.13573

Effect of incretin therapies compared to pioglitazone and gliclazide in non-alcoholic fatty liver disease in diabetic patients not controlled on metformin alone: An observational, pilot study.

PMID: 26976710
Journal: Endocrinologia y Nutricion
Year: 2016
Reference: Endocrinol Nutr. 2016 May;63(5):194-201. doi: 10.1016/j.endonu.2016.01.006. Epub 2016 Mar 11.
Impact factor:
Publication type: Paper in national publication
Authors: Garcia Diaz, Eduardo; Godoy, Teresa; Guagnozzi, Danila; Gutierrez, Veronica; Larranaga, Yulene; Maza, Cristina; Mendoza, Carmen; Perdomo, Dolores; Taleb, Ghalli et al.
DOI: 10.1016/j.endonu.2016.01.006

The Intestinal Microenvironment and Functional Gastrointestinal Disorders.

PMID: 27144620
Journal: GASTROENTEROLOGY
Year: 2016
Reference: Gastroenterology. 2016 May;150(6):1305-1318. doi: 10.1053/j.gastro.2016.02.028.
Impact factor:
Publication type: Paper in international publication
Authors: Barbara, Giovanni; Feinle-Bisset, Christine; Ghoshal, Uday C; Quigley, Eamonn M; Santos, Javier; Vanner, Steve; Vergnolle, Nathalie; Zoetendal, Erwin G et al.
DOI: 10.1053/j.gastro.2016.02.028

World gastroenterology organisation global guidelines: dysphagia--global guidelines and cascades update September 2014.

PMID: 25853874
Journal: J CLIN GASTROENTEROL
Year: 2015
Reference: J Clin Gastroenterol. 2015 May-Jun;49(5):370-8. doi: 10.1097/MCG.0000000000000307.
Impact factor:
Publication type: Paper in international publication
Authors: Bazzoli, Franco; Boeckxstaens, Guy; De Looze, Danny; Fried, Michael; Kahrilas, Peter; Le Mair, Anton; Lindberg, Greger; Malagelada, Juan-R; Malfertheiner, Peter; Salis, Graciela et al.
DOI: 10.1097/MCG.0000000000000307

The gut microbiome: What do we know?

PMID: 31040957
Journal: Clinical liver disease
Year: 2015
Reference: Clin Liver Dis (Hoboken). 2015 May 7;5(4):86-90. doi: 10.1002/cld.454. eCollection 2015 Apr.
Impact factor:
Publication type: Review in international publication
Authors: Guarner, Francisco et al.
DOI: 10.1002/cld.454

The intestinal barrier function and its involvement in digestive disease.

PMID: 26541659
Journal: REV ESP ENFERM DIG
Year: 2015
Reference: Rev Esp Enferm Dig. 2015 Nov;107(11):686-96. doi: 10.17235/reed.2015.3846/2015.
Impact factor:
Publication type: Review in international publication
Authors: Alonso Cotoner, Carmen; Casado Bedmar, Maite; Pardo Camacho, Cristina; Salvo Romero, Eloisa; Vicario, Maria et al.
DOI: 10.17235/reed.2015.3846/2015

Abdomino-Thoracic Mechanisms of Functional Abdominal Distension And Correction by Biofeedback.

PMID: 25500424
Journal: GASTROENTEROLOGY
Year: 2015
Reference: Gastroenterology. 2015 Apr;148(4):732-9. doi: 10.1053/j.gastro.2014.12.006. Epub 2014 Dec 11.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Barba, Elizabeth; Burri, Emanuel; Cisternas, Daniel; Malagelada, Juan-R; Monclus, Eva; Navazo, Isabel; Quiroga, Sergi et al.
DOI: 10.1053/j.gastro.2014.12.006

Detection of wrinkle frames in endoluminal videos using betweenness centrality measures for images.

PMID: 25375680
Journal: IEEE Journal of Biomedical and Health Informatics
Year: 2014
Reference: IEEE J Biomed Health Inform. 2014 Nov;18(6):1831-8. doi: 10.1109/JBHI.2014.2304179.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Drozdzal, Michal; Malagelada, Carolina; Radeva, Petia; Segui, Santi; Vitria, Jordi; Zaytseva, Ekaterina et al.
DOI: 10.1109/JBHI.2014.2304179

Intestinal barrier function and the brain-gut axis.

PMID: 24997030
Journal: Advances in Experimental Medicine and Biology
Year: 2014
Reference: Adv Exp Med Biol. 2014;817:73-113. doi: 10.1007/978-1-4939-0897-4_4.
Impact factor:
Publication type: Review in national publication
Authors: Alonso, Carmen; Lobo, Beatriz; Pigrau, Marc; Santos, Javier; Vicario, Maria et al.
DOI: 10.1007/978-1-4939-0897-4_4

Vitamin E and vitamin E acetate absorption from self-assembly systems under pancreas insufficiency conditions.

PMID: 24801842
Journal: CHIMIA
Year: 2014
Reference: Chimia (Aarau). 2014;68(3):129-34. doi: 10.2533/chimia.2014.129.
Impact factor:
Publication type: Clinical Trials
Authors: Acquistapace, Simone; Azpiroz, Fernando; Beaumont, Maurice; Braga-Lagache, Sophie; Courtet-Compondu, Marie-Claude; Holst, Birgit; Kussmann, Martin; Lobo, Beatriz; Malagelada, Juan Ramon; Moulin, Julie et al.
DOI: 10.2533/chimia.2014.129

From basic to applied research: lessons from the human microbiome projects.

PMID: 25291122
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2014
Reference: J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S3-4. doi: 10.1097/MCG.0000000000000242.
Impact factor:
Publication type: Paper in international publication
Authors: Guarner, Francisco; Robles-Alonso, Virginia et al.
DOI: 10.1097/MCG.0000000000000242

[Recommendations of the Spanish Pancreatic Club on the diagnosis and treatment of chronic pancreatitis: part 1 (diagnosis)].

PMID: 23566414
Journal: Gastroenterologia y Hepatologia
Year: 2013
Reference: Gastroenterol Hepatol. 2013 May;36(5):326-39. doi: 10.1016/j.gastrohep.2012.12.004. Epub 2013 Apr 6.
Impact factor:
Publication type: Paper in national publication
Authors: Abad-Gonzalez, Angel; Aparicio, Jose Ramon; Aparisi, Luis; Boadas, Jaume; Boix, Evangelina; de las Heras, Gonzalo; De-Madaria, Enrique; Dominguez-Munoz, Enrique; Farre, Antonio; Fernandez-Cruz, Laureano et al.
DOI: 10.1016/j.gastrohep.2012.12.004

Colonic necrosis due to calcium polystyrene sulfonate (Kalimate) not suspended in sorbitol.

PMID: 23859454
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2013
Reference: Rev Esp Enferm Dig. 2013 Apr;105(4):232-4. doi: 10.4321/s1130-01082013000400010.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Castillo-Cejas, Maria Dolores; de-Torres-Ramirez, Ines et al.
DOI: 10.4321/s1130-01082013000400010

Metagenomic species profiling using universal phylogenetic marker genes.

PMID: 24141494
Journal: NATURE METHODS
Year: 2013
Reference: Nat Methods. 2013 Dec;10(12):1196-9. doi: 10.1038/nmeth.2693. Epub 2013 Oct 20.
Impact factor:
Publication type: Paper in international publication
Authors: Arumugam, Manimozhiyan; Berger, Simon A; Bork, Peer; Brunak, Soren; Coelho, Luis Pedro; de Vos, Willem M; Dore, Joel; Ehrlich, S Dusko; Guarner, Francisco; Izquierdo-Carrasco, Fernando et al.
DOI: 10.1038/nmeth.2693

Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis.

PMID: 23725320
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2013
Reference: Aliment Pharmacol Ther. 2013 Jul;38(2):151-61. doi: 10.1111/apt.12365. Epub 2013 Jun 3.
Impact factor:
Publication type: Paper in international publication
Authors: Antolin, M; Borruel, N; Casellas, F; Gallart, M; Guarner, F; Manichanh, C; Torrejon, A; Varela, E et al.
DOI: 10.1111/apt.12365

Categorization and segmentation of intestinal content frames for wireless capsule endoscopy.

PMID: 24218705
Journal: IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE
Year: 2012
Reference: IEEE Trans Inf Technol Biomed. 2012 Nov;16(6):1341-52.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Drozdzal, Michal; Malagelada, Carolina; Radeva, Petia; Segui, Santi; Vilarino, Fernando; Vitria, Jordi et al.
DOI: 10.1109/TITB.2012.2221472

Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial.

PMID: 23588438
Journal: Nutricion Hospitalaria
Year: 2012
Reference: Nutr Hosp. 2012 Nov-Dec;27(6):1908-15. doi: 10.3305/nh.2012.27.6.5992.
Impact factor:
Publication type: Paper in international publication
Authors: Breton, I; Camblor, M; de la Cuerda, C; Garcia-Hernandez, J; Garcia-Peris, P; Guarner, F; Hernandez, M; Lozano, M A; Moreno, Y; Paron, L et al.
DOI: 10.3305/nh.2012.27.6.5992

Pancreatic cancer risk and levels of trace elements.

PMID: 22184070
Journal: GUT
Year: 2012
Reference: Gut. 2012 Nov;61(11):1583-8. Epub 2011 Dec 19.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/gutjnl-2011-301086

Ustekinumab induction and maintenance therapy in refractory Crohn's disease.

PMID: 23075178
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2012
Reference: N Engl J Med. 2012 Oct 18;367(16):1519-28. doi: 10.1056/NEJMoa1203572.
Impact factor:
Publication type: Paper in international publication
Authors: Aberra, F N; Abitbol, V; Abraham, B P; Abreu, M T; Allez, M; Amontree, J S; Anderson, F; Andriulli, A; Annese, Vito; Arnott, I et al.
DOI: 10.1056/NEJMoa1203572

Postoperative pain after haemorrhoidectomy: role of impaired evacuation.

PMID: 20402734
Journal: Colorectal Disease
Year: 2011
Reference: Colorectal Dis. 2011 Aug;13(8):926-9. doi: 10.1111/j.1463-1318.2010.02280.x. Epub 2010 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; et al.
DOI: 10.1111/j.1463-1318.2010.02280.x

Fitz-Hugh-Curtis syndrome: abdominal pain in women of 26 years old.

PMID: 22054272
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2011
Reference: Rev Esp Enferm Dig. 2011 Oct;103(10):546-8.
Impact factor:
Publication type: Paper in national publication
Authors: Guarner-Aguilar, Luisa; Lopez-Soriano, Elsa Maria; Rivero-Sanchez, Liseth et al.
DOI:

Guidelines for the design, conduct and reporting of human intervention studies to evaluate the health benefits of foods.

PMID: 22129662
Journal: BRITISH JOURNAL OF NUTRITION
Year: 2011
Reference: Br J Nutr. 2011 Nov;106 Suppl 2:S3-15.
Impact factor:
Publication type: Paper in international publication
Authors: Antoine, Jean-Michel; Berta, Jean-Louis; Bub, Achim; de Vries, Jan; Guarner, Francisco; Hasselwander, Oliver; Hendriks, Henk; Jakel, Martin; Koletzko, Berthold V; Patterson, Chris C et al.
DOI: 10.1017/S0007114511003606

A New Validation of the Spanish Work Productivity and Activity Impairment Questionnaire-Crohn's Disease Version.

PMID: 21914506
Journal: VALUE IN HEALTH
Year: 2011
Reference: Value Health. 2011 Sep-Oct;14(6):859-61. Epub 2011 May 28.
Impact factor:
Publication type: Paper in international publication
Authors: Calvet, Xavier; Casellas, Francesc; Gallardo, Olga; Maudsley, Michael; Montserrat, Antonia; Ricart, Elena; Suarez, David; Vergara, Mercedes; Villoria, Albert et al.
DOI: 10.1016/j.jval.2011.02.1179

Current level of consensus on probiotic science--report of an expert meeting--London, 23 November 2009.

PMID: 21637035
Journal: Gut microbes
Year: 2010
Reference: Gut Microbes. 2010 Nov-Dec;1(6):436-9. doi: 10.4161/gmic.1.6.13610.
Impact factor:
Publication type: Paper in international publication
Authors: Capurso, Lucio; Collins, Kevin; Cummings, John; Delzenne, Nathalie; Goulet, Olivier; Guarner, Francisco; Marteau, Philippe; Meier, Remy; Rowland, Ian et al.
DOI: 10.4161/gmic.1.6.13610

Consensus statements from the Workshop "Probiotics and Health: Scientific Evidence"

PMID: 21336423
Journal: Nutricion Hospitalaria
Year: 2010
Reference: Nutr Hosp. 2010 Oct;25(5):700-704.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; et al.
DOI:

The dysfunctional gut.

PMID: 20582743
Journal: Curr Gastroenterol Rep
Year: 2010
Reference: Curr Gastroenterol Rep. 2010 Aug;12(4):242-8.
Impact factor:
Publication type: Letter or abstract
Authors: Malagelada, Carolina; Malagelada, Juan-R et al.
DOI: 10.1007/s11894-010-0119-y

Crohn s disease, feeling well or healthy?

PMID: 21142381
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2010
Reference: Rev Esp Enferm Dig. 2010 Nov;102(11):621-623.
Impact factor:
Publication type: Editorial in national publication
Authors: et al.
DOI:

The challenge of developing new therapies for irritable bowel syndrome.

PMID: 21180543
Journal: Therapeutic advances in gastroenterology
Year: 2009
Reference: Therap Adv Gastroenterol. 2009 Jul;2(4):201-3. doi: 10.1177/1756283X09335638.
Impact factor:
Publication type: Editorail in international publication
Authors: Azpiroz, Fernando; Whorwell, Peter J et al.
DOI: 10.1177/1756283X09335638

Validation of the Spanish Work Productivity and Activity impairment questionnaire: Crohn's disease version.

PMID: 19404204
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2009
Reference: Eur J Gastroenterol Hepatol. 2009 Jul;21(7):809-15.
Impact factor:
Publication type: Paper in international publication
Authors: Calvet, Xavier; Casellas, Francesc; Gallardo, Olga; Maudsley, Michael; Montserrat, Antonia; Ricart, Elena; Vergara, Mercedes et al.
DOI: 10.1097/MEG.0b013e32830f4c9e

[Probiotics and the digestive system. Current evidence]

PMID: 19524118
Journal: Gastroenterol Hepatol
Year: 2009
Reference: Gastroenterol Hepatol. 2009 May;32 Suppl 1:1-14.
Impact factor:
Publication type: Letter or abstract
Authors: Guarner, Francisco; Mearin, Fermin; Verdu, Elena et al.
DOI: 10.1016/S0210-5705(09)71003-9

Intestinal motor activity, endoluminal motion and transit.

PMID: 19614865
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2009
Reference: Neurogastroenterol Motil. 2009 Dec;21(12):1264-e119.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, F; de Iorio, F; Igual, L; Malagelada, C; Malagelada, J-R; Maluenda, M; Violanti, C; Vitria, J et al.
DOI: 10.1111/j.1365-2982.2009.01363.x

Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon.

PMID: 18691825
Journal: PSYCHONEUROENDOCRINOLOGY
Year: 2008
Reference: Psychoneuroendocrinology. 2008 Oct;33(9):1248-56. doi: 10.1016/j.psyneuen.2008.07.002. Epub 2008 Aug 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Carmen; Guilarte, Mar; Perdue, Mary H; Santos, Javier; Vicario, Maria; Yates, Derrick et al.
DOI: 10.1016/j.psyneuen.2008.07.002

Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation.

PMID: 18455999
Journal: GASTROENTEROLOGY
Year: 2008
Reference: Gastroenterology. 2008 Jul;135(1):163-172.e1. doi: 10.1053/j.gastro.2008.03.036. Epub 2008 Mar 22.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Carmen; Antolin, Maria; Guilarte, Mar; Kochhar, Sunil; Malagelada, Juan Ramon; Martinez, Cristina; Ramadan, Ziad; Ramos, Laura; Rezzi, Serge; Santos, Javier et al.
DOI: 10.1053/j.gastro.2008.03.036

Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome.

PMID: 18537634
Journal: CURRENT MOLECULAR MEDICINE
Year: 2008
Reference: Curr Mol Med. 2008 Jun;8(4):258-73. doi: 10.2174/156652408784533788.
Impact factor:
Publication type: Editorail in international publication
Authors: Alonso, Carmen; Lobo, Beatriz; Malagelada, J-Ramon; Ramos, Laura; Santos, Javier; Vicario, Maria et al.
DOI: 10.2174/156652408784533788

Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome.

PMID: 18537634
Journal: CURRENT MOLECULAR MEDICINE
Year: 2008
Reference: Curr Mol Med. 2008 Jun;8(4):258-73. doi: 10.2174/156652408784533788.
Impact factor: 4.624
Publication type: Editorail in international publication
Authors: Santos, Javier, Alonso, Carmen, Vicario, Maria, Ramos, Laura, Lobo, Beatriz, Malagelada, J-Ramon et al.
DOI: 10.2174/156652408784533788

Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum.

PMID: 17005763
Journal: GUT
Year: 2007
Reference: Gut. 2007 Feb;56(2):203-9. doi: 10.1136/gut.2006.100594. Epub 2006 Sep 27.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Carmen; Casellas, Francesc; de Torres, Ines; Guilarte, Mar; Malagelada, Juan Ramon; Martinez, Cristina; Ramos, Laura; Santos, Javier; Saperas, Esteban; Vicario, Maria et al.
DOI: 10.1136/gut.2006.100594

Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum.

PMID: 17005763
Journal: GUT
Year: 2007
Reference: Gut. 2007 Feb;56(2):203-9. doi: 10.1136/gut.2006.100594. Epub 2006 Sep 27.
Impact factor: 9.002
Publication type: Paper in international publication
Authors: Guilarte, Mar, Santos, Javier, de Torres, Ines, Alonso, Carmen, Vicario, Maria, Ramos, Laura, Martinez, Cristina, Casellas, Francesc, Saperas, Esteban, Malagelada, Juan Ramon et al.
DOI: 10.1136/gut.2006.100594

Targeting mast cells in the treatment of functional gastrointestinal disorders.

PMID: 16956793
Journal: CURRENT OPINION IN PHARMACOLOGY
Year: 2006
Reference: Curr Opin Pharmacol. 2006 Dec;6(6):541-6. doi: 10.1016/j.coph.2006.08.001. Epub 2006 Sep 7.
Impact factor:
Publication type: Editorail in international publication
Authors: Alonso, Carmen; Guilarte, Mar; Malagelada, Juan Ramon; Santos, Javier; Vicario, Maria et al.
DOI: 10.1016/j.coph.2006.08.001

Targeting mast cells in the treatment of functional gastrointestinal disorders.

PMID: 16956793
Journal: CURRENT OPINION IN PHARMACOLOGY
Year: 2006
Reference: Curr Opin Pharmacol. 2006 Dec;6(6):541-6. doi: 10.1016/j.coph.2006.08.001. Epub 2006 Sep 7.
Impact factor: 5.366
Publication type: Editorail in international publication
Authors: Alonso, Carmen, Malagelada, Juan Ramon, Vicario, Maria, Guilarte, Mar, Santos, Javier et al.
DOI: 10.1016/j.coph.2006.08.001

Anisakis simplex-induced small bowel obstruction after fish ingestion: preliminary evidence for response to parenteral corticosteroids.

PMID: 16206499
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Ga
Year: 2005
Reference: Clin Gastroenterol Hepatol. 2005 Jul;3(7):667-71. doi: 10.1016/s1542-3565(05)00363-0.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Carmen; Guilarte, Mar; Malagelada, Juan Ramon; Ramos, Laura; Santos, Javier; Vilaseca, Jaime et al.
DOI: 10.1016/s1542-3565(05)00363-0

Pathogenesis of irritable bowel syndrome: the mast cell connection.

PMID: 15764142
Journal: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Year: 2005
Reference: Scand J Gastroenterol. 2005 Feb;40(2):129-40. doi: 10.1080/00365520410009410.
Impact factor:
Publication type: Editorail in international publication
Authors: Alonso, Carmen; Guilarte, Mar; Malagelada, J R; Santos, Javier et al.
DOI: 10.1080/00365520410009410

Anisakis simplex-induced small bowel obstruction after fish ingestion: preliminary evidence for response to parenteral corticosteroids.

PMID: 16206499
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Ga
Year: 2005
Reference: Clin Gastroenterol Hepatol. 2005 Jul;3(7):667-71. doi: 10.1016/s1542-3565(05)00363-0.
Impact factor: 0
Publication type: Paper in international publication
Authors: Malagelada, Juan Ramon, Santos, Javier, Guilarte, Mar, Alonso, Carmen, Ramos, Laura, Vilaseca, Jaime et al.
DOI: 10.1016/s1542-3565(05)00363-0

Pathogenesis of irritable bowel syndrome: the mast cell connection.

PMID: 15764142
Journal: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Year: 2005
Reference: Scand J Gastroenterol. 2005 Feb;40(2):129-40. doi: 10.1080/00365520410009410.
Impact factor: 1.824
Publication type: Editorail in international publication
Authors: Malagelada, J R, Alonso, Carmen, Guilarte, Mar, Santos, Javier et al.
DOI: 10.1080/00365520410009410

Thesis

Fenotip diferencial de les cèl·lules entèriques glials jejunals en la síndrome de l'intestí irritable

PhD student: Merce Albert Bayo
Director/s: Fernando Azpiroz Vidaur
University: Universitat Autònoma de Barcelona
Year: 2023

Fisiologia i Fisiopatologia de la resposta a la ingesta

PhD student: Claudia Barber Caselles
Director/s: Fernando Azpiroz Vidaur
University: Universitat Autònoma de Barcelona
Year: 2023

Integration of fungal and bacterial microbiome sequencing data.

PhD student: Zixuan Xie
Director/s: Chaysavanh Manichanh , Victor Manuel Vargas Blasco
University: Universitat Autònoma de Barcelona
Year: 2023

Evaluación de la motilidad del intesino delgado mediante manometría.

PhD student: Luis Gerardo Alcala Gonzalez, Luis Gerardo Alcala Gonzalez
Director/s: Fernando Azpiroz Vidaur, Carolina Malagelada Prats
University:
Year: 2022

Evaluación de la motilidad del intestino delgado mediante manometría intestinal de alta resolución

PhD student: Luis Gerardo Alcala Gonzalez, Luis Gerardo Alcala Gonzalez
Director/s: Carolina Malagelada Prats, Fernando Azpiroz Vidaur
University:
Year: 2022

Design and validation of a short food frequency questionnaire to relate diet with the gut microbiota

PhD student: Francisca Yañez Araya
Director/s: Chaysavanh Manichanh
University: Universidad Autònoma de Barcelona
Year: 2022

Estudi observacional en colitis ulcerosa per investigar la composició de la microbiotica intestinal en pacients en remisió de llarga durada

PhD student: Claudia Maria Herrera de Guise
Director/s: Francisco Guarner Aguilar
University: Universidad Autònoma de Barcelona
Year: 2021

Utilidad de la ecoendoscopia con contraste en el diagnóstico de lesiones subepiteliales del tracto gastrointestinal alto

PhD student: Monder Abu-Suboh Abadia
Director/s: Manuel Armengol Carrasco
University: Universidad Autònoma de Barcelona
Year: 2020

Functional profiling of the human gut microbiome using metatranscriptomic approach

PhD student: Xavier Martínez Serrano
Director/s: Chaysavanh Manichanh
University: Universidad Autònoma de Barcelona
Year: 2020

Mecanismos citotóxicos y humorales implicados en la etiopatogénesis de la esofagitis eosinofílica

PhD student: Marina Fortea Guillamon
Director/s: Fernando Azpiroz Vidaur, Maria Vicario Perez
University: Universidad Autònoma de Barcelona
Year: 2020

Relación entre dieta, función y síntomas digestivos

PhD student: José Wálter Huamán Ríos
Director/s: Ana María Accarino Garaventa, Fernando Azpiroz Vidaur, Ana María Accarino Garaventa
University: Universidad Autònoma de Barcelona
Year: 2020

Metagenómica en la enfermedad inflamatoria intestinal

PhD student: Marta Pozuelo Del Rio
Director/s: Chaysavanh Manichanh
University: Universidad Autònoma de Barcelona
Year: 2019

Implicación del eosinófilo intestinal y producción de factor liberador de corticotropina en la fisiopatología del Síndrome del Intestino Irritable con predominio de diarrea

PhD student: Eloisa Salvo Romero
Director/s: Fco Javier Santos Vicente, Maria Vicario Perez
University: Universidad Autònoma de Barcelona
Year: 2018

Estudio de las alteraciones del microbioma intestinal y extra-intestinal en ratas y humanos durante la progresión de la cirrosis

PhD student: Alba Santiago Badenas
Director/s: Chaysavanh Manichanh
University: Universidad Autònoma de Barcelona
Year: 2018

Molecular Mechanisms and effect of acute and psychosocial stress on the intestinal barrier function. Implications on the iritable bowel syndrome

PhD student: Marc Pigrau Pastor
Director/s: Fco Javier Santos Vicente, Carmen Alonso Cotoner, Maria Vicario Perez
University: Universidad Autònoma de Barcelona
Year: 2018

Mecanismo de producción de los síntomas digestivos funcionales

PhD student: Rogger Alvaro Bendezú García
Director/s: Fernando Azpiroz Vidaur
University: Universidad Autònoma de Barcelona
Year: 2016

Fisiología, fisiopatología y tratamiento de la Distensión abdominal

PhD student: Elizabeth Barba Orozco
Director/s: Elizabeth Barba Orozco, Ana María Accarino Garaventa, Fernando Azpiroz Vidaur, Ana María Accarino Garaventa
University: Universidad Autònoma de Barcelona
Year: 2015

Fisiología y Fisiopatología de la distensión abdominal: Gas intestinal

PhD student: Marianela Mego Silva
Director/s: Fernando Azpiroz Vidaur
University: Universidad Autònoma de Barcelona
Year: 2015

Efecto de la administración oral del agente estabilizador del mastocito, cromoglicato disódico, sobre la evolución clínica y biológica en pacientes con síndrome del intestino irritable con predominio de diarrea.

PhD student: Beatriz Lobo Alvarez
Director/s: Fco Javier Santos Vicente, Maria Vicario Perez
University: Universidad Autònoma de Barcelona
Year: 2013

Evaluación de la motilidad intestinal mediante análisis de imágenes endoluminales.

PhD student: Carolina Malagelada Prats, Carolina Malagelada Prats
Director/s: Fernando Azpiroz Vidaur
University: Universidad Autònoma de Barcelona
Year: 2010

Disfunción e inflamación de la mucosa intestinal inducida por el estrés psicosocial crónico y su relevancia translacional para el síndrome del intestino irritable.

PhD student: Carmen Alonso Cotoner
Director/s: Fco Javier Santos Vicente, Joan Ramón Malagelada Benaprés, Joan Ramón Malagelada Benaprés
University: Universidad Autònoma de Barcelona
Year: 2010

Interacciones de las bacterias de la flora con el sistema inmune intestinal

PhD student: Natalia Borruel Sainz, Natalia Borruel Sainz
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2005

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News

A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.

Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.