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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Carmela Iglesias i Felip

Carmela Iglesias i Felip

Translational Molecular Pathology
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Elena Antima Martinez Saez

Elena Antima Martinez Saez

Translational Molecular Pathology
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Irene Sansano Valero

Irene Sansano Valero

Translational Molecular Pathology
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Maria Teresa Salcedo Allende

Maria Teresa Salcedo Allende

Senior researcher
Translational Molecular Pathology
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Stefania Landolfi

Stefania Landolfi

Translational Molecular Pathology
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Vicente Peg Camara

Vicente Peg Camara

Translational Molecular Pathology
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Carmela Iglesias i Felip

Carmela Iglesias i Felip

Translational Molecular Pathology
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Elena Antima Martinez Saez

Elena Antima Martinez Saez

Translational Molecular Pathology
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Irene Sansano Valero

Irene Sansano Valero

Translational Molecular Pathology
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Maria Teresa Salcedo Allende

Maria Teresa Salcedo Allende

Senior researcher
Translational Molecular Pathology
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Stefania Landolfi

Stefania Landolfi

Translational Molecular Pathology
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Vicente Peg Camara

Vicente Peg Camara

Translational Molecular Pathology
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Research lines

Exercise capacity, peripheral muscle dysfunction and genotype in adults with cystic fibrosis.

To study the degree and types of skeletal muscle involvement in CF patients who present exercise intolerance and its relationship with the genotype. To determine the relationship between the type and/or degree of skeletal muscle involvement by histologic and mitochondrial respiratory chain function study, and the CF genotype. Correlation study between exercise capacity, pulmonary function and genotype.

IP: -

Expression analysis and functional elucidation of connexins and pannexins in relation to human cancer progression and malignancy.

Connexins and pannexins are structural units of gap junctions permitting direct intercellular communication. Deregulation of gap junctions is a frequent feature of carcinogenesis. We are characterizing the expression level of a variety of connexins and pannexins in primary and metastatic human tumours. In vitro we are studying how these proteins affect features related to the degree of malignancy such as migration, invasion and resistance to hypoxia. In connexin-deficient cell lines we are over-expressing specific wild-type or truncated forms of connexins and pannexins using retroviral constructs recently generated. In cell lines expressing high levels of specific connexins, we knockdown the expression levels using established lentiviral shRNA strategies. We aim to correlate connexin expression and cell communication with malignancy using a variety of well characterized assays with particular focus on colony formation, migration, invasion, epithelial-to-mesenchymal transition, changes in tumour stem cell populations, and hypoxia and drug resistance. The aim of the study is to: 1) Identify any significant correlation between the expression of various gap junction proteins and the malignancy, prognosis, chemo-resistance and overall survival in a variety of cancers 2) Gain mechanistic insight and identify direct functional roles of connexins and pannexins during tumour progression.

IP: Trond Aasen

Genomic transcriptional profile analysis in proliferative inflammatory atrophy (PIA) as a possible precursor of human prostate cancer

To analyse transcriptional profiles of normal, PIA (proliferative inflammatory atrophy), PIN (prostatic intraepithelial neoplasia) and tumoral prostate using microarrays of selected tumoral tissue of prostatectomy specimens, in order to characterize gene expression modifications in prostate cancer versus PIN and PIA. To analyse the biological response on tumoral / non-tumoral and co-culture them with monocytes in order to study transcriptional profile changes. From all the data obtained, overexpressed / underexpressed genes are being identified and validated. Stromal and inflammatory genes also will be explored for their potential use as early markers for prostatic cancer and their ability to identify PIA as a precursor lesion. (Prostate Research Traslational Unit.)

IP: Inés de Torres Ramirez

Identification of molecular targets associated with tumor progression and therapy resistance in colorectal carcinoma.

Studying in colorectal cancer mechanisms of action of the central signal transduction pathways, identify potential molecular alterations that can be used as therapeutic targets and characterize the degree of genetic inestability.

IP: Santiago Ramon y Cajal Agüeras

Projects

Exploración de la interacción clave entre las uniones tipo gap y los nanotubos de túnel en cáncer

IP: Trond Aasen
Collaborators: -
Funding agency: Asociación Española Contra el Cáncer
Funding: 20000
Reference: AECC/SEMILLA/2019/TROND_2
Duration: 01/11/2020 - 31/10/2022

Protuberancias intercelulares reguladas por Cx43 en cáncer: elucidación funcional, descubrimiento de objetivos, desarrollo de biomarcadores y detección de tumores

IP: Trond Aasen
Collaborators: Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino, Irene Sansano Valero, Konstantin Slobodnyuk , Stefan Hummer
Funding agency: Instituto de Salud Carlos III
Funding: 147620
Reference: PI21/00470
Duration: 01/01/2022 - 31/12/2024

Efectos bifásicos y formas truncadas de la Cx43 en cáncer de mama: aplicaciones pronósticas y terapéuticas

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino
Funding agency: Instituto de Salud Carlos III
Funding: 92565
Reference: PI16/00772
Duration: 01/01/2017 - 30/06/2021

Exploración de la interacción clave entre las uniones tipo gap y los nanotubos de túnel en cáncer

IP: Trond Aasen
Collaborators: -
Funding agency: Asociación Española Contra el Cáncer
Funding: 20000
Reference: AECC/SEMILLA/2019/TROND_2
Duration: 01/11/2020 - 31/10/2022

Efectos bifásicos y formas truncadas de la Cx43 en cáncer de mama: aplicaciones pronósticas y terapéuticas

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino
Funding agency: Instituto de Salud Carlos III
Funding: 92565
Reference: PI16/00772
Duration: 01/01/2017 - 30/06/2021

Exploración de la interacción clave entre las uniones tipo gap y los nanotubos de túnel en cáncer

IP: Trond Aasen
Collaborators: -
Funding agency: Asociación Española Contra el Cáncer
Funding: 20000
Reference: AECC/SEMILLA/2019/TROND_2
Duration: 01/11/2020 - 31/10/2022

Efectos bifásicos y formas truncadas de la Cx43 en cáncer de mama: aplicaciones pronósticas y terapéuticas

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino
Funding agency: Instituto de Salud Carlos III
Funding: 92565
Reference: PI16/00772
Duration: 01/01/2017 - 30/06/2021

Efectos bifásicos y formas truncadas de la Cx43 en cáncer de mama: aplicaciones pronósticas y terapéuticas

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino
Funding agency: Instituto de Salud Carlos III
Funding: 92565
Reference: PI16/00772
Duration: 01/01/2017 - 30/06/2021

El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos , Marta Sese Faustino, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 52998
Reference: PI13/00763
Duration: 01/01/2014 - 31/12/2017

Efectos bifásicos y formas truncadas de la Cx43 en cáncer de mama: aplicaciones pronósticas y terapéuticas

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino
Funding agency: Instituto de Salud Carlos III
Funding: 92565
Reference: PI16/00772
Duration: 01/01/2017 - 30/06/2021

El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos , Marta Sese Faustino, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 52998
Reference: PI13/00763
Duration: 01/01/2014 - 31/12/2017

El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos , Marta Sese Faustino, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 52998
Reference: PI13/00763
Duration: 01/01/2014 - 31/12/2017

El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, El valor diagnóstico, pronóstico y terapéutico de la expresión nuclear de la conexina 43 en tumores humanos , Marta Sese Faustino, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 52998
Reference: PI13/00763
Duration: 01/01/2014 - 31/12/2017

Expression analysis and functional elucidation of connexins in relation to human cancer progression and malignancy

IP: Trond Aasen
Collaborators: Teresa Moline Marimon
Funding agency: Instituto de Salud Carlos III
Funding: 121500
Reference: CP10/00624
Duration: 01/01/2011 - 31/12/2013

Papel de HER3 en la carcinogénesis de tumores de mama y endometrio. Búsqueda de nuevos factores predictivios de respuesta a tratamientos anti-HER

IP: Javier Hernandez Losa
Collaborators: Angel García Jiménez, Vicente Peg Camara
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 49200
Reference: FMM2009/02
Duration: 03/08/2009 - 02/08/2012

Expression analysis and functional elucidation of connexins in relation to human cancer progression and malignancy

IP: Trond Aasen
Collaborators: Teresa Moline Marimon
Funding agency: Instituto de Salud Carlos III
Funding: 121500
Reference: CP10/00624
Duration: 01/01/2011 - 31/12/2013

Papel de HER3 en la carcinogénesis de tumores de mama y endometrio. Búsqueda de nuevos factores predictivios de respuesta a tratamientos anti-HER

IP: Javier Hernandez Losa
Collaborators: Angel García Jiménez, Vicente Peg Camara
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 49200
Reference: FMM2009/02
Duration: 03/08/2009 - 02/08/2012

Expression analysis and functional elucidation of connexins in relation to human cancer progression and malignancy

IP: Trond Aasen
Collaborators: Teresa Moline Marimon
Funding agency: Instituto de Salud Carlos III
Funding: 121500
Reference: CP10/00624
Duration: 01/01/2011 - 31/12/2013

Papel de receptores epidermoides en cáncer. Papel de HER3 en tumores de mama y endometrio

IP: Javier Hernandez Losa
Collaborators: -
Funding agency: Fundación Caja Navarra
Funding: 6713.87
Reference: CAN2009-16662
Duration: 01/01/2010 - 31/12/2010

Papel de HER3 en la carcinogénesis de tumores de mama y endometrio. Búsqueda de nuevos factores predictivios de respuesta a tratamientos anti-HER

IP: Javier Hernandez Losa
Collaborators: Angel García Jiménez, Vicente Peg Camara
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 49200
Reference: FMM2009/02
Duration: 03/08/2009 - 02/08/2012

Papel de HER3 en la carcinogénesis de tumores de mama y endometrio. Búsqueda de nuevos factores predictivios de respuesta a tratamientos anti-HER

IP: Javier Hernandez Losa
Collaborators: Angel García Jiménez, Vicente Peg Camara
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 49200
Reference: FMM2009/02
Duration: 03/08/2009 - 02/08/2012

Publications

Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.

PMID: 34919756
Journal: FASEB JOURNAL
Year: 2022
Reference: FASEB J. 2022 Jan;36(1):e22091. doi: 10.1096/fj.202100819RRR.
Impact factor: 5.192
Publication type: Paper in international publication
Authors: Molina-Berenguer, Miguel; Vila-Julia, Ferran; Perez-Ramos, Sandra; Salcedo-Allende, Maria Teresa; Camara, Yolanda; Torres-Torronteras, Javier; Marti, Ramon et al.
DOI: 10.1096/fj.202100819RRR

Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?

PMID: 34928250
Journal: Journal of Lower Genital Tract Disease
Year: 2022
Reference: J Low Genit Tract Dis. 2022 Jan 1;26(1):20-26. doi: 10.1097/LGT.0000000000000635.
Impact factor: 1.925
Publication type: Paper in international publication
Authors: Bradbury, Melissa; Dinares, Maria Carme; Sainz, Alex; Castellet, Cristina; Perez-Benavente, Assumpcio; Gil-Moreno, Antonio; Centeno, Cristina; Murcia, Maria Teresa; Rabasa, Jordi et al.
DOI: 10.1097/LGT.0000000000000635

Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease.

PMID: 34514662
Journal: BRAIN PATHOLOGY
Year: 2022
Reference: Brain Pathol. 2022 Jan;32(1):e13016. doi: 10.1111/bpa.13016. Epub 2021 Sep 12.
Impact factor: 6.508
Publication type: Paper in international publication
Authors: Camacho, Jessica; Rabano, Alberto; Marazuela, Paula; Bonaterra-Pastra, Anna; Serna, Garazi; Moline, Teresa; Ramon Y Cajal, Santiago; Martinez-Saez, Elena; Hernandez-Guillamon, Mar et al.
DOI: 10.1111/bpa.13016

BCL2 translocation in high grade B cell lymphoma (NOS, DH/TH) is associated with reduced progression free survival.

PMID: 34510996
Journal: LEUKEMIA & LYMPHOMA
Year: 2022
Reference: Leuk Lymphoma. 2022 Jan;63(1):101-108. doi: 10.1080/10428194.2021.1975189. Epub 2021 Sep 11.
Impact factor: 3.28
Publication type: Paper in international publication
Authors: Gonzalez de Villambrosia, Sonia; Bastos, Mariana; Palanca, Javier Menarguez; Cruz, Jorge Gayoso; Navarro, Jose-Tomas; Tapia, Gustavo; Alonso, Sara Alvarez; Martin, Alejandro; Blanco, Oscar; Abrisqueta, Pau et al.
DOI: 10.1080/10428194.2021.1975189

When Is Sentinel Node Biopsy Indicated in High-Risk Ductal Carcinoma in situ? Four Hundred Sixty-Eight Cases from Three Institutions.

PMID: 35087365
Journal: Breast Care
Year: 2021
Reference: Breast Care (Basel). 2021 Dec;16(6):630-636. doi: 10.1159/000514849. Epub 2021 Mar 30.
Impact factor: 2.86
Publication type: Paper in international publication
Authors: Acosta, Juan, Jurado, Judith, Peiró, Ricardo, Gomez, Margarita, Gonzalez-Farré, Xavier, Martinez, Milagros, Luna, Miguel, Peg, Vicente, Gil-Moreno, Antonio, Xiberta, Manel et al.
DOI: 10.1159/000514849

The Role of Sphingolipids Metabolism in Cancer Drug Resistance.

PMID: 35004331
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Dec 23;11:807636. doi: 10.3389/fonc.2021.807636. eCollection 2021.
Impact factor: 6.244
Publication type: Review in international publication
Authors: LLeonart, Matilde Esther, Bataller, Marina, Sanchez-Garcia, Almudena, Garcia-Mayea, Yoelsis, Mir, Cristina, Rodriguez, Isabel et al.
DOI: 10.3389/fonc.2021.807636

Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report.

PMID: 34868006
Journal: Frontiers in Immunology
Year: 2021
Reference: Front Immunol. 2021 Nov 16;12:761798. doi: 10.3389/fimmu.2021.761798. eCollection 2021.
Impact factor: 7.561
Publication type: Paper in international publication
Authors: Marti, Merce, Cortes, Javier, Carrascal, Montserrat, Roura-Mir, Carme, Perez, Jose, Aran, Andrea, Peg, Vicente, Rabanal, Rosa Maria, Bernado, Cristina, Zamora, Esther et al.
DOI: 10.3389/fimmu.2021.761798

Evolution of the Early Spliceosomal Complex-From Constitutive to Regulated Splicing.

PMID: 34830325
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Nov 18;22(22). pii: ijms222212444. doi: 10.3390/ijms222212444.
Impact factor: 5.924
Publication type: Review in international publication
Authors: Ayte, Jose, Hummer, Stefan, Borao, Sonia et al.
DOI: 10.3390/ijms222212444

Autophagy Takes Center Stage as a Possible Cancer Hallmark.

PMID: 33194736
Journal: Frontiers in Oncology
Year: 2020
Reference: Front Oncol. 2020 Oct 22;10:586069. doi: 10.3389/fonc.2020.586069. eCollection 2020.
Impact factor: 4.848
Publication type: Review in international publication
Authors: Kondoh, Hiroshi, Alvarez-Meythaler, Jose G, Garcia-Mayea, Yoelsis, Mir, Cristina, LLeonart, Matilde E et al.
DOI: 10.3389/fonc.2020.586069

TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance.

PMID: 33167355
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Nov 5;12(11). pii: cancers12113269. doi: 10.3390/cancers12113269.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Garcia-Mayea, Yoelsis, Mir, Cristina, Carballo, Laia, Castellvi, Josep, Temprana-Salvador, Jordi, Lorente, Juan, Benavente, Sergi, Garcia-Pedrero, Juana M, Allonca, Eva, Rodrigo, Juan P et al.
DOI: 10.3390/cancers12113269

#EBUSTwitter: Novel Use of Social Media for Conception, Coordination, and Completion of an International, Multicenter Pathology Study.

PMID: 31846366
Journal: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Year: 2020
Reference: Archives of Pathology & Laboratory Medicine. 2020 Jul 1;144(7):878-82. doi: 10.5858/arpa.2019-0297-OA.
Impact factor: 4.094
Publication type: Paper in international publication
Authors: Lepe, Marcos, Oltulu, Pembe, Canepa, Mariana, Wu, Roseann I, Deeken, Amy, Alex, Deepu, Dinares, Carme, Doxtader, Erika E, Fitzhugh, Valerie A, Gibier, Jean-Baptiste et al.
DOI: 10.5858/arpa.2019-0297-OA

Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis.

PMID: 33147489
Journal: Cell Stem Cell
Year: 2020
Reference: Cell Stem Cell. 2020 Dec 3;27(6):920-936.e8. doi: 10.1016/j.stem.2020.10.002. Epub 2020 Nov 3.
Impact factor: 20.86
Publication type: Paper in international publication
Authors: Saade, Murielle, Ferrero, Diego S, Blanco-Ameijeiras, Jose, Gonzalez-Gobartt, Elena, Flores-Mendez, Marco, Ruiz-Arroyo, Victor M, Martinez-Saez, Elena, Ramon Y Cajal, Santiago, Akizu, Naiara, Verdaguer, Nuria et al.
DOI: 10.1016/j.stem.2020.10.002

Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients.

PMID: 32699985
Journal: Oncology and therapy
Year: 2019
Reference: Oncol Ther. 2019 Dec;7(2):131-139. doi: 10.1007/s40487-019-00099-9. Epub 2019 Aug 19.
Impact factor: 0
Publication type: Paper in international publication
Authors: Sese, Marta, Somoza, Rosa, Maestu, Inmaculada, Ureste, Maria Martin, Sanchez, Alfredo, Cordoba, Juan Felipe, Sansano, Irene, Venturas, Griselda, Ramon Y Cajal, Santiago, Hernandez-Losa, Javier et al.
DOI: 10.1007/s40487-019-00099-9

Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH.

PMID: 31882668
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Dec 27;9(1):20183. doi: 10.1038/s41598-019-56366-2.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Hide, Diana, Fernandez-Iglesias, Anabel, Gil, Mar, Barbera, Aurora, Salcedo, Maria Teresa, Augustin, Salvador, Genesca, Joan, Martell, Maria, Raurell, Imma, Bravo, Miren et al.
DOI: 10.1038/s41598-019-56366-2

Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast.

PMID: 30910878
Journal: EMBO JOURNAL
Year: 2019
Reference: EMBO J. 2019 May 15;38(10). pii: embj.2018100373. doi: 10.15252/embj.2018100373. Epub 2019 Mar 25.
Impact factor: 11.227
Publication type: Paper in international publication
Authors: Stahl, Timo, Hummer, Stefan, Ehrenfeuchter, Nikolaus, Mittal, Nitish, Fucile, Geoffrey, Spang, Anne et al.
DOI: 10.15252/embj.2018100373

Sex Hormone-Binding Globulin Expression Correlates with Acetyl-CoA Carboxylase and Triglyceride Content in Human Liver.

PMID: 30496542
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2019
Reference: J Clin Endocrinol Metab. 2019 May 1;104(5):1500-1507. doi: 10.1210/jc.2018-00740.
Impact factor: 5.605
Publication type: Paper in international publication
Authors: Saez-Lopez, Cristina, Salcedo-Allende, Maria Teresa, Hernandez, Cristina, Simo-Servat, Olga, Simo, Rafael, Selva, David M et al.
DOI: 10.1210/jc.2018-00740

Phenformin-induced mitochondrial dysfunction sensitizes hepatocellular carcinoma for dual inhibition of mTOR.

PMID: 32177313
Journal: ANNALS OF ONCOLOGY
Year: 2018
Reference: Ann Oncol. 2018 Jun;29 Suppl 5:v91. doi: 10.1093/annonc/mdy151.323. Epub 2020 Jan 7.
Impact factor: 13.926
Publication type: Letter or abstract
Authors: Veiga, S, Ge, X, Mercer, C, Hernandez-Alvarez, M, Thomas, H, Hernandez-Losa, J, Cajal, S R Y, Zorzano, A, Thomas, G, Kozma, S et al.
DOI: 10.1093/annonc/mdy151.323

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.

PMID: 29921958
Journal: NATURE MEDICINE
Year: 2018
Reference: Nat Med. 2018 Sep;24(9):1481. doi: 10.1038/s41591-018-0108-5.
Impact factor: 32.621
Publication type: Letter or abstract
Authors: Priego, Neibla, Zhu, Lucia, Monteiro, Catia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martinez, Liliana, Martinez-Saez, Elena, Ramon Y Cajal, Santiago et al.
DOI: 10.1038/s41591-018-0108-5

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.

PMID: 29169064
Journal: CURRENT OPINION IN GENETICS & DEVELOPMENT
Year: 2018
Reference: Curr Opin Genet Dev. 2018 Feb;48:89-96. doi: 10.1016/j.gde.2017.11.002. Epub 2017 Nov 21.
Impact factor: 5.825
Publication type: Review in national publication
Authors: Chu, Jennifer, Cajal, Santiago Ramon Y, Sonenberg, Nahum, Pelletier, Jerry et al.
DOI: 10.1016/j.gde.2017.11.002

The ever-evolving role of pathologists in the management of breast cancer with neoadjuvant treatment: recommendations based on the Spanish clinical experience.

PMID: 28795336
Journal: Clinical & Translational Oncology
Year: 2018
Reference: Clin Transl Oncol. 2018 Mar;20(3):382-391. doi: 10.1007/s12094-017-1725-z. Epub 2017 Aug 9.
Impact factor: 2.353
Publication type: Paper in international publication
Authors: Burgues, O, Lopez-Garcia, M feminine A, Perez-Mies, B, Santiago, P, Vieites, B, Garcia, J F, Peg, V et al.
DOI: 10.1007/s12094-017-1725-z

Corrigendum: Pio del Rio-Hortega: A Visionary in the Pathology of Central Nervous System Tumors.

PMID: 28381992
Journal: Frontiers in Neuroanatomy
Year: 2017
Reference: Front Neuroanat. 2017 Apr 3;11:27. doi: 10.3389/fnana.2017.00027. eCollection 2017.
Impact factor: 3.267
Publication type: Letter or abstract
Authors: Ramon Y Cajal Agueras, Santiago et al.
DOI: 10.3389/fnana.2017.00027

Prevalence and clinical association of MET gene overexpression and amplification in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape project.

PMID: 28838386
Journal: LUNG CANCER
Year: 2017
Reference: Lung Cancer. 2017 Sep;111:143-149. doi: 10.1016/j.lungcan.2017.07.021. Epub 2017 Jul 22.
Impact factor: 4.294
Publication type: Paper in international publication
Authors: Verbeken, Eric K, Warth, Arne, Sansano, Irene, Cheney, Richard, Speel, Ernst Jan M, Nonaka, Daisuke, Monkhorst, Kim, Hager, Henrik, Martorell, Miguel, Savic, Spasenija et al.
DOI: 10.1016/j.lungcan.2017.07.021

Intraoperative assessment of sentinel lymph node by one-step nucleic acid amplification in breast cancer patients after neoadjuvant treatment reduces the need for a second surgery for axillary lymph node dissection.

PMID: 27810698
Journal: BREAST
Year: 2017
Reference: Breast. 2017 Feb;31:40-45. doi: 10.1016/j.breast.2016.10.002. Epub 2016 Nov 2.
Impact factor: 2.74
Publication type: Paper in international publication
Authors: Espinosa-Bravo, Martin, Navarro-Cecilia, Joaquin, Diaz-Botero, Sebastian, Duenas Rodriguez, Basilio, Luque Lopez, Carolina, Ramos Grande, Teresa, Ruano Perez, Ricardo, Peg, Vicente, Rubio, Isabel T, Ramos Boyero, Manuel et al.
DOI: 10.1016/j.breast.2016.10.002

Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-beta signaling and malignant features in vitro and in vivo.

PMID: 29383126
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Dec 12;8(70):114856-114876. doi: 10.18632/oncotarget.23145. eCollection 2017 Dec 29.
Impact factor: 5.168
Publication type: Paper in international publication
Authors: Esteve-Codina, Anna, Bejar, Eva, McGrail, Kimberley, Thomas, George, Aasen, Trond, Ramon Y Cajal, Santiago, Fuentes, Pedro, Sese, Marta et al.
DOI: 10.18632/oncotarget.23145

Pio del Rio-Hortega: A Pioneer in the Pathology of Central Nervous System Tumors.

PMID: 26973470
Journal: Frontiers in Neuroanatomy
Year: 2016
Reference: Front Neuroanat. 2016 Mar 1;10:13. doi: 10.3389/fnana.2016.00013. eCollection 2016.
Impact factor: 3.26
Publication type: Review in international publication
Authors: Ramon Y Cajal Agueras, Santiago et al.
DOI: 10.3389/fnana.2016.00013

Diagnostic imaging in spontaneous rupture of a thoracic duct cyst in the mediastinum.

PMID: 27117300
Journal: Radiologia
Year: 2016
Reference: Radiologia. 2016 Nov - Dec;58(6):491-495. doi: 10.1016/j.rx.2016.03.002. Epub 2016 Apr 23.
Impact factor: 0
Publication type: Paper in national publication
Authors: Varona Porres, D, Persiva, O, Pallisa, E, Sansano, I et al.
DOI: 10.1016/j.rx.2016.03.002

Analysis of expression of PTEN/PI3K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM).

PMID: 27133741
Journal: LUNG CANCER
Year: 2016
Reference: Lung Cancer. 2016 Jun;96:1-6. doi: 10.1016/j.lungcan.2016.03.001. Epub 2016 Mar 10.
Impact factor: 3.767
Publication type: Paper in international publication
Authors: Cedres, S, Ponce-Aix, S, Pardo-Aranda, N, Navarro-Mendivil, A, Martinez-Marti, A, Zugazagoitia, J, Sansano, I, Montoro, M A, Enguita, A, Felip, E et al.
DOI: 10.1016/j.lungcan.2016.03.001

A patient with suspected non-ST elevation acute myocardial infarction and remarkably high brain natriuretic peptide levels.

PMID: 26440456
Journal: INTERNATIONAL JOURNAL OF CARDIOLOGY
Year: 2016
Reference: Int J Cardiol. 2016 Jan 1;202:485-7. doi: 10.1016/j.ijcard.2015.09.048. Epub 2015 Sep 25.
Impact factor: 4.036
Publication type: Paper in international publication
Authors: Baneras, Jordi, Buera, Irene, Oristrell, Gerard, Sansano, Irene, Fort, Joan, Ibernon, Meritxell, Marti, Gerard, Barrabes, Jose A, Dorado, David Garcia et al.
DOI: 10.1016/j.ijcard.2015.09.048

Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor.

PMID: 26306972
Journal: NEFROLOGIA
Year: 2015
Reference: Nefrologia. 2015;35(5):479-86. doi: 10.1016/j.nefro.2015.05.026. Epub 2015 Jul 7.
Impact factor: 1.223
Publication type: Paper in national publication
Authors: Jatem Escalante, Elias, Segarra Medrano, Alfons, Carnicer Caceres, Clara, Martin-Gomez, M Adoracion, Salcedo Allende, Maria Teresa, Ostos Roldan, Helena, Agraz Pamplona, Irene et al.
DOI: 10.1016/j.nefro.2015.05.026

Predictive value and clinical utility of centrally assessed ER, PgR, and Ki-67 to select adjuvant endocrine therapy for premenopausal women with hormone receptor-positive, HER2-negative early breast cancer: TEXT and SOFT trials.

PMID: 26493064
Journal: BREAST CANCER RESEARCH AND TREATMENT
Year: 2015
Reference: Breast Cancer Res Treat. 2015 Nov;154(2):275-86. doi: 10.1007/s10549-015-3612-z. Epub 2015 Oct 22.
Impact factor: 3.94
Publication type: Paper in international publication
Authors: Regan, Meredith M, Pagani, Olivia, Francis, Prudence A, Fleming, Gini F, Walley, Barbara A, Kammler, Roswitha, Dell'Orto, Patrizia, Russo, Leila, Szoke, Janos, Doimi, Franco et al.
DOI: 10.1007/s10549-015-3612-z

Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report.

PMID: 26707330
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2015
Reference: Transplant Proc. 2015 Dec;47(10):3016-9. doi: 10.1016/j.transproceed.2015.10.036.
Impact factor: 0.982
Publication type: Paper in international publication
Authors: Vellalta, G, Dopazo, C, Bilbao, I, Lazaro, J L, Montero, A, Salcedo, M T, Caralt, M, Charco, R, Sapisochin, G, Castells, L et al.
DOI: 10.1016/j.transproceed.2015.10.036

Long-term follow-up of dose-adjusted EPOCH plus rituximab (DA-EPOCH-R) in untreated patients with poor prognosis large B-cell lymphoma. A phase II study conducted by the Spanish PETHEMA Group.

PMID: 25521006
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2015
Reference: Br J Haematol. 2015 Apr;169(2):188-98. doi: 10.1111/bjh.13273. Epub 2014 Dec 18.
Impact factor: 4.959
Publication type: Paper in international publication
Authors: Purroy, Noelia, Bergua, Juan, Gallur, Laura, Prieto, Julio, Lopez, Luis A, Sancho, Juan M, Garcia-Marco, Jose A, Castellvi, Josep, Montes-Moreno, Santiago, Batlle, Ana et al.
DOI: 10.1111/bjh.13273

Prevalence, diagnostic value and clinical characteristics associated with the presence of circulating levels and renal deposits of antibodies against the M-type phospholipase A2 receptor in idiopathic membranous nephropathy.

PMID: 24798555
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014 May 21;34(3):353-9. doi: 10.3265/Nefrologia.pre2013.Dec.12291. Epub 2014 Feb 10.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Segarra-Medrano, Alfonso, Jatem-Escalante, Elias, Quiles-Perez, M Teresa, Salcedo, M Teresa, Arbos-Via, M Antonia, Ostos, Helena, Valtierra, Naiara, Carnicer-Caceres, Clara, Agraz-Pamplona, Irene et al.
DOI: 10.3265/Nefrologia.pre2013.Dec.12291

Evolution of antibody titre against the M-type phospholipase A2 receptor and clinical response in idiopathic membranous nephropathy patients treated with tacrolimus.

PMID: 25036063
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014;34(4):491-7. doi: 10.3265/Nefrologia.pre2014.Jun.12536.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Segarra-Medrano, Alfons, Jatem-Escalante, Elias, Carnicer-Caceres, Clara, Salcedo, M Teresa, Agraz-Pamplona, Irene, Valtierra, Naiara, Ostos-Roldan, Elena, Arredondo, Karla V, Jaramillo, Juliana et al.
DOI: 10.3265/Nefrologia.pre2014.Jun.12536

Sarcoidosis with complications.

PMID: 24619326
Journal: INTERN EMERG MED
Year: 2014
Reference: Intern Emerg Med. 2014 Oct;9(7):817-8. doi: 10.1007/s11739-014-1067-6. Epub 2014 Mar 12.
Impact factor: 2.41
Publication type: Letter or abstract
Authors: Fernandez-Codina, Andreu, Aleman, Carmen, Simon-Talero, Macarena, Salcedo-Allende, Maria Teresa, Pinal-Fernandez, Iago, Segura-Garcia, Antonio et al.
DOI: 10.1007/s11739-014-1067-6

Autoimmune pancreatitis type-1 associated with intraduct papillary mucinous neoplasm: report of two cases.

PMID: 25062884
Journal: PANCREATOLOGY
Year: 2014
Reference: Pancreatology. 2014 Jul-Aug;14(4):316-8. doi: 10.1016/j.pan.2014.04.032. Epub 2014 May 9.
Impact factor: 2.504
Publication type: Letter or abstract
Authors: Vaquero, Eva C, Salcedo, Maria T, Cuatrecasas, Miriam, De Leon, Hannah, Merino, Xavier, Navarro, Salvador, Gines, Angels, Abu-Suboh, Monder, Balsells, Joaquim, Fernandez-Cruz, Laureano et al.
DOI: 10.1016/j.pan.2014.04.032

Adaptive resistance to targeted therapies in cancer.

PMID: 25806228
Journal: Translational lung cancer research
Year: 2013
Reference: Transl Lung Cancer Res. 2013 Jun;2(3):152-9. doi: 10.3978/j.issn.2218-6751.2012.12.08.
Impact factor: 0
Publication type: Review in international publication
Authors: Gasco, Amaya, Rosell, Rafael, Karachaliou, Niki, Morales-Espinosa, Daniela, Costa, Carlota, Molina, Miguel Angel, Sansano, Irene, Wei, Jia, Gonzalez Cao, Maria, Martinez Bueno, Alejandro et al.
DOI: 10.3978/j.issn.2218-6751.2012.12.08

A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers.

PMID: 22641219
Journal: ONCOGENE
Year: 2013
Reference: Oncogene. 2013 Mar 14;32(11):1452-9. doi: 10.1038/onc.2012.152. Epub 2012 May 28.
Impact factor: 7.357
Publication type: Paper in international publication
Authors: Ibrahim, Y H, Bernado Morales, C, Peg, V, Bech-Serra, J J, Pandiella, A, Canals, F, Baselga, J, Rubio, I, Arribas, J, Parra-Palau, J L et al.
DOI: 10.1038/onc.2012.152

Intraoperative molecular analysis of total tumor load in sentinel lymph node: a new predictor of axillary status in early breast cancer patients.

PMID: 23576079
Journal: BREAST CANCER RESEARCH AND TREATMENT
Year: 2013
Reference: Breast Cancer Res Treat. 2013 May;139(1):87-93. doi: 10.1007/s10549-013-2524-z. Epub 2013 Apr 11.
Impact factor: 4.469
Publication type: Paper in international publication
Authors: Espinosa-Bravo, Martin, Peg, Vicente, Vieites, Begona, Vilardell, Felip, Antunez, Jose R, de Salas, Magdalena Sancho, Delgado-Sanchez, Julio J, Pinto, Willy, Gozalbo, Francisco, Petit, Anna et al.
DOI: 10.1007/s10549-013-2524-z

Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity.

PMID: 24384914
Journal: Scientific Reports
Year: 2013
Reference: Sci Rep. 2013 Dec 18;3:3544. doi: 10.1038/srep03544.
Impact factor: 2.927
Publication type: Paper in international publication
Authors: Cortes, Javier, Tabernero, Josep, Felip, Enriqueta, Cajal, Santiago Ramony, Prat, Aleix, Adamo, Barbara, Fan, Cheng, Peg, Vicente, Vidal, Maria, Galvan, Patricia et al.
DOI: 10.1038/srep03544

p38alpha limits the contribution of MAP17 to cancer progression in breast tumors.

PMID: 22266858
Journal: ONCOGENE
Year: 2012
Reference: Oncogene. 2012 Oct 11;31(41):4447-59. doi: 10.1038/onc.2011.619. Epub 2012 Jan 23.
Impact factor: 6.373
Publication type: Paper in international publication
Authors: Guijarro, M V, Vergel, M, Marin, J J, Munoz-Galvan, S, Ferrer, I, Ramon y Cajal, S, Roncador, G, Blanco-Aparicio, C, Carnero, A et al.
DOI: 10.1038/onc.2011.619

Sub-frontal approach in the treatment of esthesioneuroblastoma

PMID: 91000018
Journal: Revista Española de Cirugía Oral y Maxilofacial
Year: 2012
Reference: Rev Esp Cirug Oral y Maxilofac vol.36 no.4 Barcelona oct./dic. 2014
Impact factor: 0.3
Publication type: Paper in national publication
Authors: Mogedas Vegara, Alfonso, Gutierrez Santamaria, Javier, Lliset Rosa, Sahuquillo Barris, Joan, Ramón y Cajal Agüeras, Santiago, Malet Hernández, Daniel et al.
DOI: 10.1016/j.maxilo.2012.09.007

[Translation and validation of the Spanish version of the EAT-10 (Eating Assessment Tool-10) for the screening of dysphagia].

PMID: 23588456
Journal: Nutricion Hospitalaria
Year: 2012
Reference: Nutr Hosp. 2012 Nov-Dec;27(6):2048-54. doi: 10.3305/nh.2012.27.6.6100.
Impact factor: 1.12
Publication type: Paper in national publication
Authors: Perez-Portabella, C, Burgos, R, Sarto, B, Segurola, H, Romagosa, A, Puiggros, C, Vazquez, C, Cardenas, G, Barcons, N, Araujo, K et al.
DOI: 10.3305/nh.2012.27.6.6100

Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients.

PMID: 23355916
Journal: World journal of hepatology
Year: 2012
Reference: World J Hepatol. 2012 Dec 27;4(12):382-8. doi: 10.4254/wjh.v4.i12.382.
Impact factor: 2.62
Publication type: Paper in international publication
Authors: Vargas, Victor, Allende, Helena, Lecube, Albert, Salcedo, Maria Teresa, Baena-Fustegueras, Juan A, Fort, Jose M, Rivero, Joaquin, Ferrer, Roser, Catalan, Roberto, Pardina, Eva et al.
DOI: 10.4254/wjh.v4.i12.382

Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.

PMID: 22164285
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011;6(12):e28406. doi: 10.1371/journal.pone.0028406. Epub 2011 Dec 2.
Impact factor: 4.411
Publication type: Paper in international publication
Authors: Galan-Moya, Eva M, Llanos Valero, Maria, Callejas-Valera, Juan L, Melgar-Rojas, Pedro, Hernadez Losa, Javier, Salcedo, Mayte, Fernandez-Aramburo, Antonio, Ramon y Cajal, Santiago, Sanchez-Prieto, Ricardo, de la Cruz-Morcillo, Miguel A et al.
DOI: 10.1371/journal.pone.0028406

Modeling pharmacological inhibition of mast cell degranulation as a therapy for insulinoma.

PMID: 22131884
Journal: NEOPLASIA
Year: 2011
Reference: Neoplasia. 2011 Nov;13(11):1093-100.
Impact factor: 5.476
Publication type: Paper in international publication
Authors: Buggy, Joseph J, Kortlever, Roderik, Adimoolam, Shanthi, Monclus, Helena Allende, Allende, Maria Teresa Salcedo, Swigart, Lamorna Brown, Evan, Gerard I, Soucek, Laura et al.
DOI:

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis.

PMID: 21598252
Journal: JOURNAL OF PATHOLOGY
Year: 2011
Reference: J Pathol. 2011 Sep;225(1):73-82. doi: 10.1002/path.2905. Epub 2011 May 19.
Impact factor: 7.274
Publication type: Paper in international publication
Authors: Molina-Pinelo, Sonia, Ferrer, Irene, Blanco-Aparicio, Carmen, Peregrino, Sandra, Pastor, Maria Dolores, Alvarez-Vega, Juan, Suarez, Rocio, Verge, Mar, Marin, Juan J, Hernandez-Losa, Javier et al.
DOI: 10.1002/path.2905

KAP Degradation by Calpain Is Associated with CK2 Phosphorylation and Provides a Novel Mechanism for Cyclosporine A-Induced Proximal Tubule Injury.

PMID: 21980535
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011;6(9):e25746. Epub 2011 Sep 28.
Impact factor: 4.411
Publication type: Paper in international publication
Authors: Tornavaca, Olga, Sarro, Eduard, Pascual, Gloria, Bardaji, Beatriz, Montero, M Angeles, Salcedo, M Teresa, Plana, Maria, Lopez-Hellin, Joan, Itarte, Emilio, Meseguer, Anna et al.
DOI: 10.1371/journal.pone.0025746

Differences in the Form of Presentation between Papillary Microcarcinomas and Papillary Carcinomas of Larger Size.

PMID: 21209704
Journal: Journal of thyroid research
Year: 2010
Reference: J Thyroid Res. 2010 Dec 14;2011:639156.
Impact factor:
Publication type: Letter or abstract
Authors: Zafon, Carles, Baena, Juan Antonio, Castellvi, Josep, Obiols, Gabriel, Monroy, Gabriela, Mesa, Jordi et al.
DOI: 10.4061/2011/639156

Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer.

PMID: 21167064
Journal: Journal of Translational Medicine
Year: 2010
Reference: J Transl Med. 2010 Dec 18;8:135. doi: 10.1186/1479-5876-8-135.
Impact factor: 3.407
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1186/1479-5876-8-135

A Major Role of p95/611-CTF, a Carboxy-Terminal Fragment of HER2, in the Down-modulation of the Estrogen Receptor in HER2-Positive Breast Cancers.

PMID: 20978202
Journal: CANCER RESEARCH
Year: 2010
Reference: Cancer Res. 2010 Nov 1;70(21):8537-46. Epub 2010 Oct 26.
Impact factor: 7.543
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1158/0008-5472.CAN-10-1701

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.

PMID: 20798505
Journal: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Year: 2010
Reference: Cell Physiol Biochem. 2010;26(2):219-26. Epub 2010 Aug 24.
Impact factor: 3.563
Publication type: Paper in international publication
Authors: Bielanska, Joanna, Hernandez-Losa, Javier, Moline, Teresa, Somoza, Rosa, Ramon Y Cajal, Santiago, Condom, Enric, Ferreres, Joan Carles, Felipe, Antonio et al.
DOI: 10.1159/000320528

[Karnosfsky index as a mortality predicting factor in patients on home-based enteral nutrition].

PMID: 19593485
Journal: Nutricion Hospitalaria
Year: 2009
Reference: Nutr Hosp. 2009 Mar-Apr;24(2):156-60.
Impact factor: 1.096
Publication type: Paper in national publication
Authors: Puiggros, C, Lecha, M, Rodriguez, T, Perez-Portabella, C, Planas, M et al.
DOI:

[Nutritional support in the home-based hospitalization setting].

PMID: 19266120
Journal: Nutricion Hospitalaria
Year: 2009
Reference: Nutr Hosp. 2009 Jan-Feb;24(1):93-6.
Impact factor: 1.096
Publication type: Paper in national publication
Authors: Chicharro, L, Planas, M, Perez-Portabella, C, Velez, C, San Jose, A et al.
DOI:

[Immediate complications of feeding percutaneous gastrostomy: a 10-year experience].

PMID: 19266117
Journal: Nutricion Hospitalaria
Year: 2009
Reference: Nutr Hosp. 2009 Jan-Feb;24(1):73-6.
Impact factor: 1.096
Publication type: Paper in national publication
Authors: Perez-Portabella, C, Planas, M, Cots, I, Puiggros, C, Chicharro, L et al.
DOI:

Clinico-pathological discrepancies in the diagnosis of causes of maternal death in sub-Saharan Africa: retrospective analysis.

PMID: 19243215
Journal: PLOS MEDICINE
Year: 2009
Reference: PLoS Med. 2009 Feb 24;6(2):e1000036.
Impact factor: 12.185
Publication type: Paper in international publication
Authors: Ordi, Jaume, Ismail, Mamudo R, Carrilho, Carla, Romagosa, Cleofe, Osman, Nafissa, Machungo, Fernanda, Bombi, Josep A, Balasch, Juan, Alonso, Pedro L, Menendez, Clara et al.
DOI: 10.1371/journal.pmed.1000036

Thesis

Estudio patológico de biomarcadores en la angiopatía amiloide cerebral y la enfermedad de Alzheimer

PhD student: Jessica Camacho Soriano
Director/s: Maria Mar Hernandez Guillamon, Elena Antima Martinez Saez, Santiago Ramon y Cajal Agüeras
University: Universitat Autònoma de Barcelona
Year: 2021

Biòpsia selectiva del gangli sentinella en el carcinoma papil·lar de tiroide. Anàlisi morfològica i valor de la càrrega tumoral ganglionar

PhD student: Carmela Iglesias i Felip
Director/s: Santiago Ramon y Cajal Agüeras
University: Universitat Autònoma de Barcelona
Year: 2020

Significant roles of ITGB3 in the tumour microenvironment: EMT driver in hypoxic conditions and central axis in intercellular communication

PhD student: Pedro Fuentes Varela
Director/s: Santiago Ramon y Cajal Agüeras
University: Universitat Autònoma de Barcelona
Year: 2020

Internal Translation of Truncated Gap Junction Proteins in Health and Disease: Generation, Regulation and Function

PhD student: Maria José Muñoz Guijarro
Director/s: Trond Aasen
University: Universitat Autònoma de Barcelona
Year: 2019

Estudio de nuevas aproximaciones terapéuticas para la regeneración neural y el tratamiento de la espina bífida mediante el uso de terapia celular durante la etapa fetal

PhD student: Alejandra Fernández Martín
Director/s: Mario Marotta Baleriola, José Luis Peiró Ibáñez
University: Universitat Autònoma de Barcelona
Year: 2017

Estudi de la via de senyalització de 4E-BP1. lmplicacions pronostiques i terapeutiques en el melanoma uveal

PhD student: Mª Carme Dinarès Fernández
Director/s: Santiago Ramon y Cajal Agüeras, Javier Hernandez Losa
University: Universitat Autònoma de Barcelona
Year: 2017

Evaluación de factores moleculares asociados a la respuesta a CETUXIMAB: Integración con tratamientos de radioterapia y quimiterapia en carcinoma escamoso de cabeza y cuello

PhD student: Maria Eugenia Semidey Raven
Director/s: Santiago Ramon y Cajal Agüeras, Margarita Alberola Ferranti, Jordi Giralt López de Sagred
University: Universitat Autònoma de Barcelona
Year: 2016

Valoración de la expresión inmunohistoquímica en microarrays tisulares de RACK1, 4ebp1, p53 y Ki-67 en tumores colorrectales con correlación clínico patológica

PhD student: Paul Augusto Espinoza Madrid
Director/s: Santiago Ramon y Cajal Agüeras, Miriam Cuatrecasas Freixas
University: Universitat Autònoma de Barcelona
Year: 2016

Estudio de las Vias de señalización en cáncer de ovario y de endometrio: Implicaciones en el pronóstico

PhD student: Josep Castellví Vives
Director/s: Santiago Ramon y Cajal Agüeras, Angel García Jiménez
University: Universitat Autònoma de Barcelona
Year: 2016

Trombofilia y embarazo

PhD student: Elena Antima Martinez Saez
Director/s: Amparo Santamaría Ortiz
University: Universitat Autònoma de Barcelona
Year: 2016

Estudio de vías de señalización celular en astrocitomas infiltrantes difusos

PhD student: Elena Antima Martinez Saez
Director/s: Santiago Ramon y Cajal Agüeras
University: Universitat Autònoma de Barcelona
Year: 2015

Neoplasia intraepitelial pancreática y adenocarcinoma ductal de páncreas: Estudio de factores de las vías de señalización celular y su correlación con la clínica

PhD student: Maria Teresa Salcedo Allende
Director/s: Santiago Ramon y Cajal Agüeras, Javier Hernandez Losa
University: Universitat Autònoma de Barcelona
Year: 2015

Carga tumoral total en el ganglio centinela de pacientes con cáncer de mama en estadios iniciales

PhD student: Vicente Peg Camara
Director/s: Santiago Ramon y Cajal Agüeras, Isabel Teresa Rubio Rodríguez, Josep Lluis Parra Palau
University: Universitat Autònoma de Barcelona
Year: 2015

Estudio de la fosforilación de eIF4E y del factor 4E-T en situaciones de estrés celular en cáncer de mama

PhD student: Alba Martinez Diaz
Director/s: Santiago Ramon y Cajal Agüeras, Trond Aasen
University: Universitat Autònoma de Barcelona
Year: 2014

Estudio de vías de señalización en sarcomas

PhD student: César Serrano Garcia
Director/s: Santiago Ramon y Cajal Agüeras, Joan Carles Galceran, Cleofé Romagosa Pérez-Portabell
University: Universitat Autònoma de Barcelona
Year: 2014

Blog

News

On World Cancer Research Day, we highlight the impact of VHIR projects in the field of oncology.

The international study incorporates new magnetic resonance markers to increase sensitivity in the diagnosis of this disease.

The drug EB1 is able to block resistance pathways to standard cancer treatments and could increase the efficacy of chemotherapy or immunotherapy.

Job offers

Technician Specialist Pathology
Start date:
12/07/2022
End date:
31/07/2022
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Research technician translational molecular pathology research group
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19/05/2022
End date:
03/06/2022
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PhD position in Translational Molecular Pathology..
Start date:
04/10/2021
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18/10/2021
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