Metastasis model obtained by intravenous injection

Metastasis model obtained by intravenous injection (human model)

Induction of migraine by administration of a nitric oxide donor: A solution of nitroglycerin (10 mg / Kg) or vehicle will be injected intraperitoneally once a day on alternate days (1, 3, 5, 7 and 9 post-basal).or inflammatory mediators infuse under anesthesia a solution containing histamine (1 mM), serotonin (1 mM), bradykinin (1 mM) and prostaglandin E2 (100 μM) or vehicle in the duramater on alternate days on days 1, 3, 5, 7 and 9 of the procedure) Location of a wireless EEG/EMG recording implant on the skull that allows continuous neurophysiological recording to assess cortical activity, movement patterns and sleep/wake cycle Animals habituation to different variables that will be found during the behavior test

This mouse model generate spontaneous hipermutant small intestinal tumors and CRC tumors (when treated with DSS)

This mouse model generate spontaneous hipermutant small intestinal braf mutant tumors and CRC tumors (when treated with DSS)

Tumor cells will be inoculated in the lateral tail vein.

Tumor induction by injection of different cell lines that have been derived from UV-induced melanoma models and patientd derived xenografts

The kidney transplant species will be wistar and the recipient Lewis, which are full MHC mismatch. This method provides us the natural immunological response of two genetically different species with a mixed transplant rejection of the organ.

Bone marrow transplantation is performed ussing either autologous or allogeneic bone marrow stem cells from either recipient C57BL/6 mice or donor Balb/c mice, respectively. Such cell transplantation is performed after a conditioning regimen based on either with or without total body irradiation and cyclofosfamide.

The heart transplant species will be Balb/c and the recipient C57BL/6, which are full MHC mismatch. This method provides us the natural immunological response of two genetically different species with a mixed transplant rejection of the organ.